Flavin-Based Electron Bifurcation, Ferredoxin, Flavodoxin, and Anaerobic Respiration With Protons (Ech) or NAD+ (Rnf) as Electron Acceptors: A Historical Review

H/D exchange mass spectrometry and statistical coupling analysis reveal a role for allostery in a ferredoxin-dependent bifurcating transhydrogenase catalytic cycle

(2018) Luke Berry et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Native metals, electron bifurcation, and CO 2 reduction in early biochemical evolution

(2018) Filipa L Sousa et al.   CURRENT OPINION IN MICROBIOLOGY

Molecular basis of the flavin-based electron-bifurcating caffeyl-CoA reductase reaction

(2018) Julius K. Demmer et al.   FEBS LETTERS

Reversibility of citrate synthase allows autotrophic growth of a thermophilic bacterium

(2018) Achim Mall et al.   SCIENCE

A primordial and reversible TCA cycle in a facultatively chemolithoautotrophic thermophile

(2018) Takuro Nunoura et al.   SCIENCE

Defining Electron Bifurcation in the Electron-Transferring Flavoprotein Family

(2017) Amaya M. Garcia Costas et al.   JOURNAL OF BACTERIOLOGY

Equilibrium and ultrafast kinetic studies manipulating electron transfer: A short-lived flavin semiquinone is not sufficient for electron bifurcation

(2017) John P. Hoben et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two functionally distinct NADP + -dependent ferredoxin oxidoreductases maintain the primary redox balance of Pyrococcus furiosus

(2017) Diep M. N. Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanistic insights into energy conservation by flavin-based electron bifurcation

(2017) Carolyn E Lubner et al.   Nature Chemical Biology

Redox potentials of ubiquinone, menaquinone, phylloquinone, and plastoquinone in aqueous solution

(2017) Shinnosuke Kishi et al.   PHOTOSYNTHESIS RESEARCH

Methanogenic heterodisulfide reductase (HdrABC-MvhAGD) uses two noncubane [4Fe-4S] clusters for reduction

(2017) Tristan Wagner et al.   SCIENCE

A Ferredoxin- and F 420 H 2 -Dependent, Electron-Bifurcating, Heterodisulfide Reductase with Homologs in the Domains Bacteria and Archaea

(2017) Zhen Yan et al.   mBio

The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficile

(2017) Julius K. Demmer et al.   Nature Communications

Ferredoxin:NAD+Oxidoreductase of Thermoanaerobacterium saccharolyticum and Its Role in Ethanol Formation

(2016) Liang Tian et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

From low- to high-potential bioenergetic chains: Thermodynamic constraints of Q-cycle function

(2016) Lucie Bergdoll et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Electron bifurcation

(2016) John W Peters et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The Catalytic Bias of 2-Oxoacid:ferredoxin Oxidoreductase in CO 2 : evolution and reduction through a ferredoxin-mediated electrocatalytic assay

(2016) Bin Li et al.   ELECTROCHIMICA ACTA

Ligand binding and conformational dynamics in a flavin-based electron-bifurcating enzyme complex revealed by Hydrogen-Deuterium Exchange Mass Spectrometry

(2016) Julius K. Demmer et al.   FEBS LETTERS

Genomic composition and dynamics among Methanomicrobiales predict adaptation to contrasting environments

(2016) Patrick Browne et al.   ISME Journal

Classic Spotlight: Electron Bifurcation, a Unifying Concept for Energy Conservation in Anaerobes

(2016) William W. Metcalf   JOURNAL OF BACTERIOLOGY

Reduction of Flavodoxin by Electron Bifurcation and Sodium Ion-dependent Reoxidation by NAD+Catalyzed by Ferredoxin-NAD+Reductase (Rnf)

(2016) Nilanjan Pal Chowdhury et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Praise of Error

(2016) Günter Wächtershäuser   JOURNAL OF MOLECULAR EVOLUTION

Fermentative Cyclohexane Carboxylate Formation in Syntrophus aciditrophicus

(2016) Matthias Boll et al.   JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY

Genome-Guided Analysis and Whole Transcriptome Profiling of the Mesophilic Syntrophic Acetate Oxidising Bacterium Syntrophaceticus schinkii

(2016) Shahid Manzoor et al.   PLoS One

Comparative Proteomic Analysis of Desulfotomaculum reducens MI-1: Insights into the Metabolic Versatility of a Gram-Positive Sulfate- and Metal-Reducing Bacterium

(2016) Anne E. Otwell et al.   Frontiers in Microbiology

HydDB: A web tool for hydrogenase classification and analysis

(2016) Dan Søndergaard et al.   Scientific Reports

My Lifelong Passion for Biochemistry and Anaerobic Microorganisms

(2015) Rudolf Kurt Thauer   Annual Review of Microbiology

Energy Conservation Model Based on Genomic and Experimental Analyses of a Carbon Monoxide-Utilizing, Butyrate-Forming Acetogen, Eubacterium limosum KIST612

(2015) Jiyeong Jeong et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A theoretical multiscale treatment of protein–protein electron transfer: The ferredoxin/ferredoxin-NADP+ reductase and flavodoxin/ferredoxin-NADP+ reductase systems

(2015) Suwipa Saen-oon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

[FeFe]- and [NiFe]-hydrogenase diversity, mechanism, and maturation

(2015) John W. Peters et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Elimination of hydrogenase active site assembly blocks H2 production and increases ethanol yield in Clostridium thermocellum

(2015) Ranjita Biswas et al.   Biotechnology for Biofuels

The FlxABCD-HdrABC proteins correspond to a novel NADH dehydrogenase/heterodisulfide reductase widespread in anaerobic bacteria and involved in ethanol metabolism inDesulfovibrio vulgaris Hildenborough

(2015) Ana Raquel Ramos et al.   ENVIRONMENTAL MICROBIOLOGY

Stoichiometry and deletion analyses of subunits in the heterotrimeric F-ATP synthasecring from the acetogenic bacteriumAcetobacterium woodii

(2015) Karsten Brandt et al.   FEBS Journal

Reduction of ferredoxin or oxygen by flavin-based electron bifurcation inMegasphaera elsdenii

(2015) Nilanjan P. Chowdhury et al.   FEBS Journal

Energy Conservation Associated with Ethanol Formation from H2and CO2in Clostridium autoethanogenum Involving Electron Bifurcation

(2015) Johanna Mock et al.   JOURNAL OF BACTERIOLOGY

Heterotrimeric NADH-Oxidizing Methylenetetrahydrofolate Reductase from the Acetogenic Bacterium Acetobacterium woodii

(2015) Johannes Bertsch et al.   JOURNAL OF BACTERIOLOGY

Insights into Flavin-based Electron Bifurcation via the NADH-dependent Reduced Ferredoxin:NADP Oxidoreductase Structure

(2015) Julius K. Demmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic analysis reveals metabolic and regulatory systems involved in the syntrophic and axenic lifestyle of Syntrophomonas wolfei

(2015) Jessica R. Sieber et al.   Frontiers in Microbiology

Electron transport phosphorylation in rumen butyrivibrios: unprecedented ATP yield for glucose fermentation to butyrate

(2015) Timothy J. Hackmann et al.   Frontiers in Microbiology

NADPH-generating systems in bacteria and archaea

(2015) Sebastiaan K. Spaans et al.   Frontiers in Microbiology

New Mode of Energy Metabolism in the Seventh Order of Methanogens as Revealed by Comparative Genome Analysis of “Candidatus Methanoplasma termitum”

(2014) Kristina Lang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The Fuel Cell Model of Abiogenesis: A New Approach to Origin-of-Life Simulations

(2014) Laura M. Barge et al.   ASTROBIOLOGY

Metabolic versatility in methanogens

(2014) Kyle C Costa et al.   CURRENT OPINION IN BIOTECHNOLOGY

The energy-conserving electron transfer system used by D esulfovibrio alaskensis strain G20 during pyruvate fermentation involves reduction of endogenously formed fumarate and cytoplasmic and membrane-bound complexes, Hdr-Flox and Rnf

(2014) Birte Meyer et al.   ENVIRONMENTAL MICROBIOLOGY

The genome ofSyntrophorhabdus aromaticivoransstrain UI provides new insights for syntrophic aromatic compound metabolism and electron flow

(2014) Masaru K. Nobu et al.   ENVIRONMENTAL MICROBIOLOGY

A novel mode of lactate metabolism in strictly anaerobic bacteria

(2014) Marie Charlotte Weghoff et al.   ENVIRONMENTAL MICROBIOLOGY

Hydrogen Formation and Its Regulation in Ruminococcus albus: Involvement of an Electron-Bifurcating [FeFe]-Hydrogenase, of a Non-Electron-Bifurcating [FeFe]-Hydrogenase, and of a Putative Hydrogen-Sensing [FeFe]-Hydrogenase

(2014) Y. Zheng et al.   JOURNAL OF BACTERIOLOGY

Evidence for a Hexaheteromeric Methylenetetrahydrofolate Reductase in Moorella thermoacetica

(2014) J. Mock et al.   JOURNAL OF BACTERIOLOGY

The genetic basis of energy conservation in the sulfate-reducing bacterium Desulfovibrio alaskensis G20

(2014) Morgan N. Price et al.   Frontiers in Microbiology

Lactate oxidation in human skeletal muscle mitochondria

(2013) Robert A. Jacobs et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Clostridium acidurici Electron-Bifurcating Formate Dehydrogenase

(2013) Shuning Wang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Bioenergetics and anaerobic respiratory chains of aceticlastic methanogens

(2013) Cornelia Welte et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Anaerobic degradation of homocyclic aromatic compounds via arylcarboxyl-coenzyme A esters: organisms, strategies and key enzymes

(2013) Matthias Boll et al.   ENVIRONMENTAL MICROBIOLOGY

Methanotrophic archaea possessing diverging methane-oxidizing and electron-transporting pathways

(2013) Feng-Ping Wang et al.   ISME Journal

Effect of an Oxygen-Tolerant Bifurcating Butyryl Coenzyme A Dehydrogenase/Electron-Transferring Flavoprotein Complex from Clostridium difficile on Butyrate Production in Escherichia coli

(2013) E.-H. Aboulnaga et al.   JOURNAL OF BACTERIOLOGY

A Reversible Electron-Bifurcating Ferredoxin- and NAD-Dependent [FeFe]-Hydrogenase (HydABC) in Moorella thermoacetica

(2013) S. Wang et al.   JOURNAL OF BACTERIOLOGY

NADP-Specific Electron-Bifurcating [FeFe]-Hydrogenase in a Functional Complex with Formate Dehydrogenase in Clostridium autoethanogenum Grown on CO

(2013) S. Wang et al.   JOURNAL OF BACTERIOLOGY

Interaction between NADH and electron-transferring flavoprotein from Megasphaera elsdenii

(2013) K. Sato et al.   JOURNAL OF BIOCHEMISTRY

Identification of Global Ferredoxin Interaction Networks inChlamydomonas reinhardtii

(2013) Erin A. Peden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Studies on the Mechanism of Electron Bifurcation Catalyzed by Electron Transferring Flavoprotein (Etf) and Butyryl-CoA Dehydrogenase (Bcd) ofAcidaminococcus fermentans

(2013) Nilanjan Pal Chowdhury et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ferredoxin:NAD+Oxidoreductase (Rnf) from the AcetogenAcetobacterium woodiiRequires Na+and Is Reversibly Coupled to the Membrane Potential

(2013) Verena Hess et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Electron-bifurcating Caffeyl-CoA Reductase

(2013) Johannes Bertsch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of the Complete Genomes of Acholeplasma brassicae, A. palmae and A. laidlawii and Their Comparison to the Obligate Parasites from ‘Candidatus Phytoplasma'

(2013) Michael Kube et al.   JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY

Early bioenergetic evolution

(2013) F. L. Sousa et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

H2-Independent Growth of the Hydrogenotrophic Methanogen Methanococcus maripaludis

(2013) K. C. Costa et al.   mBio

The Genome of Nitrospina gracilis Illuminates the Metabolism and Evolution of the Major Marine Nitrite Oxidizer

(2013) Sebastian Lücker et al.   Frontiers in Microbiology

Engineering Escherichia coli with acrylate pathway genes for propionic acid synthesis and its impact on mixed-acid fermentation

(2012) Vijayalakshmi Kandasamy et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

On the universal core of bioenergetics

(2012) Barbara Schoepp-Cothenet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Energy conservation via electron bifurcating ferredoxin reduction and proton/Na+ translocating ferredoxin oxidation

(2012) Wolfgang Buckel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Unifying concepts in anaerobic respiration: Insights from dissimilatory sulfur metabolism

(2012) Fabian Grein et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

HdrC2 from Acidithiobacillus ferrooxidans Owns Two Iron–Sulfur Binding Motifs But Binds Only One Variable Cluster Between [4Fe–4S] and [3Fe–4S]

(2012) Yuandong Liu et al.   CURRENT MICROBIOLOGY

Regulation of NAD(H) pool and NADH/NAD+ ratio by overexpression of nicotinic acid phosphoribosyltransferase for succinic acid production in Escherichia coli NZN111

(2012) Liya Liang et al.   ENZYME AND MICROBIAL TECHNOLOGY

Electron transport during aceticlastic methanogenesis byMethanosarcina acetivoransinvolves a sodium-translocating Rnf complex

(2012) Katharina Schlegel et al.   FEBS Journal

Stability of a biogas-producing bacterial, archaeal and fungal community degrading food residues

(2012) Frank R. Bengelsdorf et al.   FEMS MICROBIOLOGY ECOLOGY

Variation among Desulfovibrio Species in Electron Transfer Systems Used for Syntrophic Growth

(2012) B. Meyer et al.   JOURNAL OF BACTERIOLOGY

Electron Bifurcation Involved in the Energy Metabolism of the Acetogenic Bacterium Moorella thermoacetica Growing on Glucose or H2 plus CO2

(2012) H. Huang et al.   JOURNAL OF BACTERIOLOGY

A Bacterial Electron-bifurcating Hydrogenase

(2012) Kai Schuchmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Ancient Pathway Combining Carbon Dioxide Fixation with the Generation and Utilization of a Sodium Ion Gradient for ATP Synthesis

(2012) Anja Poehlein et al.   PLoS One

The Wolfe cycle comes full circle

(2012) R. K. Thauer   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rnf Complex of Clostridium ljungdahlii Is a Proton-Translocating Ferredoxin:NAD+ Oxidoreductase Essential for Autotrophic Growth

(2012) P.-L. Tremblay et al.   mBio

Enzyme catalyzed radical dehydrations of hydroxy acids

(2011) Wolfgang Buckel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Redox bifurcations: Mechanisms and importance to life now, and at its origin

(2011) Wolfgang Nitschke et al.   BIOESSAYS

Hydrogen, metals, bifurcating electrons, and proton gradients: The early evolution of biological energy conservation

(2011) William F. Martin   FEBS LETTERS

Complete Genome of the Cellulolytic Ruminal Bacterium Ruminococcus albus 7

(2011) G. Suen et al.   JOURNAL OF BACTERIOLOGY

Coupling of ferredoxin and heterodisulfide reduction via electron bifurcation in hydrogenotrophic methanogenic archaea

(2011) A.-K. Kaster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sulfur Metabolism in the Extreme Acidophile Acidithiobacillus Caldus

(2011) Stefanie Mangold et al.   Frontiers in Microbiology

A Comparative Genomic Analysis of Energy Metabolism in Sulfate Reducing Bacteria and Archaea

(2011) Inês A. Cardoso Pereira et al.   Frontiers in Microbiology

Hydrogenases from Methanogenic Archaea, Nickel, a Novel Cofactor, and H2Storage

(2010) Rudolf K. Thauer et al.   Annual Review of Biochemistry

Alternative Pathways of Carbon Dioxide Fixation: Insights into the Early Evolution of Life?

