Mucorales Species and Macrophages

A Novel Resistance Pathway for Calcineurin Inhibitors in the Human-Pathogenic Mucorales Mucor circinelloides

(2020) Sandeep Vellanki et al.   mBio

Broad antifungal resistance mediated by RNAi-dependent epimutation in the basal human fungal pathogen Mucor circinelloides

(2019) Zanetta Chang et al.   PLoS Genetics

Mucor circinelloides Thrives inside the Phagosome through an Atf-Mediated Germination Pathway

(2019) Carlos Pérez-Arques et al.   mBio

Pathogenicity patterns of mucormycosis: epidemiology, interaction with immune cells and virulence factors

(2019) Mohamed I Abdelwahab Hassan et al.   MEDICAL MYCOLOGY

A Revised Species Concept for Opportunistic Mucor Species Reveals Species-Specific Antifungal Susceptibility Profiles

(2019) Lysett Wagner et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Fungal evolution: diversity, taxonomy and phylogeny of the Fungi

(2019) Miguel A. Naranjo‐Ortiz et al.   BIOLOGICAL REVIEWS

Outbreaks of Mucorales and the Species Involved

(2019) Grit Walther et al.   MYCOPATHOLOGIA

Drug-Resistant Epimutants Exhibit Organ-Specific Stability and Induction during Murine Infections Caused by the Human Fungal Pathogen Mucor circinelloides

(2019) Zanetta Chang et al.   mBio

Sporulation on blood serum increases the virulence of Mucor circinelloides

(2019) J. Alberto Patiño-Medina et al.   MICROBIAL PATHOGENESIS

Heterotrimeric G-alpha subunits Gpa11 and Gpa12 define a transduction pathway that control spore size and virulence in Mucor circinelloides

(2019) J. Alberto Patiño-Medina et al.   PLoS One

Robust Phagocyte Recruitment Controls the Opportunistic Fungal Pathogen Mucor circinelloides in Innate Granulomas In Vivo

(2018) Sarah Inglesfield et al.   mBio

Components of a new gene family of ferroxidases involved in virulence are functionally specialized in fungal dimorphism

(2018) María Isabel Navarro-Mendoza et al.   Scientific Reports

Inhibition of EGFR Signaling Protects from Mucormycosis

(2018) Tonya N. Watkins et al.   mBio

Iron restriction inside macrophages regulates pulmonary host defense against Rhizopus species

(2018) Angeliki M. Andrianaki et al.   Nature Communications

An Adult Zebrafish Model Reveals that Mucormycosis Induces Apoptosis of Infected Macrophages

(2018) Azucena López-Muñoz et al.   Scientific Reports

Antifungal resistance in mucorales

(2017) E. Dannaoui   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Intrinsic short-tailed azole resistance in mucormycetes is due to an evolutionary conserved aminoacid substitution of the lanosterol 14α-demethylase

(2017) Rita Caramalho et al.   Scientific Reports

A non-canonical RNA degradation pathway suppresses RNAi-dependent epimutations in the human fungal pathogen Mucor circinelloides

(2017) Silvia Calo et al.   PLoS Genetics

RNAi-Based Functional Genomics Identifies New Virulence Determinants in Mucormycosis

(2017) Trung Anh Trieu et al.   PLoS Pathogens

Aspergillus Cell Wall Melanin Blocks LC3-Associated Phagocytosis to Promote Pathogenicity

(2016) Tonia Akoumianaki et al.   Cell Host & Microbe

Initial use of combination treatment does not impact survival of 106 patients with haematologic malignancies and mucormycosis: a propensity score analysis

(2016) A. Kyvernitakis et al.   CLINICAL MICROBIOLOGY AND INFECTION

Mucormycoses

(2016) Dimitrios Farmakiotis et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

A phylum-level phylogenetic classification of zygomycete fungi based on genome-scale data

(2016) Joseph W. Spatafora et al.   MYCOLOGIA

Interactions of fungal pathogens with phagocytes

(2016) Lars P. Erwig et al.   NATURE REVIEWS MICROBIOLOGY

An integrated genomic and transcriptomic survey of mucormycosis-causing fungi

(2016) Marcus C. Chibucos et al.   Nature Communications

A zebrafish larval model reveals early tissue-specific innate immune responses to Mucor circinelloides

(2015) K. Voelz et al.   Disease Models & Mechanisms

Phylogenetic analysis of fungal heterotrimeric G protein-encoding genes and their expression during dimorphism in Mucor circinelloides

(2015) Marco Iván Valle-Maldonado et al.   Fungal Biology

Calcineurin orchestrates dimorphic transitions, antifungal drug responses and host-pathogen interactions of the pathogenic mucoralean fungusMucor circinelloides

(2015) Soo Chan Lee et al.   MOLECULAR MICROBIOLOGY

Natural killer cell-mediated damage of clinical isolates of mucormycetes

(2015) Stanislaw Schmidt et al.   MYCOSES

A Non-canonical RNA Silencing Pathway Promotes mRNA Degradation in Basal Fungi

(2015) Trung Anh Trieu et al.   PLoS Genetics

Mucormycosis – from the pathogens to the disease

(2014) U. Binder et al.   CLINICAL MICROBIOLOGY AND INFECTION

Virulent strain ofLichtheimia corymbiferashows increased phagocytosis by macrophages as revealed by automated microscopy image analysis

(2014) Kaswara Kraibooj et al.   MYCOSES

Antifungal drug resistance evoked via RNAi-dependent epimutations

(2014) Silvia Calo et al.   NATURE

Platelet immunology in fungal infections

(2014) Cornelia Speth et al.   THROMBOSIS AND HAEMOSTASIS

Corticosteroids Block Autophagy Protein Recruitment in Aspergillus fumigatus Phagosomes via Targeting Dectin-1/Syk Kinase Signaling

(2013) I. Kyrmizi et al.   JOURNAL OF IMMUNOLOGY

Risk factors for early mortality in haematological malignancy patients with pulmonary mucormycosis

(2013) Russell E. Lewis et al.   MYCOSES

Rhizopus oryzae hyphae are damaged by human natural killer (NK) cells, but suppress NK cell mediated immunity

(2012) Stanislaw Schmidt et al.   IMMUNOBIOLOGY

Fungi and the Rise of Mammals

(2012) Arturo Casadevall   PLoS Pathogens

Mucorales-specific T cells emerge in the course of invasive mucormycosis and may be used as a surrogate diagnostic marker in high-risk patients

(2011) L. Potenza et al.   BLOOD

Zygomycosis in Europe: analysis of 230 cases accrued by the registry of the European Confederation of Medical Mycology (ECMM) Working Group on Zygomycosis between 2005 and 2007

(2011) A. Skiada et al.   CLINICAL MICROBIOLOGY AND INFECTION

Sporangiospore Size Dimorphism Is Linked to Virulence of Mucor circinelloides

(2011) Charles H. Li et al.   PLoS Pathogens

The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic mice

(2010) Mingfu Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

The high affinity iron permease is a key virulence factor required for Rhizopus oryzae pathogenesis

(2010) Ashraf S. Ibrahim et al.   MOLECULAR MICROBIOLOGY

Endogenous short RNAs generated by Dicer 2 and RNA-dependent RNA polymerase 1 regulate mRNAs in the basal fungus Mucor circinelloides

(2010) Francisco Esteban Nicolas et al.   NUCLEIC ACIDS RESEARCH

Generation of IL-23 Producing Dendritic Cells (DCs) by Airborne Fungi Regulates Fungal Pathogenicity via the Induction of TH-17 Responses

(2010) Georgios Chamilos et al.   PLoS One

Outbreak of Intestinal Infection Due to Rhizopus microsporus

(2009) V. C. C. Cheng et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Potential Antifungal Effects of Human Platelets against Zygomycetes In Vitro

(2009) Susanne Perkhofer et al.   JOURNAL OF INFECTIOUS DISEASES

Evidence of a Role for Monocytes in Dissemination and Brain Invasion by Cryptococcus neoformans

(2008) C. Charlier et al.   INFECTION AND IMMUNITY