Review
Biochemistry & Molecular Biology
Vivek Makwana, Santosh Rudrawar, Shailendra Anoopkumar-Dukie
Summary: Hexosamine biosynthetic (HBP) and PI3K/AKT/mTOR pathways play crucial roles in the proliferation and survival of prostate cancer cells by increasing androgen receptor expression and protein levels. Inhibition of a single pathway is insufficient to halt disease progression, suggesting that targeting multiple pathways at common junctions may be beneficial for effective management of prostate cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Mingming Yang, Chenliang Wang, Mi Zhou, Lei Bao, Yanan Wang, Ashwani Kumar, Chao Xing, Weibo Luo, Yingfei Wang
Summary: This study identifies the role of PARP-1 and KDM6B in alkylating agent-induced PARthanatic cancer cell death. KDM6B regulates the switch of PARP-1 signaling by inhibiting MGMT expression and DNA repair activity. These findings provide new insights into the epigenetic regulation of PARP-1 signaling and cell death mechanisms, and identify KDM6B as a biomarker for predicting cancer cell vulnerability to alkylating agent treatment.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Medicine, Research & Experimental
Weichen Wang, Qing Yin, Shanshan Guo, Jun Wang
Summary: In liver cancer, high NEIL3 expression is associated with tumor grade and survival time. NEIL3 is abundantly expressed in liver cancer cell lines, and its knockdown impairs cell functions, causes cell cycle arrest at G2 phase, and increases apoptotic rate. Additionally, NEIL3 regulates the PI3K/Akt/mTOR signaling pathway in liver cancer.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Antonino Glaviano, Aaron S. C. Foo, Hiu Y. Lam, Kenneth C. H. Yap, William Jacot, Robert H. Jones, Huiyan Eng, Madhumathy G. Nair, Pooyan Makvandi, Birgit Geoerger, Matthew H. Kulke, Richard D. Baird, Jyothi S. Prabhu, Daniela Carbone, Camilla Pecoraro, Daniel B. L. Teh, Gautam Sethi, Vincenzo Cavalieri, Kevin H. Lin, Nathalie R. Javidi-Sharifi, Eneda Toska, Matthew S. Davids, Jennifer R. Brown, Patrizia Diana, Justin Stebbing, David A. Fruman, Alan P. Kumar
Summary: The PI3K/AKT/mTOR (PAM) signaling pathway plays a crucial role in cell survival, growth, and cell cycle progression. Dysregulation of this pathway is associated with cancer development and resistance to therapy. This review focuses on the major dysregulations in the PAM signaling pathway in cancer and discusses strategies for overcoming treatment resistance. The role of PAM signaling in immunology and immunotherapies is also discussed.
Review
Pharmacology & Pharmacy
Nazanin Momeni Roudsari, Naser-Aldin Lashgari, Saeideh Momtaz, Shaghayegh Abaft, Fatemeh Jamali, Pardis Safaiepour, Kiyana Narimisa, Gloria Jackson, Anusha Bishayee, Nima Rezaei, Amir Hossein Abdolghaffari, Anupam Bishayee
Summary: The importance of the PI3K/Akt/mTOR pathway in prostate cancer treatment and the clinical applications of natural agents and small molecule inhibitors targeting this pathway are discussed in the study. Research suggests that natural mTOR inhibitors can interfere with the PI3K/Akt/mTOR pathway through multiple mechanisms, with inhibition of Akt and suppression of mTOR 1 activity being the main therapeutic approaches. Combination therapy has been shown to improve the efficacy of these inhibitors in suppressing prostate cancer progression or overcoming resistance by cancer cells.
Review
Cell Biology
Kunrui Zhu, Yanqi Wu, Ping He, Yu Fan, Xiaorong Zhong, Hong Zheng, Ting Luo
Summary: Phosphatidylinositol 3-kinase (PI3K), protein kinase B (PKB/AKT) and mechanistic target of rapamycin (mTOR) (PAM) pathways play important roles in breast tumorigenesis and offer potential targets for cancer therapy.
