Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles

Extraction of Extracellular Vesicles from Whole Tissue

(2019) Stephanie N. Hurwitz et al.   Jove-Journal of Visualized Experiments

ALIX increases protein content and protective function of iPSC-derived exosomes

(2019) Ruiting Sun et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Differential Effects of Extracellular Vesicles of Lineage-Specific Human Pluripotent Stem Cells on the Cellular Behaviors of Isogenic Cortical Spheroids

(2019) Mark Marzano et al.   Cells

Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models

(2019) Inger Lauritzen et al.   Translational Neurodegeneration

Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

(2018) Maitrayee Sardar Sinha et al.   ACTA NEUROPATHOLOGICA

An optimized method for enrichment of whole brain-derived extracellular vesicles reveals insight into neurodegenerative processes in a mouse model of Alzheimer’s disease

(2018) Stephanie N. Hurwitz et al.   JOURNAL OF NEUROSCIENCE METHODS

Nonenvelopment Role for the ESCRT-III Complex during Human Cytomegalovirus Infection

(2018) Nicholas T. Streck et al.   JOURNAL OF VIROLOGY

Exosomes and their role in the intercellular trafficking of normal and disease associated prion proteins

(2018) Lesley Cheng et al.   MOLECULAR ASPECTS OF MEDICINE

The release and transmission of amyloid precursor protein via exosomes

(2018) Tingting Zheng et al.   NEUROCHEMISTRY INTERNATIONAL

Wnt/Yes-Associated Protein Interactions During Neural Tissue Patterning of Human Induced Pluripotent Stem Cells

(2018) Julie Bejoy et al.   TISSUE ENGINEERING PART A

Derivation of Cortical Spheroids from Human Induced Pluripotent Stem Cells in a Suspension Bioreactor

(2018) Yuanwei Yan et al.   TISSUE ENGINEERING PART A

The interactome of EBV LMP1 evaluated by proximity-based BioID approach

(2018) Mark A. Rider et al.   VIROLOGY

Neuroprotective Activities of Heparin, Heparinase III, and Hyaluronic Acid on the Aβ42-Treated Forebrain Spheroids Derived from Human Stem Cells

(2018) Julie Bejoy et al.   ACS Biomaterials-Science & Engineering

Neuroprotective Activities of Heparin, Heparinase III, and Hyaluronic Acid on the Aβ42-Treated Forebrain Spheroids Derived from Human Stem Cells

(2018) Julie Bejoy et al.   ACS Biomaterials Science & Engineering

Contribution of the Endosomal-Lysosomal and Proteasomal Systems in Amyloid-β Precursor Protein Derived Fragments Processing

(2018) Caroline Evrard et al.   Frontiers in Cellular Neuroscience

Tetraspanin CD63 Bridges Autophagic and Endosomal Processes To Regulate Exosomal Secretion and Intracellular Signaling of Epstein-Barr Virus LMP1

(2017) Stephanie N. Hurwitz et al.   JOURNAL OF VIROLOGY

Extracellular Vesicles: Unique Intercellular Delivery Vehicles

(2017) Sybren L.N. Maas et al.   TRENDS IN CELL BIOLOGY

Neural patterning of human induced pluripotent stem cells in 3-D cultures for studying biomolecule-directed differential cellular responses

(2016) Yuanwei Yan et al.   Acta Biomaterialia

Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology

(2016) Inger Lauritzen et al.   ACTA NEUROPATHOLOGICA

Exosomes in the Pathology of Neurodegenerative Diseases

(2016) Jason Howitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stimulating the Release of Exosomes Increases the Intercellular Transfer of Prions

(2016) Belinda B. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis

(2016) Robert J. Andrew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD63 Regulates Epstein-Barr Virus LMP1 Exosomal Packaging, Enhancement of Vesicle Production, and Noncanonical NF-κB Signaling

(2016) Stephanie N. Hurwitz et al.   JOURNAL OF VIROLOGY

The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review

(2016) Shanmugam Manoharan et al.   Oxidative Medicine and Cellular Longevity

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ExtraPEG: A Polyethylene Glycol-Based Method for Enrichment of Extracellular Vesicles

(2016) Mark A. Rider et al.   Scientific Reports

Differential effects of acellular embryonic matrices on pluripotent stem cell expansion and neural differentiation

(2015) Yuanwei Yan et al.   BIOMATERIALS

Heparanase activates the syndecan-syntenin-ALIX exosome pathway

(2015) Bart Roucourt et al.   CELL RESEARCH

Extracellular Vesicles in Alzheimer’s Disease: Friends or Foes? Focus on Aβ-Vesicle Interaction

(2015) Pooja Joshi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer’s disease

(2015) S Kim et al.   MOLECULAR PSYCHIATRY

Amyloid beta receptors responsible for neurotoxicity and cellular defects in Alzheimer’s disease

(2014) Tae-In Kam et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

(2014) Michael B. Dinkins et al.   NEUROBIOLOGY OF AGING

Tetraspanins in Extracellular Vesicle Formation and Function

(2014) Zoraida Andreu et al.   Frontiers in Immunology

Mitochondrial Dysfunction Indirectly Elevates ROS Production by the Endoplasmic Reticulum

(2013) Michael P. Murphy   Cell Metabolism

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

(2013) Marina Colombo et al.   JOURNAL OF CELL SCIENCE

Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes

(2013) Takeshi Katsuda et al.   Scientific Reports

Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease

(2012) Marta Pera et al.   ACTA NEUROPATHOLOGICA

Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia

(2012) Kohei Yuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The  -Secretase-Derived C-Terminal Fragment of  APP, C99, But Not A , Is a Key Contributor to Early Intraneuronal Lesions in Triple-Transgenic Mouse Hippocampus

(2012) I. Lauritzen et al.   JOURNAL OF NEUROSCIENCE

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Exosomes: Vehicles for the Transfer of Toxic Proteins Associated with Neurodegenerative Diseases?

(2012) Shayne A. Bellingham et al.   Frontiers in Physiology

The role of mitochondria in apoptosis

(2011) Seon-Yong Jeong et al.   BMB Reports

Mouse models of Alzheimer's disease

(2011) Alicia M. Hall et al.   BRAIN RESEARCH BULLETIN

Insights into Alzheimer disease pathogenesis from studies in transgenic animal models

(2011) Evelin L. Schaeffer et al.   Clinics

The ESCRT Pathway

(2011) William M. Henne et al.   DEVELOPMENTAL CELL

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

(2011) Guillaume van Niel et al.   DEVELOPMENTAL CELL

Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

(2011) Sudad Saman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ESCRT & Co

(2010) Ingrid Roxrud et al.   BIOLOGY OF THE CELL

Quantifying Synapses: an Immunocytochemistry-based Assay to Quantify Synapse Number

(2010) Dominic M. Ippolito et al.   Jove-Journal of Visualized Experiments

Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein

(2009) Benjamin Harris et al.   BRAIN RESEARCH

ESCRT complexes and the biogenesis of multivesicular bodies

(2008) James H Hurley   CURRENT OPINION IN CELL BIOLOGY

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/ -secretase expression

(2008) S. S. Hebert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE