Mouse brain transcriptome responses to inhaled nanoparticulate matter differed by sex and APOE in Nrf2-Nfkb interactions

Long-term exposure to ambient air pollution, APOE-ε4 status, and cognitive decline in a cohort of older adults in northern Manhattan

(2020) Erin R. Kulick et al.   ENVIRONMENT INTERNATIONAL

Toxicity of urban air pollution particulate matter in developing and adult mouse brain: Comparison of total and filter-eluted nanoparticles

(2020) Amin Haghani et al.   ENVIRONMENT INTERNATIONAL

Alzheimer disease starts in childhood in polluted Metropolitan Mexico City. A major health crisis in progress

(2020) Lilian Calderón-Garcidueñas et al.   ENVIRONMENTAL RESEARCH

Air pollution alters Caenorhabditis elegans development and lifespan: responses to traffic-related nanoparticulate matter (nPM)

(2019) Amin Haghani et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Cyclic O3 exposure synergizes with aging leading to memory impairment in male APOEε3, but not APOEε4, targeted replacement mice

(2019) Chunsun Jiang et al.   NEUROBIOLOGY OF AGING

The Alzheimer's Disease Exposome

(2019) Caleb E. Finch et al.   Alzheimers & Dementia

Improving and Expanding Estimates of the Global Burden of Disease Due to Environmental Health Risk Factors

(2019) Rachel M. Shaffer et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Traffic-related air pollutants (TRAP-PM) promote neuronal amyloidogenesis through oxidative damage to lipid rafts

(2019) Mafalda Cacciottolo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cell-based assays that predict in vivo neurotoxicity of urban ambient nano-sized particulate matter

(2019) Hongqiao Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Genetic polymorphisms of GRIN2A and GRIN2B modify the neurobehavioral effects of low-level lead exposure in children

(2018) James P.K. Rooney et al.   ENVIRONMENTAL RESEARCH

The Lancet Commission on pollution and health

(2018) Philip J Landrigan et al.   LANCET

Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH

(2018) Hari Prasad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain Cell Type Specific Gene Expression and Co-expression Network Architectures

(2018) Andrew T. McKenzie et al.   Scientific Reports

Neuroinflammation, Hyperphosphorylated Tau, Diffuse Amyloid Plaques, and Down-Regulation of the Cellular Prion Protein in Air Pollution Exposed Children and Young Adults

(2018) Lilian Calderón-Garcidueñas et al.   JOURNAL OF ALZHEIMERS DISEASE

Activation of Nrf2 in the liver is associated with stress resistance mediated by suppression of the growth hormone-regulated STAT5b transcription factor

(2018) John Rooney et al.   PLoS One

The impact of exposure to air pollution on cognitive performance

(2018) Xin Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: Molecular mechanisms and possible therapeutic approaches

(2018) Farzane Sivandzade et al.   Redox Biology

Temporal changes in glutathione biosynthesis during the lipopolysaccharide-induced inflammatory response of THP-1 macrophages

(2017) Hongqiao Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Delayed Nrf2-regulated antioxidant gene induction in response to silica nanoparticles

(2017) Hongqiao Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Generation of a microglial developmental index in mice and in humans reveals a sex difference in maturation and immune reactivity

(2017) Richa Hanamsagar et al.   GLIA

Apolipoprotein E4, Gender, Body Mass Index, Inflammation, Insulin Resistance, and Air Pollution Interactions: Recipe for Alzheimer’s Disease Development in Mexico City Young Females

(2017) Lilian Calderón-Garcidueñas et al.   JOURNAL OF ALZHEIMERS DISEASE

Toll-like receptor 4 in glial inflammatory responses to air pollution in vitro and in vivo

(2017) Nicholas C. Woodward et al.   Journal of Neuroinflammation

17β-Estradiol via SIRT1/Acetyl-p53/NF-kB Signaling Pathway Rescued Postnatal Rat Brain Against Acute Ethanol Intoxication

(2017) Mehtab Khan et al.   MOLECULAR NEUROBIOLOGY

Traffic-related air pollution impact on mouse brain accelerates myelin and neuritic aging changes with specificity for CA1 neurons

(2017) Nicholas C. Woodward et al.   NEUROBIOLOGY OF AGING

Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models

(2017) M Cacciottolo et al.   Translational Psychiatry

Role of Nrf2 and protective effects of Metformin against tobacco smoke-induced cerebrovascular toxicity

(2017) Shikha Prasad et al.   Redox Biology

GRIN1 GENOTYPES AND APOE GENE HAPLOTYPES AFFECT THE AGE AT ONSET OF ALZHEIMER'S DISEASE DEMENTIA BUT NOT COGNITIVE OR FUNCTIONAL RESPONSE TO MEMANTINE

(2016) Fabricio Ferreira de Oliveira et al.   Alzheimers & Dementia

Nanoscale Particulate Matter from Urban Traffic Rapidly Induces Oxidative Stress and Inflammation in Olfactory Epithelium with Concomitant Effects on Brain

(2016) Hank Cheng et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Gene-environment interactions linking air pollution and inflammation in Parkinson's disease

(2016) Pei-Chen Lee et al.   ENVIRONMENTAL RESEARCH

Exposure to air pollution and cognitive functioning across the life course – A systematic literature review

(2016) Angela Clifford et al.   ENVIRONMENTAL RESEARCH

LXR Regulation of Brain Cholesterol: From Development to Disease

(2016) Rebecca Courtney et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Association between Traffic-Related Air Pollution in Schools and Cognitive Development in Primary School Children: A Prospective Cohort Study

(2015) Jordi Sunyer et al.   PLOS MEDICINE

Transcription Factors NRF2 and NF-κB Are Coordinated Effectors of the Rho Family, GTP-binding Protein RAC1 during Inflammation

(2014) Antonio Cuadrado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fine Particulate Matter Air Pollution and Cognitive Function Among U.S. Older Adults

(2014) Jennifer A. Ailshire et al.   JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES

Associations between Traffic-Related Black Carbon Exposure and Attention in a Prospective Birth Cohort of Urban Children

(2013) Yueh-Hsiu Mathilda Chiu et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Gene expression changes in rat brain after short and long exposures to particulate matter in Los Angeles basin air: Comparison with human brain tumors

(2013) Julia Y. Ljubimova et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

NRF2-regulation in brain health and disease: Implication of cerebral inflammation

(2013) Mats Sandberg et al.   NEUROPHARMACOLOGY

Components of air pollution and cognitive function in middle-aged and older adults in Los Angeles

(2013) Nicole M. Gatto et al.   NEUROTOXICOLOGY

ApoE influences amyloid-  (A ) clearance despite minimal apoE/A  association in physiological conditions

(2013) P. B. Verghese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nrf2-regulated phase II enzymes are induced by chronic ambient nanoparticle exposure in young mice with age-related impairments

(2012) Hongqiao Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

NF- B, the first quarter-century: remarkable progress and outstanding questions

(2012) M. S. Hayden et al.   GENES & DEVELOPMENT

APOE genotype alters glial activation and loss of synaptic markers in mice

(2012) Yuangui Zhu et al.   GLIA

APOE4-specific Changes in Aβ Accumulation in a New Transgenic Mouse Model of Alzheimer Disease

(2012) Katherine L. Youmans et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mrp14 Deficiency Ameliorates Amyloid   Burden by Increasing Microglial Phagocytosis and Modulation of Amyloid Precursor Protein Processing

(2012) M. P. Kummer et al.   JOURNAL OF NEUROSCIENCE

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

Nrf2-Keap1 Antioxidant Defense and Cell Survival Signaling Are Upregulated by 17�-Estradiol in Homocysteine-Treated Dopaminergic SH-SY5Y Cells

(2012) Cheng-Sheng Chen et al.   NEUROENDOCRINOLOGY

Sex and estradiol influence glial pro-inflammatory responses to lipopolysaccharide in rats

(2012) Lisa C. Loram et al.   PSYCHONEUROENDOCRINOLOGY

Association of GRIN1 and GRIN2A-D With schizophrenia and genetic interaction with maternal herpes simplex virus-2 infection affecting disease risk

(2011) Ditte Demontis et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Glutamatergic Neurons in Rodent Models Respond to Nanoscale Particulate Urban Air Pollutants in Vivo and in Vitro

(2011) Todd E. Morgan et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Nrf2-dependent gene expression is affected by the proatherogenic apoE4 genotype—studies in targeted gene replacement mice

(2011) Anne-Christin Graeser et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Apolipoprotein E Gene Polymorphisms Are Strong Predictors of Inflammation and Dyslipidemia in Rheumatoid Arthritis

(2011) T. E. TOMS et al.   JOURNAL OF RHEUMATOLOGY

Air pollution impairs cognition, provokes depressive-like behaviors and alters hippocampal cytokine expression and morphology

(2011) L K Fonken et al.   MOLECULAR PSYCHIATRY

When NRF2 Talks, Who's Listening?

(2010) Nobunao Wakabayashi et al.   ANTIOXIDANTS & REDOX SIGNALING

Sex differences in β-amyloid accumulation in 3xTg-AD mice: Role of neonatal sex steroid hormone exposure

(2010) Jenna C. Carroll et al.   BRAIN RESEARCH

Suppression of NF-κB signaling by KEAP1 regulation of IKKβ activity through autophagic degradation and inhibition of phosphorylation

(2010) Jeong-Eun Kim et al.   CELLULAR SIGNALLING

Association analysis of GRIN1 and GRIN2B polymorphisms and Parkinson's disease in a hospital-based case–control study

(2010) Shey-Lin Wu et al.   NEUROSCIENCE LETTERS

Protective actions of sex steroid hormones in Alzheimer’s disease

(2009) Christian J. Pike et al.   FRONTIERS IN NEUROENDOCRINOLOGY

KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ

(2009) Dung-Fang Lee et al.   MOLECULAR CELL

NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

(2008) Guang-Hui Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS

Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model

(2008) Chiho Hirata-Fukae et al.   BRAIN RESEARCH

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS

(2008) Robert W. Mahley et al.   JOURNAL OF LIPID RESEARCH

Complement C3 Deficiency Leads to Accelerated Amyloid   Plaque Deposition and Neurodegeneration and Modulation of the Microglia/Macrophage Phenotype in Amyloid Precursor Protein Transgenic Mice

(2008) M. Maier et al.   JOURNAL OF NEUROSCIENCE

Neurobehavioral effects of ambient air pollution on cognitive performance in US adults

(2008) Jiu-Chiuan Chen et al.   NEUROTOXICOLOGY