Review
Biochemistry & Molecular Biology
Torki A. Zughaibi, Mohd Suhail, Mohammad Tarique, Shams Tabrez
Summary: Cancer is a leading cause of death globally, and current therapies often fail due to side effects, drug resistance, and limited accessibility. Studies have shown that flavonoids, found in herbal/plant sources, may act as complementary treatments for cancer patients with their broad biological properties and anticancer activity by affecting different signaling cascades.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Lei Zhang, Xinyue Zhang, Delu Che, Lizhong Zeng, Yu Zhang, Kai Nan, Xinxin Zhang, Hui Zhang, Zengjun Guo
Summary: This study investigated the effect and mechanism of 6-MDS in breast cancer using network pharmacology, molecular docking, and molecular dynamics simulation. The results showed that 6-MDS inhibited breast cancer through the PI3K/AKT/mTOR signaling pathway, inducing apoptosis and autophagy in MCF-7 cells. Furthermore, 6-MDS triggered the generation of reactive oxygen species, which contributed to its inhibitory effects on breast cancer.
PHYTOTHERAPY RESEARCH
(2023)
Article
Cell Biology
Li Wang, Weizhou Jiang, Jing Wang, Yuanyuan Xie, Weisi Wang
Summary: Studies have found that puerarin can enhance the viability of cigarette smoke stimulated bronchial epithelial cells, reduce apoptosis, and restore mitochondrial function by regulating FUNDC1 mediated mitophagy, indicating its potential in COPD treatment.
Article
Food Science & Technology
Xu Li, Jin Zhao, Tingcai Yan, Jingjing Mu, Yang Lin, Jing Chen, Haotian Deng, Xianjun Meng
Summary: The combination of cisplatin with cyanidin-3-O-glucoside was found to inhibit proliferation and induce cell cycle arrest and apoptosis in cervical cancer cells. The combination treatment showed enhanced anticancer effects compared to individual treatments. These findings suggest a potential strategy to reduce adverse effects of chemotherapy in cervical cancer.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Medicine, Research & Experimental
Maryam Akbarzadeh, Ainaz Mihanfar, Shabnam Akbarzadeh, Bahman Yousefi, Maryam Majidinia
Summary: The PI3K/AKT/mTOR signaling pathway plays a crucial role in cancer and has been found to interact with miRNAs, which is important for understanding cancer biology.
Article
Cell Biology
I-Lun Hsin, Huang-Pin Shen, Hui-Yi Chang, Jiunn-Liang Ko, Po-Hui Wang
Summary: The study revealed a novel mechanism of the PI3K/mTOR dual inhibitor, PQR309, in lowering cell viability in endometrial cancer cells by disrupting the PI3K/Akt/mTOR/c-Myc/mtp53 positive feedback loop.
Article
Oncology
Haowei Wang, Yujia Chen, Qinzi Yuan, Lixia Chen, Peiling Dai, Xuenong Li
Summary: This study found that HRK is lowly expressed in colorectal cancer tissues. For the first time, it was shown that HRK promotes apoptosis and inhibits proliferation of colorectal cancer cells by inhibiting the PI3K/AKT/mTOR signaling pathway. HRK represents a potential target for the treatment of colorectal cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Medicinal
Ai-Yuan Xiu, Qian Ding, Zhen Li, Chun-Qing Zhang
Summary: Doxazosin inhibits autophagy by activating the PI3K/Akt/mTOR signaling pathway, attenuating liver fibrosis. It also blocks HSC proliferation and migration, inducing cell apoptosis in a concentration-dependent manner. Additionally, doxazosin activates the PI3K/Akt/mTOR pathway which regulates fibrosis, autophagy, and apoptosis in HSCs.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Yong-Peng Wang, Yu-Dan Wang, Ya-Ping Liu, Jian-Xin Cao, Mei-Lian Yang, Yi-Fen Wang, Afsar Khan, Tian-Rui Zhao, Gui-Guang Cheng
Summary: The study found that 6'-O-caffeoylarbutin (CA) in Que Zui tea has a hepatoprotective effect against acetaminophen-induced liver damage through regulating the PI3K/Akt and Nrf2 signaling pathways. This research contributes to a better understanding of the pharmacological effects of Que Zui tea.