Article
Cardiac & Cardiovascular Systems
Federico Biscetti, Giovanni Tinelli, Maria Margherita Rando, Elisabetta Nardella, Andrea Leonardo Cecchini, Flavia Angelini, Giuseppe Straface, Marco Filipponi, Vincenzo Arena, Dario Pitocco, Antonio Gasbarrini, Massimo Massetti, Andrea Flex
Summary: The study found that HMGB1 is an independent risk factor for carotid plaque vulnerability in diabetic patients, with higher levels of HMGB1 and inflammatory cytokines in ICAS patients compared to WICAS patients. Among ICAS patients, those with unstable plaque had even higher levels of these cytokines. HMGB1 and osteoprotegerin were independently associated with unstable plaque in ICAS patients.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Cell Biology
Lujia Feng, Liang Liang, Shaochong Zhang, Jinglu Yang, Yanan Yue, Xuedong Zhang
Summary: This study investigated the relationship between HMGB1, the macroautophagy/autophagy-lysosome pathway, and DR, finding that high glucose inhibited autophagy and diminished its degradative capacity due to lysosome membrane permeabilization. HMGB1 was involved in lysosome membrane permeabilization via the CTSB-dependent pathway in the early stages of DR.
Review
Biochemistry & Molecular Biology
Tapan Behl, Eshita Sharma, Aayush Sehgal, Ishnoor Kaur, Arun Kumar, Rashmi Arora, Giridhari Pal, Munish Kakkar, Ravinder Kumar, Simona Bungau
Summary: Diabetes mellitus is a major healthcare challenge globally, with inflammation being a key pathogenic mechanism affecting various body parts. High-mobility group box 1 (HMGB1) is a significant non-histone protein triggering the inflammatory response, making it a potential target in diabetes research.
MOLECULAR BIOLOGY REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Samanta Taurone, Chiara De Ponte, Dante Rotili, Elena De Santis, Antonello Mai, Francesco Fiorentino, Susanna Scarpa, Marco Artico, Alessandra Micera
Summary: Diabetic retinopathy is a leading cause of blindness worldwide, with its incidence increasing steadily. Recent studies have shown that the development of this disease is primarily attributed to the complex relationship between inflammation, generation of free oxygen species, and oxidative stress caused by prolonged hyperglycemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Zijing Huang, Wai Kit Chu, Tsz Kin Ng, Shaolang Chen, Jiajian Liang, Chong-Bo Chen, Yanxuan Xu, Biyao Xie, Shuping Ke, Qingping Liu, Weiqi Chen, Dingguo Huang
Summary: The study suggests that nattokinase (NK) has therapeutic potential for early diabetic retinopathy (DR) by improving the blood-retinal barrier function, protecting retinal neurons and inhibiting inflammation caused by diabetes.
JOURNAL OF DIABETES
(2023)
Review
Biochemistry & Molecular Biology
Liyang Ji, Hong Tian, Keith A. Webster, Wei Li
Summary: Diabetic retinopathy is the leading cause of vision loss in working adults in developed countries, now recognized as a neurovascular disorder. Disturbance of the neurovascular unit can lead to vision-threatening clinical manifestations. While VEGF inhibitors are widely used to treat DR, their limited efficacy suggests the involvement of other signaling molecules in the pathogenesis of the disease.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Nutrition & Dietetics
Agostino Milluzzo, Martina Barchitta, Andrea Maugeri, Roberta Magnano San Lio, Giuliana Favara, Maria Grazia Mazzone, Laura Sciacca, Antonella Agodi
Summary: Diabetic retinopathy is a multifactorial neuro-microvascular disease with high prevalence and severe consequences. There are limited treatment options for early stage or prevention, while advanced stage requires invasive and expensive therapies. A systematic review of observational and interventional studies suggests that certain nutrients, such as vitamins B, D, and E, may have a preventive role in DR. However, further research is needed to determine the clinical application of nutraceuticals in the prevention and treatment of DR.
Review
Nanoscience & Nanotechnology
Yuxin Liu, Na Wu
Summary: Diabetic retinopathy is a chronic complication of diabetes that can lead to vision problems or even blindness. Current treatments include laser photocoagulation, anti-VEGF drugs, and vitrectomy. Nanotechnology shows potential for innovative treatment approaches in DR.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Pharmacology & Pharmacy
Urvi M. Parmar, Manjiri P. Jalgaonkar, Yogesh A. Kulkarni, Manisha J. Oza
Summary: The incidence of diabetes is increasing globally, and it is associated with hyperglycemia and disrupted metabolic pathways. Autophagy plays a crucial role in maintaining cellular homeostasis, but disrupted autophagy contributes to metabolic disorders such as obesity and diabetes. Nutrient-sensing pathways, including SIRT1, mTOR, and AMPK, regulate autophagy and they could be potential therapeutic targets for reducing diabetic complications.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Manjiri P. P. Jalgaonkar, Urvi M. M. Parmar, Yogesh A. A. Kulkarni, Manisha J. J. Oza
Summary: The prevalence of diabetes is increasing, leading to microvascular and macrovascular complications. The interaction between SIRT1 and FOXOs plays an important role in controlling and alleviating diabetic complications, suggesting them as potential therapeutic targets.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Klausen Oliveira-Abreu, Jose Cipolla-Neto, Jose Henrique Leal-Cardoso
Summary: Studies suggest that melatonin (MEL) has therapeutic potential as an adjunct treatment for neural complications of diabetes mellitus (DM). However, variations in dosage, treatment duration, and treatment timing hinder objective analysis of the progress and establishment of parameters for the validation of MEL in the treatment of neural complications of DM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Sarah Saxena, Veronique Kruys, Raf De Jongh, Joseph Vamecq, Mervyn Maze
Summary: Aseptic surgical trauma induces the release of HMGB1, triggering the immune response and resulting in postoperative cognitive decline.
Review
Endocrinology & Metabolism
Yuntian Shen, Ming Li, Kexin Wang, Guangdong Qi, Hua Liu, Wei Wang, Yanan Ji, Mengyuan Chang, Chunyan Deng, Feng Xu, Mi Shen, Hualin Sun
Summary: Diabetes mellitus is a chronic disease that can lead to complications such as kidney disease, cardiovascular disease, neuropathy, and skeletal muscle atrophy. Understanding the molecular regulatory mechanisms of diabetic muscular atrophy is important in developing new treatment strategies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Gen Miura
Summary: Visual evoked potentials (VEP) can detect visual pathway dysfunction in diabetes mellitus caused by abnormalities in blood glucose levels. Previous studies have shown that VEP can detect neuropathy before fundus examination and evaluate the correlation between VEP waveforms and disease duration, HbA1c, glycemic control, and short-term blood glucose fluctuations. VEP may be useful for predicting postoperative prognosis and assessing visual function in diabetic retinopathy. Further research with larger cohorts is needed to establish a more detailed relationship between diabetes mellitus and VEP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ellen Steffenssen Sauesund, Oystein Kalsnes Jorstad, Cathrine Brunborg, Morten Carstens Moe, Maja Gran Erke, Dag Sigurd Fosmark, Goran Petrovski
Summary: This study investigated the baseline parameters of a population with diabetes mellitus (DM) included in a pilot diabetic retinopathy (DR) screening program at Oslo University Hospital (OUH), Norway. The results showed that a significant number of patients with DM had never undergone eye examinations, highlighting the need for implementing a systematic screening program to improve their screening adherence and prevent vision loss.
Letter
Ophthalmology
Ludovico Alisi, Marta Armentano, Lorenzo Sampalmieri, Simone Bruschi, Roberta Zito, Ludovico Iannetti
Summary: This case report presents a young male who developed bilateral panuveitis after extensive tattooing. The patient was successfully treated with long-term corticosteroid therapy and achieved full recovery.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Review
Pharmacology & Pharmacy
Matteo Fallico, Iacopo Macchi, Andrea Maugeri, Giuliana Favara, Martina Barchitta, Roberta Magnano San Lio, Antonella Agodi, Andrea Russo, Antonio Longo, Teresio Avitabile, Niccolo Castellino, Michele Reibaldi, Francesco Pignatelli, Maria Vadala, Clara Patane, Marcella Nebbioso, Vincenza Bonfiglio
Summary: The study aimed to assess the functional and anatomical outcomes of intravitreal anti-VEGF monotherapy compared to a combination therapy with verteporfin PDT for retinal angiomatous proliferation (RAP). The results showed that the combination therapy group had better improvements in best corrected visual acuity and central macular thickness compared to the anti-VEGF monotherapy group. The importance rating for this study is 8 out of 10.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Alice Bruscolini, Giacomo Visioli, Marco Marenco, Veronica Cherubini, Anna Maria Comberiati, Gaspare Palaia, Massimo Ralli, Livia Ottolenghi, Alessandro Lambiase, Antonella Polimeni
Summary: Italy serves as a gateway for refugees and migrants entering Europe, with a significant number requiring socio-economic and health assistance. A new intervention strategy, known as the PROTECT project, aimed to evaluate the eye health of vulnerable applicants and international protection holders in the head-neck area. 3023 migrants participated in the project, with demographic factors and eye history collected through a questionnaire. Results showed a high prevalence of vision impairment, with various ocular diseases identified. The PROTECT project improves accessibility to preventive care for head-neck diseases and highlights the importance of early identification and prevention of ocular diseases in disadvantaged populations.
APPLIED SCIENCES-BASEL
(2023)
Review
Chemistry, Multidisciplinary
Valeria Iannucci, Priscilla Manni, Giulia Mecarelli, Sara Giammaria, Francesca Giovannetti, Alessandro Lambiase, Alice Bruscolini
Summary: Uveitic glaucoma (UG) is a common cause of secondary glaucoma in pediatric ophthalmology, caused by intraocular inflammation. Managing UG is challenging and requires a multidisciplinary approach. Overlap with steroid-induced glaucoma (SIG) is common, and there are limited papers discussing the treatment options for pediatric UG.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Marta Armentano, Luca Lucchino, Ludovico Alisi, Antonio Valerio Chicca, Valerio Di Martino, Emanuele Miraglia, Ludovico Iannetti, Anna Maria Comberiati, Sandra Giustini, Alessandro Lambiase, Antonietta Moramarco
Summary: Neurofibromatosis type 2 (NF2) is a genetically determined tumor-predisposing syndrome with ocular manifestations including cataracts, epiretinal membranes, retinal hamartomas, optic disk gliomas, and optic nerve sheath meningiomas. Other indirect signs such as optic disk edema, optical atrophy, motility disorders, pupil and lid dysfunction, and neurotrophic keratitis can also be observed.
APPLIED SCIENCES-BASEL
(2023)
Article
Ophthalmology
Giacomo Visioli, Ludovico Alisi, Elvia Mastrogiuseppe, Giuseppe Maria Albanese, Enrico Romano, Ludovico Iannetti, Marta Armentano, Francesca Giovannetti, Magda Gharbiya
Summary: This study examines the impact of OCT features on visual acuity improvement after DEX-I injection in DME patients. Thicker baseline CST may serve as a positive predictor for early visual improvement, while the presence of SND at baseline may be a negative prognostic factor for CST increase at 4 months.
INTERNATIONAL JOURNAL OF RETINA AND VITREOUS
(2023)
Review
Biochemistry & Molecular Biology
Fabiana Mallone, Ludovico Alisi, Luca Lucchino, Valerio Di Martino, Marcella Nebbioso, Marta Armentano, Alessandro Lambiase, Antonietta Moramarco
Summary: Neurofibromatosis type 1 (NF1) is a rare genetic disorder that affects the skin, nervous system, and eyes. Ocular diagnostic hallmarks of NF1 include various abnormalities in the eyes such as nodules, neurofibromas, and spots. Recent advancements in imaging techniques have allowed for better characterization of these eye abnormalities in NF1 patients. This paper reviews the latest progress in understanding and diagnosing choroidal and retinal abnormalities in NF1 patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biology
Valeria Iannucci, Priscilla Manni, Ludovico Alisi, Giulia Mecarelli, Alessandro Lambiase, Alice Bruscolini
Summary: Ocular trauma is a common problem worldwide and can lead to secondary glaucoma. Angle recession, usually unilateral, is a major cause of post-traumatic glaucoma after blunt eye trauma. This paper investigates the possible causes of bilateral angle recession and presents a case of chronic post-traumatic glaucoma, possibly caused by an airbag.
Article
Medicine, General & Internal
Ludovico Iannetti, Fabio Scarinci, Ludovico Alisi, Marta Armentano, Lorenzo Sampalmieri, Maurizio La Cava, Magda Gharbiya
Summary: The characteristics of macular edema in young patients with idiopathic intermediate uveitis were described and correlated with visual acuity using spectral domain optical coherence tomography (SD-OCT). The study found a negative correlation between best-corrected visual acuity (BCVA) and Ellipsoid Zone disruption, cystoid pattern, central subfield thickness (CST), and serous retinal detachment.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Ludovico Iannetti, Fabio Scarinci, Ludovico Alisi, Alessandro Beccia, Andrea Cacciamani, Maria Carmela Saturno, Magda Gharbiya
Summary: This article reports an uncommon presentation of Eales disease associated with cocaine abuse, presenting as blurred vision in the left eye. Serologic panel was negative except for the heterozygous mutation of factor V Leiden. Clinical and biochemical parameters suggested a diagnosis of Eales disease. Treatment with dexamethasone and peripheral laser photocoagulation allowed symptom relief.
MEDICINA-LITHUANIA
(2023)