FBXO45 is a potential therapeutic target for cancer therapy

m6A-induced lncRNA RP11 triggers the dissemination of colorectal cancer cells via upregulation of Zeb1

(2019) Yingmin Wu et al.   Molecular Cancer

FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation

(2019) Kai T. Richter et al.   CELL DEATH AND DIFFERENTIATION

The Insulin-Like Growth Factor 2 mRNA Binding Protein IMP2/IGF2BP2 is Overexpressed and Correlates with Poor Survival in Pancreatic Cancer

(2019) Charlotte Dahlem et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Association Study Reveals One Susceptibility Locus with Vitiligo in the Chinese Han Population

(2019) Xianfa Tang et al.   Genetic Testing and Molecular Biomarkers

Regulation of F-box proteins by noncoding RNAs in human cancers

(2019) Min Lin et al.   CANCER LETTERS

Emerging roles of F-box proteins in cancer drug resistance

(2019) Linzhi Yan et al.   DRUG RESISTANCE UPDATES

A genome-wide association study of coping behaviors suggests FBXO45 is associated with emotional expression

(2018) C. Shimanoe et al.   GENES BRAIN AND BEHAVIOR

PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2

(2018) Muriel Desbois et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of aberrantly expressed F-box proteins in squamous-cell lung carcinoma

(2018) Kai Wang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

FBXW7: a critical tumor suppressor of human cancers

(2018) Chien-Hung Yeh et al.   Molecular Cancer

Palmitoylation enables MAPK-dependent proteostasis of axon survival factors

(2018) Daniel W. Summers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spinal TNF-α impedes Fbxo45-dependent Munc13-1 ubiquitination to mediate neuropathic allodynia in rats

(2018) Ming-Chun Hsieh et al.   Cell Death & Disease

FLASH protects ZEB1 from degradation and supports cancer cells' epithelial-to-mesenchymal transition

(2016) C F Abshire et al.   Oncogenesis

Cullin 3 Ubiquitin Ligases in Cancer Biology: Functions and Therapeutic Implications

(2016) Hsin-Yi Chen et al.   Frontiers in Oncology

Hey bHLH Proteins Interact with a FBXO45 Containing SCF Ubiquitin Ligase Complex and Induce Its Translocation into the Nucleus

(2015) Daniela Salat et al.   PLoS One

Atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 controls the core epithelial-to-mesenchymal transition-inducing transcription factors

(2015) Ming Xu et al.   Oncotarget

Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival

(2014) X Chen et al.   CELL DEATH AND DIFFERENTIATION

Fbxo45 Inhibits Calcium-sensitive Proteolysis of N-cadherin and Promotes Neuronal Differentiation

(2014) Fu-Zon Chung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel rare variants in F-box protein 45 (FBXO45) in schizophrenia

(2014) Chenyao Wang et al.   SCHIZOPHRENIA RESEARCH

Intracellular protein degradation: From a vague idea through the lysosome and the ubiquitin–proteasome system and onto human diseases and drug targeting

(2013) Aaron Ciechanover   BIOORGANIC & MEDICINAL CHEMISTRY

Proteomic analysis of the NOS2 interactome in human airway epithelial cells

(2013) Matthew W. Foster et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Differential response of multiple zebrafish hepatic F-box protein genes to 17α-ethinylestradiol treatment

(2011) Hongping Zheng et al.   JOURNAL OF ENVIRONMENTAL SCIENCES

Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets

(2010) Lynn Bedford et al.   NATURE REVIEWS DRUG DISCOVERY

Ubiquitin ligase complexes: from substrate selectivity to conjugational specificity

(2009) Vanja Nagy et al.   BIOLOGICAL CHEMISTRY

Fbxo45, a Novel Ubiquitin Ligase, Regulates Synaptic Activity

(2009) Hirobumi Tada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fbxo45 Forms a Novel Ubiquitin Ligase Complex and Is Required for Neuronal Development

(2009) T. Saiga et al.   MOLECULAR AND CELLULAR BIOLOGY

The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73

(2009) A Peschiaroli et al.   ONCOGENE