(2010) Georg Fuchs   Annual Review of Microbiology

The electron transfer flavoprotein: Ubiquinone oxidoreductases

(2010) Nicholas J. Watmough et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Clostridium sticklandii, a specialist in amino acid degradation:revisiting its metabolism through its genome sequence

(2010) Nuria Fonknechten et al.   BMC GENOMICS

The genome of Syntrophomonas wolfei: new insights into syntrophic metabolism and biohydrogen production

(2010) Jessica R. Sieber et al.   ENVIRONMENTAL MICROBIOLOGY

Two respiratory enzyme systems in Campylobacter jejuni NCTC 11168 contribute to growth on l -lactate

(2010) Marie T. Thomas et al.   ENVIRONMENTAL MICROBIOLOGY

NADP+ Reduction with Reduced Ferredoxin and NADP+ Reduction with NADH Are Coupled via an Electron-Bifurcating Enzyme Complex in Clostridium kluyveri

(2010) S. Wang et al.   JOURNAL OF BACTERIOLOGY

The surprising diversity of clostridial hydrogenases: a comparative genomic perspective

(2010) M. Calusinska et al.   MICROBIOLOGY-SGM

Protein complexing in a methanogen suggests electron bifurcation and electron delivery from formate to heterodisulfide reductase

(2010) K. C. Costa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clostridium ljungdahlii represents a microbial production platform based on syngas

(2010) M. Kopke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial Na+-translocating ferredoxin:NAD+ oxidoreductase

(2010) E. Biegel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complete genome sequence of Acidaminococcus fermentans type strain (VR4T)

(2010) Yun-Juan Chang et al.   Standards in Genomic Sciences

Induced Fit and Equilibrium Dynamics for High Catalytic Efficiency in Ferredoxin-NADP(H) Reductases

(2009) Darío H. Paladini et al.   BIOCHEMISTRY

Genome sequence ofDesulfobacterium autotrophicumHRM2, a marine sulfate reducer oxidizing organic carbon completely to carbon dioxide

(2009) Axel W. Strittmatter et al.   ENVIRONMENTAL MICROBIOLOGY

Involvement of NADH:Acceptor Oxidoreductase and Butyryl Coenzyme A Dehydrogenase in Reversed Electron Transport during Syntrophic Butyrate Oxidation by Syntrophomonas wolfei

(2009) N. Muller et al.   JOURNAL OF BACTERIOLOGY

The Iron-Hydrogenase of Thermotoga maritima Utilizes Ferredoxin and NADH Synergistically: a New Perspective on Anaerobic Hydrogen Production

(2009) G. J. Schut et al.   JOURNAL OF BACTERIOLOGY

Can Reaction Mechanisms Be Proven?

(2009) Allen Buskirk et al.   JOURNAL OF CHEMICAL EDUCATION

Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli

(2009) Bryson D Bennett et al.   Nature Chemical Biology

Discovery of a Ferredoxin:NAD+-Oxidoreductase (Rnf) in Acetobacterium woodii

(2008) Volker Müller et al.   Annals of the New York Academy of Sciences

Covalent Binding of Flavins to RnfG and RnfD in the Rnf Complex fromVibrio cholerae†

(2008) Julianne Backiel et al.   BIOCHEMISTRY

The CCG-domain-containing subunit SdhE of succinate:quinone oxidoreductase from Sulfolobus solfataricus P2 binds a [4Fe–4S] cluster

(2008) Nils Hamann et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Escherichia coli arcA Mutants: Metabolic Profile Characterization of Microaerobic Cultures using Glycerol as a Carbon Source

(2008) Pablo I. Nikel et al.   JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY

Methanogenic archaea: ecologically relevant differences in energy conservation

(2008) Rudolf K. Thauer et al.   NATURE REVIEWS MICROBIOLOGY

The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features

(2008) H. Seedorf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA