Converting 2D Nanofiber Membranes to 3D Hierarchical Assemblies with Structural and Compositional Gradients Regulates Cell Behavior

Fast transformation of 2D nanofiber membranes into pre-molded 3D scaffolds with biomimetic and oriented porous structure for biomedical applications

(2020) Shixuan Chen et al.   Applied Physics Reviews

Engineering biological gradients

(2019) L Sardelli et al.   Journal of Applied Biomaterials & Functional Materials

Three-Dimensional Objects Consisting of Hierarchically Assembled Nanofibers with Controlled Alignments for Regenerative Medicine

(2019) Shixuan Chen et al.   NANO LETTERS

Buoyancy-Driven Gradients for Biomaterial Fabrication and Tissue Engineering

(2019) Chunching Li et al.   ADVANCED MATERIALS

Enhancing cell seeding and osteogenesis of MSCs on 3D printed scaffolds through injectable BMP2 immobilized ECM-Mimetic gel

(2019) Farahnaz Fahimipour et al.   DENTAL MATERIALS

Regulating Electrical Cue and Mechanotransduction in Topological Gradient Structure Modulated Piezoelectric Scaffolds to Predict Neural Cell Response

(2019) Jeong In Kim et al.   ADVANCED FUNCTIONAL MATERIALS

CO 2 -expanded nanofiber scaffolds maintain activity of encapsulated bioactive materials and promote cellular infiltration and positive host response

(2018) Jiang Jiang et al.   Acta Biomaterialia

Direct 3D Printing of High Strength Biohybrid Gradient Hydrogel Scaffolds for Efficient Repair of Osteochondral Defect

(2018) Fei Gao et al.   ADVANCED FUNCTIONAL MATERIALS

3D Jet Writing: Functional Microtissues Based on Tessellated Scaffold Architectures

(2018) Jacob H. Jordahl et al.   ADVANCED MATERIALS

Inverse Opal Scaffolds with Gradations in Mineral Content for Spatial Control of Osteogenesis

(2018) Chunlei Zhu et al.   ADVANCED MATERIALS

Fabrication of injectable and superelastic nanofiber rectangle matrices (“peanuts”) and their potential applications in hemostasis

(2018) Shixuan Chen et al.   BIOMATERIALS

Repair of Critical-Sized Mandible Defects in Aged Rat Using Hypoxia Preconditioned BMSCs with Up-regulation of Hif-1α

(2018) Jiankang Zhang et al.   International Journal of Biological Sciences

Morphogen gradient reconstitution reveals Hedgehog pathway design principles

(2018) Pulin Li et al.   SCIENCE

Bio-Inspired Micropatterned Platforms Recapitulate 3D Physiological Morphologies of Bone and Dentinal Cells

(2018) Chi Ma et al.   Advanced Science

The microstructure and micromechanics of the tendon–bone insertion

(2017) L. Rossetti et al.   NATURE MATERIALS

Functional gradients and heterogeneities in biological materials: Design principles, functions, and bioinspired applications

(2017) Zengqian Liu et al.   PROGRESS IN MATERIALS SCIENCE

Directed migration of cancer cells guided by the graded texture of the underlying matrix

(2016) JinSeok Park et al.   NATURE MATERIALS

Expanded 3D Nanofiber Scaffolds: Cell Penetration, Neovascularization, and Host Response

(2016) Jiang Jiang et al.   Advanced Healthcare Materials

Morphogen rules: design principles of gradient-mediated embryo patterning

(2015) J. Briscoe et al.   DEVELOPMENT

A three-dimensional engineered tumour for spatial snapshot analysis of cell metabolism and phenotype in hypoxic gradients

(2015) Darren Rodenhizer et al.   NATURE MATERIALS

Simultaneous or Sequential Orthogonal Gradient Formation in a 3D Cell Culture Microfluidic Platform

(2015) Sebastien G. M. Uzel et al.   Small

Endochondral Ossification for Enhancing Bone Regeneration: Converging Native Extracellular Matrix Biomaterials and Developmental EngineeringIn Vivo

(2015) S. Connor Dennis et al.   TISSUE ENGINEERING PART B-REVIEWS

Expanding Two-Dimensional Electrospun Nanofiber Membranes in the Third Dimension By a Modified Gas-Foaming Technique

(2015) Jiang Jiang et al.   ACS Biomaterials-Science & Engineering

Expanding Two-Dimensional Electrospun Nanofiber Membranes in the Third Dimension By a Modified Gas-Foaming Technique

(2015) Jiang Jiang et al.   ACS Biomaterials Science & Engineering

Directed Axonal Outgrowth Using a Propagating Gradient of IGF-1

(2014) Wonjae Lee et al.   ADVANCED MATERIALS

Spatially Gradated Hydrogel Platform as a 3D Engineered Tumor Microenvironment

(2014) Sara Pedron et al.   ADVANCED MATERIALS

Extraordinary strain hardening by gradient structure

(2014) X. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biochemical and Physical Signal Gradients in Hydrogels to Control Stem Cell Behavior

(2013) Oju Jeon et al.   ADVANCED MATERIALS

Screening Mesenchymal Stem Cell Attachment and Differentiation on Porous Silicon Gradients

(2012) Peng-Yuan Wang et al.   ADVANCED FUNCTIONAL MATERIALS

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Gradient biomaterials for soft-to-hard interface tissue engineering

(2011) Azadeh Seidi et al.   Acta Biomaterialia

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

(2011) T. R. Cox et al.   Disease Models & Mechanisms

Toward delivery of multiple growth factors in tissue engineering

(2010) Fa-Ming Chen et al.   BIOMATERIALS

Fibroblast Growth Factors: Biology, Function, and Application for Tissue Regeneration

(2010) Ye-Rang Yun et al.   Journal of Tissue Engineering

Rapid Generation of Biologically Relevant Hydrogels Containing Long-Range Chemical Gradients

(2009) Jiankang He et al.   ADVANCED FUNCTIONAL MATERIALS

Nanofiber Scaffolds with Gradations in Mineral Content for Mimicking the Tendon-to-Bone Insertion Site

(2009) Xiaoran Li et al.   NANO LETTERS

TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation

(2009) Yi Tang et al.   NATURE MEDICINE

Paper-supported 3D cell culture for tissue-based bioassays

(2009) R. Derda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Basic Science of Articular Cartilage: Structure, Composition, and Function

(2009) Alice J. Sophia Fox et al.   Sports Health-A Multidisciplinary Approach

Strategies and Applications for Incorporating Physical and Chemical Signal Gradients in Tissue Engineering

(2008) Milind Singh et al.   TISSUE ENGINEERING PART B-REVIEWS