The genomic landscape of ribosomal peptides containing thiazole and oxazole heterocycles

HIV Protease Inhibitors Block Streptolysin S Production

(2015) Tucker Maxson et al.   ACS Chemical Biology

Insights into Methyltransferase Specificity and Bioactivity of Derivatives of the Antibiotic Plantazolicin

(2015) Yue Hao et al.   ACS Chemical Biology

Enzyme Function Initiative-Enzyme Similarity Tool (EFI-EST): A web tool for generating protein sequence similarity networks

(2015) John A. Gerlt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Identification of the minimal cytolytic unit for streptolysin S and an expansion of the toxin family

(2015) Evelyn M. Molloy et al.   BMC MICROBIOLOGY

Identification of an Auxiliary Leader Peptide-Binding Protein Required for Azoline Formation in Ribosomal Natural Products

(2015) Kyle L. Dunbar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemoenzymatic Synthesis of Thiazolyl Peptide Natural Products Featuring an Enzyme-Catalyzed Formal [4 + 2] Cycloaddition

(2015) Walter J. Wever et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A prevalent peptide-binding domain guides ribosomal natural product biosynthesis

(2015) Brandon J Burkhart et al.   Nature Chemical Biology

High Divergence of the Precursor Peptides in Combinatorial Lanthipeptide Biosynthesis

(2014) Qi Zhang et al.   ACS Chemical Biology

Discovery of a new ATP-binding motif involved in peptidic azoline biosynthesis

(2014) Kyle L Dunbar et al.   Nature Chemical Biology

Revealing Nature’s Synthetic Potential Through the Study of Ribosomal Natural Product Biosynthesis

(2013) Kyle L. Dunbar et al.   ACS Chemical Biology

Comparative genomics of actinomycetes with a focus on natural product biosynthetic genes

(2013) James R Doroghazi et al.   BMC GENOMICS

Arg-Thz is a minimal substrate for the Nα,Nα-arginyl methyltransferase involved in the biosynthesis of plantazolicin

(2013) Natalia A. Piwowarska et al.   CHEMICAL COMMUNICATIONS

Structure of Microcin B-Like Compounds Produced by Pseudomonas syringae and Species Specificity of Their Antibacterial Action

(2013) M. Metelev et al.   JOURNAL OF BACTERIOLOGY

Novel Twin Streptolysin S-Like Peptides Encoded in the sag Operon Homologue of Beta-Hemolytic Streptococcus anginosus

(2013) A. Tabata et al.   JOURNAL OF BACTERIOLOGY

Genomics-enabled discovery of phosphonate natural products and their biosynthetic pathways

(2013) Kou-San Ju et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Detecting Sequence Homology at the Gene Cluster Level with MultiGeneBlast

(2013) Marnix H. Medema et al.   MOLECULAR BIOLOGY AND EVOLUTION

MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0

(2013) Koichiro Tamura et al.   MOLECULAR BIOLOGY AND EVOLUTION

antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers

(2013) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

Structural and functional insight into an unexpectedly selective N-methyltransferase involved in plantazolicin biosynthesis

(2013) J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The posttranslational modification cascade to the thiopeptide berninamycin generates linear forms and altered macrocyclic scaffolds

(2013) S. J. Malcolmson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into the evolution of lanthipeptide biosynthesis

(2013) Yi Yu et al.   PROTEIN SCIENCE

Structures of Cyanobactin Maturation Enzymes Define a Family of Transamidating Proteases

(2012) Vinayak Agarwal et al.   CHEMISTRY & BIOLOGY

Selectivity, Directionality, and Promiscuity in Peptide Processing from a Bacillus sp. Al Hakam Cyclodehydratase

(2012) Joel O. Melby et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

(2012) Paul G. Arnison et al.   NATURAL PRODUCT REPORTS

YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations

(2012) Kyle L Dunbar et al.   Nature Chemical Biology

The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocyclase domain

(2012) Jesko Koehnke et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure Determination and Interception of Biosynthetic Intermediates for the Plantazolicin Class of Highly Discriminating Antibiotics

(2011) Katie J. Molohon et al.   ACS Chemical Biology

Linking Chemistry and Genetics in the Growing Cyanobactin Natural Products Family

(2011) Mohamed S. Donia et al.   CHEMISTRY & BIOLOGY

Thiazole/oxazole-modified microcins: complex natural products from ribosomal templates

(2011) Joel O Melby et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Expansion of Type II CAAX Proteases Reveals Evolutionary Origin of γ-Secretase Subunit APH-1

(2011) Jimin Pei et al.   JOURNAL OF MOLECULAR BIOLOGY

Streptolysin S-like virulence factors: the continuing sagA

(2011) Evelyn M. Molloy et al.   NATURE REVIEWS MICROBIOLOGY

InterPro in 2011: new developments in the family and domain prediction database

(2011) S. Hunter et al.   NUCLEIC ACIDS RESEARCH

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

(2011) Marnix H. Medema et al.   NUCLEIC ACIDS RESEARCH

HMMER web server: interactive sequence similarity searching

(2011) R. D. Finn et al.   NUCLEIC ACIDS RESEARCH

Isolation and Characterization of the Gene Cluster for Biosynthesis of the Thiopeptide Antibiotic TP-1161

(2010) K. Engelhardt et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Production of a New Thiopeptide Antibiotic, TP-1161, by a Marine Nocardiopsis Species

(2010) K. Engelhardt et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Cyanobactins—ribosomal cyclic peptides produced by cyanobacteria

(2010) Kaarina Sivonen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family

(2010) Daniel H Haft et al.   BMC BIOLOGY

Genome mining for ribosomally synthesized natural products

(2010) Juan E Velásquez et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Plantazolicin, a Novel Microcin B17/Streptolysin S-Like Natural Product from Bacillus amyloliquefaciens FZB42

(2010) R. Scholz et al.   JOURNAL OF BACTERIOLOGY

Genetic Interception and Structural Characterization of Thiopeptide Cyclization Precursors fromBacillus cereus

(2010) Albert A. Bowers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria

(2010) B. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A strain-variable bacteriocin in Bacillus anthracis and Bacillus cereus with repeated Cys-Xaa-Xaa motifs

(2009) Daniel H Haft   Biology Direct

Structural and Functional Dissection of the Heterocyclic Peptide Cytotoxin Streptolysin S

(2009) Douglas A. Mitchell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Using Marine Natural Products to Discover a Protease that Catalyzes Peptide Macrocyclization of Diverse Substrates

(2009) Jaeheon Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Follow the leader: the use of leader peptides to guide natural product biosynthesis

(2009) Trent J Oman et al.   Nature Chemical Biology

A global assembly line for cyanobactins

(2008) Mohamed S Donia et al.   Nature Chemical Biology

Discovery of a widely distributed toxin biosynthetic gene cluster

(2008) S. W. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA