Article
Multidisciplinary Sciences
Rong Cai, Jiayu Ren, Mengyu Guo, Taotao Wei, Ying Liu, Chunyu Xie, Peng Zhang, Zhiling Guo, Andrew J. Chetwynd, Pu Chun Ke, Iseult Lynch, Chunying Chen
Summary: The nanomaterial-protein corona plays a crucial role in the cellular uptake and subcellular distribution of nanomaterials. Understanding its biological and toxicological characteristics is essential for the development of nanomedicine and nanosafety. However, the dynamics of intracellular release and exchange of the protein corona from nanomaterials remains unclear, and the biological footprints of the nanoparticle-protein corona inside cells are not well understood. This study investigates the evolution of the intracellular protein corona along the endocytotic pathway and reveals its impact on cell metabolism.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Paula Saavedra-Garcia, Monica Roman-Trufero, Hibah A. Al-Sadah, Kevin Blighe, Elena Lopez-Jimenez, Marilena Christoforou, Lucy Penfold, Daria Capece, Xiaobei Xiong, Yirun Miao, Katarzyna Parzych, Valentina S. Caputo, Alexandros P. Siskos, Vesela Encheva, Zijing Liu, Denise Thiel, Martin F. Kaiser, Paolo Piazza, Aristeidis Chaidos, Anastasios Karadimitris, Guido Franzoso, Ambrosius P. Snijders, Hector C. Keun, Diego A. Oyarzun, Mauricio Barahona, Holger W. Auner
Summary: The study reveals the complex mechanisms of proteotoxic stress resolution in cancer cells recovering from chemotherapy-induced stress, involving extensive changes across the transcriptome, proteome, and metabolome, as well as dynamic alterations in glucose and lipid metabolism and suppression of mitochondrial function. Additionally, recovering cells are more vulnerable to specific insults, with a key vulnerability associated with cellular response to amino acid scarcity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Correction
Biochemistry & Molecular Biology
Franziska Ottens, Andre Franz, Thorsteny Hoppe
Summary: A correction to the paper has been published.
CELL DEATH AND DIFFERENTIATION
(2022)
Review
Pharmacology & Pharmacy
Md. Ataur Rahman, Md. Abdul Hannan, Raju Dash, MD. Hasanur Rahman, Rokibul Islam, Md Jamal Uddin, Abdullah Al Mamun Sohag, Md. Habibur Rahman, Hyewhon Rhim
Summary: Bioactive plant derived compounds play an important role in therapeutic applications, particularly in targeting autophagy and apoptosis pathways for anticancer effects. Pharmacological targeting of these pathways using phytochemicals presents a promising strategy in cancer treatment, although challenges remain in the development of phytochemical-based anticancer drugs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Kayo Machihara, Sou Kageyama, Shoma Oki, Hiroki Makino, Masamichi Sasaki, Hiroyasu Iwahashi, Takushi Namba
Summary: Cell aging leads to reduced cellular functions and disruption of cellular homeostasis, with mitochondrial dysfunction playing a crucial role. The study demonstrates that lotus germ extract can rejuvenate aging fibroblasts by restoring mitochondrial function and clearing abnormal proteins.
Review
Oncology
Francesca Ascenzi, Claudia De Vitis, Marcello Maugeri-Sacca, Christian Napoli, Gennaro Ciliberto, Rita Mancini
Summary: Autophagy is an intracellular degradation system that interacts with lipid metabolism, where fatty acids play a crucial role. SCD1 plays a significant role in promoting cell proliferation and metastasis in cancer, but its role in autophagy remains controversial, potentially resulting in either cancer promotion or inhibition depending on cancer heterogeneity and plasticity.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biology
Nilay Nandi, Zuhair Zaidi, Charles Tracy, Helmut Kramer
Summary: This study identified the mechanisms regulating neuronal autophagy. It was found that the PPM-type phosphatase Nil counterbalances the phosphorylation of Acinus-serine(437) and controls the level of neuronal autophagy. It was also discovered that exposure to Cd2+ increases the phosphorylation of Acinus-serine(437), leading to increased autophagy and protection against Cd2+-induced cytotoxicity.
Review
Biochemistry & Molecular Biology
Martina Parente, Claudia Tonini, Marco Segatto, Valentina Pallottini
Summary: Cholesterol, discovered over two centuries ago, plays a crucial role in human physiology and its alterations are associated with various pathologies. The search for new molecular targets and compounds to modulate cholesterol metabolism has been a focus of global research groups for many years. In addition to known regulators, new pathways have been uncovered in this important physiological process.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Geriatrics & Gerontology
Ana Maria Cuervo, Derek M. Huffman, Jan Vijg, Sofiya Milman, Rajat Singh, Nir Barzilai
Summary: The Einstein-Nathan Shock Center aims to make scientific discoveries in geroscience, translate them towards drug discovery, and confirm their relevance to humans. Through cutting-edge research programs and unique support cores, the center integrates key hallmarks of aging and facilitates translational biological research programs. The collaborative nature of the supporting research cores forms the foundation of research success at the E-NSC, allowing for expansion in translational research and new drug design services targeting the hallmarks of aging.
Review
Biochemistry & Molecular Biology
Ryan C. Russell, Kun-Liang Guan
Summary: Autophagy is a cellular degradation pathway that plays a crucial role in maintaining cellular homeostasis. It can both suppress tumorigenesis and promote cancer development. This article summarizes the effects of autophagy on cancer initiation, progression, immune infiltration, and metabolism, as well as discussing the efforts to target autophagy pharmacologically and future research directions.
Review
Biochemistry & Molecular Biology
Jorg Hoehfeld, Thomas Benzing, Wilhelm Bloch, Dieter O. Fuerst, Sebastian Gehlert, Michael Hesse, Bernd Hoffmann, Thorsten Hoppe, Pitter F. Huesgen, Maja Koehn, Waldemar Kolanus, Rudolf Merkel, Carien M. Niessen, Wojciech Pokrzywa, Markus M. Rinschen, Dagmar Wachten, Bettina Warscheid
Summary: Mechanical stress can threaten protein structure and proteome integrity, but cells have folding and degradation systems to combat this stress. These systems play crucial roles in cell differentiation, adhesion, and migration, and are essential for maintaining the integrity of various tissues.
Article
Biochemistry & Molecular Biology
Pingting Liu, Md Razaul Karim, Ana Covelo, Yuan Yue, Michael K. K. Lee, Wensheng Lin
Summary: The unfolded protein response (UPR) is a major mechanism for maintaining cellular proteostasis. It is involved in regulating neuron viability and function in neurodegenerative diseases, but its role is controversial. While evidence suggests UPR activation in neurons under normal conditions, deficiency of individual UPR branches has no major effect on brain neurons in animals. To determine the physiological role of UPR, mice with double deletion of PERK and ATF6α in neurons were generated. The results showed that UPR is required for maintaining neuronal proteostasis and the viability and function of neurons in the hippocampus of adult mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Natalia Frankowska, Ewa Bryl, Tamas Fulop, Jacek M. Witkowski
Summary: This study found that at least one intracellular proteolytic system in the peripheral blood lymphocytes of centenarians is as abundant as in young individuals, while the elderly population shows a significant decrease. The study aimed to investigate how different types of cells in long-lived people maintain the quality and quantity of their proteins. The results suggested that robust proteodynamics may contribute to longevity, as most aspects of cellular protein maintenance showed better performance in centenarians compared to the average elderly, approaching levels seen in young individuals, except for mitochondrial status and chaperone function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Catherine P. Ward, Lucy Peng, Samuel Yuen, Michael Chang, Rozalina Karapetyan, Edna Nyangau, Hussein Mohammed, Hector Palacios, Naveed Ziari, Larry K. Joe, Ashley E. Frakes, Mohamad Dandan, Andrew Dillin, Marc K. Hellerstein
Summary: Using metabolic labeling and mass spectrometric analysis, we characterized the metabolic changes in mouse livers induced by UPRER. We found that under UPRER conditions, hepatic de novo lipogenesis and cholesterogenesis were reduced, and the liver uptake of fatty acids was from free fatty acids rather than whole glycerolipids. Additionally, the synthesis of most liver proteins was suppressed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Tiejian Nie, Kai Tao, Lin Zhu, Lu Huang, Sijun Hu, Ruixin Yang, Pingyi Xu, Zixu Mao, Qian Yang
Summary: This study demonstrates the critical role of chaperone-mediated autophagy (CMA) in maintaining proper mitochondria dynamics. Loss of this regulatory control may occur in Parkinson's disease (PD), leading to impaired mitochondria function. Increasing CMA activity promotes MARCHF5 turnover, reduces mitochondria fragmentation, and alleviates mitochondrial dysfunction under oxidative stress.