tRNA methylation: An unexpected link to bacterial resistance and persistence to antibiotics and beyond

Targeting the Bacterial Epitranscriptome for Antibiotic Development: Discovery of Novel tRNA-(N1G37) Methyltransferase (TrmD) Inhibitors

(2019) Wenhe Zhong et al.   ACS Infectious Diseases

tRNA Methylation Is a Global Determinant of Bacterial Multi-drug Resistance

(2019) Isao Masuda et al.   Cell Systems

Development of Inhibitors against Mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches

(2019) Andrew J. Whitehouse et al.   JOURNAL OF MEDICINAL CHEMISTRY

Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism

(2019) Wenhe Zhong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal structure and catalytic mechanism of the essential m1G37 tRNA methyltransferase TrmD from Pseudomonas aeruginosa

(2019) Juthamas Jaroensuk et al.   RNA

Leveraging a large microbial strain collection for natural product discovery

(2019) Andrew D. Steele et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A short translational ramp determines the efficiency of protein synthesis

(2019) Manasvi Verma et al.   Nature Communications

Codon-specific translation reprogramming promotes resistance to targeted therapy

(2018) Francesca Rapino et al.   NATURE

The outer membrane is an essential load-bearing element in Gram-negative bacteria

(2018) Enrique R. Rojas et al.   NATURE

Effect of Nascent Peptide Steric Bulk on Elongation Kinetics in the Ribosome Exit Tunnel

(2017) Pengse Po et al.   JOURNAL OF MOLECULAR BIOLOGY

Ribosome Collision Is Critical for Quality Control during No-Go Decay

(2017) Carrie L. Simms et al.   MOLECULAR CELL

Predictive compound accumulation rules yield a broad-spectrum antibiotic

(2017) Michelle F. Richter et al.   NATURE

Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells

(2016) Yingying Pu et al.   MOLECULAR CELL

Distinguishing between resistance, tolerance and persistence to antibiotic treatment

(2016) Asher Brauner et al.   NATURE REVIEWS MICROBIOLOGY

Methyl transfer by substrate signaling from a knotted protein fold

(2016) Thomas Christian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Methyl transfer by substrate signaling from a knotted protein fold

(2016) Thomas Christian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural and thermodynamic basis of proline-induced transmembrane complex stabilization

(2016) Thomas Schmidt et al.   Scientific Reports

The UGG Isoacceptor of tRNAPro Is Naturally Prone to Frameshifts

(2015) Howard Gamper et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Blind Pose Prediction, Scoring, and Affinity Ranking of the CSAR 2014 Dataset

(2015) Virginie Y. Martiny et al.   Journal of Chemical Information and Modeling

ESKAPEing the labyrinth of antibacterial discovery

(2015) Ruben Tommasi et al.   NATURE REVIEWS DRUG DISCOVERY

Structural basis for methyl-donor–dependent and sequence-specific binding to tRNA substrates by knotted methyltransferase TrmD

(2015) Takuhiro Ito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maintenance of protein synthesis reading frame by EF-P and m1G37-tRNA

(2015) Howard B. Gamper et al.   Nature Communications

Permeability Barrier of Gram-Negative Cell Envelopes and Approaches To Bypass It

(2015) Helen I. Zgurskaya et al.   ACS Infectious Diseases

An Integrated Approach Reveals Regulatory Controls on Bacterial Translation Elongation

(2014) Arvind R. Subramaniam et al.   CELL

Trends and Exceptions of Physical Properties on Antibacterial Activity for Gram-Positive and Gram-Negative Pathogens

(2014) Dean G. Brown et al.   JOURNAL OF MEDICINAL CHEMISTRY

On the essentiality of lipopolysaccharide to Gram-negative bacteria

(2013) Ge Zhang et al.   CURRENT OPINION IN MICROBIOLOGY

Selective Inhibitors of Bacterial t-RNA-(N1G37) Methyltransferase (TrmD) That Demonstrate Novel Ordering of the Lid Domain

(2013) Pamela J. Hill et al.   JOURNAL OF MEDICINAL CHEMISTRY

eIF5A Promotes Translation of Polyproline Motifs

(2013) Erik Gutierrez et al.   MOLECULAR CELL

EF-P Is Essential for Rapid Synthesis of Proteins Containing Consecutive Proline Residues

(2012) L. K. Doerfel et al.   SCIENCE

Translation Elongation Factor EF-P Alleviates Ribosome Stalling at Polyproline Stretches

(2012) S. Ude et al.   SCIENCE

Challenges of Antibacterial Discovery

(2011) L. L. Silver   CLINICAL MICROBIOLOGY REVIEWS

Eukaryote-Like Serine/Threonine Kinases and Phosphatases in Bacteria

(2011) S. F. F. Pereira et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

From the regulation of peptidoglycan synthesis to bacterial growth and morphology

(2011) Athanasios Typas et al.   NATURE REVIEWS MICROBIOLOGY

Mechanism and Function of the Outer Membrane Channel TolC in Multidrug Resistance and Physiology of Enterobacteria

(2011) Helen I. Zgurskaya et al.   Frontiers in Microbiology

An Evolutionarily Conserved Mechanism for Controlling the Efficiency of Protein Translation

(2010) Tamir Tuller et al.   CELL

Control of Catalytic Cycle by a Pair of Analogous tRNA Modification Enzymes

(2010) Thomas Christian et al.   JOURNAL OF MOLECULAR BIOLOGY

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

(2010) Julian G. Hurdle et al.   NATURE REVIEWS MICROBIOLOGY

Pseudomonas Genome Database: improved comparative analysis and population genomics capability for Pseudomonas genomes

(2010) G. L. Winsor et al.   NUCLEIC ACIDS RESEARCH

Escherichia coliK-12 Suppressor-free Mutants Lacking Early Glycosyltransferases and Late Acyltransferases

(2009) Gracjana Klein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tertiary structure checkpoint at anticodon loop modification in tRNA functional maturation

(2009) Sakurako Goto-Ito et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Eukaryotic-like Ser/Thr Kinase Signals Bacteria to Exit Dormancy in Response to Peptidoglycan Fragments

(2008) Ishita M. Shah et al.   CELL

A complete collection of single-gene deletion mutants of Acinetobacter baylyi ADP1

(2008) Véronique de Berardinis et al.   Molecular Systems Biology

Crystal structure of archaeal tRNA(m1G37)methyltransferase aTrm5

(2008) Sakurako Goto-Ito et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS