Cancer-Associated Substitutions in RNA Recognition Motifs of PUF60 and U2AF65 Reveal Residues Required for Correct Folding and 3′ Splice-Site Selection

Quantitative proteomics and biochemical analyses reveal the role of endoplasmin in the regulation of the expression and secretion of A Disintegrin And Metalloproteinase 12

(2018) Lipeng Xiong et al.   Journal of Proteomics

UBE2M Is a Stress-Inducible Dual E2 for Neddylation and Ubiquitylation that Promotes Targeted Degradation of UBE2F

(2018) Weihua Zhou et al.   MOLECULAR CELL

Toward an integrated map of genetic interactions in cancer cells

(2018) Benedikt Rauscher et al.   Molecular Systems Biology

UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites

(2018) Vyacheslav Akimov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PUF60-activated exons uncover altered 3′ splice-site selection by germline missense mutations in a single RRM

(2018) Jana Královičová et al.   NUCLEIC ACIDS RESEARCH

UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites

(2018) Vyacheslav Akimov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Comprehensive Genomic Characterization of RNA-Binding Proteins across Human Cancers

(2018) Ze-Lin Wang et al.   Cell Reports

Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

(2018) Zaira Boussadia et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

SF3b1 mutations associated with myelodysplastic syndromes alter the fidelity of branchsite selection in yeast

(2017) Tucker J. Carrocci et al.   NUCLEIC ACIDS RESEARCH

Neddylation E2 UBE2F Promotes the Survival of Lung Cancer Cells by Activating CRL5 to Degrade NOXA via the K11 Linkage

(2016) Weihua Zhou et al.   CLINICAL CANCER RESEARCH

Dominant variants in the splicing factor PUF60 cause a recognizable syndrome with intellectual disability, heart defects and short stature

(2016) Salima El Chehadeh et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Spliceosomal gene mutations in myelodysplasia: molecular links to clonal abnormalities of hematopoiesis

(2016) Daichi Inoue et al.   GENES & DEVELOPMENT

Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations

(2016) Constantin Cretu et al.   MOLECULAR CELL

Alternative splicing ofU2AF1reveals a shared repression mechanism for duplicated exons

(2016) Jana Kralovicova et al.   NUCLEIC ACIDS RESEARCH

COSMIC: somatic cancer genetics at high-resolution

(2016) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

An extended U2AF65–RNA-binding domain recognizes the 3′ splice site signal

(2016) Anant A. Agrawal et al.   Nature Communications

Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage

(2016) Samar Alsafadi et al.   Nature Communications

Differential Aspartate Usage Identifies a Subset of Cancer Cells Particularly Dependent on OGDH

(2016) Eric L. Allen et al.   Cell Reports

Altered mRNA Splicing, Chondrocyte Gene Expression and Abnormal Skeletal Development due to SF3B4 Mutations in Rodriguez Acrofacial Dysostosis

(2016) Felipe Marques et al.   PLoS Genetics

Structural basis for two-step glucose trimming by glucosidase II involved in ER glycoprotein quality control

(2016) Tadashi Satoh et al.   Scientific Reports

A novel 3′ splice site recognition by the two zinc fingers in the U2AF small subunit

(2015) Hisashi Yoshida et al.   GENES & DEVELOPMENT

The CamSol Method of Rational Design of Protein Mutants with Enhanced Solubility

(2015) Pietro Sormanni et al.   JOURNAL OF MOLECULAR BIOLOGY

Concomitant expression of far upstream element (FUSE ) binding protein (FBP ) interacting repressor (FIR) and its splice variants induce migration and invasion of non-small cell lung cancer (NSCLC) cells

(2015) Benedikt Müller et al.   JOURNAL OF PATHOLOGY

Identification of U2AF(35)-dependent exons by RNA-Seq reveals a link between 3′ splice-site organization and activity of U2AF-related proteins

(2015) Jana Kralovicova et al.   NUCLEIC ACIDS RESEARCH

Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point

(2015) Rachel B. Darman et al.   Cell Reports

Protein Domain-Level Landscape of Cancer-Type-Specific Somatic Mutations

(2015) Fan Yang et al.   PLoS Computational Biology

Targeting Neddylation Pathways to Inactivate Cullin-RING Ligases for Anticancer Therapy

(2014) Yongchao Zhao et al.   ANTIOXIDANTS & REDOX SIGNALING

Structure-Functional Prediction and Analysis of Cancer Mutation Effects in Protein Kinases

(2014) Anshuman Dixit et al.   Computational and Mathematical Methods in Medicine

Overexpression of far upstream element (FUSE) binding protein (FBP)-interacting repressor (FIR) supports growth of hepatocellular carcinoma

(2014) Mona Malz et al.   HEPATOLOGY

U2AF1 mutations alter sequence specificity of pre-mRNA binding and splicing

(2014) T Okeyo-Owuor et al.   LEUKEMIA

RNA sequencing identifies novel markers of non-small cell lung cancer

(2014) Seon-Sook Han et al.   LUNG CANCER

RNF43 is frequently mutated in colorectal and endometrial cancers

(2014) Marios Giannakis et al.   NATURE GENETICS

Mechanisms for U2AF to define 3′ splice sites and regulate alternative splicing in the human genome

(2014) Changwei Shao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SCRIB and PUF60 Are Primary Drivers of the Multisystemic Phenotypes of the 8q24.3 Copy-Number Variant

(2013) Andrew Dauber et al.   AMERICAN JOURNAL OF HUMAN GENETICS

mCSM: predicting the effects of mutations in proteins using graph-based signatures

(2013) Douglas E. V. Pires et al.   BIOINFORMATICS

Direct Competition between hnRNP C and U2AF65 Protects the Transcriptome from the Exonization of Alu Elements

(2013) Kathi Zarnack et al.   CELL

Identification of genes with a correlation between copy number and expression in gastric cancer

(2012) Lei Cheng et al.   BMC Medical Genomics

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

(2012) Christopher E Barbieri et al.   NATURE GENETICS

Prediction of single-nucleotide substitutions that result in exon skipping: identification of a splicing silencer in BRCA1 exon 6

(2011) Michela Raponi et al.   HUMAN MUTATION

Frequent pathway mutations of splicing machinery in myelodysplasia

(2011) Kenichi Yoshida et al.   NATURE

Allele-specific recognition of the 3′ splice site of INS intron 1

(2010) Jana Kralovicova et al.   HUMAN GENETICS

Molecular basis of FIR-mediated c-myc transcriptional control

(2010) Cyprian D Cukier et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of Candidate Growth Promoting Genes in Ovarian Cancer through Integrated Copy Number and Expression Analysis

(2010) Manasa Ramakrishna et al.   PLoS One

E2-RING Expansion of the NEDD8 Cascade Confers Specificity to Cullin Modification

(2009) Danny T. Huang et al.   MOLECULAR CELL

Dimerization and Protein Binding Specificity of the U2AF Homology Motif of the Splicing Factor Puf60

(2008) Lorenzo Corsini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY