Skin Microbiota and its Interplay with Wound Healing

Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity

(2020) Tao Ni et al.   Science Advances

Single cell analyses reveal specific distribution of anti-bacterial molecule Perforin-2 in human skin and its modulation by wounding and Staphylococcus aureus infection

(2019) N. Strbo et al.   EXPERIMENTAL DERMATOLOGY

Strain- and Species-Level Variation in the Microbiome of Diabetic Wounds Is Associated with Clinical Outcomes and Therapeutic Efficacy

(2019) Lindsay R. Kalan et al.   Cell Host & Microbe

Research Techniques Made Simple: Profiling the Skin Microbiota

(2019) Max D. Grogan et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Rapid detection of biofilm by wound blotting following sharp debridement of chronic pressure ulcers predicts wound healing: A preliminary study

(2019) Gojiro Nakagami et al.   International Wound Journal

The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1

(2019) Siew Siew Pang et al.   Nature Communications

A bioengineered living cell construct activates metallothionein/zinc/MMP8 and inhibits TGF β to stimulate remodeling of fibrotic venous leg ulcers

(2019) Rivka C. Stone et al.   WOUND REPAIR AND REGENERATION

The Potential Impact of Social Genomics on Wound Healing

(2019) Rachel A. Fayne et al.   Advances in Wound Care

Descriptive vs mechanistic scientific approach to study wound healing and its inhibition: Is there a value of translational research involving human subjects?

(2018) Irena Pastar et al.   EXPERIMENTAL DERMATOLOGY

Staphylococcus aureus Triggers Induction of miR-15B-5P to Diminish DNA Repair and Deregulate Inflammatory Response in Diabetic Foot Ulcers

(2018) Horacio A. Ramirez et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

An Economic Evaluation of the Impact, Cost, and Medicare Policy Implications of Chronic Nonhealing Wounds

(2018) Samuel R. Nussbaum et al.   VALUE IN HEALTH

Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury

(2018) Oliver J. Harrison et al.   SCIENCE

Temporal Stability in Chronic Wound Microbiota Is Associated With Poor Healing

(2017) Michael Loesche et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Performing Skin Microbiome Research: A Method to the Madness

(2017) Heidi H. Kong et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A bioengineered living cell construct activates an acute wound healing response in venous leg ulcers

(2017) Rivka C. Stone et al.   Science Translational Medicine

Biofilm detection by wound blotting can predict slough development in pressure ulcers: A prospective observational study

(2017) Gojiro Nakagami et al.   WOUND REPAIR AND REGENERATION

The prevalence of biofilms in chronic wounds: a systematic review and meta-analysis of published data

(2017) M. Malone et al.   Journal of Wound Care

Redefining the Chronic-Wound Microbiome: Fungal Communities Are Prevalent, Dynamic, and Associated with Delayed Healing

(2016) Lindsay Kalan et al.   mBio

Measurements of CD34+/CD45-dim Stem Cells Predict Healing of Diabetic Neuropathic Wounds

(2015) Stephen R. Thom et al.   DIABETES

Perforin-2/Mpeg1 and other pore-forming proteins throughout evolution

(2015) R. McCormack et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Chronic wound repair and healing in older adults: Current status and future research

(2015) Lisa Gould et al.   WOUND REPAIR AND REGENERATION

Analysis of the chronic wound microbiota of 2,963 patients by 16S rDNA pyrosequencing

(2015) Randall D. Wolcott et al.   WOUND REPAIR AND REGENERATION

Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria

(2015) Ryan M McCormack et al.   eLife

A Novel Model of Chronic Wounds: Importance of Redox Imbalance and Biofilm-Forming Bacteria for Establishment of Chronicity

(2014) Sandeep Dhall et al.   PLoS One

Wound repair and regeneration: Mechanisms, signaling, and translation

(2014) S. A. Eming et al.   Science Translational Medicine

Quantitation and Composition of Cutaneous Microbiota in Diabetic and Nondiabetic Men

(2013) H. Redel et al.   JOURNAL OF INFECTIOUS DISEASES

Interactions of Methicillin Resistant Staphylococcus aureus USA300 and Pseudomonas aeruginosa in Polymicrobial Wound Infection

(2013) Irena Pastar et al.   PLoS One

The Wound Microbiome: Modern Approaches to Examining the Role of Microorganisms in Impaired Chronic Wound Healing

(2013) Ana M. Misic et al.   Advances in Wound Care

The Neuropathic Diabetic Foot Ulcer Microbiome Is Associated With Clinical Factors

(2012) S. E. Gardner et al.   DIABETES

Comparison of Culture and Molecular Identification of Bacteria in Chronic Wounds

(2012) Daniel D. Rhoads et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Comparative Analysis of Single-Species and Polybacterial Wound Biofilms Using a Quantitative, In Vivo, Rabbit Ear Model

(2012) Akhil K. Seth et al.   PLoS One

Microbiome dynamics of human epidermis following skin barrier disruption

(2012) Patrick LJM Zeeuwen et al.   GENOME BIOLOGY

An In Vivo Polymicrobial Biofilm Wound Infection Model to Study Interspecies Interactions

(2011) Trevor Dalton et al.   PLoS One

Macroscale spatial variation in chronic wound microbiota: A cross-sectional study

(2010) Lance B. Price et al.   WOUND REPAIR AND REGENERATION

Evaluation of the bacterial diversity among and within individual venous leg ulcers using bacterial tag-encoded FLX and Titanium amplicon pyrosequencing and metagenomic approaches

(2009) Randall D Wolcott et al.   BMC MICROBIOLOGY

Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury

(2009) Yuping Lai et al.   NATURE MEDICINE

Community Analysis of Chronic Wound Bacteria Using 16S rRNA Gene-Based Pyrosequencing: Impact of Diabetes and Antibiotics on Chronic Wound Microbiota

(2009) Lance B. Price et al.   PLoS One

Microbial diversity in chronic open wounds

(2009) Daniel N. Frank et al.   WOUND REPAIR AND REGENERATION

Biofilms in chronic wounds

(2008) Garth A. James et al.   WOUND REPAIR AND REGENERATION