Article
Chemistry, Multidisciplinary
Elham Seyyednia, Fatemeh Oroojalian, Behzad Baradaran, Javid Shahbazi Mojarrad, Ahad Mokhtarzadeh, Hadi Valizadeh
Summary: The two major challenges in cancer treatment are lack of early detection and side effects from therapies. Angiogenesis plays a key role in the growth and spread of tumors. Surface modified nanoparticles using peptide ligands facilitate efficient delivery of therapeutic and imaging agents.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Bozhao Li, Jingyan Wei, Chunzhi Di, Zefang Lu, Feilong Qi, Yinlong Zhang, Wei Sun Leong, Lele Li, Guangjun Nie, Suping Li
Summary: The tumor-specific tTF delivery system developed in this study, by coupling tTF with AS1411, selectively targets tumor vascular endothelial cells, inducing tumor necrosis without significant side effects.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Biochemistry & Molecular Biology
Ayca Ece Nezir, Melek Parlak Khalily, Sevgi Gulyuz, Salih Ozcubukcu, S. Guniz Kucukguzel, Ozgur Yilmaz, Dilek Telci
Summary: Peptide 563 showed superior binding capacity to PSMA compared to peptides 562, 9-mer, and 5-mer, making it a potent targeting agent for both high PSMA positive and moderate PSMA positive prostate cancer tumors.
Review
Biotechnology & Applied Microbiology
Dongjie Zhu, Yang Li, Zhengjia Zhang, Zeyu Xue, Zhenglai Hua, Xinyi Luo, Ting Zhao, Cheng Lu, Yuanyan Liu
Summary: Tumor vessels play a crucial role in tumor development, and nanotechnology offers a promising approach to target abnormal tumor vessels and specific microenvironments with precise delivery and reduced side effects, achieving combined therapy for maximum anti-tumor effects.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Instruments & Instrumentation
Syed Faheem Askari Rizvi, Samiah Shahid, Shuai Mu, Haixia Zhang
Summary: A novel hybridized dual-targeting peptide-based nanoprobe was successfully designed, showing excellent dual-imaging potential and improved apoptosis-inducing feature by damaging mitochondria. It also exhibited selective receptor binding capabilities against U87MG cells, making it a promising theranostic probe for treating brain tumor glioblastoma multiforme.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Hongliang Zou, Fan Yang, Zhijian Yin
Summary: In this study, a novel machine learning method was proposed to distinguish tumor homing peptides (THPs). The method achieved higher classification accuracy compared to existing predictors, indicating its potential as a useful tool in identifying THPs.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ying Cui, Yufei Zhao, Xiaohui Chen, Yang Jiang, Hui Mao, Shenghong Ju, Xin-Gui Peng
Summary: Non-contrast-enhanced vessel wall MRI shows promise in evaluating the degree of vessel wall invasion in retroperitoneal tumors.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Materials Science, Biomaterials
Yifan Yang, Zhongxiong Fan, Kaili Zheng, Dao Shi, Guanghao Su, Dongtao Ge, Qingliang Zhao, Xu Fu, Zhenqing Hou
Summary: Sonodynamic therapy is gaining attention for its deep tissue penetration, but sonosensitizers face challenges. The self-targeting TPGS-PEM nanoplatform achieves active drug delivery and tumor enrichment while reducing side effects. The platform shows promising potential for tumor diagnosis, prognosis, and targeted therapy under precise guidance of photoacoustic/fluorescence imaging.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Biology
Laith R. Sultan, Mrigendra B. Karmacharya, Stephen J. Hunt, Andrew K. W. Wood, Chandra M. Sehgal
Summary: The study evaluated the use of repeated subsequent AVUS therapy to optimize therapeutic efficacy in treating hepatocellular carcinoma (HCC). Short intervals between subsequent AVUS treatments showed significant improvement in tumor perfusion reduction, while longer intervals resulted in diminished effects. The findings suggest the importance of tumor viability in maximizing the therapeutic effects of targeted tumor vasculature therapies.
Article
Instruments & Instrumentation
Ruchika Goyal, Gaurav Jerath, Aneesh Chandrasekharan, Yvonne Christian, T. R. Santhosh Kumar, Vibin Ramakrishnan
Summary: This study developed a peptide-based drug delivery unit with a tumor homing domain chemically linked to a cell-penetrating domain, showing selective toxicity to MDA-MB-231 breast cancer cells and superior penetration in three-dimensional MDA-MB-231 tumorospheres.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
Palmira Alessia Cavallaro, Marzia De Santo, Emilia Lucia Belsito, Camilla Longobucco, Manuela Curcio, Catia Morelli, Luigi Pasqua, Antonella Leggio
Summary: Breast cancer is a common and deadly disease, and overexpression of HER2 is a major contributing factor. This review provides an overview of the diagnosis and treatment approaches for HER2-positive breast cancer in the past decade. Antibodies and peptides are explored as targeting strategies, with nanotechnology offering potential solutions to current clinical challenges in breast cancer imaging, targeting, and therapy.
Article
Nanoscience & Nanotechnology
Yang Zhang, Sijie Cheng, Yu He, Chaojie Tang, Feng Liu, Yun Sun, Shuo Zhao, Greta S. P. Mok, Hong Yang, Zhiguo Zhou, Wu Wang
Summary: This study demonstrates that a nanoplatform can enhance the detection of an aneurysm-related thrombus as well as aneurysm itself to assist further treatment of IA.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Pharmacology & Pharmacy
Darshan Vyas, Mital Patel, Sarika Wairkar
Summary: A complete cure for cancer is still a challenge for scientists. The current treatment methods such as surgery, radiation and chemotherapy have limitations and can affect healthy tissues. Therefore, researchers are actively exploring active tumor-targeting drug delivery systems to reduce adverse effects on healthy tissues.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Yuyi Wang, Ombretta Salvucci, Hidetaka Ohnuki, Andy D. Tran, Taekyu Ha, Jing-Xin Feng, Michael DiPrima, Hyeongil Kwak, Dunrui Wang, Yanlin Yu, Michael Kruhlak, Giovanna Tosato
Summary: SHP2 is essential for promoting endothelial cell survival and growth in tumor vasculature remodeling. Inhibiting SHP2 activity leads to reduced tumor growth and degeneration of tumor vasculature. Combination of SHP2 inhibitors with Ang2/TIE2 inhibitors shows promise in effectively targeting the tumor endothelium.
EMBO MOLECULAR MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Zhufeng Dong, Lin Tang, Yu Zhang, Xiaoyue Ma, Ying Yin, Lei Kuang, Qin Fan, Bingyi Wang, Xiaoye Hu, Tieying Yin, Yazhou Wang
Summary: This study introduces a precise biomimetic drug delivery system that can effectively treat secondary injury caused by stroke. The system has multiple targeting capabilities and can deliver drugs accurately to the damaged site. Preliminary experiments showed that the system has good safety profile in treating stroke.
ADVANCED FUNCTIONAL MATERIALS
(2023)