Endothelial to mesenchymal transition (EndMT) and vascular remodeling in pulmonary hypertension and idiopathic pulmonary fibrosis

Guidelines and definitions for research on epithelial–mesenchymal transition

(2020) Jing Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inflammation and Immunity in IPF Pathogenesis and Treatment

(2019) P. Heukels et al.   RESPIRATORY MEDICINE

Molecular Mechanisms of Pulmonary Fibrogenesis and Its Progression to Lung Cancer: A Review

(2019) Tomonari Kinoshita et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The effectiveness of immunosuppressive cyclosporin in attenuating the progression of interstitial lung diseases

(2019) Mathew Suji Eapen et al.   Journal of Thoracic Disease

A Twist on Pulmonary Vascular Remodeling: Endothelial to Mesenchymal Transition?

(2018) Grazyna Kwapiszewska et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Digital Clubbing Is Associated with Higher Serum KL-6 Levels and Lower Pulmonary Function in Patients with Interstitial Lung Disease

(2018) Kazushige Shiraishi et al.   Canadian Respiratory Journal

NLRP3 Inflammasome Activation Contributes to Mechanical Stretch–Induced Endothelial-Mesenchymal Transition and Pulmonary Fibrosis

(2018) Zhou Lv et al.   CRITICAL CARE MEDICINE

EP4 Agonist L-902,688 Suppresses EndMT and Attenuates Right Ventricular Cardiac Fibrosis in Experimental Pulmonary Arterial Hypertension

(2018) Ying-Ju Lai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Idiopathic Pulmonary Fibrosis

(2018) David J. Lederer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Endothelial to Mesenchymal Transition Represents a Key Link in the Interaction between Inflammation and Endothelial Dysfunction

(2018) Jin Gu Cho et al.   Frontiers in Immunology

Inflammation induces endothelial-to-mesenchymal transition and promotes vascular calcification through downregulation of BMPR2

(2018) Gonzalo Sánchez-Duffhues et al.   JOURNAL OF PATHOLOGY

Activation of Nrf2 Attenuates Pulmonary Vascular Remodeling via Inhibiting Endothelial-to-Mesenchymal Transition: an Insight from a Plant Polyphenol

(2017) Yucai Chen et al.   International Journal of Biological Sciences

Idiopathic pulmonary fibrosis

(2017) Luca Richeldi et al.   LANCET

CXCR7 attenuates the TGF-β-induced endothelial-to-mesenchymal transition and pulmonary fibrosis

(2017) Shuhong Guan et al.   Molecular BioSystems

WNT Signaling in Cardiac and Vascular Disease

(2017) Sébastien Foulquier et al.   PHARMACOLOGICAL REVIEWS

‘WNT-er is coming’ : WNT signalling in chronic lung diseases

(2017) H A Baarsma et al.   THORAX

The molecular basis of endothelial cell plasticity

(2017) Elisabetta Dejana et al.   Nature Communications

Pulmonary Hypertension in Idiopathic Pulmonary Fibrosis: Prevalence and Clinical Progress

(2017) D. Castria et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Salvianolic acid A attenuates vascular remodeling in a pulmonary arterial hypertension rat model

(2016) Yu-cai Chen et al.   ACTA PHARMACOLOGICA SINICA

Endothelial Mesenchymal Transition: Comparative Analysis of Different Induction Methods

(2016) Mariana T. Pinto et al.   BIOLOGICAL PROCEDURES ONLINE

The role of PDGF-B/TGF-β1/neprilysin network in regulating endothelial-to-mesenchymal transition in pulmonary artery remodeling

(2016) Shasha Song et al.   CELLULAR SIGNALLING

Endothelial-to-Mesenchymal Transition

(2016) Kurt R. Stenmark et al.   CIRCULATION

p300/β-Catenin Interactions Regulate Adult Progenitor Cell Differentiation Downstream of WNT5a/Protein Kinase C (PKC)

