Precision installation of a highly efficient suicide gene safety switch in human induced pluripotent stem cells

Human Genomic Safe Harbors and the Suicide Gene‐Based Safeguard System for iPSC‐Based Cell Therapy

(2019) Yasuyoshi Kimura et al.   Stem Cells Translational Medicine

Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature

(2019) Lucas-Sebastian Spitzhorn et al.   Stem Cell Research & Therapy

‘Reprogrammed’ stem cells approved to mend human hearts for the first time

(2018) David Cyranoski   NATURE

Linking a cell-division gene and a suicide gene to define and improve cell therapy safety

(2018) Qin Liang et al.   NATURE

Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration

(2017) Michiko Mandai et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fail-Safe System against Potential Tumorigenicity after Transplantation of iPSC Derivatives

(2017) Go Itakura et al.   Stem Cell Reports

Serial Activation of the Inducible Caspase 9 Safety Switch After Human Stem Cell Transplantation

(2016) Xiaoou Zhou et al.   MOLECULAR THERAPY

Multiple mechanisms determine the sensitivity of human-induced pluripotent stem cells to the inducible caspase-9 safety switch

(2016) Shigeki Yagyu et al.   Molecular Therapy-Methods & Clinical Development

An Inducible Caspase-9 Suicide Gene to Improve the Safety of Therapy Using Human Induced Pluripotent Stem Cells

(2015) Shigeki Yagyu et al.   MOLECULAR THERAPY

A Safeguard System for Induced Pluripotent Stem Cell-Derived Rejuvenated T Cell Therapy

(2015) Miki Ando et al.   Stem Cell Reports

An iCRISPR Platform for Rapid, Multiplexable, and Inducible Genome Editing in Human Pluripotent Stem Cells

(2014) Federico González et al.   Cell Stem Cell

Stable Enhanced Green Fluorescent Protein Expression After Differentiation and Transplantation of Reporter Human Induced Pluripotent Stem Cells Generated by AAVS1 Transcription Activator-Like Effector Nucleases

(2014) Yongquan Luo et al.   Stem Cells Translational Medicine

Improving the safety of cell therapy products by suicide gene transfer

(2014) Benjamin S. Jones et al.   Frontiers in Pharmacology

Development of an inducible caspase-9 safety switch for pluripotent stem cell–based therapies

(2014) Chuanfeng Wu et al.   Molecular Therapy-Methods & Clinical Development

Steps Toward Safe Cell Therapy Using Induced Pluripotent Stem Cells

(2013) Hideyuki Okano et al.   CIRCULATION RESEARCH

A Scalable Approach to Prevent Teratoma Formation of Human Embryonic Stem Cells

(2012) Zhili Rong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High density micromass cultures of a human chondrocyte cell line: A reliable assay system to reveal the modulatory functions of pharmacological agents

(2011) K.V. Greco et al.   BIOCHEMICAL PHARMACOLOGY

Somatic coding mutations in human induced pluripotent stem cells

(2011) Athurva Gore et al.   NATURE

Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells

(2011) Ryan Lister et al.   NATURE

Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy

(2011) Antonio Di Stasi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome

(2010) R. C. DeKelver et al.   GENOME RESEARCH

Systematic Comparison of Constitutive Promoters and the Doxycycline-Inducible Promoter

(2010) Jane Yuxia Qin et al.   PLoS One

Quantitative Comparison of Constitutive Promoters in Human ES cells

(2010) Karin Norrman et al.   PLoS One

Variation in the safety of induced pluripotent stem cell lines

(2009) Kyoko Miura et al.   NATURE BIOTECHNOLOGY