Testosterone treatment is associated with reduced adipose tissue dysfunction and nonalcoholic fatty liver disease in obese hypogonadal men

Testosterone is sequestered in dysfunctional adipose tissue, modifying androgen-responsive genes

(2020) Andrea Di Nisio et al.   INTERNATIONAL JOURNAL OF OBESITY

Physical activity counteracts metabolic syndrome-induced hypogonadotropic hypogonadism and erectile dysfunction in the rabbit

(2019) Annamaria Morelli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mitochondrial localization, import and mitochondrial function of the androgen receptor

(2019) Prachi Bajpai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Testosterone Deficiency Caused by Castration Modulates Mitochondrial Biogenesis Through the AR/PGC1α/TFAM Pathway

(2019) Can Liu et al.   Frontiers in Genetics

UCP 2 gene polymorphisms in obesity and diabetes, and the role of UCP 2 in cancer

(2019) Jinran Li et al.   FEBS LETTERS

Testosterone alleviates mitochondrial ROS accumulation and mitochondria-mediated apoptosis in the gastric mucosa of orchiectomized rats

(2018) Jie Kang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion

(2018) Ilan Y. Benador et al.   Cell Metabolism

The safety of available treatments of male hypogonadism in organic and functional hypogonadism

(2018) G. Corona et al.   Expert Opinion On Drug Safety

Testosterone Deprivation Aggravates Left-Ventricular Dysfunction in Male Obese Insulin-Resistant Rats via Impairing Cardiac Mitochondrial Function and Dynamics Proteins

(2018) Nattayaporn Apaiajai et al.   GERONTOLOGY

INT-767 prevents NASH and promotes visceral fat brown adipogenesis and mitochondrial function

(2018) Paolo Comeglio et al.   JOURNAL OF ENDOCRINOLOGY

Possible mechanisms underlying fatty liver in a rat model of male hypogonadism: A protective role for testosterone

(2018) Hussein F. Sakr et al.   STEROIDS

Mitochondria, glycogen, and lipid droplets in skeletal muscle during testosterone treatment and strength training: a randomized, double-blinded, placebo-controlled trial

(2018) R. C. Jensen et al.   Andrology

Mitochondrial role in the neonatal predisposition to developing nonalcoholic fatty liver disease

(2018) Peter R. Baker et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial dysfunction in diabetes and the regulatory roles of antidiabetic agents on the mitochondrial function

(2018) Habib Yaribeygi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Low testosterone levels are related to oxidative stress, mitochondrial dysfunction and altered subclinical atherosclerotic markers in type 2 diabetic male patients

(2017) Susana Rovira-Llopis et al.   FREE RADICAL BIOLOGY AND MEDICINE

Foxc2 coordinates inflammation and browning of white adipose by leptin-STAT3-PRDM16 signal in mice

(2017) L Gan et al.   INTERNATIONAL JOURNAL OF OBESITY

The Effect of Testosterone on Cardiovascular Biomarkers in the Testosterone Trials

(2017) Emile R Mohler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Anti-fibrotic effects of chronic treatment with the selective FXR agonist obeticholic acid in the bleomycin-induced rat model of pulmonary fibrosis

(2017) Paolo Comeglio et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Insights into Stearoyl-CoA Desaturase-1 Regulation of Systemic Metabolism

(2017) Ahmed M. ALJohani et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Effects of Testosterone and Evoked Resistance Exercise after Spinal Cord Injury (TEREX-SCI): study protocol for a randomised controlled trial

(2017) Ashraf S Gorgey et al.   BMJ Open

Adipose tissue macrophages impair preadipocyte differentiation in humans

(2017) Li Fen Liu et al.   PLoS One

Male Hypogonadism Causes Obesity Associated with Impairment of Hepatic Gluconeogenesis in Mice

(2016) Akira Aoki et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Effect of testosterone on insulin sensitivity, oxidative metabolism and body composition in aging men with type 2 diabetes on metformin monotherapy

(2016) Line V. Magnussen et al.   DIABETES OBESITY & METABOLISM

Testosterone therapy increases muscle mass in men with cirrhosis and low testosterone: A randomised controlled trial

(2016) Marie Sinclair et al.   JOURNAL OF HEPATOLOGY

Tadalafil reduces visceral adipose tissue accumulation by promoting preadipocytes differentiation towards a metabolically healthy phenotype: Studies in rabbits

(2016) Elena Maneschi et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Mitofusins, from Mitochondria to Metabolism

(2016) Emilie Schrepfer et al.   MOLECULAR CELL

α-MSH and Foxc2 promote fatty acid oxidation through C/EBPβ negative transcription in mice adipose tissue

(2016) Lu Gan et al.   Scientific Reports

Testosterone supplementation and body composition: results from a meta-analysis of observational studies

(2016) G. Corona et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Role of microenvironment on neuroblastoma SK-N-AS SDHB-silenced cell metabolism and function

(2015) E. Rapizzi et al.   ENDOCRINE-RELATED CANCER

THERAPY OF ENDOCRINE DISEASE: Testosterone supplementation and body composition: results from a meta-analysis study

(2015) Giovanni Corona et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Effects of long-term treatment with testosterone on weight and waist size in 411 hypogonadal men with obesity classes I-III: observational data from two registry studies

(2015) F Saad et al.   INTERNATIONAL JOURNAL OF OBESITY

Development of and Recovery from Secondary Hypogonadism in Aging Men: Prospective Results from the EMAS

(2015) Giulia Rastrelli et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

NAFLD: A multisystem disease

(2015) Christopher D. Byrne et al.   JOURNAL OF HEPATOLOGY

Obesity and late-onset hypogonadism

(2015) G. Corona et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Unraveling the roles of PLIN5: linking cell biology to physiology

(2015) Rachael R. Mason et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

Ultrasound of the male genital tract in relation to male reproductive health

(2014) F. Lotti et al.   HUMAN REPRODUCTION UPDATE

STAMPing into Mitochondria

(2014) Seong Keun Yoo et al.   International Journal of Biological Sciences

Testosterone suppresses the expression of regulatory enzymes of fatty acid synthesis and protects against hepatic steatosis in cholesterol-fed androgen deficient mice

(2014) Daniel M. Kelly et al.   LIFE SCIENCES

Nonalcoholic steatohepatitis as a novel player in metabolic syndrome-induced erectile dysfunction: An experimental study in the rabbit

(2014) Linda Vignozzi et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Effects of testosterone undecanoate replacement and withdrawal on cardio-metabolic, hormonal and body composition outcomes in severely obese hypogonadal men: a pilot study

(2014) D. Francomano et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Mitochondrial dysfunction has divergent, cell type-dependent effects on insulin action

(2014) Sheree D. Martin et al.   Molecular Metabolism

Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure

(2013) Marc Liesa et al.   Cell Metabolism

The response to testosterone undecanoate in men with type 2 diabetes is dependent on achieving threshold serum levels (the BLAST study)

(2013) G. Hackett et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

FXR activation normalizes insulin sensitivity in visceral preadipocytes of a rabbit model of MetS

(2013) Elena Maneschi et al.   JOURNAL OF ENDOCRINOLOGY

Associations between UCP1 -3826A/G, UCP2 -866G/A, Ala55Val and Ins/Del, and UCP3 -55C/T Polymorphisms and Susceptibility to Type 2 Diabetes Mellitus: Case-Control Study and Meta-Analysis

(2013) Bianca M. de Souza et al.   PLoS One

UCP2 -866G/A, Ala55Val and UCP3 -55C/T Polymorphisms in Association with Obesity Susceptibility — A Meta-Analysis Study

(2013) Li Qian et al.   PLoS One

Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria

(2012) Andriy Fedorenko et al.   CELL

Early Mitochondrial Adaptations in Skeletal Muscle to Diet-Induced Obesity Are Strain Dependent and Determine Oxidative Stress and Energy Expenditure But Not Insulin Sensitivity

