Review
Hematology
M. R. Thomas, M. Scully
Summary: MAHA with thrombocytopenia in cancer patients can be caused by the malignancy itself, treatment, or separate incidental diagnoses. Prompt differentiation of different types of TMA is crucial for treatment and outcome. The causes and treatment strategies for TMA in cancer patients are complex and diverse.
Review
Hematology
Jeremy W. Jacobs, Cristina A. Figueroa Villalba, Garrett S. Booth, Jennifer S. Woo, Laura D. Stephens, Brian D. Adkins
Summary: Paroxysmal cold hemoglobinuria (PCH) is a rare autoimmune hemolytic anemia that is often overlooked and challenging to diagnose due to the complicated testing methods required. A systematic review of reported cases revealed that PCH most commonly occurs in children with a preceding viral infection, and corticosteroid use is frequent but potentially ineffective. The presence of complement and absence of IgG bound to red blood cells is the most common DAT result, although other findings were observed in a third of cases.
Review
Pharmacology & Pharmacy
Zhengrui Xiao, Irina Murakhovskaya
Summary: AIHA is a rare autoimmune disorder characterized by the destruction of red blood cells mediated by autoantibodies, presenting challenges in treatment. Traditional first-line therapies have associated adverse effects and treatment failures, with high rates of relapse. Some patients are refractory to available treatments, leading to the importance of novel therapies.
Review
Immunology
Ainsley Ryan Yan Bin Lee, Shi Yin Wong, Sen Hee Tay
Summary: This study conducted a systematic review and meta-analysis on the efficacy of COVID-19 booster vaccines. The results showed that booster doses are effective in inducing seroconversion in non-responders and are not associated with major adverse events.
Article
Gastroenterology & Hepatology
Marco Lanzillotta, Emanuel Della-Torre, Zachary S. Wallace, John H. Stone, Omer Karadag, Andreu Fernandez-Codina, Paolo Giorgio Arcidiacono, Massimo Falconi, Lorenzo Dagna, Gabriele Capurso
Summary: Rituximab shows a high rate of remission in pancreato-biliary IgG4-RD, with a significant relapse rate, especially in patients with multiorgan involvement. The incidence of rituximab-related adverse events is moderate. Further research is needed to evaluate its long-term efficacy and safety.
Review
Medicine, General & Internal
Juri Alessandro Giannotta, Bruno Fattizzo, Francesca Cavallaro, Wilma Barcellini
Summary: This review provides an overview of the frequency and types of infectious complications in patients with autoimmune hemolytic anemia (AIHA), as well as the risks associated with various treatments. It also discusses infectious complications in AIHA secondary to other diseases and viral and bacterial reactivations during immune suppressive therapies, along with suggested screening and prophylactic strategies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Immunology
Ines Bernardoff, Alexandre Picq, Pierre Loiseau, Thomas Foret, Virginie Dufrost, Thomas Moulinet, Ozan Unlu, Doruk Erkan, Denis Wahl, Stephane Zuily
Summary: This study conducted a systematic review and meta-analysis to evaluate the association of antiphospholipid antibodies (aPL) with autoimmune hemolytic anemia in systemic lupus erythematosus (SLE) patients. The results showed a strong association between the presence of aPL and the occurrence of hemolytic anemia in SLE patients, with lupus anticoagulant and anti beta 2Glycoprotein I antibodies having the highest risk. IgM isotypes also indicated an increased risk of hemolytic anemia in SLE.
AUTOIMMUNITY REVIEWS
(2022)
Article
Pediatrics
Anthie Damianaki, Marianna Tzanoudaki, Maria Kanariou, Emmanouil Liatsis, Alexandros Panos, Alexandra Soldatou, Lydia Kossiva
Summary: This is a case of a 3-year-old boy with severe and refractory warm antibody autoimmune hemolytic anemia. Despite B-cell recovery, the patient continued to have hypogammaglobulinemia 20 months after receiving rituximab therapy.
Review
Dermatology
Zhipeng Lin, Yixin Zhao, Feng Li, Jinzhuo Li, Xianqiong Huang
Summary: Biologic agents have become an important treatment option for autoimmune blistering diseases. A meta-analysis showed that treatment with biologics had fewer adverse events compared to systemic corticosteroids, with similar efficacy and recurrence rates.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Review
Oncology
Robert Lam, Nicholas Tarangelo, Rong Wang, Masayasu Horibe, Alyssa A. Grimshaw, Dhanpat Jain, Samir Haffar, Fateh Bazerbachi, Pamela L. Kunz, Darrick K. Li
Summary: Microangiopathic hemolytic anemia (MAHA) is a rare paraneoplastic syndrome associated with gastric signet ring cell carcinoma (SRCC), and its clinical and prognostic features have been poorly described. Patients with MAHA commonly present with symptoms such as back pain, bone pain, and dyspnea. The study found that patients with gastric SRCC and MAHA have significantly shorter survival compared to those with metastatic gastric SRCC alone.
Article
Immunology
Flavia Dei Zotti, Annie Qiu, Francesca La Carpia, Chiara Moriconi, Krystalyn E. Hudson
Summary: Autoimmune hemolytic anemia is a severe disease with limited treatment options and challenges in RBC transfusions due to autoantibodies against ubiquitous RBC antigens.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Chao Zhen, Ying Hou, Bing Zhao, Xiaotian Ma, Tingjun Dai, Chuanzhu Yan
Summary: Rituximab (RTX) is a novel treatment option for refractory idiopathic inflammatory myopathies (IIMs). This meta-analysis showed that about 65% of IIMs patients had a response to RTX, with 45% achieving complete response and 39% achieving partial response. The overall efficacy rates for muscle, lungs, and skin involvement were 59%, 65%, and 81% respectively. Studies conducted in Germany and the United States demonstrated excellent response rates of 90% and 77% respectively. The incidence of severe adverse events and infections was relatively low.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Qichen Liang, Xu Li, Qingyu Niu, Huiping Zhao, Li Zuo
Summary: In this meta-analysis, roxadustat was found to be more effective and safer than ESAs in treating anemia in Chinese HD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Hematology
Bruno Fattizzo, Silvia Cantoni, Rachele Zavaglia, Juri Alessandro Giannotta, Wilma Barcellini, Marta Bortolotti, Laura Bandiera
Summary: Cyclosporine A (CyA) may be a viable treatment option for patients with ITP and AIHA, particularly when previous methods have been ineffective or unsuitable.
THERAPEUTIC ADVANCES IN HEMATOLOGY
(2022)
Article
Hematology
Alexander Roeth, Sigbjorn Berentsen, Wilma Barcellini, Shirley D'Sa, Bernd Jilma, Marc Michel, Ilene C. Weitz, Masaki Yamaguchi, Jun-ichi Nishimura, Josephine M. Vos, Michael Storek, Nancy Wong, Parija Patel, Xiaoyu Jiang, Deepthi S. Vagge, Marek Wardecki, Frank Shafer, Michelle Lee, Catherine M. Broome
Summary: Sutimlimab, a humanized monoclonal antibody, shows potential as an important advancement in the treatment of cold agglutinin disease (CAD) by selectively inhibiting the classical complement pathway and rapidly halting hemolysis.
Letter
Rheumatology
Chin-Fang Su, Hsien-Tzung Liao, Chang-Youh Tsai
Review
Biochemistry & Molecular Biology
Ko-Jen Li, Cheng-Han Wu, Cheng-Hsun Lu, Chieh-Yu Shen, Yu-Min Kuo, Chang-Youh Tsai, Song-Chou Hsieh, Chia-Li Yu
Summary: Trogocytosis refers to the rapid bidirectional transfer of surface membrane fragments and associated proteins between cells. Its biological actions include information exchange, cell clearance, and immunoregulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Chang-Youh Tsai, Song-Chou Hsieh, Chih-Wei Liu, Cheng-Shiun Lu, Cheng-Han Wu, Hsien-Tzung Liao, Ming-Han Chen, Ko-Jen Li, Chieh-Yu Shen, Yu-Min Kuo, Chia-Li Yu
Summary: Polymorphonuclear neutrophils (PMNs) are not only professional phagocytic and acute inflammatory cells, but also exhibit many important biological functions, such as cytokine production, exosome release, and modulation of immune responses in surrounding cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Chang-Youh Tsai, Song-Chou Hsieh, Chih-Wei Liu, Cheng-Hsun Lu, Hsien-Tzung Liao, Ming-Han Chen, Ko-Jen Li, Cheng-Han Wu, Cheih-Yu Shen, Yu-Min Kuo, Chia-Li Yu
Summary: Rheumatoid arthritis is a typical autoimmune disease characterized by chronic synovitis in the joints, triggered by the production of autoantibodies through interactions among immune cells. Aberrant gene mutations, epigenetic regulation, and non-coding RNA expression are closely linked to the development of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Tzu-Hao Li, Chih-Wei Liu, Chia-Chang Huang, Yu-Lien Tsai, Shiang-Fen Huang, Ying-Ying Yang, Chang-Youh Tsai, Ming-Chih Hou, Han-Chieh Lin
Summary: This study investigated the effects of NSBBs on cirrhotic complications such as infection, AKI, chronic renal function declination, and sarcopenic changes. The results showed that chronic NSBB use reduced episodes of infection and AKIs, while non-NSBB was associated with sarcopenic changes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cell Biology
Hsien-Tzung Liao, Chang-Youh Tsai, Chien-Chih Lai, Song-Chou Hsieh, Yi-Syuan Sun, Ko-Jen Li, Chieh-Yu Shen, Cheng-Han Wu, Cheng-Hsun Lu, Yu-Min Kuo, Tzu-Hao Li, Chung-Tei Chou, Chia-Li Yu
Summary: Ankylosing spondylitis is an immune-mediated disease characterized by inflammation and immune dysfunction in the axial skeleton and peripheral joints. The pathogenesis involves a complex interplay of genetic and non-genetic factors, including epigenetic regulations of gene expression. Understanding these factors is crucial for unraveling the mysteries of AS.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Rheumatology
H-T Liao, H-Y Tung, C-T Chou, H-C Tsai, Y-N Yen, C-Y Tsai
Summary: This study demonstrates that nucleic acid-based vaccines against SARS-CoV-2 are immunogenic in the majority of patients with autoimmune rheumatic diseases (ARDs), although patients with systemic lupus erythematosus or rheumatoid arthritis have lower humoral responses to the vaccine compared to those with other ARDs.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2022)
Article
Medicine, General & Internal
Tsai-Hung Wu, Hsien-Tzung Liao, Tzu-Hao Li, Hung-Cheng Tsai, Niang-Cheng Lin, Cheng-Yen Chen, Shih-Feng Tsai, Tzu-Hao Huang, Chang-Youh Tsai, Chia-Li Yu
Summary: By monitoring the sequence change of B-cell receptor immunoglobulin in renal transplant patients, it is possible to detect the occurrence of rejection or graft failure. The change in clonal diversity is correlated with various clinical events, indicating its potential as a biomarker for detecting renal graft failure/rejection.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Tsai-Hung Wu, Song-Chou Hsieh, Tsu-Hao Li, Cheng-Hsun Lu, Hsien-Tzung Liao, Chieh-Yu Shen, Ko-Jen Li, Cheng-Han Wu, Yu-Min Kuo, Chang-Youh Tsai, Chia-Li Yu
Summary: Polymorphonuclear neutrophils (PMNs) are the most abundant white blood cells in circulation and play a crucial role in defending against pathogens and maintaining immune homeostasis. Recent studies have discovered novel biological functions of PMNs, which exhibit paradoxical activities in inflammation/anti-inflammation, antibacterial/autoimmunity, pro-cancer/anticancer, and antiviral infection/COVID-19-induced immunothrombotic dysregulation.
Editorial Material
Rheumatology
Jui-Yun Lee, Chang-Youh Tsai, Hsien-Tzung Liao
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Chien-Chih Lai, Fei-Lan Liu, Chang-Youh Tsai, Shu-Li Wang, Deh-Ming Chang
Summary: This study aimed to investigate the effects of phthalates on inflammation and osteoporosis in premenopausal and postmenopausal females. The results showed that DEHP treatment led to osteoporosis and impaired microstructure of femur trabecula in mice, with inflammation playing a role. Additionally, phthalate exposure negatively affected bone mass in both premenopausal and postmenopausal women.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Jan-Mou Lee, Ming-Huang Chen, Kai-Yuan Chou, Yee Chao, Ming-Han Chen, Chang-Youh Tsai
Summary: The comparison of immunoprofiling between patients with SLE and healthy controls revealed distinct patterns, which could be used to develop an immune signature algorithm for supporting SLE diagnosis. This study sheds light on the future studies of SLE pathogenesis and immune-based diagnostic tool development.
LUPUS SCIENCE & MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Vivia Khosasih, Kai-Ming Liu, Chung-Ming Huang, Lieh-Bang Liou, Ming-Shium Hsieh, Chian-Her Lee, Chang-Youh Tsai, San-Yuan Kuo, Su-Yang Hwa, Chia-Li Yu, Chih-Hao Chang, Cheng-Jyh Lin, Song-Chou Hsieh, Chun-Ying Cheng, Wei-Ming Chen, Liang-Kuang Chen, Hui-Ping Chuang, Ying-Ting Chen, Pei-Chun Tsai, Liang-Suei Lu, Weng-Siong H'ng, Yanfei Zhang, Hsiang-Cheng Chen, Chien-Hsiun Chen, Ming Ta Michael Lee, Jer-Yuarn Wu
Summary: A genome-wide association study in the Han Chinese population identified six genetic variants associated with hand osteoarthritis, located at the 2p13.2 region downstream of the CYP26B1 gene. Among these variants, rs12713768 was found to be associated with susceptibility to and severity of hand osteoarthritis, suggesting the involvement of the retinoic acid signaling pathway in its pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Chang-Youh Tsai, Ko-Jen Li, Chieh-Yu Shen, Cheng-Hsun Lu, Hui-Ting Lee, Tsai-Hung Wu, Yee-Yung Ng, Yen-Po Tsao, Song-Chou Hsieh, Chia-Li Yu
Summary: Lupus nephritis is a severe complication in systemic lupus erythematosus patients. It is traditionally believed to be caused by immune complex deposition and complement interactions. Recent research has revealed that resident kidney cells and genetically restricted adaptive immune cells also play a role in the inflammation. Biomarkers for diagnosis and monitoring of lupus nephritis are important, as well as developing specific therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
H-T. Liao, C-Y. Tsai
Summary: The aim of this study was to investigate the correlations among cytokines and regulatory T cells (T-regs) in ankylosing spondylitis (AS) patients, as well as their changes after anti-tumour necrosis factor-alpha (TNF-alpha) treatment. The results showed that the frequency of T-regs in peripheral blood was positively correlated to disease activity indices and inflammatory markers in AS patients. After TNF-alpha treatment, there was a significant decrease in TNF-alpha levels, IL-10 levels, TGF-beta levels, and frequency of T-regs in peripheral blood of AS patients.
BONE & JOINT RESEARCH
(2023)