Review
Cell Biology
Elena V. Mitroshina, Maria O. Savyuk, Evgeni Ponimaskin, Maria V. Vedunova
Summary: Hypoxia is a common pathological condition induced by various events, with the body's adaptation to it being crucial for health and disease. HIFs, a family of transcription factors, play a key role in cellular responses to hypoxia and are increasingly viewed as potential targets for treating a range of hypoxia-associated diseases. The role of HIFs in adaptation to hypoxia is universal across tissue types, including the CNS, where they are involved in regulating neurogenesis, nerve cell differentiation, and neuronal apoptosis, potentially offering new therapeutic opportunities.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Clinical Neurology
Eli R. Lebowitz, Carla E. Marin, Meital Orbach, Natalina Salmaso, Flora M. Vaccarino, Wendy K. Silverman
Summary: This study examines the intergenerational pathway linking fibroblast growth factor 2 (FGF2) levels in mothers to FGF2 levels in children, and to the children's anxiety and depressive symptoms. The results show a significant positive correlation between FGF2 levels in mothers and children, and a significant negative correlation between children's FGF2 levels and their anxiety and depression symptoms. Structural equation modeling reveals that increases in maternal FGF2 levels are associated with increases in child FGF2 levels, which in turn are associated with decreases in child anxiety and depression symptoms, controlling for maternal anxiety and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Chunsik Lee, Rongyuan Chen, Guangli Sun, Xialin Liu, Xianchai Lin, Chang He, Liying Xing, Lixian Liu, Lasse D. Jensen, Anil Kumar, Harald F. Langer, Xiangrong Ren, Jianing Zhang, Lijuan Huang, Xiangke Yin, JongKyong Kim, Juanhua Zhu, Guanqun Huang, Jiani Li, Weiwei Lu, Wei Chen, Juanxi Liu, Jiaxin Hu, Qihang Sun, Weisi Lu, Lekun Fang, Shasha Wang, Haiqing Kuang, Yihan Zhang, Geng Tian, Jia Mi, Bi-Ang Kang, Masashi Narazaki, Aaron Prodeus, Luc Schoonjans, David M. Ornitz, Jean Gariepy, Guy Eelen, Mieke Dewerchin, Yunlong Yang, Jing-Song Ou, Antonio Mora, Jin Yao, Chen Zhao, Yizhi Liu, Peter Carmeliet, Yihai Cao, Xuri Li
Summary: Although the angiogenic effect of VEGF-B is not well understood, inhibitors of VEGF-B are being used in the treatment of neovascular diseases. In this study, we reveal a previously unrecognized function of VEGF-B as an endogenous inhibitor of angiogenesis by inhibiting the FGF2/FGFR1 pathway. We found that VEGF-B binds to FGFR1, induces FGFR1/VEGFR1 complex formation, suppresses FGF2-induced Erk activation, and inhibits FGF2-driven angiogenesis and tumor growth.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Cell Biology
Danfei Liu, Tongyue Zhang, Xiaoping Chen, Bixiang Zhang, Yijun Wang, Meng Xie, Xiaoyu Ji, Mengyu Sun, Wenjie Huang, Limin Xia
Summary: The transcription factor ONECUT2 acts as an oncogene in promoting hepatocellular carcinoma (HCC) metastasis by upregulating the expression of FGF2 and ACLY. Furthermore, FGF2 can induce the expression of ONECUT2 through the FGFR1/ERK/ELK1 pathway, forming a positive feedback loop. Patients with co-expression of ONECUT2/FGF2 or ONECUT2/ACLY show the worst prognosis. Targeting the ONECUT2-mediated oncogenic signaling pathway may provide a promising therapeutic strategy against HCC metastasis.
CELL DEATH & DISEASE
(2021)
Review
Immunology
Essa M. Sabi, Anuja Singh, Ziyad M. Althafar, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Saurabh Bhatia, Ahmed Al-Harrasi, Hosam M. Alqahtani, Simona Bungau
Summary: Rheumatoid arthritis is a chronic disease that affects millions of people worldwide and is closely associated with factors such as hypoxia and angiogenesis. This review will examine how hypoxia activates molecular pathways and how other pathways involving inflammatory signals develop and sustain synovitis in rheumatoid arthritis.