(2016) Megan E. Rieger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FGF2 inhibits endothelial–mesenchymal transition through microRNA-20a-mediated repression of canonical TGF-β signaling

(2016) Ana C. P. Correia et al.   JOURNAL OF CELL SCIENCE

In Brief: Endothelial-to-mesenchymal transition

(2016) Gonzalo Sanchez-Duffhues et al.   JOURNAL OF PATHOLOGY

Canonical Wnt signaling in systemic sclerosis

(2016) Christina Bergmann et al.   LABORATORY INVESTIGATION

Ponatinib attenuates experimental pulmonary arterial hypertension by modulating Wnt signaling and vasohibin-2/vasohibin-1

(2016) Zechun Kang et al.   LIFE SCIENCES

Endothelial to mesenchymal transition (EndoMT) in the pathogenesis of Systemic Sclerosis-associated pulmonary fibrosis and pulmonary arterial hypertension. Myth or reality?

(2016) Sergio A. Jimenez et al.   MATRIX BIOLOGY

Auscultation of Velcro Crackles is Associated With Usual Interstitial Pneumonia

(2016) Jacobo Sellarés et al.   MEDICINE

Endothelial to Mesenchymal Transition (EndoMT) in the Pathogenesis of Human Fibrotic Diseases

(2016) Sonsoles Piera-Velazquez et al.   Journal of Clinical Medicine

Stimulation of Transforming Growth Factor-β1-Induced Endothelial-To-Mesenchymal Transition and Tissue Fibrosis by Endothelin-1 (ET-1): A Novel Profibrotic Effect of ET-1

(2016) Peter J. Wermuth et al.   PLoS One

Inhibition of Matrix Metalloproteinase Activity Reverses Corneal Endothelial-Mesenchymal Transition

(2015) Wei-Ting Ho et al.   AMERICAN JOURNAL OF PATHOLOGY

Endothelial to Mesenchymal Transition Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension

(2015) Robert B. Good et al.   AMERICAN JOURNAL OF PATHOLOGY

Reemergence of Hedgehog Mediates Epithelial–Mesenchymal Crosstalk in Pulmonary Fibrosis

(2015) Biao Hu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Sonic Hedgehog Signaling in the Lung. From Development to Disease

(2015) Matthias C. Kugler et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

MicroRNA regulatory networks in idiopathic pulmonary fibrosis

(2015) Kusum V. Pandit et al.   Biochemistry and Cell Biology

Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis

(2015) Rafael Kramann et al.   Cell Stem Cell

Protective Effect of Spironolactone on Endothelial-to-Mesenchymal Transition in HUVECs via Notch Pathway

(2015) Xiao Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Enhancer of zeste homolog-2 (EZH2) methyltransferase regulates transgelin/smooth muscle-22α expression in endothelial cells in response to interleukin-1β and transforming growth factor-β2

(2015) Monika Maleszewska et al.   CELLULAR SIGNALLING

MiR-125b is Critical for Fibroblast-to-Myofibroblast Transition and Cardiac Fibrosis

(2015) Varun Nagpal et al.   CIRCULATION

Endothelial-to-Mesenchymal Transition in Pulmonary Hypertension

(2015) B. Ranchoux et al.   CIRCULATION

A Hypoxia-Induced Vascular Endothelial-to-Mesenchymal Transition in Development of Radiation-Induced Pulmonary Fibrosis

(2015) S.-H. Choi et al.   CLINICAL CANCER RESEARCH

When endothelial cells go rogue

(2015) P.-Y. Chen et al.   EMBO Molecular Medicine

Comorbidities in idiopathic pulmonary fibrosis patients: a systematic literature review

(2015) Ganesh Raghu et al.   EUROPEAN RESPIRATORY JOURNAL

Kallistatin inhibits TGF-β-induced endothelial–mesenchymal transition by differential regulation of microRNA-21 and eNOS expression

(2015) Youming Guo et al.   EXPERIMENTAL CELL RESEARCH

Non-canonical WNT signalling in the lung

(2015) Changgong Li et al.   JOURNAL OF BIOCHEMISTRY

Snail Is a Direct Target of Hypoxia-inducible Factor 1α (HIF1α) in Hypoxia-induced Endothelial to Mesenchymal Transition of Human Coronary Endothelial Cells

(2015) Xingbo Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial-to-mesenchymal transition drives atherosclerosis progression

(2015) Pei-Yu Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

The Endothelial-mesenchymal Transition in Systemic Sclerosis Is Induced by Endothelin-1 and Transforming Growth Factor-  and May Be Blocked by Macitentan, a Dual Endothelin-1 Receptor Antagonist

(2015) P. Cipriani et al.   JOURNAL OF RHEUMATOLOGY

C3a and C5a receptor antagonists ameliorate endothelial-myofibroblast transition via the Wnt/β-catenin signaling pathway in diabetic kidney disease

(2015) Ling Li et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Sulindac metabolites decrease cerebrovascular malformations inCCM3-knockout mice

(2015) Luca Bravi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relaxin inhibits cardiac fibrosis and endothelial–mesenchymal transition via the Notch pathway

(2015) Xi Zhou et al.   Drug Design Development and Therapy

To be EndMT or not to be, that is the question in pulmonary hypertension

(2015) Jianhua Xiong   Protein & Cell

Cellular Mechanisms of Tissue Fibrosis. 7. New insights into the cellular mechanisms of pulmonary fibrosis

(2014) Christina E. Barkauskas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Wnt CoreceptorLrp5Is a Driver of Idiopathic Pulmonary Fibrosis

(2014) Anna P. Lam et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Nuclear factor-kappa-B signaling in lung development and disease: One pathway, numerous functions

(2014) Cristina M. Alvira   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Linagliptin-Mediated DPP-4 Inhibition Ameliorates Kidney Fibrosis in Streptozotocin-Induced Diabetic Mice by Inhibiting Endothelial-to-Mesenchymal Transition in a Therapeutic Regimen

(2014) Keizo Kanasaki et al.   DIABETES

Anti-Fibrosis Effect of Scutellarin via Inhibition of Endothelial–Mesenchymal Transition on Isoprenaline-Induced Myocardial Fibrosis in Rats

(2014) Hao Zhou et al.   MOLECULES

Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures

(2014) Sofia Movérare-Skrtic et al.   NATURE MEDICINE

Noncoding RNAs and myocardial fibrosis

(2014) Thomas Thum   Nature Reviews Cardiology

Vascular remodelling in the pathogenesis of idiopathic pulmonary fibrosis

(2014) S. Barratt et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Inflammatory cytokines in pulmonary hypertension

(2014) Alexandra Groth et al.   RESPIRATORY RESEARCH

TGF-  Signaling Mediates Endothelial-to-Mesenchymal Transition (EndMT) During Vein Graft Remodeling

(2014) B. C. Cooley et al.   Science Translational Medicine

Noncanonical Wnt5a enhances Wnt/β-catenin signaling during osteoblastogenesis

(2014) Masanori Okamoto et al.   Scientific Reports

Wnt Signaling Pathway in Non-Small Cell Lung Cancer

(2013) D. J. Stewart   JNCI-Journal of the National Cancer Institute

The WNT signaling pathway from ligand secretion to gene transcription: Molecular mechanisms and pharmacological targets

(2013) Hoeke A. Baarsma et al.   PHARMACOLOGY & THERAPEUTICS

Endothelial Progenitor Cells in the Pathogenesis of Idiopathic Pulmonary Fibrosis: An Evolving Concept

(2013) Foteini Malli et al.   PLoS One

microRNA 126 Inhibits the Transition of Endothelial Progenitor Cells to Mesenchymal Cells via the PIK3R2-PI3K/Akt Signalling Pathway

(2013) Junfeng Zhang et al.   PLoS One

MicroRNAs in Kidney Fibrosis and Diabetic Nephropathy: Roles on EMT and EndMT

(2013) Swayam Prakash Srivastava et al.   Biomed Research International

The Hedgehog System Machinery Controls Transforming Growth Factor-β–Dependent Myofibroblastic Differentiation in Humans

(2012) Natacha Cigna et al.   AMERICAN JOURNAL OF PATHOLOGY

Hedgehog-Gli Pathway Activation during Kidney Fibrosis

(2012) Steven L. Fabian et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of Sonic Hedgehog in idiopathic pulmonary fibrosis

(2012) Alfredo Lozano Bolaños et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells

(2012) Jun Wei et al.   ARTHRITIS AND RHEUMATISM

Molecular basis of cardiac endothelial-to-mesenchymal transition (EndMT): Differential expression of microRNAs during EndMT

(2012) Asish K. Ghosh et al.   CELLULAR SIGNALLING

Platelet-derived growth factor (PDGF) induces pulmonary vascular remodeling through 15-LO/15-HETE pathway under hypoxic condition

(2012) Lei Zhang et al.   CELLULAR SIGNALLING

Out-of-Proportion Pulmonary Hypertension

(2012) Sergio Harari   CHEST

Epithelial-to-Mesenchymal and Endothelial-to-Mesenchymal Transition

(2012) Jason C. Kovacic et al.   CIRCULATION

Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development

(2012) Renée van Amerongen et al.   DEVELOPMENTAL BIOLOGY

The Notch pathway controls fibrotic and regenerative repair in the adult heart

(2012) Mohamed Nemir et al.   EUROPEAN HEART JOURNAL

Sonic Hedgehog Signaling Mediates Epithelial-Mesenchymal Communication and Promotes Renal Fibrosis

(2012) H. Ding et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Endothelial–mesenchymal transition and its contribution to the emergence of stem cell phenotype

(2012) Damian Medici et al.   SEMINARS IN CANCER BIOLOGY

FGF Regulates TGF-β Signaling and Endothelial-to-Mesenchymal Transition via Control of let-7 miRNA Expression

(2012) Pei-Yu Chen et al.   Cell Reports

Wnt5a: its signalling, functions and implication in diseases

(2011) A. Kikuchi et al.   Acta Physiologica

Inflammation-Induced Endothelial-to-Mesenchymal Transition

(2011) Florian Rieder et al.   AMERICAN JOURNAL OF PATHOLOGY

HIF and the Lung

(2011) Larissa A. Shimoda et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management

(2011) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Nuclear β-Catenin Is Increased in Systemic Sclerosis Pulmonary Fibrosis and Promotes Lung Fibroblast Migration and Proliferation

(2011) Anna P. Lam et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Transforming Growth Factor-β–Induced Endothelial-to-Mesenchymal Transition Is Partly Mediated by MicroRNA-21

(2011) Regalla Kumarswamy et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Protein kinase Cδ and c-Abl kinase are required for transforming growth factor β induction of endothelial-mesenchymal transition in vitro

(2011) Zhaodong Li et al.   ARTHRITIS AND RHEUMATISM

Transforming growth factor-β2 promotes Snail-mediated endothelial–mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling

(2011) Damian Medici et al.   BIOCHEMICAL JOURNAL

Regulation of endothelial cell plasticity by TGF-β

(2011) Laurens A. van Meeteren et al.   CELL AND TISSUE RESEARCH

Notch Initiates the Endothelial-to-Mesenchymal Transition in the Atrioventricular Canal through Autocrine Activation of Soluble Guanylyl Cyclase

(2011) Alex C.Y. Chang et al.   DEVELOPMENTAL CELL

Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition

(2011) O. Aisagbonhi et al.   Disease Models & Mechanisms

Targeted gene delivery of BMPR2 attenuates pulmonary hypertension

(2011) A. M. Reynolds et al.   EUROPEAN RESPIRATORY JOURNAL

Pulmonary Hypertension in Idiopathic Pulmonary Fibrosis: A Review

(2011) Georgia Pitsiou et al.   RESPIRATION

Idiopathic Pulmonary Fibrosis Is Associated With Endothelial To Mesenchymal Transition

(2010) Dilip Nataraj et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pulmonary Hypertension and Idiopathic Pulmonary Fibrosis

(2010) Laszlo Farkas et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Role of Endothelin-1 in the Pathogenesis of Idiopathic Pulmonary Fibrosis

(2010) Jeffrey J. Swigris et al.   BIODRUGS

Noncanonical Wnt signaling in vertebrate development, stem cells, and diseases

(2010) Ryohichi Sugimura et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Endothelial Cell–Derived Endothelin-1 Promotes Cardiac Fibrosis in Diabetic Hearts Through Stimulation of Endothelial-to-Mesenchymal Transition

(2010) Bambang Widyantoro et al.   CIRCULATION

Signaling by members of the TGF-β family in vascular morphogenesis and disease

(2010) Evangelia Pardali et al.   TRENDS IN CELL BIOLOGY

Possible role of NFĸB in the embryonic vascular remodeling and the endothelial-mesenchymal transition process

(2010) Enrique Arciniegas et al.   Cell Adhesion & Migration

WNT5A Is a Regulator of Fibroblast Proliferation and Resistance to Apoptosis

(2009) Louis J. Vuga et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Endothelial–Mesenchymal Transition in Bleomycin-Induced Pulmonary Fibrosis

(2009) Naozumi Hashimoto et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Obstructive Sleep Apnea Is Common in Idiopathic Pulmonary Fibrosis

(2009) Lisa H. Lancaster et al.   CHEST

Idiopathic Pulmonary Fibrosis and Emphysema

(2009) Mayra Mejía et al.   CHEST

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Differential Regulation of Transforming Growth Factor β Signaling Pathways by Notch in Human Endothelial Cells

(2009) YangXin Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs

(2009) R. Grant Rowe et al.   JOURNAL OF CELL BIOLOGY

GLI3 Repressor Controls Nephron Number via Regulation of Wnt11 and Ret in Ureteric Tip Cells

(2009) Jason E. Cain et al.   PLoS One

TGF-β signaling in vascular biology and dysfunction

(2008) Marie-José Goumans et al.   CELL RESEARCH

Signaling cross-talk between TGF-β/BMP and other pathways

(2008) Xing Guo et al.   CELL RESEARCH

The role of the ZEB family of transcription factors in development and disease

(2008) C. Vandewalle et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Pulmonary hypertension in interstitial lung disease

(2008) J. Behr et al.   EUROPEAN RESPIRATORY JOURNAL

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

(2008) Kyle Niessen et al.   JOURNAL OF CELL BIOLOGY

The many facets of Notch ligands

(2008) B D'Souza et al.   ONCOGENE

Idiopathic pulmonary fibrosis

(2008) Eric B Meltzer et al.   Orphanet Journal of Rare Diseases

TGF-β1 targets the GSK-3β/β-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts

(2008) F CARACI et al.   PHARMACOLOGICAL RESEARCH

Functional Wnt Signaling Is Increased in Idiopathic Pulmonary Fibrosis

(2008) Melanie Königshoff et al.   PLoS One

Serial Development of Pulmonary Hypertension in Patients with Idiopathic Pulmonary Fibrosis

(2008) Steven D. Nathan et al.   RESPIRATION

Alternative Wnt Signaling Is Initiated by Distinct Receptors

(2008) R. van Amerongen et al.   Science Signaling

The Role of Inflammation in the Pathogenesis of Idiopathic Pulmonary Fibrosis

(2007) Benjamin D. Bringardner et al.   ANTIOXIDANTS & REDOX SIGNALING