The Long-Lasting Effects of “Placebo Injections” in Knee Osteoarthritis: A Meta-Analysis

Intra-articular Injection of Platelet-Rich Plasma Is Superior to Hyaluronic Acid or Saline Solution in the Treatment of Mild to Moderate Knee Osteoarthritis: A Randomized, Double-Blind, Triple-Parallel, Placebo-Controlled Clinical Trial

(2019) Kuan-Yu Lin et al.   ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY

Intra-Articular Injection of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis: A Phase IIb, Randomized, Placebo-Controlled Clinical Trial

(2019) Woo-Suk Lee et al.   Stem Cells Translational Medicine

Determinants of daily pain trajectories and relationship with pain acceptability in hip and knee osteoarthritis. A national prospective cohort study on 886 patients

(2018) Anne-Priscille Trouvin et al.   JOINT BONE SPINE

Effects of a Single Intra-Articular Injection of a Microsphere Formulation of Triamcinolone Acetonide on Knee Osteoarthritis Pain

(2018) Philip G. Conaghan et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Efficacy and safety of single-dose onabotulinumtoxinA in the treatment of symptoms of osteoarthritis of the knee: results of a placebo-controlled, double-blind study

(2018) T.E. McAlindon et al.   OSTEOARTHRITIS AND CARTILAGE

A Multicenter, Double-Blind, Phase III Clinical Trial to Evaluate the Efficacy and Safety of a Cell and Gene Therapy in Knee Osteoarthritis Patients

(2018) Myung-Ku Kim et al.   Human Gene Therapy Clinical Development

Single intra-articular injection of lightly cross-linked hyaluronic acid reduces knee pain in symptomatic knee osteoarthritis: a multicenter, double-blind, randomized, placebo-controlled trial

(2018) Stephanie C. Petterson et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Safety and efficacy of allogenic placental mesenchymal stem cells for treating knee osteoarthritis: a pilot study

(2018) SHAYESTEH KHALIFEH SOLTANI et al.   CYTOTHERAPY

Effect of Intra-articular Triamcinolone vs Saline on Knee Cartilage Volume and Pain in Patients With Knee Osteoarthritis

(2017) Timothy E. McAlindon et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A double-blind, randomized, saline-controlled study of the efficacy and safety of co-administered intra-articular injections of Tr14 and Ze14 for treatment of painful osteoarthritis of the knee: The MOZArT trial

(2017) Carlos J. Lozada et al.   European Journal of Integrative Medicine

Brief Report: A Phase IIb Trial of a Novel Extended-Release Microsphere Formulation of Triamcinolone Acetonide for Intraarticular Injection in Knee Osteoarthritis

(2017) Philip G. Conaghan et al.   Arthritis & Rheumatology

Intraarticular Injection of a Cross-Linked Sodium Hyaluronate Combined with Triamcinolone Hexacetonide (Cingal) to Provide Symptomatic Relief of Osteoarthritis of the Knee: A Randomized, Double-Blind, Placebo-Controlled Multicenter Clinical Trial

(2017) Laszlo Hangody et al.   Cartilage

The efficacy of intra-articular lidocaine administration in chronic knee pain due to osteoarthritis: A randomized, double-blind, controlled study

(2017) H. Evren Eker et al.   Anaesthesia Critical Care & Pain Medicine

The Therapeutic Effect of Intra-articular Normal Saline Injections for Knee Osteoarthritis: A Meta-analysis of Evidence Level 1 Studies

(2016) Bryan M. Saltzman et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Intra-articular Autologous Conditioned Plasma Injections Provide Safe and Efficacious Treatment for Knee Osteoarthritis

(2016) Patrick A. Smith   AMERICAN JOURNAL OF SPORTS MEDICINE

Extracting data from figures with software was faster, with higher interrater reliability than manual extraction

(2016) Antonia Jelicic Kadic et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Non-surgical treatments for the management of early osteoarthritis

(2016) Giuseppe Filardo et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Preliminary Trial of Intra-articular LMWF-5A for Osteoarthritis of the Knee

(2016) John Schwappach et al.   ORTHOPEDICS

Short-term placebo response in trials of patients with symptomatic osteoarthritis: differences between hip and knee

(2016) S. Reiter-Niesert et al.   OSTEOARTHRITIS AND CARTILAGE

Clinical benefit of intra-articular saline as a comparator in clinical trials of knee osteoarthritis treatments: A systematic review and meta-analysis of randomized trials

(2016) Roy D. Altman et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Effectiveness and Implications of Alternative Placebo Treatments

(2015) Raveendhara R. Bannuru et al.   ANNALS OF INTERNAL MEDICINE

Comparative Effectiveness of Pharmacologic Interventions for Knee Osteoarthritis

(2015) Raveendhara R. Bannuru et al.   ANNALS OF INTERNAL MEDICINE

No Difference Between Intra-Articular Injection of Hyaluronic Acid and Placebo for Mild to Moderate Knee Osteoarthritis: A Randomized, Controlled, Double-Blind Trial

(2015) Walter van der Weegen et al.   JOURNAL OF ARTHROPLASTY

Survey of Cochrane protocols found methods for data extraction from figures not mentioned or unclear

(2015) Katarina Vucic et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis: a randomized, double-blind, placebo-controlled trial

(2015) Gökay Görmeli et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

The neuroscience of placebo effects: connecting context, learning and health

(2015) Tor D. Wager et al.   NATURE REVIEWS NEUROSCIENCE

Placebo Effects in Medicine

(2015) Ted J. Kaptchuk et al.   NEW ENGLAND JOURNAL OF MEDICINE

A placebo-controlled randomised trial to assess the effect of TGF-ß1-expressing chondrocytes in patients with arthritis of the knee

(2015) M C Lee et al.   Bone & Joint Journal

A Randomized Clinical Trial to Evaluate Two Doses of an Intra-Articular Injection of LMWF-5A in Adults with Pain Due to Osteoarthritis of the Knee

(2014) David Bar-Or et al.   PLoS One

Effects of intra-articular clodronate in the treatment of knee osteoarthritis: results of a double-blind, randomized placebo-controlled trial

(2014) Maurizio Rossini et al.   RHEUMATOLOGY INTERNATIONAL

An algorithm recommendation for the management of knee osteoarthritis in Europe and internationally: A report from a task force of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)

(2014) Olivier Bruyère et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Treatment With Platelet-Rich Plasma Is More Effective Than Placebo for Knee Osteoarthritis

(2013) Sandeep Patel et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement

(2013) David Moher   ANNALS OF INTERNAL MEDICINE

A randomized saline-controlled trial of NASHA hyaluronic acid for knee osteoarthritis

(2013) Nigel K. Arden et al.   CURRENT MEDICAL RESEARCH AND OPINION

The placebo response in medicine: minimize, maximize or personalize?

(2013) Paul Enck et al.   NATURE REVIEWS DRUG DISCOVERY

The placebo effect: powerful, powerless or redundant?

(2012) Steven J Kamper et al.   BRITISH JOURNAL OF SPORTS MEDICINE

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Theo Vos et al.   LANCET

A multicenter, randomized controlled trial comparing a single intra-articular injection of Gel-200, a new cross-linked formulation of hyaluronic acid, to phosphate buffered saline for treatment of osteoarthritis of the knee

(2012) V. Strand et al.   OSTEOARTHRITIS AND CARTILAGE

A 40-month multicentre, randomised placebo-controlled study to assess the efficacy and carry-over effect of repeated intra-articular injections of hyaluronic acid in knee osteoarthritis: the AMELIA project

(2011) F. Navarro-Sarabia et al.   ANNALS OF THE RHEUMATIC DISEASES

Intra-articular injections of sodium hyaluronate (Hyalgan®) in osteoarthritis of the knee. a randomized, controlled, double-blind, multicenter trial in the asian population

(2011) Teng-Le Huang et al.   BMC MUSCULOSKELETAL DISORDERS

Intra-articular hyaluronan is without clinical effect in knee osteoarthritis: a multicentre, randomised, placebo-controlled, double-blind study of 337 patients followed for 1 year

(2010) A. Jorgensen et al.   ANNALS OF THE RHEUMATIC DISEASES

Inflammatory Characteristics on Ultrasound Predict Poorer Longterm Response to Intraarticular Corticosteroid Injections in Knee Osteoarthritis

(2010) J. CHAO et al.   JOURNAL OF RHEUMATOLOGY

Single, intra-articular treatment with 6 ml hylan G-F 20 in patients with symptomatic primary osteoarthritis of the knee: a randomised, multicentre, double-blind, placebo controlled trial

(2009) X Chevalier et al.   ANNALS OF THE RHEUMATIC DISEASES

A Double-Blind, Randomized, Saline-Controlled Study of the Efficacy and Safety of EUFLEXXA® for Treatment of Painful Osteoarthritis of the Knee, With an Open-Label Safety Extension (The FLEXX Trial)

(2009) Roy D. Altman et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

The placebo effect and its determinants in osteoarthritis: meta-analysis of randomised controlled trials

(2008) W Zhang et al.   ANNALS OF THE RHEUMATIC DISEASES

Autologous conditioned serum (Orthokine) is an effective treatment for knee osteoarthritis

(2008) A.W.A. Baltzer et al.   OSTEOARTHRITIS AND CARTILAGE

Intra‐articular sodium hyaluronate 2 mL versus physiological saline 20 mL versus physiological saline 2 mL for painful knee osteoarthritis: a randomized clinical trial

(2008) C. Lundsgaard et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Autologous interleukin-1 receptor antagonist improves function and symptoms in osteoarthritis when compared to placebo in a prospective randomized controlled trial

(2007) K.G. Auw Yang et al.   OSTEOARTHRITIS AND CARTILAGE