INFLAMMOPHARMACOLOGY
(2022)
Article
Cell Biology
Baris Afsar, Mehmet Kanbay, Rengin Elsurer Afsar
Summary: Bone marrow hematopoiesis is regulated by various factors, including bone components, EPO, and FGF23. The interaction between these factors involves HIF pathway, direct stimulation of FGF23 synthesis, and cleavage of FGF23. Recent evidence suggests a complex relationship between FGF23, klotho, EPO, and HIF in hematopoiesis.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Dermatology
F. Toberer, H. A. Haenssle, M. Heinzel-Gutenbrunner, A. Enk, W. Hartschuh, P. Helmbold, H. Kutzner
Summary: The study highlights the crucial role of HIF-1α in MCC pathogenesis and suggests significant metabolic differences between McPyV(+) and McPyV(-) tumors.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Review
Pharmacology & Pharmacy
Baoqi Yu, Xia Wang, Yanting Song, Guomin Xie, Shiyu Jiao, Li Shi, Xuejie Cao, Xinyao Han, Aijuan Qu
Summary: Cardiovascular diseases are the leading cause of death worldwide, and hypoxia-inducible factors (HIFs) play an important role in their pathogenesis. Recent studies have revealed the role of cell-specific HIFs in various cardiovascular diseases, but the potential clinical application of HIF inhibitors in the treatment of cardiovascular diseases is not well understood.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Oncology
Chao Fang, Lei Dai, Cun Wang, Chuanwen Fan, Yongyang Yu, Lie Yang, Hongxin Deng, Zongguang Zhou
Summary: Research showed that SCG2 expression was associated with the survival of CRC patients, and it exhibited anti-tumor and anti-angiogenesis effects by inhibiting HIF-1 alpha/VEGF activity.
MOLECULAR ONCOLOGY
(2021)
Article
Engineering, Biomedical
Leidan Huang, Carole Quesada, Mitra Aliabouzar, J. Brian Fowlkes, Renny T. Franceschi, Zheng Liu, Andrew J. Putnam, Mario L. Fabiilli
Summary: Vascularization following tissue implantation is crucial for viability, and the ability to spatially control this process using acoustically responsive scaffolds has been demonstrated in this study. The study found that spatially-defined patterns of acoustic droplet vaporization can elicit spatially-defined patterns of angiogenesis.
ACTA BIOMATERIALIA
(2021)
Article
Oncology
Chengheng Liao, Xijuan Liu, Cheng Zhang, Qing Zhang
Summary: Hypoxia, characterized by diminished oxygen availability, has a significant impact on the tumor microenvironment, leading to abnormal vasculature, altered metabolism, and immune suppression. Limited effectiveness and development of resistance to anti-tumor therapy are also associated with hypoxia in the tumor microenvironment. This review summarizes the molecular mechanisms underlying hypoxic cellular responses and adaptations, and emphasizes the effects of hypoxia on angiogenesis, cellular metabolism, and immune suppression within the tumor microenvironment. Additionally, the recent advances in targeting hypoxia for therapeutic implications are discussed. A comprehensive understanding of hypoxia and its role in tumors will contribute to the development of improved cancer treatments.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Zhiyu Dai, Jianding Cheng, Bin Liu, Dan Yi, Anlin Feng, Ting Wang, Lingling An, Chen Gao, Yibin Wang, Maggie M. Zhu, Xianming Zhang, You-Yang Zhao
Summary: The study reveals the unexpected role of endothelial PHD2 deficiency in inducing cardiac hypertrophy and fibrosis in an HIF-2 alpha-dependent manner, suggesting it as a potential novel therapeutic approach for treating pathological cardiac hypertrophy and heart failure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Pharmacology & Pharmacy
Jingxuan Han, Lailiu Luo, Yicheng Wang, Shourong Wu, Vivi Kasim
Summary: This article highlights the recent advances in salidroside in treating ischemic diseases and discusses its pharmacological functions and underlying molecular mechanisms.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Nashwa Amin, Shijia Chen, Qiannan Ren, Xiaoning Tan, Benson O. A. Botchway, Zhiying Hu, Fengpei Chen, Shan Ye, Xiaoxue Du, Zuobing Chen, Marong Fang
Summary: The study found that in a focal cerebral ischemia mouse model, the activator of hypoxia-inducible factor 1 significantly increased IL-10 levels while decreasing inflammatory factors iNOS, TNF-alpha, and NF-kB levels, exerting an anti-inflammatory role to alleviate brain damage. Additionally, astrocytic activation was inhibited, and hypoxia-inducible factor 1 induction alleviated neuronal soma damage and cell death.
Article
Oncology
Baoshen Wang, Chunyan Zhang, Dongmei Chu, Xiaofang Ma, Tian Yu, Xiaozhi Liu, Changqing Hu
Summary: The study confirmed that AS-IV promotes angiogenesis in hypoxic conditions by affecting the SUMO modification of HIF-1α. Rapid attenuation and delayed compensation of SUMO1 activity led to fluctuations in HIF-1α levels, while SUMO1 overexpression stabilized HIF-1α and improved blood vessel morphology.
MOLECULAR MEDICINE REPORTS
(2021)
