Review
Gastroenterology & Hepatology
Calen A. Steiner, Jeffrey A. Berinstein, Jeremy Louissaint, Peter D. R. Higgins, Jason R. Spence, Carol Shannon, Cathy Lu, Ryan W. Stidham, Joel G. Fletcher, David H. Bruining, Brian G. Feagan, Vipul Jairath, Mark E. Baker, Dominik Bettenworth, Florian Rieder
Summary: This comprehensive systematic review examines biomarkers for predicting and diagnosing Crohn's disease-associated strictures. Thirty-five potential biomarkers were identified across three groups, including promising markers such as cartilage oligomeric matrix protein and hepatocyte growth factor activator. However, limitations exist, including the lack of standardized definition for stricturing disease and incomplete knowledge of their operating properties.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Esther Caparros, Reiner Wiest, Michael Scharl, Gerhard Rogler, Ana Gutierrez Casbas, Bahtiyar Yilmaz, Marcin Wawrzyniak, Ruben Frances
Summary: This review delves into the modification of the gut microbiota cluster network during CD progression and discusses how this shift compromises the gut barrier integrity, allowing the translocation of microbes and their products. It also retraces gut microbiota dysbiosis interactions with the main pathophysiologic factors of CD, providing insights on genetic background, immune inflammatory processes, and potential benefits of targeting a specific gut microbiota.
Review
Oncology
M. Hornschuh, E. Wirthgen, M. Wolfien, K. P. Singh, O. Wolkenhauer, J. Daebritz
Summary: Epigenetics plays a crucial role in inflammatory bowel diseases, particularly in Crohn's disease, which is believed to be a result of a complex interplay between genetic susceptibility, environmental factors, and altered intestinal microbiota. While many genetic variants have been associated with Crohn's disease, the influence of epigenetics in its pathogenesis remains relatively unknown.
CLINICAL EPIGENETICS
(2021)
Article
Clinical Neurology
Maria Carna, Isaac. G. G. Onyango, Stanislav Katina, Dusan Holub, Jan Sebastian Novotny, Marketa Nezvedova, Durga Jha, Zuzana Nedelska, Valentina Lacovich, Thijs Vande Vyvere, Ruben Houbrechts, Krystine Garcia-Mansfield, Ritin Sharma, Victoria David-Dirgo, Martin Vyhnalek, Katerina Texlova, Hernan Chaves, Nadine Bakkar, Lucia Pertierra, Mojmir Vinkler, Hana Markova, Jan Laczo, Katerina Sheardova, Marcela Hortova-Kohoutkova, Jan Fric, Giancarlo Forte, Petr Kanovsky, Silvie Belaskova, Jiri Damborsky, Jakub Hort, Nicholas. T. T. Seyfried, Robert Bowser, Gustavo Sevlever, Robert. A. A. Rissman, Richard. A. A. Smith, Marian Hajduch, Patrick Pirrotte, Zdenek Spacil, Eric. B. B. Dammer, Clara Limback-Stokin, Gorazd. B. B. Stokin
Summary: Cerebrospinal fluid (CSF) changes in aging and Alzheimer's disease (AD) are indicative of choroid plexus (ChP) dysfunction and involvement in AD pathogenesis. AD-related CSF alterations are consistent with perturbed aging process and accompanied by accumulation of inflammatory signals and active proteins in the ChP. Magnetic resonance imaging (MRI) shows significant remodeling of ChP in AD, which correlates with age and cognitive decline.
ALZHEIMERS & DEMENTIA
(2023)
Article
Immunology
Camila Hartmann, Anna Flavia Ribeiro dos Santos Miggiolaro, Jarbas da Silva Motta, Lucas Baena Carstens, Caroline Busatta Vaz De Paula, Sarah Fagundes Grobe, Larissa Hermann de Souza Nunes, Gustavo Lenci Marques, Peter Libby, Lidia Zytynski Moura, Lucia de Noronha, Cristina Pellegrino Baena
Summary: Myocardial injury in COVID-19 patients is significantly associated with mortality and appears to be related to local inflammation and associated interstitial edema, rather than primary myocardiocyte involvement. Increased expression of TGF-beta and interstitial collagen in COVID-affected hearts may indicate a potential risk of chronic myocardial fibrosis.Continued clinical surveillance for myocardial dysfunction and arrythmias is recommended for patients after recovery from the acute phase of COVID-19.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Ashkan Rezazadeh Ardabili, Danny Goudkade, Dion Wintjens, Marielle Romberg-Camps, Bjorn Winkens, Marie Pierik, Heike Grabsch, Daisy Jonkers
Summary: The study found that certain histopathological features in colonic biopsies at the diagnosis of Crohn's disease may help predict the severity of the disease course, offering a novel approach to improving patient stratification and guiding clinical decision-making.
JOURNAL OF CROHNS & COLITIS
(2021)
Review
Immunology
Shanshan Xiong, Jinyu Tan, Yu Wang, Jinshen He, Fan Hu, Xiaomin Wu, Zishan Liu, Sinan Lin, Xuehua Li, Zhihui Chen, Ren Mao
Summary: This article summarizes the possible mechanisms of creeping fat fibrosis and its impact on other diseases. It illustrates the role of different cells and molecules in the pathogenesis of fat fibrosis in other diseases to understand the role of creeping fat fibrosis in Crohn's disease pathogenesis. Future research will provide key information on the role of fat fibrosis in creeping fat formation and intestinal damage, helping to identify novel targets for the diagnosis and treatment of Crohn's disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Gastroenterology & Hepatology
Joseph Sleiman, Sara El Ouali, Taha Qazi, Benjamin Cohen, Scott R. Steele, Mark E. Baker, Florian Rieder
Summary: Fibrostenosis is a major feature of Crohn's disease (CD) and poses a challenge in the clinical management of inflammatory bowel disease patients. While there are no specific therapies to prevent or treat fibrosis in CD currently, efforts are being made to standardize definitions and propose endpoints for better management, along with research to develop future anti-fibrotic therapies.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Immunology
Jing Wang, Zejian Li, Jun Xiao, Luyao Wu, Ke Chen, Tianqi Zhu, Chenzhao Feng, Didi Zhuansun, Xinyao Meng, Jiexiong Feng
Summary: This study investigates the underlying mechanism and biomarkers for the co-occurrence of Hirschsprung disease (HSCR) and Crohn's disease (CD). Through functional annotation and protein-protein interaction network analysis, key genes related to immune and inflammation processes were identified. The expression of these genes in HSCR and CD samples were validated and demonstrated strong diagnostic value.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Rong Huang, Wenjia Wang, Ziyi Chen, Jing Chai, Qin Qi, Handan Zheng, Bingli Chen, Huangan Wu, Huirong Liu
Summary: This study investigated the molecular immune mechanisms associated with Crohn's disease (CD) and its fibrosis through bioinformatics analysis. The results identified MMP2, COL1A1, CXCL10, and FGF2 as key genes for CD, with COL1A1 also being a potential diagnostic biomarker.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Giovanni Santacroce, Marco Vincenzo Lenti, Antonio Di Sabatino
Summary: Intestinal fibrosis is a threatening complication of Crohn's disease. The mechanisms underlying its development are not fully understood, and targeted therapies are currently lacking. This review provides an overview of the main therapeutic targets and the most promising anti-fibrotic therapies for intestinal fibrosis.
Article
Gastroenterology & Hepatology
Aito Ueno, Humberto B. Jijon, Richard Peng, Steven Sparksman, Barbara Mainoli, Alexis Filyk, Yan Li, Stephanie Wilson, Kerri Novak, Remo Panaccione, Simon Hirota, Antoine Dufour, Cathy Lu, Paul L. Beck
Summary: This study provides evidence supporting a potential role of fibrocytes in collagen deposition in Crohn's disease strictures and suggests that fibrocyte numbers may predict the need for therapy escalation.
INFLAMMATORY BOWEL DISEASES
(2022)
Review
Medicine, General & Internal
Ali S. Alyami
Summary: Inflammatory bowel disease (IBD) is a global health concern that has been on the rise in recent years. Imaging techniques, particularly radiomics analysis, have emerged as a valuable tool for the detection, diagnosis, treatment planning, and monitoring of IBD. Recent advancements in artificial intelligence technology and machine learning have enabled the automated evaluation of medical images, providing accurate and rapid non-invasive tools for IBD diagnostics, treatment response monitoring, and prognosis.
Review
Pathology
Priyanka Singh, Saba Naaz Ali, Sufian Zaheer, Mukul Singh
Summary: Interstitial lung diseases (ILDs) are a group of rare pulmonary pathologies that involve injury, inflammation, and scarring in the lungs. The exact causes of these diseases are largely unknown, but various cellular mechanisms play important roles in the development of fibrosis, influenced by occupational, environmental, and genetic factors. This study aims to provide new insights into the interactions and cellular contributions in the pathogenesis of idiopathic pulmonary fibrosis.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Biochemistry & Molecular Biology
Alexander Blagov, Elena B. Zhigmitova, Margarita A. Sazonova, Liudmila M. Mikhaleva, Vladislav Kalmykov, Nikolay K. Shakhpazyan, Varvara A. Orekhova, Alexander N. Orekhov
Summary: Crohn's disease is a challenging problem in modern medicine, and understanding its molecular and cellular pathologic processes is crucial for the development of new and safer therapies. Recent research has shown the involvement of mitochondrial dysfunction and chronic inflammation in these processes. This review discusses published works on pathogenetic models of Crohn's disease, which provides insights into the role of mitochondrial dysfunction in the disease's development and advances the development of novel therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)