Older Than Genes: The Acetyl CoA Pathway and Origins

Bioenergetic constraints on the origin of autotrophic metabolism

(2020) Eric S. Boyd et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

A hydrogen-dependent geochemical analogue of primordial carbon and energy metabolism

(2020) Martina Preiner et al.   Nature Ecology & Evolution

Methanogenesis involves direct hydride transfer from H2 to an organic substrate

(2020) Gangfeng Huang et al.   Nature Reviews Chemistry

Energy conservation by a hydrogenase-dependent chemiosmotic mechanism in an ancient metabolic pathway

(2019) Marie Charlotte Schoelmerich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis and breakdown of universal metabolic precursors promoted by iron

(2019) Kamila B. Muchowska et al.   NATURE

Carbon–Metal Bonds: Rare and Primordial in Metabolism

(2019) William F. Martin   TRENDS IN BIOCHEMICAL SCIENCES

Class I and II Aminoacyl‐tRNA Synthetase tRNA Groove Discrimination Created the First Synthetase–tRNA Cognate Pairs and Was Therefore Essential to the Origin of Genetic Coding

(2019) Charles W. Carter et al.   IUBMB LIFE

Peptide ligation by chemoselective aminonitrile coupling in water

(2019) Pierre Canavelli et al.   NATURE

Environmental boundary conditions for the origin of life converge to an organo-sulfur metabolism

(2019) Joshua E. Goldford et al.   Nature Ecology & Evolution

Native metals, electron bifurcation, and CO 2 reduction in early biochemical evolution

(2018) Filipa L Sousa et al.   CURRENT OPINION IN MICROBIOLOGY

Acetyl Phosphate as a Primordial Energy Currency at the Origin of Life

(2018) Alexandra Whicher et al.   ORIGINS OF LIFE AND EVOLUTION OF BIOSPHERES

Reversibility of citrate synthase allows autotrophic growth of a thermophilic bacterium

(2018) Achim Mall et al.   SCIENCE

A primordial and reversible TCA cycle in a facultatively chemolithoautotrophic thermophile

(2018) Takuro Nunoura et al.   SCIENCE

Deeply-sourced formate fuels sulfate reducers but not methanogens at Lost City hydrothermal field

(2018) Susan Q. Lang et al.   Scientific Reports

Flavin-Based Electron Bifurcation, Ferredoxin, Flavodoxin, and Anaerobic Respiration With Protons (Ech) or NAD+ (Rnf) as Electron Acceptors: A Historical Review

(2018) Wolfgang Buckel et al.   Frontiers in Microbiology

Native iron reduces CO2 to intermediates and end-products of the acetyl-CoA pathway

(2018) Sreejith J. Varma et al.   Nature Ecology & Evolution

A new era for electron bifurcation

(2018) John W Peters et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Something special about CO-dependent CO2 fixation

(2018) Joana C. Xavier et al.   FEBS Journal

The biomass and biodiversity of the continental subsurface

(2018) C. Magnabosco et al.   Nature Geoscience

The last universal common ancestor between ancient Earth chemistry and the onset of genetics

(2018) Madeline C. Weiss et al.   PLoS Genetics

The rocky road to biomolecules

(2018) John A. Baross   NATURE

Abiotic synthesis of amino acids in the recesses of the oceanic lithosphere

(2018) Bénédicte Ménez et al.   NATURE

Non-canonical nucleosides and chemistry of the emergence of life

(2018) Sidney Becker et al.   Nature Communications

Genomic and in-situ Transcriptomic Characterization of the Candidate Phylum NPL-UPL2 From Highly Alkaline Highly Reducing Serpentinized Groundwater

