PRP Injections for the Treatment of Knee Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials

Is platelet-rich plasma effective for the treatment of knee osteoarthritis? A systematic review and meta-analysis of level 1 and 2 randomized controlled trials

(2020) Erik Hohmann et al.   European Journal of Orthopaedic Surgery and Traumatology

Differentiating factors of intra-articular injectables have a meaningful impact on knee osteoarthritis outcomes: a network meta-analysis

(2020) Mark Phillips et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Platelet-rich plasma versus hyaluronic acid in knee osteoarthritis: A meta-analysis with the consistent ratio of injection

(2020) Qipeng Wu et al.   Journal of Orthopaedic Surgery

The Long-Lasting Effects of “Placebo Injections” in Knee Osteoarthritis: A Meta-Analysis

(2020) Davide Previtali et al.   Cartilage

Intra-articular Injection of Platelet-Rich Plasma Is Superior to Hyaluronic Acid or Saline Solution in the Treatment of Mild to Moderate Knee Osteoarthritis: A Randomized, Double-Blind, Triple-Parallel, Placebo-Controlled Clinical Trial

(2019) Kuan-Yu Lin et al.   ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY

Intra-articular injections of platelet-rich plasma, hyaluronic acid or corticosteroids for knee osteoarthritis

(2019) Yong Huang et al.   ORTHOPADE

Meta-analysis Comparing Platelet-Rich Plasma vs Hyaluronic Acid Injection in Patients with Knee Osteoarthritis

(2019) Yanhong Han et al.   PAIN MEDICINE

Platelet rich plasma in osteoarthritis the efficiency of platelet rich plasma treatment in patients with knee osteoarthritis

(2019) Hüseyin Elik et al.   JOURNAL OF BACK AND MUSCULOSKELETAL REHABILITATION

Platelet‐Rich Plasma (PRP) From Older Males With Knee Osteoarthritis Depresses Chondrocyte Metabolism and Upregulates Inflammation

(2019) Christian O’Donnell et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Multiple Platelet-Rich Plasma Injections Versus Single Platelet-Rich Plasma Injection in Early Osteoarthritis of the Knee: An Experimental Study in a Guinea Pig Model of Early Knee Osteoarthritis

(2019) Devendra K. Chouhan et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Anti-Inflammatory Effects of Novel Standardized Platelet Rich Plasma Releasates on Knee Osteoarthritic Chondrocytes and Cartilage in Vitro

(2019) Lucia Gato-Calvo et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

RoB 2: a revised tool for assessing risk of bias in randomised trials

(2019) Jonathan A C Sterne et al.   BMJ-British Medical Journal

Intra-articular platelet-rich plasma injection for knee osteoarthritis: a summary of meta-analyses

(2019) Pu Chen et al.   Journal of Orthopaedic Surgery and Research

Efetividade do plasma rico em plaquetas no tratamento da dor em osteoartrite de joelho: estudo comparativo randômico e duplo‐cego

(2019) Babita Ghai et al.   Revista Brasileira de Anestesiologia

Effects of Platelet-Rich Plasma on Pain and Muscle Strength in Patients With Knee Osteoarthritis

(2018) Yung-Tsan Wu et al.   AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION

Intra-articular Injections of Platelet-Rich Plasma Releasate Reduce Pain and Synovial Inflammation in a Mouse Model of Osteoarthritis

(2018) Sohrab Khatab et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Growth Factors Levels Determine Efficacy of Platelets Rich Plasma Injection in Knee Osteoarthritis: A Randomized Double Blind Noninferiority Trial Compared With Viscosupplementation

(2018) Marie Laure Louis et al.   ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY

Comparison of hyaluronic acid and PRP intra-articular injection with combined intra-articular and intraosseous PRP injections to treat patients with knee osteoarthritis

(2018) Ke Su et al.   CLINICAL RHEUMATOLOGY

Clinical outcomes are associated with changes in ultrasonographic structural appearance after platelet-rich plasma treatment for knee osteoarthritis

(2018) Hamada S. Ahmad et al.   International Journal of Rheumatic Diseases

Minimum clinically important differences in chronic pain vary considerable by baseline pain and methodological factors: systematic review of empirical studies

(2018) Mette Frahm Olsen et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

The use of platelets in regenerative medicine and proposal for a new classification system: guidance from the SSC of the ISTH

(2018) Paul Harrison et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis

(2018) Poupak Rahimzadeh et al.   Clinical Interventions in Aging

Platelet-Rich Plasma Versus Hyaluronic Acid Injections for the Treatment of Knee Osteoarthritis: Results at 5 Years of a Double-Blind, Randomized Controlled Trial

(2018) Alessandro Di Martino et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Platelet-Rich Plasma for the Management of Hip and Knee Osteoarthritis

(2017) Kim L. Bennell et al.   Current Rheumatology Reports

Functional Recovery in Osteoarthritic Chondrocytes Through Hyaluronic Acid and Platelet-Rich Plasma–Inhibited Infrapatellar Fat Pad Adipocytes

(2016) Wei-Hong Chen et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

The Therapeutic Effect of Intra-articular Normal Saline Injections for Knee Osteoarthritis: A Meta-analysis of Evidence Level 1 Studies

