Synthesis of cyclophosphamide metabolites by a peroxygenase from Marasmius rotula for toxicological studies on human cancer cells

Benchmarking of laboratory evolved unspecific peroxygenases for the synthesis of human drug metabolites

(2019) Patricia Gomez de Santos et al.   TETRAHEDRON

Comparison of Drug Metabolism and Its Related Hepatotoxic Effects in HepaRG, Cryopreserved Human Hepatocytes, and HepG2 Cell Cultures

(2018) Yuichi Yokoyama et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the “Metabolites in Safety Testing” Regulatory Guidance

(2018) Simone Schadt et al.   DRUG METABOLISM AND DISPOSITION

Selective Synthesis of the Human Drug Metabolite 5′-Hydroxypropranolol by an Evolved Self-Sufficient Peroxygenase

(2018) Patricia Gomez de Santos et al.   ACS Catalysis

Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoic acid/HIF-1α/VEGF signalling in MCF-7 breast cancer cells

(2018) Valerio Ciccone et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Metabolic activity testing can underestimate acute drug cytotoxicity as revealed by HepG2 cell clones overexpressing cytochrome P450 2C19 and 3A4

(2018) Susanne Steinbrecht et al.   TOXICOLOGY

Accessing Drug Metabolites via Transition-Metal Catalyzed C−H Oxidation: The Liver as Synthetic Inspiration

(2016) Julien Genovino et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The effect of cyclophosphamide on the immune system: implications for clinical cancer therapy

(2016) Martina Ahlmann et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

One-pot synthesis of human metabolites of SAR548304 by fungal peroxygenases

(2015) Jan Kiebist et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Prediction of Drug-Induced Liver Injury in HepG2 Cells Cultured with Human Liver Microsomes

(2015) Jong Min Choi et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Tandem-yeast expression system for engineering and producing unspecific peroxygenase

(2015) Patricia Molina-Espeja et al.   ENZYME AND MICROBIAL TECHNOLOGY

Predicting drug metabolism: experiment and/or computation?

(2015) Johannes Kirchmair et al.   NATURE REVIEWS DRUG DISCOVERY

Phosphoramide mustard exposure induces DNA adduct formation and the DNA damage repair response in rat ovarian granulosa cells

(2015) Shanthi Ganesan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Directed Evolution of Unspecific Peroxygenase from Agrocybe aegerita

(2014) Patricia Molina-Espeja et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Cytochromes P450 as promising catalysts for biotechnological application: chances and limitations

(2014) Rita Bernhardt et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Oxidations catalyzed by fungal peroxygenases

(2014) Martin Hofrichter et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Filamentous fungal biofilm for production of human drug metabolites

(2013) Jessica Amadio et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Metalloporphyrin-catalyzed hydroxylation of the N,N-dimethylamide function of the drug molecule SSR180575 to a stable N-methyl-N-carbinolamide

(2013) Irène Nicolas et al.   COMPTES RENDUS CHIMIE

Preparation of labeled human drug metabolites and drug-drug interaction-probes with fungal peroxygenases

(2013) Marzena Poraj-Kobielska et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Pd-Catalyzed CH Oxygenation with TFA/TFAA: Expedient Access to Oxygen-Containing Heterocycles and Late-Stage Drug Modification

(2012) Gang Shan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Oxazaphosphorine bioactivation and detoxification: the role of xenobiotic receptors

(2012) Duan Wang et al.   Acta Pharmaceutica Sinica B

Preparation of human drug metabolites using fungal peroxygenases

(2011) Marzena Poraj-Kobielska et al.   BIOCHEMICAL PHARMACOLOGY

Lead diversification. Application to existing drug molecules: Mifepristone 1 and antalarmin 8

(2011) M. Abid Masood et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

CYP3A4 Mediates Growth of Estrogen Receptor-positive Breast Cancer Cells in Part by Inducing Nuclear Translocation of Phospho-Stat3 through Biosynthesis of (±)-14,15-Epoxyeicosatrienoic Acid (EET)

(2011) Ranjana Mitra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Managing the challenge of chemically reactive metabolites in drug development

(2011) B. Kevin Park et al.   NATURE REVIEWS DRUG DISCOVERY

Cytochrome P450 monooxygenases: an update on perspectives for synthetic application

(2011) Vlada B. Urlacher et al.   TRENDS IN BIOTECHNOLOGY

High-yield production of aromatic peroxygenase by the agaric fungus Marasmius rotula

(2011) Glenn Gröbe et al.   AMB Express

Lidocaine Oxidation by Electrogenerated Reactive Oxygen Species in the Light of Oxidative Drug Metabolism

(2010) Eslam Nouri-Nigjeh et al.   ANALYTICAL CHEMISTRY

New and classic families of secreted fungal heme peroxidases

(2010) Martin Hofrichter et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Recombinant human cytochrome P450 monooxygenases for drug metabolite synthesis

(2010) Kirsten Schroer et al.   BIOTECHNOLOGY AND BIOENGINEERING

Similarities and Differences in the Expression of Drug-Metabolizing Enzymes between Human Hepatic Cell Lines and Primary Human Hepatocytes

(2010) L. Guo et al.   DRUG METABOLISM AND DISPOSITION

Combined Effects on Selectivity in Fe-Catalyzed Methylene Oxidation

(2010) M. S. Chen et al.   SCIENCE

Production of human phase 1 and 2 metabolites by whole-cell biotransformation with recombinant microbes

(2010) Andy Zöllner et al.   Bioanalysis

CH Hydroxylation Using a Heterocyclic Catalyst and Aqueous H2O2

(2009) Nichole D. Litvinas et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regioselective preparation of 5-hydroxypropranolol and 4′-hydroxydiclofenac with a fungal peroxygenase

(2009) Matthias Kinne et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Metabolites in safety testing: metabolite identification strategies in discovery and development

(2009) Angus N. R. Nedderman   BIOPHARMACEUTICS & DRUG DISPOSITION

Gef gene therapy enhances the therapeutic efficacy of doxorubicin to combat growth of MCF-7 breast cancer cells

(2009) Jose Prados et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Interpretation and Considerations on the Safety Evaluation of Human Drug Metabolites

(2009) Aisar H. Atrakchi   CHEMICAL RESEARCH IN TOXICOLOGY

A Holistic Strategy for Characterizing the Safety of Metabolites through Drug Discovery and Development

(2009) Don Walker et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A Panel of Cytochrome P450 BM3 Variants to Produce Drug Metabolites and Diversify Lead Compounds

(2009) Andrew M. Sawayama et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of isotopically labelled SGLT inhibitors and their metabolites

(2009) Volker Derdau et al.   TETRAHEDRON

Catalytic Oxidation of Organic Substrates by Molecular Oxygen and Hydrogen Peroxide by Multistep Electron Transfer—A Biomimetic Approach

(2008) Julio Piera et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cytochrome P450 and Chemical Toxicology

(2007) F. Peter Guengerich   CHEMICAL RESEARCH IN TOXICOLOGY