(2018) Shino Suzuki et al.   Frontiers in Microbiology

Early trace of life from 3.95 Ga sedimentary rocks in Labrador, Canada

(2017) Takayuki Tashiro et al.   NATURE

Mechanisms of gene flow in archaea

(2017) Alexander Wagner et al.   NATURE REVIEWS MICROBIOLOGY

Physiology, phylogeny, early evolution, and GAPDH

(2017) William F. Martin et al.   PROTOPLASMA

Metals promote sequences of the reverse Krebs cycle

(2017) Kamila B. Muchowska et al.   Nature Ecology & Evolution

Evolution of Oxygenic Photosynthesis

(2016) Woodward W. Fischer et al.   Annual Review of Earth and Planetary Sciences

Electron Bifurcation: A Long-Hidden Energy-Coupling Mechanism

(2016) Volker Müller et al.   Annual Review of Microbiology

“Hot” acetogenesis

(2016) Mirko Basen et al.   EXTREMOPHILES

Autocatalytic, bistable, oscillatory networks of biologically relevant organic reactions

(2016) Sergey N. Semenov et al.   NATURE

Structure of NDP-forming Acetyl-CoA synthetase ACD1 reveals a large rearrangement for phosphoryl transfer

(2016) Renato H.-J. Weiße et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methane production from coal by a single methanogen

(2016) D. Mayumi et al.   SCIENCE

The methanogenic CO2 reducing-and-fixing enzyme is bifunctional and contains 46 [4Fe-4S] clusters

(2016) T. Wagner et al.   SCIENCE

The radical mechanism of biological methane synthesis by methyl-coenzyme M reductase

(2016) T. Wongnate et al.   SCIENCE

On the Origin of Heterotrophy

(2016) Peter Schönheit et al.   TRENDS IN MICROBIOLOGY

The physiology and habitat of the last universal common ancestor

(2016) Madeline C. Weiss et al.   Nature Microbiology

My Lifelong Passion for Biochemistry and Anaerobic Microorganisms

(2015) Rudolf Kurt Thauer   Annual Review of Microbiology

The widespread role of non-enzymatic reactions in cellular metabolism

(2015) Markus A Keller et al.   CURRENT OPINION IN BIOTECHNOLOGY

Early Microbial Evolution: The Age of Anaerobes

(2015) William F. Martin et al.   Cold Spring Harbor Perspectives in Biology

A genome-guided analysis of energy conservation in the thermophilic, cytochrome-free acetogenic bacterium Thermoanaerobacter kivui

(2015) Verena Hess et al.   BMC GENOMICS

ATP synthases from archaea: The beauty of a molecular motor

(2014) Gerhard Grüber et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Biochemical fossils of the ancient transition from geoenergetics to bioenergetics in prokaryotic one carbon compound metabolism

(2014) Filipa L. Sousa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Abiotic Gas: Atypical, But Not Rare

(2014) G. Etiope et al.   Elements

Non-enzymatic glycolysis and pentose phosphate pathway-like reactions in a plausible Archean ocean

(2014) M. A. Keller et al.   Molecular Systems Biology

Origins of major archaeal clades correspond to gene acquisitions from bacteria

(2014) Shijulal Nelson-Sathi et al.   NATURE

Autotrophy at the thermodynamic limit of life: a model for energy conservation in acetogenic bacteria

(2014) Kai Schuchmann et al.   NATURE REVIEWS MICROBIOLOGY

A Bioenergetic Basis for Membrane Divergence in Archaea and Bacteria

(2014) Víctor Sojo et al.   PLOS BIOLOGY

Microbial life under extreme energy limitation

(2013) Tori M. Hoehler et al.   NATURE REVIEWS MICROBIOLOGY

Beating the acetyl coenzyme A-pathway to the origin of life

(2013) W. Nitschke et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Early bioenergetic evolution

(2013) F. L. Sousa et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Direct and Reversible Hydrogenation of CO2 to Formate by a Bacterial Carbon Dioxide Reductase

(2013) K. Schuchmann et al.   SCIENCE

Processes on the Young Earth and the Habitats of Early Life

(2012) Nicholas T. Arndt et al.   Annual Review of Earth and Planetary Sciences

Energy conservation via electron bifurcating ferredoxin reduction and proton/Na+ translocating ferredoxin oxidation

(2012) Wolfgang Buckel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The Origin of Membrane Bioenergetics

(2012) Nick Lane et al.   CELL

Acquisition of 1,000 eubacterial genes physiologically transformed a methanogen at the origin of Haloarchaea

(2012) S. Nelson-Sathi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methanogens: a window into ancient sulfur metabolism

(2012) Yuchen Liu et al.   TRENDS IN MICROBIOLOGY

Benchmark Reaction Rates, the Stability of Biological Molecules in Water, and the Evolution of Catalytic Power in Enzymes

(2011) Richard Wolfenden   Annual Review of Biochemistry

Ecological Aspects of the Distribution of Different Autotrophic CO2Fixation Pathways

(2011) Ivan A. Berg   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The origin of a derived superkingdom: how a gram-positive bacterium crossed the desert to become an archaeon

(2011) Ruben E Valas et al.   Biology Direct

Hydrogenases and the Global H2 Cycle

(2011) Rudolf Kurt Thauer   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Hydrogen, metals, bifurcating electrons, and proton gradients: The early evolution of biological energy conservation

(2011) William F. Martin   FEBS LETTERS

Serpentinite and the dawn of life

(2011) N. H. Sleep et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Beyond the Calvin Cycle: Autotrophic Carbon Fixation in the Ocean

(2010) Michael Hügler et al.   Annual Review of Marine Science

Alternative Pathways of Carbon Dioxide Fixation: Insights into the Early Evolution of Life?

(2010) Georg Fuchs   Annual Review of Microbiology

How did LUCA make a living? Chemiosmosis in the origin of life

(2010) Nick Lane et al.   BIOESSAYS

Serpentinization as a source of energy at the origin of life

(2010) M. J. RUSSELL et al.   Geobiology

The Last Universal Common Ancestor (LUCA) and the Ancestors of Archaea and Bacteria were Progenotes

(2010) Massimo Di Giulio   JOURNAL OF MOLECULAR EVOLUTION

Fructose 1,6-bisphosphate aldolase/phosphatase may be an ancestral gluconeogenic enzyme

(2010) Rafael F. Say et al.   NATURE

Autotrophic carbon fixation in archaea

(2010) Ivan A. Berg et al.   NATURE REVIEWS MICROBIOLOGY

Bioenergetics and Life's Origins

(2010) D. Deamer et al.   Cold Spring Harbor Perspectives in Biology

A Life with Acetogens, Thermophiles, and Cellulolytic Anaerobes

(2009) Lars G. Ljungdahl   Annual Review of Microbiology

Nickel-based Enzyme Systems

(2009) Stephen W. Ragsdale   JOURNAL OF BIOLOGICAL CHEMISTRY

Biological calorimetry and the thermodynamics of the origination and evolution of life

(2009) Lee D. Hansen et al.   PURE AND APPLIED CHEMISTRY

Old Acetogens, New Light

(2008) Harold L. Drake et al.   Annals of the New York Academy of Sciences

Enzymology of the Wood-Ljungdahl Pathway of Acetogenesis

(2008) Stephen W. Ragsdale   Annals of the New York Academy of Sciences

Xenon in and at the End of the Tunnel of Bifunctional Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase†,‡

(2008) Tzanko I. Doukov et al.   BIOCHEMISTRY

Acetogenesis and the Wood–Ljungdahl pathway of CO2 fixation

(2008) Stephen W. Ragsdale et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Methanogenic archaea: ecologically relevant differences in energy conservation

(2008) Rudolf K. Thauer et al.   NATURE REVIEWS MICROBIOLOGY

Abiogenic Hydrocarbon Production at Lost City Hydrothermal Field

(2008) G. Proskurowski et al.   SCIENCE

The Implausibility of Metabolic Cycles on the Prebiotic Earth

(2008) Leslie E Orgel   PLOS BIOLOGY