In silico and in vitro identification of secoisolariciresinol as a re-sensitizer of P-glycoprotein-dependent doxorubicin-resistance NCI/ADR-RES cancer cells

Using the lentiviral vector system to stably express chicken P-gp and BCRP in MDCK cells for screening the substrates and studying the interplay of both transporters

(2018) Yujuan Zhang et al.   ARCHIVES OF TOXICOLOGY

Comparison of mechanistic transport cycle models of ABC exporters

(2018) Dániel Szöllősi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Advances in Studies of P-Glycoprotein and Its Expression Regulators

(2018) Kentaro Yano et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

In silico comparisons between natural inhibitors of ABCB1/P-glycoprotein to overcome doxorubicin-resistance in the NCI/ADR-RES cell line

(2018) Mohamed A. Morsy et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Flaxseed Lignans Enhance the Cytotoxicity of Chemotherapeutic Agents against Breast Cancer Cell Lines MDA-MB-231 and SKBR3

(2018) Yunyun Di et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

The reliability of molecular dynamics simulations of the multidrug transporter P-glycoprotein in a membrane environment

(2018) Karmen Condic-Jurkic et al.   PLoS One

Flaxseed Bioactive Compounds and Colorectal Cancer Prevention

(2018) Jennifer A. A. DeLuca et al.   Current Oncology Reports

An altered tissue distribution of flaxseed lignans and their metabolites in Abcg2 knockout mice

(2018) Dafne García-Mateos et al.   Food & Function

High salt induces P-glycoprotein mediated treatment resistance in breast cancer cells through store operated calcium influx

(2018) Duaa Babaer et al.   Oncotarget

Anticancer potentiality of lignan rich fraction of six Flaxseed cultivars

(2018) Shahira M. Ezzat et al.   Scientific Reports

Stimuli-Responsive Nanomedicines for Overcoming Cancer Multidrug Resistance

(2018) Lei Zhou et al.   Theranostics

Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018

(2018) J. Ferlay et al.   EUROPEAN JOURNAL OF CANCER

Influence of Flaxseed Lignan Supplementation to Older Adults on Biochemical and Functional Outcome Measures of Inflammation

(2017) Yunyun Di et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Unidirectional Transport Mechanism in an ATP Dependent Exporter

(2017) Yanyan Xu et al.   ACS Central Science

Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity

(2016) Lothar Esser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of CD44 and ERM Proteins in Expression and Functionality of P-glycoprotein in Breast Cancer Cells

(2016) Deep Pokharel et al.   MOLECULES

Combination Nanopreparations of a Novel Proapoptotic Drug – NCL-240, TRAIL and siRNA

(2016) Robert Riehle et al.   PHARMACEUTICAL RESEARCH

Structural modification of P-glycoprotein induced by OH radicals: Insights from atomistic simulations

(2016) N. Khosravian et al.   Scientific Reports

Multiple Drug Transport Pathways through Human P-Glycoprotein

(2015) James W. McCormick et al.   BIOCHEMISTRY

The Flaxseed-Derived Lignan Phenolic Secoisolariciresinol Diglucoside (SDG) Protects Non-Malignant Lung Cells from Radiation Damage

(2015) Anastasia Velalopoulou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural Characterization of Two Metastable ATP-Bound States of P-Glycoprotein

(2014) Megan L. O’Mara et al.   PLoS One

Mechanistic picture for conformational transition of a membrane transporter at atomic resolution

(2013) M. Moradi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mass spectrometry reveals synergistic effects of nucleotides, lipids, and drugs binding to a multidrug resistance efflux pump

(2013) J. Marcoux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Refined structures of mouse P-glycoprotein

(2013) Jingzhi Li et al.   PROTEIN SCIENCE

Drug promiscuity of P-glycoprotein and its mechanism of interaction with paclitaxel and doxorubicin

(2013) Junqiao Zhang et al.   Soft Matter

Probing the ATP Hydrolysis Cycle of the ABC Multidrug Transporter LmrA by Pulsed EPR Spectroscopy

(2012) Ute A. Hellmich et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans

(2012) Mi Sun Jin et al.   NATURE

Characterization of an Asymmetric Occluded State of P-glycoprotein with Two Bound Nucleotides

(2010) Alena Siarheyeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nilotinib (AMN107, Tasigna ® ) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters

(2009) Amit K. Tiwari et al.   BIOCHEMICAL PHARMACOLOGY

The Effect of Breast Cancer Resistance Protein and P-Glycoprotein on the Brain Penetration of Flavopiridol, Imatinib Mesylate (Gleevec), Prazosin, and 2-Methoxy-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)propanoic Acid (PF-407288) in Mice

(2009) L. Zhou et al.   DRUG METABOLISM AND DISPOSITION

Cytosolic Region of TM6 in P-Glycoprotein: Topographical Analysis and Functional Perturbation by Site Directed Labeling†

(2008) Janet Storm et al.   BIOCHEMISTRY

Opening of the ADP-bound active site in the ABC transporter ATPase dimer: Evidence for a constant contact, alternating sites model for the catalytic cycle

(2008) Peter M. Jones et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS