Hypercoagulopathy and Adipose Tissue Exacerbated Inflammation May Explain Higher Mortality in COVID-19 Patients With Obesity

Annals for Educators - 7 January 2020

(2020) Darren B. Taichman   ANNALS OF INTERNAL MEDICINE

Influence of Cardiometabolic Risk Factors on Platelet Function

(2020) Cristina Barale et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

(2020) Ning Tang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa

(2020) Hao Xu et al.   International Journal of Oral Science

Influenza and obesity: its odd relationship and the lessons for COVID-19 pandemic

(2020) Livio Luzi et al.   ACTA DIABETOLOGICA

Hematological findings and complications of COVID ‐19

(2020) Evangelos Terpos et al.   AMERICAN JOURNAL OF HEMATOLOGY

COVID-19 Related Genes in Sputum Cells in Asthma: Relationship to Demographic Features and Corticosteroids

(2020) Michael C Peters et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

COVID-19 and its implications for thrombosis and anticoagulation

(2020) Jean Marie Connors et al.   BLOOD

Changes in blood coagulation in patients with severe coronavirus disease 2019 (COVID‐19): a meta‐analysis

(2020) Mi Xiong et al.   BRITISH JOURNAL OF HAEMATOLOGY

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

(2020) Shuai Xia et al.   CELL RESEARCH

Pathological evidence for residual SARS-CoV-2 in pulmonary tissues of a ready-for-discharge patient

(2020) Xiao-Hong Yao et al.   CELL RESEARCH

The Science Underlying COVID-19: Implications for the Cardiovascular System

(2020) Peter P. Liu et al.   CIRCULATION

Association of Inpatient Use of Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers with Mortality Among Patients With Hypertension Hospitalized With COVID-19

(2020) Peng Zhang et al.   CIRCULATION RESEARCH

Obesity in Patients Younger Than 60 Years Is a Risk Factor for COVID-19 Hospital Admission

(2020) Jennifer Lighter et al.   CLINICAL INFECTIOUS DISEASES

Exploring Diseases/Traits and Blood Proteins Causally Related to Expression of ACE2, the Putative Receptor of SARS-CoV-2: A Mendelian Randomization Analysis Highlights Tentative Relevance of Diabetes-Related Traits

(2020) Shitao Rao et al.   DIABETES CARE

Should anti-diabetic medications be reconsidered amid COVID-19 pandemic?

(2020) Rimesh Pal et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Does epicardial fat contribute to COVID-19 myocardial inflammation?

(2020) Alexis Elias Malavazos et al.   EUROPEAN HEART JOURNAL

Inhaled corticosteroids and COVID-19: a systematic review and clinical perspective

(2020) David M.G. Halpin et al.   EUROPEAN RESPIRATORY JOURNAL

Angiotensin‐converting enzyme 2 in severe acute respiratory syndrome coronavirus and SARS‐CoV‐2: A double‐edged sword?

(2020) Tiantian Yan et al.   FASEB JOURNAL

Clinical characteristics of 145 patients with corona virus disease 2019 (COVID-19) in Taizhou, Zhejiang, China

(2020) Qingqing Chen et al.   INFECTION

Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State

(2020) Matt Arentz et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

(2020) Safiya Richardson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy

(2020) Graziano Onder et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19)

(2020) James M. Sanders et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Predicting mortality due to SARS-CoV-2: A mechanistic score relating obesity and diabetes to COVID-19 outcomes in Mexico

(2020) Omar Yaxmehen Bello-Chavolla et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

The many faces of the anti-COVID immune response

(2020) Santosha A. Vardhana et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Platelet‐to‐lymphocyte ratio is associated with prognosis in patients with Corona Virus Disease‐19

(2020) Rong Qu et al.   JOURNAL OF MEDICAL VIROLOGY

Hypercoagulability of COVID‐19 patients in Intensive Care Unit. A Report of Thromboelastography Findings and other Parameters of Hemostasis

(2020) Mauro Panigada et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy

(2020) Ning Tang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The procoagulant pattern of patients with COVID‐19 acute respiratory distress syndrome

(2020) Marco Ranucci et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Obesity could shift severe COVID-19 disease to younger ages

(2020) David A Kass et al.   LANCET

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

Smell and taste dysfunction in patients with COVID-19

(2020) Michael S Xydakis et al.   LANCET INFECTIOUS DISEASES

Corticosteroid treatment of patients with coronavirus disease 2019 ( COVID ‐19)

(2020) Lei Zha et al.   MEDICAL JOURNAL OF AUSTRALIA

Obesity�‑�a risk factor for increased COVID‑19 prevalence, severity and lethality (Review)

(2020) Demetrios Petrakis et al.   Molecular Medicine Reports

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

(2020) Waradon Sungnak et al.   NATURE MEDICINE

Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19

(2020) Muthiah Vaduganathan et al.   NEW ENGLAND JOURNAL OF MEDICINE

The role of adipocytes and adipocyte‐like cells in the severity of COVID‐19 infections

(2020) Ilja L. Kruglikov et al.   Obesity

High prevalence of obesity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation

(2020) Arthur Simonnet et al.   Obesity

Obesity accompanying COVID‐19: the role of epicardial fat

(2020) Lei Zhao   Obesity

Acute Pulmonary Embolism Associated with COVID-19 Pneumonia Detected by Pulmonary CT Angiography

(2020) Franck Grillet et al.   RADIOLOGY

COVID-19-Related Severe Hypercoagulability in Patients Admitted to Intensive Care Unit for Acute Respiratory Failure

(2020) Luca Spiezia et al.   THROMBOSIS AND HAEMOSTASIS

Non-steroidal anti-inflammatory drugs and covid-19

(2020) Paul Little   BMJ-British Medical Journal

Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients

(2020) Gian Paolo Rossi et al.   eLife

Antihypertensive drugs and risk of COVID-19?

(2020) Joshua D Brown   Lancet Respiratory Medicine

Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?

(2020) Lei Fang et al.   Lancet Respiratory Medicine

SARS-CoV-2 in Spanish Intensive Care Units: Early experience with 15-day survival in Vitoria

(2020) Helena Barrasa et al.   Anaesthesia Critical Care & Pain Medicine

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

(2020) Xin Zou et al.   Frontiers of Medicine

Type 1 interferons as a potential treatment against COVID-19

(2020) Erwan Sallard et al.   ANTIVIRAL RESEARCH

A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids

(2020) Liuliu Yang et al.   Cell Stem Cell

Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis

(2020) Giuseppe Lippi et al.   CLINICA CHIMICA ACTA

Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?

(2020) Bingwen Liu et al.   JOURNAL OF AUTOIMMUNITY

Coagulopathy in COVID‐19

(2020) Toshiaki Iba et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Interleukin-6 as a potential biomarker of COVID-19 progression

(2020) Zulvikar Syambani Ulhaq et al.   MEDECINE ET MALADIES INFECTIEUSES

Letter to the Editor: COVID-19 in patients with diabetes: Risk factors that increase morbidity

(2020) David C. Klonoff et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Letter to the Editor: Obesity as a risk factor for greater severity of COVID-19 in patients with metabolic associated fatty liver disease

(2020) Kenneth I. Zheng et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Genomewide Association Study of Severe Covid-19 with Respiratory Failure

(2020) David Ellinghaus et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chronic obstructive pulmonary disease is associated with severe coronavirus disease 2019 (COVID-19)

(2020) Giuseppe Lippi et al.   RESPIRATORY MEDICINE

Incidence of thrombotic complications in critically ill ICU patients with COVID-19

(2020) F.A. Klok et al.   THROMBOSIS RESEARCH

COVID-19 and obesity—lack of clarity, guidance, and implications for care

(2020) Stuart William Flint et al.   Lancet Diabetes & Endocrinology

Concise Review: Adipose-Derived Stem Cells (ASCs) and Adipocyte-Secreted Exosomal microRNA (A-SE-miR) Modulate Cancer Growth and proMote Wound Repair

(2019) Pietro Gentile et al.   Journal of Clinical Medicine

Type I and type III interferons differ in their adjuvant activities for influenza vaccines

(2019) Liang Ye et al.   JOURNAL OF VIROLOGY

ACE2 exerts anti-obesity effect via stimulating brown adipose tissue and induction of browning in white adipose tissue

(2019) Yasuhiro Kawabe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Fatty airways: implications for obstructive disease

(2019) John G. Elliot et al.   EUROPEAN RESPIRATORY JOURNAL

Systemic Corticosteroid Therapy May Delay Viral Clearance in Patients with Middle East Respiratory Syndrome Coronavirus Infection

(2018) David S. Hui   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Obesity as a Disease, Not a Behavior

(2018) Penny Gordon-Larsen et al.   CIRCULATION

OUP accepted manuscript

(2018)   JOURNAL OF INFECTIOUS DISEASES

Obesity as a Disease

(2018) Jagriti Upadhyay et al.   MEDICAL CLINICS OF NORTH AMERICA

Wild-type human coronaviruses prefer cell-surface TMPRSS2 to endosomal cathepsins for cell entry

(2018) Kazuya Shirato et al.   VIROLOGY

Obesity and nonalcoholic fatty liver disease: current perspectives

(2018) Raiya Sarwar et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Association of ACE2 genetic polymorphisms with hypertension-related target organ damages in south Xinjiang

(2018) Yi Luo et al.   HYPERTENSION RESEARCH

Platelet biology and functions: new concepts and clinical perspectives

(2018) Paola E. J. van der Meijden et al.   Nature Reviews Cardiology

The Impact of Obesity on the Cardiovascular System

(2018) Imre Csige et al.   Journal of Diabetes Research

GPVI surface expression and signalling pathway activation are increased in platelets from obese patients: Elucidating potential anti-atherothrombotic targets in obesity

(2018) María N. Barrachina et al.   ATHEROSCLEROSIS

Sphingolipids in obesity and related complications

(2017) Pin-Lan Li   Frontiers in Bioscience-Landmark

Inflammatory mechanisms linking obesity and metabolic disease

(2017) Alan R. Saltiel et al.   JOURNAL OF CLINICAL INVESTIGATION

Orexin activation counteracts decreases in nonexercise activity thermogenesis (NEAT) caused by high-fat diet

(2017) P.E. Bunney et al.   PHYSIOLOGY & BEHAVIOR

Combined metformin and insulin treatment reverses metabolically impaired omental adipogenesis and accumulation of 4-hydroxynonenal in obese diabetic patients

(2017) Morana Jaganjac et al.   Redox Biology

Sex matters: The effects of biological sex on adipose tissue biology and energy metabolism

(2017) Teresa G. Valencak et al.   Redox Biology

The adipose tissue and the involvement of the renin–angiotensin–aldosterone system in cardiometabolic syndrome

(2016) F. Borghi et al.   CELL AND TISSUE RESEARCH

Colonic Pro-inflammatory Macrophages Cause Insulin Resistance in an Intestinal Ccl2/Ccr2-Dependent Manner

(2016) Yoshinaga Kawano et al.   Cell Metabolism

Role of the ACE2/Angiotensin 1–7 Axis of the Renin–Angiotensin System in Heart Failure

(2016) Vaibhav B. Patel et al.   CIRCULATION RESEARCH

Role of Leptin and SOCS3 in Inhibiting the Type I Interferon Response During Obesity

(2016) Elí Terán-Cabanillas et al.   INFLAMMATION

Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry

(2016) Kazuya Shirato et al.   JOURNAL OF VIROLOGY

Body Fatness and Cancer — Viewpoint of the IARC Working Group

(2016) Béatrice Lauby-Secretan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunothrombosis in Acute Respiratory Distress Syndrome: Cross Talks between Inflammation and Coagulation

(2016) Frantzeska Frantzeskaki et al.   RESPIRATION

Tissue factor as a link between inflammation and coagulation

(2016) Marco Witkowski et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Obesity and hypertension

(2016) Shu-Zhong Jiang et al.   Experimental and Therapeutic Medicine

Type-I Interferon Responses: From Friend to Foe in the Battle against Chronic Viral Infection

(2016) Armstrong Murira et al.   Frontiers in Immunology

Tissue specific up regulation of ACE2 in rabbit model of atherosclerosis by atorvastatin: Role of epigenetic histone modifications

(2015) Kulbhushan Tikoo et al.   BIOCHEMICAL PHARMACOLOGY

ACE2 deficiency worsens epicardial adipose tissue inflammation and cardiac dysfunction in response to diet-induced obesity

(2015) Vaibhav B. Patel et al.   DIABETES

Activation of the GLP-1 Receptor by Liraglutide Increases ACE2 Expression, Reversing Right Ventricle Hypertrophy, and Improving the Production of SP-A and SP-B in the Lungs of Type 1 Diabetes Rats

(2015) Marina Romaní-Pérez et al.   ENDOCRINOLOGY

Local and systemic effects of the multifaceted epicardial adipose tissue depot

(2015) Gianluca Iacobellis   Nature Reviews Endocrinology

Interaction of obesity and infections

(2015) N. V. Dhurandhar et al.   Obesity Reviews

Obesity and Antiplatelets-Does One Size Fit All?

