Leveraging a large microbial strain collection for natural product discovery

Discovery of Kirromycins with Anti-Wolbachia Activity from Streptomyces sp. CB00686

(2019) Zhengren Xu et al.   ACS Chemical Biology

Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections

(2019) Malina A. Bakowski et al.   Science Translational Medicine

Herbicidins from Streptomyces sp. CB01388 Showing Anti-Cryptosporidium Activity

(2018) Jian-Jun Chen et al.   JOURNAL OF NATURAL PRODUCTS

Discovery of Alternative Producers of the Enediyne Antitumor Antibiotic C-1027 with High Titers

(2018) Xiaohui Yan et al.   JOURNAL OF NATURAL PRODUCTS

Comparative Studies of the Biosynthetic Gene Clusters for Anthraquinone-Fused Enediynes Shedding Light into the Tailoring Steps of Tiancimycin Biosynthesis

(2018) Xiaohui Yan et al.   ORGANIC LETTERS

Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne

(2017) Xiaohui Yan et al.   ORGANIC LETTERS

Discovery of the leinamycin family of natural products by mining actinobacterial genomes

(2017) Guohui Pan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A high-throughput phenotypic screen identifies clofazimine as a potential treatment for cryptosporidiosis

(2017) Melissa S. Love et al.   PLoS Neglected Tropical Diseases

Titer improvement and pilot-scale production of platensimycin from Streptomyces platensis SB12026

(2016) Jun Shi et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

IMG-ABC: new features for bacterial secondary metabolism analysis and targeted biosynthetic gene cluster discovery in thousands of microbial genomes

(2016) Michalis Hadjithomas et al.   NUCLEIC ACIDS RESEARCH

Strain Prioritization and Genome Mining for Enediyne Natural Products

(2016) Xiaohui Yan et al.   mBio

Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways

(2016) Yumei Yan et al.   Scientific Reports

Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion

(2015) Caroline Mauvezin et al.   Autophagy

A New Golden Age of Natural Products Drug Discovery

(2015) Ben Shen   CELL

Adipostatins A–D from Streptomyces sp. 4875 inhibiting Brugia malayi asparaginyl-tRNA synthetase and killing adult Brugia malayi parasites

(2015) Mostafa E Rateb et al.   JOURNAL OF ANTIBIOTICS

Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery

(2015) Jeffrey D. Rudolf et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

A genetically amenable platensimycin- and platencin-overproducer as a platform for biosynthetic explorations: a showcase of PtmO4, a long-chain acyl-CoA dehydrogenase

(2015) Jeffrey D. Rudolf et al.   Molecular BioSystems

C-S bond cleavage by a polyketide synthase domain

(2015) Ming Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters

(2014) Peter Cimermancic et al.   CELL

Strain Prioritization for Natural Product Discovery by a High-Throughput Real-Time PCR Method

(2014) Hindra et al.   JOURNAL OF NATURAL PRODUCTS

Cycloheximide and Actiphenol Production in Streptomyces sp. YIM56141 Governed by Single Biosynthetic Machinery Featuring an Acyltransferase-less Type I Polyketide Synthase

(2014) Min Yin et al.   ORGANIC LETTERS

Thoughts and facts about antibiotics: Where we are now and where we are heading

(2012) János Bérdy   JOURNAL OF ANTIBIOTICS

Draft Genome Sequence of Streptomyces globisporus C-1027, Which Produces an Antitumor Antibiotic Consisting of a Nine-Membered Enediyne with a Chromoprotein

(2012) L. Wang et al.   JOURNAL OF BACTERIOLOGY

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

New WS9326A Congeners from Streptomyces sp. 9078 Inhibiting Brugia malayi Asparaginyl-tRNA Synthetase

(2012) Zhiguo Yu et al.   ORGANIC LETTERS

A Cell-Based Screen Reveals that the Albendazole Metabolite, Albendazole Sulfone, Targets Wolbachia

(2012) Laura R. Serbus et al.   PLoS Pathogens

Improvement of the Enediyne Antitumor Antibiotic C-1027 Production by Manipulating Its Biosynthetic Pathway Regulation inStreptomyces globisporus

(2011) Yihua Chen et al.   JOURNAL OF NATURAL PRODUCTS

Tirandamycins fromStreptomycessp. 17944 Inhibiting the ParasiteBrugia malayiAsparagine tRNA Synthetase

(2011) Zhiguo Yu et al.   ORGANIC LETTERS

Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis

(2011) M. J. Smanski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Manipulation of pathway regulation in Streptomyces globisporus for overproduction of the enediyne antitumor antibiotic C-1027

(2010) Yihua Chen et al.   JOURNAL OF ANTIBIOTICS

Bafilomycins produced by an endophytic actinomycete Streptomyces sp. YIM56209

(2010) Zhiguo Yu et al.   JOURNAL OF ANTIBIOTICS

Cycloheximide and congeners as inhibitors of eukaryotic protein synthesis from endophytic actinomycetes Streptomyces sps. YIM56132 and YIM56141

(2010) Sheng-Xiong Huang et al.   JOURNAL OF ANTIBIOTICS

Engineering ofStreptomyces platensisMA7339 for Overproduction of Platencin and Congeners

(2010) Zhiguo Yu et al.   ORGANIC LETTERS

Engineered Streptomyces platensis Strains That Overproduce Antibiotics Platensimycin and Platencin

(2009) M. J. Smanski et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Biosynthesis of Enediyne Antitumor Antibiotics

(2008) Steven Van Lanen et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY