Role of Mitochondria-Cytoskeleton Interactions in the Regulation of Mitochondrial Structure and Function in Cancer Stem Cells

FoxM1-dependent and fatty acid oxidation-mediated ROS modulation is a cell-intrinsic drug resistance mechanism in cancer stem-like cells

(2020) Hae-Ji Choi et al.   Redox Biology

Targeting cancer energy metabolism: a potential systemic cure for cancer

(2019) Soo-Youl Kim   ARCHIVES OF PHARMACAL RESEARCH

A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats

(2019) Julio C. B. Ferreira et al.   Nature Communications

Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma

(2019) Yufeng Shi et al.   NATURE

Mitochondria-centric bioenergetic characteristics in cancer stem-like cells

(2019) Min-Kyue Shin et al.   ARCHIVES OF PHARMACAL RESEARCH

Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related Analogues

(2019) Paul R. Graves et al.   ACS Chemical Biology

Glycolytic suppression dramatically changes the intracellular metabolic profile of multiple cancer cell lines in a mitochondrial metabolism-dependent manner

(2019) Reika Shiratori et al.   Scientific Reports

Cancer Metabolism: a Hope for Curing Cancer

(2018) Soo-Youl Kim   Biomolecules & Therapeutics

Cancer Energy Metabolism: Shutting Power off Cancer Factory

(2018) Soo-Youl Kim   Biomolecules & Therapeutics

New metformin derivative HL156A prevents oral cancer progression by inhibiting the insulin-like growth factor/AKT/mammalian target of rapamycin pathways

(2018) Thuy Giang Lam et al.   CANCER SCIENCE

Myosin VI-Dependent Actin Cages Encapsulate Parkin-Positive Damaged Mitochondria

(2018) Antonina J. Kruppa et al.   DEVELOPMENTAL CELL

ONC201 kills breast cancer cells in vitro by targeting mitochondria

(2018) Yoshimi Endo Greer et al.   Oncotarget

VDAC1 as Pharmacological Target in Cancer and Neurodegeneration: Focus on Its Role in Apoptosis

(2018) Andrea Magrì et al.   Frontiers in Chemistry

KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism

(2018) Angelina V. Vaseva et al.   CANCER CELL

Loss of CAMSAP3 promotes EMT via the modification of microtubule–Akt machinery

(2018) Varisa Pongrakhananon et al.   JOURNAL OF CELL SCIENCE

Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade

(2017) Hui-wen Lue et al.   GENES & DEVELOPMENT

Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer

(2017) M. Cecilia Caino et al.   JOURNAL OF CLINICAL INVESTIGATION

Miro1-mediated mitochondrial positioning shapes intracellular energy gradients required for cell migration

(2017) Max-Hinderk Schuler et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of bioenergetics through dual inhibition of aldehyde dehydrogenase and mitochondrial complex I suppresses glioblastoma tumorspheres

(2017) Junseong Park et al.   NEURO-ONCOLOGY

Microtubules acquire resistance from mechanical breakage through intralumenal acetylation

(2017) Zhenjie Xu et al.   SCIENCE

Mitochondrial Function and Cell Size: An Allometric Relationship

(2017) Teemu P. Miettinen et al.   TRENDS IN CELL BIOLOGY

ONC201: a new treatment option being tested clinically for recurrent glioblastoma

(2017) Marie D. Ralff et al.   Translational Cancer Research

Knockdown of stem cell regulator Oct4A in ovarian cancer reveals cellular reprogramming associated with key regulators of cytoskeleton-extracellular matrix remodelling

(2017) Chantel Samardzija et al.   Scientific Reports

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton

(2016) Hai Hu et al.   CELL

Mitochondria and Cancer

(2016) Sejal Vyas et al.   CELL

Structures of human mitofusin 1 provide insight into mitochondrial tethering

(2016) Yuanbo Qi et al.   JOURNAL OF CELL BIOLOGY

Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis

(2016) Xinjian Li et al.   MOLECULAR CELL

ERK/Drp1-dependent mitochondrial fission is involved in the MSC-induced drug resistance of T-cell acute lymphoblastic leukemia cells

(2016) Jianye Cai et al.   Cell Death & Disease

A neuronal network of mitochondrial dynamics regulates metastasis

(2016) M. Cecilia Caino et al.   Nature Communications

Dynamic actin cycling through mitochondrial subpopulations locally regulates the fission–fusion balance within mitochondrial networks

(2016) Andrew S. Moore et al.   Nature Communications

Inhibiting stemness and invasive properties of glioblastoma tumorsphere by combined treatment with temozolomide and a newly designed biguanide (HL156A)

(2016) Junjeong Choi et al.   Oncotarget

Aldehyde dehydrogenase 1A1 in stem cells and cancer

(2016) Hiroyuki Tomita et al.   Oncotarget

Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia

(2015) Alicia Cole et al.   CANCER CELL

MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells

(2015) Patricia Sancho et al.   Cell Metabolism

SIRT1/PGC1 -Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer

(2015) T. T. Vellinga et al.   CLINICAL CANCER RESEARCH

Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics

(2015) Angelika S. Rambold et al.   DEVELOPMENTAL CELL

Emerging concepts in bioenergetics and cancer research: Metabolic flexibility, coupling, symbiosis, switch, oxidative tumors, metabolic remodeling, signaling and bioenergetic therapy

(2015) Emilie Obre et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mitochondrial Division Is Requisite to RAS-Induced Transformation and Targeted by Oncogenic MAPK Pathway Inhibitors

(2015) Madhavika N. Serasinghe et al.   MOLECULAR CELL

Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-Driven Tumor Growth

(2015) Jennifer A. Kashatus et al.   MOLECULAR CELL

PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion

(2015) M. Cecilia Caino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic stress induces a Wnt-dependent cancer stem cell-like state transition

(2015) E Lee et al.   Cell Death & Disease

Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells

(2015) Arianna De Luca et al.   Oncotarget

High mitochondrial mass identifies a sub-population of stem-like cancer cells that are chemo-resistant

(2015) Gillian Farnie et al.   Oncotarget

Actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites

(2015) Wei-ke Ji et al.   eLife

A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division

(2015) Uri Manor et al.   eLife

Actin Cytoskeleton Regulation of Epithelial Mesenchymal Transition in Metastatic Cancer Cells

(2015) Jay Shankar et al.   PLoS One

Cancer stem cells from epithelial ovarian cancer patients privilege oxidative phosphorylation, and resist glucose deprivation

(2015) Anna Pastò et al.   Oncotarget

Movers and shakers: cell cytoskeleton in cancer metastasis

(2014) C M Fife et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Role for Myosin II in Mammalian Mitochondrial Fission

(2014) Farida Korobova et al.   CURRENT BIOLOGY

Transforming growth factor-β1-induced epithelial to mesenchymal transition increases mitochondrial content in the A549 non-small cell lung cancer cell line

(2014) YUNHUA XU et al.   Molecular Medicine Reports

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

E-Cadherin and EpCAM expression by NSCLC tumour cells associate with normal fibroblast activation through a pathway initiated by integrin αvβ6 and maintained through TGFβ signalling

(2014) C Eberlein et al.   ONCOGENE

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

(2014) William W Wheaton et al.   eLife

Mitochondrial morphology transitions and functions: implications for retrograde signaling?

(2013) Martin Picard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

ATP Transport through VDAC and the VDAC–Tubulin Complex Probed by Equilibrium and Nonequilibrium MD Simulations

(2013) Sergei Yu. Noskov et al.   BIOCHEMISTRY

New insights into the function and regulation of mitochondrial fission

(2013) Hidenori Otera et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial Localization and the Persistent Migration of Epithelial Cancer cells

(2013) Salil P. Desai et al.   BIOPHYSICAL JOURNAL

PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress

(2013) Francisca Vazquez et al.   CANCER CELL

Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1Bhigh Cells

(2013) Alexander Roesch et al.   CANCER CELL

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

(2013) Eleni D. Lagadinou et al.   Cell Stem Cell

Resveratrol Impedes the Stemness, Epithelial-Mesenchymal Transition, and Metabolic Reprogramming of Cancer Stem Cells in Nasopharyngeal Carcinoma through p53 Activation

(2013) Yao-An Shen et al.   Evidence-based Complementary and Alternative Medicine

Voltage-dependent Anion Channels Modulate Mitochondrial Metabolism in Cancer Cells

(2013) Eduardo N. Maldonado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Principles of the mitochondrial fusion and fission cycle in neurons

(2013) M. Cagalinec et al.   JOURNAL OF CELL SCIENCE

Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells

(2013) M. Cecilia Caino et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases

(2013) Stephen L. Archer   NEW ENGLAND JOURNAL OF MEDICINE

Metformin Targets the Metabolic Achilles Heel of Human Pancreatic Cancer Stem Cells

(2013) Enza Lonardo et al.   PLoS One

An Actin-Dependent Step in Mitochondrial Fission Mediated by the ER-Associated Formin INF2

(2013) F. Korobova et al.   SCIENCE

Landscape of the mitochondrial Hsp90 metabolome in tumours

(2013) Young Chan Chae et al.   Nature Communications

CD133 Expression in Normal Skin and in Epithelial Cutaneous Tumors

(2013) S. H. Nam-Cha et al.   Biomed Research International

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

(2012) M. Janiszewska et al.   GENES & DEVELOPMENT

The axonal transport of mitochondria

(2012) W. M. Saxton et al.   JOURNAL OF CELL SCIENCE

Actin stress fibers - assembly, dynamics and biological roles

(2012) S. Tojkander et al.   JOURNAL OF CELL SCIENCE

Isotopically nonstationary 13C flux analysis of Myc-induced metabolic reprogramming in B-cells

(2012) Taylor A. Murphy et al.   METABOLIC ENGINEERING

Mitochondrial fusion: A mechanism of cisplatin-induced resistance in neuroblastoma cells?

(2012) Giada Santin et al.   NEUROTOXICOLOGY

Mitochondrial dynamics regulates migration and invasion of breast cancer cells

(2012) J Zhao et al.   ONCOGENE

Mitochondrial Structure, Function and Dynamics Are Temporally Controlled by c-Myc

(2012) J. Anthony Graves et al.   PLoS One

Reactive Oxygen Species Regulate Protrusion Efficiency by Controlling Actin Dynamics

(2012) Nicolas Taulet et al.   PLoS One

Mitochondrial quality control: an integrated network of pathways

(2012) Fabian Fischer et al.   TRENDS IN BIOCHEMICAL SCIENCES

Intracellular ATP Levels Are a Pivotal Determinant of Chemoresistance in Colon Cancer Cells

(2011) Y. Zhou et al.   CANCER RESEARCH

Aldehyde dehydrogenase: Its role as a cancer stem cell marker comes down to the specific isoform

(2011) Paola Marcato et al.   CELL CYCLE

Role of CD44 in the organization of keratinocyte pericellular hyaluronan

(2011) Sanna Pasonen-Seppänen et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Mitochondrial and energy metabolism-related properties as novel indicators of lung cancer stem cells

(2011) Xiao-Qun Ye et al.   INTERNATIONAL JOURNAL OF CANCER

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation

(2011) A. S. Rambold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic state of glioma stem cells and nontumorigenic cells

(2011) E. Vlashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

Free Tubulin Modulates Mitochondrial Membrane Potential in Cancer Cells

(2010) E. N. Maldonado et al.   CANCER RESEARCH

Inhibition of Drp1-dependent mitochondrial fragmentation and apoptosis by a polypeptide antagonist of calcineurin

(2010) G M Cereghetti et al.   CELL DEATH AND DIFFERENTIATION

Myc-dependent Mitochondrial Generation of Acetyl-CoA Contributes to Fatty Acid Biosynthesis and Histone Acetylation during Cell Cycle Entry

(2010) Fionnuala Morrish et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells

(2010) Hidenori Otera et al.   JOURNAL OF CELL BIOLOGY

Nerve Growth Factor Induces Axonal Filopodia through Localized Microdomains of Phosphoinositide 3-Kinase Activity That Drive the Formation of Cytoskeletal Precursors to Filopodia

(2010) A. Ketschek et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial fusion proteins: Dual regulators of morphology and metabolism

(2010) Antonio Zorzano et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cooperation of Cancer Stem Cell Properties and Epithelial-Mesenchymal Transition in the Establishment of Breast Cancer Metastasis

(2010) Tetsu Hayashida et al.   Journal of Oncology

Regulation of respiration controlled by mitochondrial creatine kinase in permeabilized cardiac cells in situ

(2009) Rita Guzun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

A subpopulation of CD133+ cancer stem-like cells characterized in human oral squamous cell carcinoma confer resistance to chemotherapy

(2009) Qunzhou Zhang et al.   CANCER LETTERS

Association of Breast Cancer Stem Cells Identified by Aldehyde Dehydrogenase 1 Expression with Resistance to Sequential Paclitaxel and Epirubicin-Based Chemotherapy for Breast Cancers

(2009) T. Tanei et al.   CLINICAL CANCER RESEARCH

Mitochondrial ‘kiss-and-run’: interplay between mitochondrial motility and fusion–fission dynamics

(2009) Xingguo Liu et al.   EMBO JOURNAL

Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases

(2009) H. Chen et al.   HUMAN MOLECULAR GENETICS

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

Docking of Axonal Mitochondria by Syntaphilin Controls Their Mobility and Affects Short-Term Facilitation

(2008) Jian-Sheng Kang et al.   CELL

Mitochondrial dynamics and apoptosis

(2008) D.-F. Suen et al.   GENES & DEVELOPMENT

VDAC regulation: role of cytosolic proteins and mitochondrial lipids

(2008) Tatiana K. Rostovtseva et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Regulation of respiration in brain mitochondria and synaptosomes: restrictions of ADP diffusion in situ, roles of tubulin, and mitochondrial creatine kinase

(2008) Claire Monge et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Proteomic characterization of cytoskeletal and mitochondrial class III  -tubulin

(2008) L. Cicchillitti et al.   MOLECULAR CANCER THERAPEUTICS

Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respiration

(2008) T. K. Rostovtseva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA