Antibody-Dependent Cellular Phagocytosis of HIV-1-Infected Cells Is Efficiently Triggered by IgA Targeting HIV-1 Envelope Subunit gp41

Rare Detection of Antiviral Functions of Polyclonal IgA Isolated from Plasma and Breast Milk Compartments in Women Chronically Infected with HIV-1

(2019) Matthew Zirui Tay et al.   JOURNAL OF VIROLOGY

Bridging vaccine-induced HIV-1 neutralizing and effector antibody responses in rabbit and rhesus macaque animal models

(2019) Justin Pollara et al.   JOURNAL OF VIROLOGY

A Multiparametric and High-Throughput Assay to Quantify the Influence of Target Size on Phagocytosis

(2019) Lorraine Montel et al.   BIOPHYSICAL JOURNAL

Potent Fc Receptor Signaling by IgA Leads to Superior Killing of Cancer Cells by Neutrophils Compared to IgG

(2019) Arianne M. Brandsma et al.   Frontiers in Immunology

Antibody Fc effector functions and IgG3 associate with decreased HIV-1 risk

(2019) Scott D. Neidich et al.   JOURNAL OF CLINICAL INVESTIGATION

Mucosal Antibodies: Defending Epithelial Barriers against HIV-1 Invasion

(2019) Ruth M. Ruprecht et al.   Vaccines

Neutrophils mediate HIV-specific antibody-dependent phagocytosis and ADCC

(2018) Matthew J. Worley et al.   JOURNAL OF IMMUNOLOGICAL METHODS

HIV-1-Specific IgA Monoclonal Antibodies from an HIV-1 Vaccinee Mediate Galactosylceramide Blocking and Phagocytosis

(2018) Saintedym Wills et al.   JOURNAL OF VIROLOGY

IgA Targeting Human Immunodeficiency Virus-1 Envelope gp41 Triggers Antibody-Dependent Cellular Cytotoxicity Cross-Clade and Cooperates with gp41-Specific IgG to Increase Cell Lysis

(2018) Maxence Duchemin et al.   Frontiers in Immunology

The Multifaceted Nature of Immunoglobulin A and Its Complex Role in HIV

(2018) Ester Lopez et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Route of immunization defines multiple mechanisms of vaccine-mediated protection against SIV

(2018) Margaret E. Ackerman et al.   NATURE MEDICINE

Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge

(2017) Todd Bradley et al.   Nature Communications

Des anticorps qui détruisent les cellules infectées par le VIH-1

(2016) Timothée Bruel et al.   M S-MEDECINE SCIENCES

Fc receptor-mediated phagocytosis in tissues as a potent mechanism for preventive and therapeutic HIV vaccine strategies

(2016) M Sips et al.   Mucosal Immunology

Elimination of HIV-1-infected cells by broadly neutralizing antibodies

(2016) Timothée Bruel et al.   Nature Communications

Antibody-Mediated Internalization of Infectious HIV-1 Virions Differs among Antibody Isotypes and Subclasses

(2016) Matthew Zirui Tay et al.   PLoS Pathogens

Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology

(2015) Amy W. Chung et al.   CELL

The role of Fc receptors in HIV prevention and therapy

(2015) Austin W. Boesch et al.   IMMUNOLOGICAL REVIEWS

Env-Specific IgA from Viremic HIV-Infected Subjects Compromises Antibody-Dependent Cellular Cytotoxicity

(2015) María Julia Ruiz et al.   JOURNAL OF VIROLOGY

Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys

(2015) D. H. Barouch et al.   SCIENCE

Machine Learning Methods Enable Predictive Modeling of Antibody Feature:Function Relationships in RV144 Vaccinees

(2015) Ickwon Choi et al.   PLoS Computational Biology

Mucosal Correlates of Protection in HIV-1-Exposed Sero-negative Persons

(2014) Ruizhong Shen et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Broadly Neutralizing Anti-HIV-1 Antibodies Require Fc Effector Functions for In Vivo Activity

(2014) Stylianos Bournazos et al.   CELL

HIV-specific antibody-dependent phagocytosis matures during HIV infection

(2014) Fernanda Ana-Sosa-Batiz et al.   IMMUNOLOGY AND CELL BIOLOGY

Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection

(2014) P. Acharya et al.   JOURNAL OF VIROLOGY

Structure and immune recognition of trimeric pre-fusion HIV-1 Env

(2014) Marie Pancera et al.   NATURE

Polyfunctional Fc-Effector Profiles Mediated by IgG Subclass Selection Distinguish RV144 and VAX003 Vaccines

(2014) A. W. Chung et al.   Science Translational Medicine

Neutrophil-Mediated Phagocytosis of Staphylococcus aureus

(2014) Kok P. M. van Kessel et al.   Frontiers in Immunology

A Programmable Sensor to Probe the Internalization of Proteins and Nanoparticles in Live Cells

(2013) Haiyin Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Protective Efficacy of a Global HIV-1 Mosaic Vaccine against Heterologous SHIV Challenges in Rhesus Monkeys

(2013) Dan H. Barouch et al.   CELL

Opportunities to Exploit Non-Neutralizing HIV-Specific Antibody Activity

(2013) Margaret Ackerman et al.   CURRENT HIV RESEARCH

Fc Receptor-Mediated Immune Responses: New Tools But Increased Complexity in HIV Prevention

(2013) Diego Vargas-Inchaustegui et al.   CURRENT HIV RESEARCH

Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity

(2013) Margaret E. Ackerman et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies

(2013) Guang Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Enhanced Phagocytic Activity of HIV-Specific Antibodies Correlates with Natural Production of Immunoglobulins with Skewed Affinity for Fc R2a and Fc R2b

(2013) M. E. Ackerman et al.   JOURNAL OF VIROLOGY

Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG

(2013) G. D. Tomaras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial

(2012) Barton F. Haynes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Isotype modulates epitope specificity, affinity, and antiviral activities of anti-HIV-1 human broadly neutralizing 2F5 antibody

(2012) D. Tudor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The broadly neutralizing HIV-1 IgG 2F5 elicits gp41-specific antibody-dependent cell cytotoxicity in a FcγRI-dependent manner

(2011) Daniela Tudor et al.   AIDS

Emerging Concepts on the Role of Innate Immunity in the Prevention and Control of HIV Infection

(2011) Margaret E. Ackerman et al.   Annual Review of Medicine

Immunization with HIV-1 gp41 Subunit Virosomes Induces Mucosal Antibodies Protecting Nonhuman Primates against Vaginal SHIV Challenges

(2011) Morgane Bomsel et al.   IMMUNITY

Functional Characteristics of the High Affinity IgG Receptor, Fc RI

(2011) C. E. van der Poel et al.   JOURNAL OF IMMUNOLOGY

Decreased Fc receptor expression on innate immune cells is associated with impaired antibody-mediated cellular phagocytic activity in chronically HIV-1 infected individuals

(2011) Anne-Sophie Dugast et al.   VIROLOGY

A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples

(2010) Margaret E. Ackerman et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Antibody 2G12 Recognizes Di-Mannose Equivalently in Domain- and Nondomain-Exchanged Forms but Only Binds the HIV-1 Glycan Shield if Domain Exchanged

(2010) Katie J. Doores et al.   JOURNAL OF VIROLOGY

HIV-1 gp41-specific monoclonal mucosal IgAs derived from highly exposed but IgG-seronegative individuals block HIV-1 epithelial transcytosis and neutralize CD4+ cell infection: an IgA gene and functional analysis

(2009) D Tudor et al.   Mucosal Immunology

The ‘immunologic advantage’ of HIV-exposed seronegative individuals

(2008) Masaaki Miyazawa et al.   AIDS

Specificity and affinity of human Fc  receptors and their polymorphic variants for human IgG subclasses

(2008) P. Bruhns et al.   BLOOD