(2016) Bryan M. Saltzman et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Hyaluronic Acid Versus Platelet-Rich Plasma: A Prospective, Double-Blind Randomized Controlled Trial Comparing Clinical Outcomes and Effects on Intra-articular Biology for the Treatment of Knee Osteoarthritis

(2016) Brian J. Cole et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Intra-articular Autologous Conditioned Plasma Injections Provide Safe and Efficacious Treatment for Knee Osteoarthritis

(2016) Patrick A. Smith   AMERICAN JOURNAL OF SPORTS MEDICINE

Intra-articular injection of photo-activated platelet-rich plasma in patients with knee osteoarthritis: a double-blind, randomized controlled pilot study

(2016) Kade L. Paterson et al.   BMC MUSCULOSKELETAL DISORDERS

Non-surgical treatments for the management of early osteoarthritis

(2016) Giuseppe Filardo et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Choice of intra-articular injection in treatment of knee osteoarthritis: platelet-rich plasma, hyaluronic acid or ozone options

(2016) Tahir Mutlu Duymus et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Leukocyte-Rich Platelet-Rich Plasma Injections Do Not Up-Modulate Intra-Articular Pro-Inflammatory Cytokines in the Osteoarthritic Knee

(2016) Erminia Mariani et al.   PLoS One

Effect of Leukocyte Concentration on the Efficacy of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis

(2015) Jonathan C. Riboh et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Platelet-Rich Plasma Intra-articular Knee Injections Show No Superiority Versus Viscosupplementation

(2015) Giuseppe Filardo et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Comparative Effectiveness of Pharmacologic Interventions for Knee Osteoarthritis

(2015) Raveendhara R. Bannuru et al.   ANNALS OF INTERNAL MEDICINE

Leukocyte presence does not increase microbicidal activity of Platelet-rich Plasma in vitro

(2015) Erminia Mariani et al.   BMC MICROBIOLOGY

Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis: a randomized, double-blind, placebo-controlled trial

(2015) Gökay Görmeli et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Inflammation in joint injury and post-traumatic osteoarthritis

(2015) J. Lieberthal et al.   OSTEOARTHRITIS AND CARTILAGE

The Effect of Platelet-Rich Plasma Formulations and Blood Products on Human Synoviocytes

(2014) Hillary J. Braun et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Does Platelet-Rich Plasma Freeze-Thawing Influence Growth Factor Release and Their Effects on Chondrocytes and Synoviocytes?

(2014) Alice Roffi et al.   Biomed Research International

The Anti-inflammatory and Matrix Restorative Mechanisms of Platelet-Rich Plasma in Osteoarthritis

(2013) Emily A. Sundman et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Treatment With Platelet-Rich Plasma Is More Effective Than Placebo for Knee Osteoarthritis

(2013) Sandeep Patel et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement

(2013) David Moher   ANNALS OF INTERNAL MEDICINE

Comparison of Intra-Articular Injections of Plasma Rich in Growth Factors (PRGF-Endoret) Versus Durolane Hyaluronic Acid in the Treatment of Patients With Symptomatic Osteoarthritis: A Randomized Controlled Trial

(2013) Víctor Vaquerizo et al.   ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY

Platelet-rich plasma: why intra-articular? A systematic review of preclinical studies and clinical evidence on PRP for joint degeneration

(2013) G. Filardo et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Comparison Between Hyaluronic Acid and Platelet-Rich Plasma, Intra-articular Infiltration in the Treatment of Gonarthrosis

(2012) Fabio Cerza et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

A Randomized Clinical Trial Evaluating Plasma Rich in Growth Factors (PRGF-Endoret) Versus Hyaluronic Acid in the Short-Term Treatment of Symptomatic Knee Osteoarthritis

(2012) Mikel Sánchez et al.   ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY

New methods can extend the use of minimal important difference units in meta-analyses of continuous outcome measures

(2012) Bradley C. Johnston et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Platelet-rich plasma loaded hydrogel scaffold enhances chondrogenic differentiation and maturation with up-regulation of CB1 and CB2

(2012) Hye-Rim Lee et al.   JOURNAL OF CONTROLLED RELEASE

Growth Factor and Catabolic Cytokine Concentrations Are Influenced by the Cellular Composition of Platelet-Rich Plasma

(2011) Emily A. Sundman et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Platelet-Rich Plasma Intra-Articular Injection Versus Hyaluronic Acid Viscosupplementation as Treatments for Cartilage Pathology: From Early Degeneration to Osteoarthritis

(2011) Elizaveta Kon et al.   ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY

Human platelet-rich plasma stimulates migration and chondrogenic differentiation of human subchondral progenitor cells

(2011) Jan Philipp Krüger et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Platelet-rich plasma intra-articular injections for cartilage degeneration and osteoarthritis: single- versus double-spinning approach

(2011) Giuseppe Filardo et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Platelet-rich plasma: any substance into it?

(2010) O. Mei-Dan et al.   BRITISH JOURNAL OF SPORTS MEDICINE

Platelet-rich plasma (PRP) to treat sports injuries: evidence to support its use

(2010) Elizaveta Kon et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Platelet-Rich Plasma

(2009) Timothy E. Foster et al.   AMERICAN JOURNAL OF SPORTS MEDICINE