(2012) Sihem Boudina et al.   ENDOCRINOLOGY

Body compositional and cardiometabolic effects of testosterone therapy in obese men with severe obstructive sleep apnoea: a randomised placebo-controlled trial

(2012) Camilla M Hoyos et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

PGC1  and mitochondrial metabolism - emerging concepts and relevance in ageing and neurodegenerative disorders

(2012) S. Austin et al.   JOURNAL OF CELL SCIENCE

Testosterone treatment improves metabolic syndrome-induced adipose tissue derangements

(2012) Elena Maneschi et al.   JOURNAL OF ENDOCRINOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

(2012) D. Sebastian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Uncoupling protein-2 (UCP2) gene expression in subcutaneous and omental adipose tissue of Asian Indians

(2012) Sujata R. Mahadik et al.   Adipocyte

The Adipocyte-Expressed Forkhead Transcription Factor Foxc2 Regulates Metabolism Through Altered Mitochondrial Function

(2011) M. E. Lidell et al.   DIABETES

Testosterone Replacement in Hypogonadal Men With Type 2 Diabetes and/or Metabolic Syndrome (the TIMES2 Study)

(2011) T. H. Jones et al.   DIABETES CARE

Molecular mechanisms and physiologic functions of mitochondrial dynamics

(2011) H. Otera et al.   JOURNAL OF BIOCHEMISTRY

Update on AUA Guideline on the Management of Benign Prostatic Hyperplasia

(2011) Kevin T. McVary et al.   JOURNAL OF UROLOGY

PGC-1alpha downstream transcription factors NRF-1 and TFAM are genetic modifiers of Huntington disease

(2011) Elahe Taherzadeh-Fard et al.   Molecular Neurodegeneration

Phosphodiesterase type 5 (PDE5) in the adipocyte: a novel player in fat metabolism?

(2011) Andrea Armani et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Testosterone modulates gene expression pathways regulating nutrient accumulation, glucose metabolism and protein turnover in mouse skeletal muscle

(2010) M. T. Haren et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Farnesoid X Receptor Activation Improves Erectile Function in Animal Models of Metabolic Syndrome and Diabetes

(2010) Linda Vignozzi et al.   Journal of Sexual Medicine

Identification of Late-Onset Hypogonadism in Middle-Aged and Elderly Men

(2010) Frederick C.W. Wu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adipocyte Turnover: Relevance to Human Adipose Tissue Morphology

(2009) E. Arner et al.   DIABETES

Improvement of the Metabolic Syndrome and of Non-alcoholic Liver Steatosis upon Treatment of Hypogonadal Elderly Men with Parenteral Testosterone Undecanoate

(2009) A. Haider et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

(2009) Ethan J. Anderson et al.   JOURNAL OF CLINICAL INVESTIGATION

Number matters: control of mammalian mitochondrial DNA copy number

(2009) Laura L. Clay Montier et al.   Journal of Genetics and Genomics

Testosterone Partially Ameliorates Metabolic Profile and Erectile Responsiveness to PDE5 Inhibitors in an Animal Model of Male Metabolic Syndrome

(2009) Sandra Filippi et al.   Journal of Sexual Medicine

Investigation, Treatment, and Monitoring of Late-Onset Hypogonadism in Males: ISA, ISSAM, EAU, EAA, and ASA Recommendations

(2008) Christina Wang et al.   EUROPEAN UROLOGY

Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases

(2008) Sudheer K. Mantena et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial dynamics and apoptosis

(2008) D.-F. Suen et al.   GENES & DEVELOPMENT

Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor

(2008) Hung-Yun Lin et al.   HEPATOLOGY

Up-Regulation of Mitochondrial Activity and Acquirement of Brown Adipose Tissue-Like Property in the White Adipose Tissue of Fsp27 Deficient Mice

(2008) Shen Yon Toh et al.   PLoS One