Hot Spot TERT Promoter Mutations Are Rare in Sporadic Pancreatic Neuroendocrine Neoplasms and Associated with Telomere Length and Epigenetic Expression Patterns

Pan-cancer analysis of whole genomes

(2020)   NATURE

The evolutionary history of 2,658 cancers

(2020) Moritz Gerstung et al.   NATURE

Genomic footprints of activated telomere maintenance mechanisms in cancer

(2020) Lina Sieverling et al.   Nature Communications

Biomarkers for Bladder Cancer Diagnosis and Surveillance: A Comprehensive Review

(2020) Rui Batista et al.   Diagnostics

TERT promoter mutations and telomeres during tumorigenesis

(2020) Franziska K Lorbeer et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Regulation of human telomerase in homeostasis and disease

(2020) Caitlin M. Roake et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Preoperative Clinical Risk Score Including C-Reactive Protein Predicts Histological Tumor Characteristics and Patient Survival after Surgery for Sporadic Non-Functional Pancreatic Neuroendocrine Neoplasms: An International Multicenter Cohort Study

(2020) Florian Primavesi et al.   Cancers

Genetics and Epigenetics of Gastroenteropancreatic Neuroendocrine Neoplasms

(2019) Andrea Mafficini et al.   ENDOCRINE REVIEWS

Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players

(2019) Xiaotian Yuan et al.   ONCOGENE

Telomerase reverse transcriptase promoter mutations and solar elastosis in cutaneous melanoma

(2018) Johanne Lade-Keller et al.   MELANOMA RESEARCH

Telomere Maintenance Mechanisms in Cancer

(2018) Tiago Bordeira Gaspar et al.   Genes

HDAC-Linked “Proliferative” miRNA Expression Pattern in Pancreatic Neuroendocrine Tumors

(2018) Eckhard Klieser et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exploring the surgical landscape of pancreatic neuroendocrine neoplasia in Austria: Results from the ASSO pNEN study group

(2018) Florian Primavesi et al.   EJSO

Comprehensive immunohistochemical analysis of histone deacetylases in pancreatic neuroendocrine tumors: HDAC5 as a predictor of poor clinical outcome

(2017) Eckhard Klieser et al.   HUMAN PATHOLOGY

The C-Circle Assay for alternative-lengthening-of-telomeres activity

(2017) Jeremy D. Henson et al.   METHODS

Mutations in the promoter of the telomerase geneTERTcontribute to tumorigenesis by a two-step mechanism

(2017) Kunitoshi Chiba et al.   SCIENCE

Epigenetic Regulation of Telomere Maintenance for Therapeutic Interventions in Gliomas

(2017) et al.   Genes

A meta-analysis of prognostic roles of molecular markers in papillary thyroid carcinoma

(2017) Huy Gia Vuong et al.   Endocrine Connections

HDAC9 regulates the alternative lengthening of telomere (ALT) pathway via the formation of ALT-associated PML bodies

(2016) Mohd. Raeed Jamiruddin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

High incidence of TERT mutation in brain tumor cell lines

(2016) Tanner M. Johanns et al.   Brain Tumor Pathology

Alternative Lengthening of Telomeres in Primary Pancreatic Neuroendocrine Tumors Is Associated with Aggressive Clinical Behavior and Poor Survival

(2016) Joo Young Kim et al.   CLINICAL CANCER RESEARCH

Clinicopathological significance of TERT promoter mutation in papillary thyroid carcinomas: a systematic review and meta-analysis

(2016) De-tao Yin et al.   CLINICAL ENDOCRINOLOGY

Surgical and molecular pathology of pancreatic neoplasms

(2016) Wenzel M. Hackeng et al.   Diagnostic Pathology

TERTpromoter mutations and long-term survival in patients with thyroid cancer

(2016) Tae Hyuk Kim et al.   ENDOCRINE-RELATED CANCER

Understanding TERT Promoter Mutations: A Common Path to Immortality

(2016) R. J. A. Bell et al.   MOLECULAR CANCER RESEARCH

Alternative lengthening of telomeres does exist in various canine sarcomas

(2016) Theresa Kreilmeier et al.   MOLECULAR CARCINOGENESIS

TERT promoter mutations in pancreatic endocrine tumours are rare and mainly found in tumours from patients with hereditary syndromes

(2016) João Vinagre et al.   Scientific Reports

Telomere Transcripts Target Telomerase in Human Cancer Cells

(2016) Theresa Kreilmeier et al.   Genes

TERT promoter mutations and long telomere length predict poor survival and radiotherapy resistance in gliomas

(2015) Ke Gao et al.   Oncotarget

TERTpromoter mutations predict worse survival in laryngeal cancer patients

(2014) Yiping Qu et al.   INTERNATIONAL JOURNAL OF CANCER

TERT promoter mutations in primary and secondary glioblastomas

(2013) Naosuke Nonoguchi et al.   ACTA NEUROPATHOLOGICA

Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss

(2013) Hideyuki Arita et al.   ACTA NEUROPATHOLOGICA

Loss of DAXX and ATRX Are Associated With Chromosome Instability and Reduced Survival of Patients With Pancreatic Neuroendocrine Tumors

(2013) Ilaria Marinoni et al.   GASTROENTEROLOGY

Low frequency ofTERTpromoter mutations in a large cohort of gallbladder and gastric cancers

(2013) Yiping Qu et al.   INTERNATIONAL JOURNAL OF CANCER

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

(2013) P. J. Killela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly Recurrent TERT Promoter Mutations in Human Melanoma

(2013) F. W. Huang et al.   SCIENCE

Frequency of TERT promoter mutations in human cancers

(2013) João Vinagre et al.   Nature Communications

Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors

(2012) Roeland F de Wilde et al.   MODERN PATHOLOGY

Prevalence of the Alternative Lengthening of Telomeres Telomere Maintenance Mechanism in Human Cancer Subtypes

(2011) Christopher M. Heaphy et al.   AMERICAN JOURNAL OF PATHOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Altered Telomeres in Tumors with ATRX and DAXX Mutations

(2011) C. M. Heaphy et al.   SCIENCE

Comparison of Sanger Sequencing, Pyrosequencing, and Melting Curve Analysis for the Detection of KRAS Mutations

(2010) Athanasios C. Tsiatis et al.   JOURNAL OF MOLECULAR DIAGNOSTICS