(2015) Craig J. Beavers et al.   THROMBOSIS RESEARCH

Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury

(2015) Philipp Kruger et al.   PLoS Pathogens

Inflammatory Cytokines in General and Central Obesity and Modulating Effects of Physical Activity

(2015) Frank M. Schmidt et al.   PLoS One

Quantitative Influence of ABO Blood Groups on Factor VIII and Its Ratio to von Willebrand Factor, Novel Observations from an ARIC Study of 11,673 Subjects

(2015) Jaewoo Song et al.   PLoS One

The physiological basis of pulmonary gas exchange: implications for clinical interpretation of arterial blood gases

(2014) P. D. Wagner   EUROPEAN RESPIRATORY JOURNAL

Effects of renin-angiotensin system blockade on islet function in diabetic rats

(2014) L. Yuan et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice

(2014) Annie Mirsoian et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pioglitazone Upregulates Angiotensin Converting Enzyme 2 Expression in Insulin-Sensitive Tissues in Rats with High-Fat Diet-Induced Nonalcoholic Steatohepatitis

(2014) Wei Zhang et al.   TheScientificWorldJOURNAL

ABO blood group and thrombotic vascular disease

(2014) Pier Mannuccio Mannucci et al.   THROMBOSIS AND HAEMOSTASIS

Hypercoagulability in overweight and obese subjects who are asymptomatic for thrombotic events

(2014) E. Campello et al.   THROMBOSIS AND HAEMOSTASIS

Obesity-induced chronic inflammation is associated with the reduced efficacy of influenza vaccine

(2014) Hye-Lim Park et al.   Human Vaccines & Immunotherapeutics

Mechanism linking diabetes mellitus and obesity

(2014) Abdullah Algoblan et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Pathophysiology of Human Visceral Obesity: An Update

(2013) André Tchernof et al.   PHYSIOLOGICAL REVIEWS

Obesity and Inflammation: Epidemiology, Risk Factors, and Markers of Inflammation

(2013) Heriberto Rodríguez-Hernández et al.   International Journal of Endocrinology

Ibuprofen, paracetamol, and steam for patients with respiratory tract infections in primary care: pragmatic randomised factorial trial

(2013) P. Little et al.   BMJ-British Medical Journal

Plasminogen activator inhitor-1 associates with cardiovascular risk factors in healthy young adults in the Cardiovascular Risk in Young Finns Study

(2012) Juho R.H. Raiko et al.   ATHEROSCLEROSIS

Role of renin–angiotensin–aldosterone system in adipose tissue dysfunction

(2012) Fei Jing et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Decreased interferon-α and interferon-β production in obesity and expression of suppressor of cytokine signaling

(2012) Eli Teran-Cabanillas et al.   NUTRITION

Infection and Inflammation as Risk Factors for Thrombosis and Atherosclerosis

(2012) Marcel Levi et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Energy Intake and Response to Infection with Influenza

(2011) Elizabeth M. Gardner et al.   Annual Review of Nutrition

Beyond Thrombosis

(2011) Jason N. Katz et al.   CHEST

A Novel Risk Factor for a Novel Virus: Obesity and 2009 Pandemic Influenza A (H1N1)

(2011) J. K. Louie et al.   CLINICAL INFECTIOUS DISEASES

Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets

(2011) J. M. Luther et al.   DIABETOLOGIA

Obesity is associated with impaired immune response to influenza vaccination in humans

(2011) P A Sheridan et al.   INTERNATIONAL JOURNAL OF OBESITY

Diet-Induced Obesity Dramatically Reduces the Efficacy of a 2009 Pandemic H1N1 Vaccine in a Mouse Model

(2011) Yong-Hoon Kim et al.   JOURNAL OF INFECTIOUS DISEASES

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

(2010) V. B. Matthews et al.   DIABETOLOGIA

Association between H1N1 Infection Severity and Obesity—Adiponectin as a Potential Etiologic Factor

(2010) C. Tsatsanis et al.   JOURNAL OF INFECTIOUS DISEASES

Interferons and viral infections

(2009) Volker Fensterl et al.   BIOFACTORS

Critically Ill Patients With 2009 Influenza A(H1N1) in Mexico

(2009) Guillermo Domínguez-Cherit   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Obesity and lung inflammation

(2009) Peter Mancuso   JOURNAL OF APPLIED PHYSIOLOGY

Platelet dysfunction in central obesity

(2009) G. Anfossi et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Update on tissue renin–angiotensin systems

(2008) Michael Bader et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE

Modulation of TNF- -converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-  production and facilitates viral entry

(2008) S. Haga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Obesity and the lung: 1 {middle dot} Epidemiology

(2008) K M McClean et al.   THORAX