Ligustilide Attenuates Ischemia Reperfusion-Induced Hippocampal Neuronal Apoptosis via Activating the PI3K/Akt Pathway

Ligustilide attenuates vascular inflammation and activates Nrf2/HO-1 induction and, NO synthesis in HUVECs

(2018) Eun Sik Choi et al.   PHYTOMEDICINE

Diverse roles of mitochondria in ischemic stroke

(2018) Jenq-Lin Yang et al.   Redox Biology

Mitochondria as a therapeutic target for common pathologies

(2018) Michael P. Murphy et al.   NATURE REVIEWS DRUG DISCOVERY

BAX to basics: How the BCL2 gene family controls the death of retinal ganglion cells

(2017) Margaret E. Maes et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Precision Medicine for Ischemic Stroke, Let Us Move Beyond Time Is Brain

(2017) Shao-Hua Yang et al.   Translational Stroke Research

Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice

(2017) Ulkan Kilic et al.   Redox Biology

Therapeutic Effect of Ligustilide-Stimulated Adipose-Derived Stem Cells in a Mouse Thromboembolic Stroke Model

(2016) Kang Chi et al.   CELL TRANSPLANTATION

Locally and traditionally used Ligusticum species – A review of their phytochemistry, pharmacology and pharmacokinetics

(2016) Paul Owusu Donkor et al.   JOURNAL OF ETHNOPHARMACOLOGY

Protection against β-amyloid-induced neurotoxicity by naturally occurring Z-ligustilide through the concurrent regulation of p38 and PI3-K/Akt pathways

(2016) Wei Xu et al.   NEUROCHEMISTRY INTERNATIONAL

The High Cost of Stroke and Stroke Cytoprotection Research

(2016) Paul A. Lapchak et al.   Translational Stroke Research

Extending the Time Window for Endovascular and Pharmacological Reperfusion

(2016) Nils Henninger et al.   Translational Stroke Research

Ligustilide inhibits tumour necrosis factor-alpha-induced autophagy during C2C12 cells differentiation

(2015) Ying Shi et al.   BIOMEDICINE & PHARMACOTHERAPY

Distinct mPTP activation mechanisms in ischaemia–reperfusion: contributions of Ca2+, ROS, pH, and inorganic polyphosphate

(2015) Lea K. Seidlmayer et al.   CARDIOVASCULAR RESEARCH

ELABELA Is an Endogenous Growth Factor that Sustains hESC Self-Renewal via the PI3K/AKT Pathway

(2015) Lena Ho et al.   Cell Stem Cell

Ligustilide ameliorates neuroinflammation and brain injury in focal cerebral ischemia/reperfusion rats: involvement of inhibition of TLR4/peroxiredoxin 6 signaling

(2014) Xi Kuang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Helium preconditioning protects mouse liver against ischemia and reperfusion injury through the PI3K/Akt pathway

(2014) Rongjia Zhang et al.   JOURNAL OF HEPATOLOGY

Panaxatriol Saponins Attenuated Oxygen-Glucose Deprivation Injury in PC12 Cells via Activation of PI3K/Akt and Nrf2 Signaling Pathway

(2014) Yongliang Huang et al.   Oxidative Medicine and Cellular Longevity

Global and regional burden of stroke during 1990–2010: findings from the Global Burden of Disease Study 2010

(2013) Valery L Feigin et al.   LANCET

Multiple interacting cell death mechanisms in the mediation of excitotoxicity and ischemic brain damage: A challenge for neuroprotection

(2013) Julien Puyal et al.   PROGRESS IN NEUROBIOLOGY

MiR-124 suppresses cell proliferation in hepatocellular carcinoma by targeting PIK3CA

(2012) Qingbo Lang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance

(2012) Edita Aksamitiene et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mitochondria: master regulators of danger signalling

(2012) Lorenzo Galluzzi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Potential roles of PI3K/Akt and Nrf2–Keap1 pathways in regulating hormesis of Z-ligustilide in PC12 cells against oxygen and glucose deprivation

(2011) Hongyi Qi et al.   NEUROPHARMACOLOGY

Activation of the Central Histaminergic System is Involved in Hypoxia-Induced Stroke Tolerance in Adult Mice

(2010) Yan-Ying Fan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuronal caspase-3 and PARP-1 correlate differentially with apoptosis and necrosis in ischemic human stroke

(2009) Tiina Sairanen et al.   ACTA NEUROPATHOLOGICA