Structure basis of the FERM domain of kindlin-3 in supporting integrin αIIbβ3 activation in platelets

The binding interface of kindlin-2 and ILK involves Asp344/Asp352/Thr356 in kindlin-2 and Arg243/Arg334 in ILK

(2018) Si-Yu Guan et al.   FEBS LETTERS

Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading

(2017) Ralph T. Böttcher et al.   JOURNAL OF CELL BIOLOGY

Kindlin supports platelet integrin αIIbβ3 activation by interacting with paxillin

(2017) Juan Gao et al.   JOURNAL OF CELL SCIENCE

Structural basis of kindlin-mediated integrin recognition and activation

(2017) Huadong Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and lipid-binding properties of the kindlin-3 pleckstrin homology domain

(2016) Tao Ni et al.   BIOCHEMICAL JOURNAL

Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin

(2016) Marina Theodosiou et al.   eLife

NMR Characterization and Membrane Interactions of the Loop Region of Kindlin-3 F1 Subdomain

(2016) Geok-Lin Chua et al.   PLoS One

A structural dissection of large protein-protein crystal packing contacts

(2015) Jiesi Luo et al.   Scientific Reports

ADAP interactions with talin and kindlin promote platelet integrin  IIb 3 activation and stable fibrinogen binding

(2014) A. Kasirer-Friede et al.   BLOOD

Molecular Basis of Kindlin-2 Binding to Integrin-linked Kinase Pseudokinase for Regulating Cell Adhesion

(2014) Koichi Fukuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differences in binding to the ILK complex determines kindlin isoform adhesion localization and integrin activation

(2014) C. Huet-Calderwood et al.   JOURNAL OF CELL SCIENCE

Integrity of kindlin-2 FERM subdomains is required for supporting integrin activation

(2013) Zhen Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Mechanism of Kindlin-Mediated Activation of Integrin αIIbβ3

(2013) Feng Ye et al.   CURRENT BIOLOGY

Biophysical Analysis of Kindlin-3 Reveals an Elongated Conformation and Maps Integrin Binding to the Membrane-distal β-Subunit NPXY Motif

(2012) Luke A. Yates et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Conserved Lipid-binding Loop in the Kindlin FERM F1 Domain Is Required for Kindlin-mediated αIIbβ3 Integrin Coactivation

(2012) Mohamed Bouaouina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of kindlin-2 PH domain reveals a conformational transition for its membrane anchoring and regulation of integrin activation

(2012) Yan Liu et al.   Protein & Cell

Structural Basis of Phosphoinositide Binding to Kindlin-2 Protein Pleckstrin Homology Domain in Regulating Integrin Activation

(2011) Jianmin Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Binding of the N-Terminal Ubiquitin-Like Domain of kindlin-2 Is Crucial for Its Regulation of Integrin Activation

(2011) H. Dhanuja Perera et al.   STRUCTURE

The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain

(2010) Paul R. Elliott et al.   STRUCTURE

The Structure of the N-Terminus of Kindlin-1: A Domain Important for αIIbβ3 Integrin Activation

(2009) Benjamin T. Goult et al.   JOURNAL OF MOLECULAR BIOLOGY

Kindlin-3 is required for β2 integrin–mediated leukocyte adhesion to endothelial cells

(2009) Markus Moser et al.   NATURE MEDICINE

A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans

(2009) Nikolay L Malinin et al.   NATURE MEDICINE

Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation

(2009) Lena Svensson et al.   NATURE MEDICINE

The Tail of Integrins, Talin, and Kindlins

(2009) M. Moser et al.   SCIENCE

LAD-1/variant syndrome is caused by mutations inFERMT3

(2008) Taco W. Kuijpers et al.   BLOOD

Kindlins: essential regulators of integrin signalling and cell–matrix adhesion

(2008) Hannu Larjava et al.   EMBO REPORTS

Kindlin-2 (Mig-2): a co-activator of β3integrins

(2008) Yan-Qing Ma et al.   JOURNAL OF CELL BIOLOGY