Candidiasis and Mechanisms of Antifungal Resistance

Lipid Systems for the Delivery of Amphotericin B in Antifungal Therapy

(2020) Faustino et al.   Pharmaceutics

Mutations in TAC1B: a Novel Genetic Determinant of Clinical Fluconazole Resistance in Candida auris

(2020) Jeffrey M. Rybak et al.   mBio

Vacuolar sequestration of azoles: A novel strategy of azole antifungal resistance conserved across pathogenic and non-pathogenic yeast

(2019) Nitesh Kumar Khandelwal et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Review on Antifungal Resistance Mechanisms in the Emerging Pathogen Candida auris

(2019) Farid Chaabane et al.   Frontiers in Microbiology

A Double-Edged Sword: Aneuploidy is a Prevalent Strategy in Fungal Adaptation

(2019) Hung-Ji Tsai et al.   Genes

Effect of cumulative intravenous voriconazole dose on renal function in hematological patients

(2018) Takeo Yasu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Enhanced Efflux Pump Activity in Old Candida glabrata Cells

(2018) Somanon Bhattacharya et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

CgPDR1 gain-of-function mutations lead to azole-resistance and increased adhesion in clinical Candida glabrata strains

(2018) Qi Ni et al.   MYCOSES

Spotlight on isavuconazole in the treatment of invasive aspergillosis and mucormycosis: design, development, and place in therapy

(2018) Jeffrey D Jenks et al.   Drug Design Development and Therapy

Overexpression or Deletion of Ergosterol Biosynthesis Genes Alters Doubling Time, Response to Stress Agents, and Drug Susceptibility in Saccharomyces cerevisiae

(2018) Somanon Bhattacharya et al.   mBio

Spontaneous Mutational Frequency and FKS Mutation Rates Vary by Echinocandin Agent against Candida glabrata

(2018) Ryan K. Shields et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Multidrug-Resistant Candida: Epidemiology, Molecular Mechanisms, and Treatment

(2017) Maiken Cavling Arendrup et al.   JOURNAL OF INFECTIOUS DISEASES

A chromosome 4 trisomy contributes to increased fluconazole resistance in a clinical isolate of Candida albicans

(2017) Matthew Z. Anderson et al.   MICROBIOLOGY-SGM

Oral Azole Antifungal Medications and Risk of Acute Liver Injury, Overall and by Chronic Liver Disease Status

(2016) Vincent Lo Re et al.   AMERICAN JOURNAL OF MEDICINE

A Combination Fluorescence Assay Demonstrates Increased Efflux Pump Activity as a Resistance Mechanism in Azole-Resistant Vaginal Candida albicans Isolates

(2016) Somanon Bhattacharya et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Executive Summary: Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America

(2016) Peter G. Pappas et al.   CLINICAL INFECTIOUS DISEASES

Novel point mutations in the ERG11 gene in clinical isolates of azole resistant Candida species

(2016) Danielly Beraldo dos Santos Silva et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Clotrimazole Drug Resistance in Candida glabrata Clinical Isolates Correlates with Increased Expression of the Drug:H+ Antiporters CgAqr1, CgTpo1_1, CgTpo3, and CgQdr2

(2016) Catarina Costa et al.   Frontiers in Microbiology

Role of isavuconazole in the treatment of invasive fungal infections

(2016) Dustin Wilson et al.   Therapeutics and Clinical Risk Management

Upregulation of the Adhesin Gene EPA1 Mediated by PDR1 in Candida glabrata Leads to Enhanced Host Colonization

(2016) Luis A. Vale-Silva et al.   mSphere

Development of fluconazole resistance in a series of Candida parapsilosis isolates from a persistent candidemia patient with prolonged antifungal therapy

(2015) Li Zhang et al.   BMC INFECTIOUS DISEASES

Echinocandins: The Expanding Antifungal Armamentarium

(2015) Daniel Aguilar-Zapata et al.   CLINICAL INFECTIOUS DISEASES

Trisomy of chromosome R confers resistance to triazoles in Candida albicans

(2015) Xingxing Li et al.   MEDICAL MYCOLOGY

Stress response and expression of fluconazole resistance associated genes in the pathogenic yeast Candida glabrata deleted in the CgPDR16 gene

(2015) Hana Culakova et al.   MICROBIOLOGICAL RESEARCH

Investigation of Mutations in Transcription Factors of Efflux Pump Genes in Fluconazole-Resistant Candida albicans Strains Overexpressing the Efflux Pumps

(2015) Kemal Turan KALKANDELEN et al.   MIKROBIYOLOJI BULTENI

Structural mechanism of ergosterol regulation by fungal sterol transcription factor Upc2

(2015) Huiseon Yang et al.   Nature Communications

The evolution of drug resistance in clinical isolates of Candida albicans

(2015) Christopher B Ford et al.   eLife

Changes in the Sterol Composition of the Plasma Membrane Affect Membrane Potential, Salt Tolerance and the Activity of Multidrug Resistance Pumps in Saccharomyces cerevisiae

(2015) Marie Kodedová et al.   PLoS One

MFS multidrug transporters in pathogenic fungi: do they have real clinical impact?

(2014) Catarina Costa et al.   Frontiers in Physiology

Candida glabrata Drug:H+Antiporter CgQdr2 Confers Imidazole Drug Resistance, Being Activated by Transcription Factor CgPdr1

(2013) Catarina Costa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Amphotericin B Formulations: A Comparative Review of Efficacy and Toxicity

(2013) Richard J. Hamill   DRUGS

Comparison of Sterol Import under Aerobic and Anaerobic Conditions in Three Fungal Species, Candida albicans, Candida glabrata, and Saccharomyces cerevisiae

(2013) Martin Zavrel et al.   EUKARYOTIC CELL

Distinct Roles of Candida albicans Drug Resistance Transcription Factors TAC1 , MRR1 , and UPC2 in Virulence

(2013) Andrea Lohberger et al.   EUKARYOTIC CELL

Erg11mutations associated with azole resistance in clinical isolates ofCandida albicans

(2013) Ming-Jie Xiang et al.   FEMS YEAST RESEARCH

Reactive oxygen species-inducing antifungal agents and their activity against fungal biofilms

(2013) Nicolas Delattin et al.   Future Medicinal Chemistry

Profile of isavuconazole and its potential in the treatment of severe invasive fungal infections

(2013) Alessandro Pasqualotto et al.   Infection and Drug Resistance

Facultative Sterol Uptake in an Ergosterol-Deficient Clinical Isolate of Candida glabrata Harboring a Missense Mutation inERG11and Exhibiting Cross-Resistance to Azoles and Amphotericin B

(2012) Claire M. Hull et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Fks1 and Fks2 Are Functionally Redundant but Differentially Regulated in Candida glabrata: Implications for Echinocandin Resistance

(2012) Santosh K. Katiyar et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Epidemiology and outcomes of candidemia in 3648 patients: data from the Prospective Antifungal Therapy (PATH Alliance®) registry, 2004–2008

(2012) Michael Pfaller et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Gain-of-Function Mutations in UPC2 Are a Frequent Cause of ERG11 Upregulation in Azole-Resistant Clinical Isolates of Candida albicans

(2012) Stephanie A. Flowers et al.   EUKARYOTIC CELL

Aneuploidy and Drug Resistance in Pathogenic Fungi

(2012) Kyung J. Kwon-Chung et al.   PLoS Pathogens

Differential Requirement of the Transcription Factor Mcm1 for Activation of the Candida albicans Multidrug Efflux PumpMDR1by Its Regulators Mrr1 and Cap1

(2011) Selene Mogavero et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Current perspectives on echinocandin class drugs

(2011) David S Perlin   Future Microbiology

An A643V Amino Acid Substitution in Upc2p Contributes to Azole Resistance in Well-Characterized Clinical Isolates ofCandida albicans

(2010) Samantha J. Hoot et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Transcription factors CgUPC2A and CgUPC2B regulate ergosterol biosynthetic genes in Candida glabrata

(2010) Minoru Nagi et al.   GENES TO CELLS

Azole Drugs Are Imported By Facilitated Diffusion in Candida albicans and Other Pathogenic Fungi

(2010) Bryce E. Mansfield et al.   PLoS Pathogens

Evolutionary divergence in the fungal response to fluconazole revealed by soft clustering

(2010) Dwight Kuo et al.   GENOME BIOLOGY

Acquisition of Flucytosine, Azole, and Caspofungin Resistance in Candida glabrata Bloodstream Isolates Serially Obtained from a Hematopoietic Stem Cell Transplant Recipient

(2009) F. Chapeland-Leclerc et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

An A643T Mutation in the Transcription Factor Upc2p Causes Constitutive ERG11 Upregulation and Increased Fluconazole Resistance in Candida albicans

(2009) C. J. Heilmann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Relative Contributions of the Candida albicans ABC Transporters Cdr1p and Cdr2p to Clinical Azole Resistance

(2009) S. Tsao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Clinical Practice Guidelines for the Management of Candidiasis: 2009 Update by the Infectious Diseases Society of America

(2009) Peter G. Pappas et al.   CLINICAL INFECTIOUS DISEASES

Efflux-Mediated Antifungal Drug Resistance

(2009) R. D. Cannon et al.   CLINICAL MICROBIOLOGY REVIEWS

Antifungal drug resistance mechanisms in fungal pathogens from the perspective of transcriptional gene regulation

(2009) Dominique Sanglard et al.   FEMS YEAST RESEARCH

Fungal echinocandin resistance

(2009) Louise A. Walker et al.   FUNGAL GENETICS AND BIOLOGY

Treatment of onychomycosis: An update

(2009) AA Shirwaikar et al.   INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES

Formation of new chromosomes as a virulence mechanism in yeastCandida glabrata

(2009) Silvia Poláková et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gain of Function Mutations in CgPDR1 of Candida glabrata Not Only Mediate Antifungal Resistance but Also Enhance Virulence

(2009) Sélène Ferrari et al.   PLoS Pathogens

Gain-of-Function Mutations in the Transcription Factor MRR1 Are Responsible for Overexpression of the MDR1 Efflux Pump in Fluconazole-Resistant Candida dubliniensis Strains

(2008) S. Schubert et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Abc1p Is a Multidrug Efflux Transporter That Tips the Balance in Favor of Innate Azole Resistance in Candida krusei

(2008) E. Lamping et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Membrane homoeostasis and multidrug resistance in yeast

(2008) Sneh Lata Panwar et al.   BIOSCIENCE REPORTS

Candida albicans UPC2 is transcriptionally induced in response to antifungal drugs and anaerobicity through Upc2p-dependent and -independent mechanisms

(2008) S. J. Hoot et al.   MICROBIOLOGY-SGM

Mutations in the multi-drug resistance regulatorMRR1, followed by loss of heterozygosity, are the main cause ofMDR1overexpression in fluconazole-resistantCandida albicansstrains

(2008) Nico Dunkel et al.   MOLECULAR MICROBIOLOGY