Article
Pharmacology & Pharmacy
Zhenwei Yu, Xiaoyan Wu, Jianping Zhu, Jiayi Jin, Yuhua Zhao, Lingyan Yu
Summary: The study analyzed the trends in topical prescription treatment for elderly patients with dry eye disease in China, revealing an increase in treatment cost and medication use. Ocular lubricants were the main treatment option, with sodium hyaluronate being the most frequently used drug. These observed trends have the potential to lead to more efficient allocation of healthcare resources in China.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Su Li, Zhouyu Lu, Yue Huang, Yin Wang, Qiao Jin, Xingchao Shentu, Juan Ye, Jian Ji, Ke Yao, Haijie Han
Summary: The researchers have developed micelle-based eye drops for managing dry eye disease (DED), which includes inhibitors and scavengers to reduce inflammation and oxidative stress. This treatment effectively suppresses inflammation, repairs corneal defects, restores tear secretion, and alleviates DED symptoms.
Article
Biochemistry & Molecular Biology
Marc Labetoulle, Jose Manuel Benitez-del-Castillo, Stefano Barabino, Rocio Herrero Vanrell, Philippe Daull, Jean-Sebastien Garrigue, Maurizio Rolando
Summary: This review describes the main categories of ingredients in tear substitutes and their effects on the ocular surface. It also provides insights into how to select the appropriate tear substitute formulations based on the predominant causes of dry eye disease (DED).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Pei-Hsuan Lin, Hong-Jyuan Jian, Yu-Jia Li, Yu-Fen Huang, Anisha Anand, Chih-Ching Huang, Han-Jia Lin, Jui-Yang Lai
Summary: In this study, carbonized nanogels (CNGs) were developed as long-lasting eye drops for the treatment of dry eye syndrome (DES). These CNGs show high biocompatibility and anti-inflammatory properties, providing significant therapeutic effects and holding great potential as innovative drugs for the treatment of dry eye disease.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Kristina Krajcikova, Agnieszka Balicka, Maria Lapsanska, Alexandra Trbolova, Zuzana Gulasova, Daria Kondrakhova, Vladimir Komanicky, Adriana Rasiova, Vladimira Tomeckova
Summary: Dry eye disease is a chronic ophthalmological disease for which current therapy focuses on symptom suppression. Polyphenols have shown potential in improving dry eye disease therapy. This study aimed to target pathophysiological mechanisms by adding fisetin to the cyclosporine treatment protocol, but it was found that fisetin did not restore tear production but influenced molecular pathological events through MMP-9.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Songjiao Zhao, Nan Song, Lan Gong
Summary: Upper blepharoplasty may lead to increased tear inflammatory cytokines release and tear film instability, contributing to the development of postoperative dry eye. Dry eye patients showed significantly shortened tear film stability at 1 month postoperatively, but symptoms were relieved after 6 months. Preexisting dry eye is a higher risk factor for worse and persistent ocular surface damage after upper blepharoplasty.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yu-Ting Hsiao, Yu-Ting Huang, Hun-Ju Yu, Po-Chiung Fang, Ming-Tse Kuo
Summary: This study investigates the tear protein alterations in dry eye disease (DED) with primary Sjogren syndrome (pSS) and secondary Sjogren syndrome (sSS). The researchers identify ADAM10 and EGF as novel biomarkers for differentiating between primary and secondary SS patients with DED.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Zhenyu Wei, Yuandong Su, Guanyu Su, Christophe Baudouin, Antoine Labbe, Qingfeng Liang
Summary: This study aimed to investigate the change in dynamic optical quality in dry eye patients after the use of artificial tears. The study found that optical quality indices were significantly higher in dry eye patients compared to the control group, but decreased significantly after 5 minutes of artificial tear instillation in severe dry eye patients. There were no significant differences in optical quality parameters among the three groups after 30 minutes.
Article
Ophthalmology
Padmapriya Ramamoorthy, Safal Khanal, Jason J. Nichols
Summary: This study found that the tear film of individuals with contact lens-related dry eye (CLDE) contains increased levels of several inflammatory mediators. These results support the potential role of inflammation in CLDE.
CONTACT LENS & ANTERIOR EYE
(2022)
Article
Biology
Hung-yin Lai, Alexander Chen, Po-chiung Fang, Hun-ju Yu, Ming-tse Kuo
Summary: This study compared tear film viscosity in Sjogren and non-Sjogren dry eye diseases. They found that Sjogren patients had lower tear film viscosity indices and higher symptom severity. The researchers concluded that tear film viscosity indices can be useful in early detection of Sjogren dry eye disease.
Article
Ophthalmology
Maria L. Merino, Javier Belmonte, Jose Rosas, M. Carmen Acosta, Juana Gallar, Carlos Belmonte
Summary: This study aims to measure the tear flow changes evoked by controlled sensory stimulation of the eye surface using i-Onion (TM), a new stimulation device, in healthy subjects and dry eye disease (DED) patients. The results showed that CO2 stimulation significantly increased tear volume in 78% of control subjects, while DED patients had lower basal tear volume (BTV) and stimulated tear volume (STV) compared to healthy controls.
Article
Chemistry, Multidisciplinary
Deborah Lee, Seoyoon Song, Geonho Cho, Lucia C. Dalle Ore, Noah Malmstadt, Ahmed Fuwad, Sun Min Kim, Tae-Joon Jeon
Summary: This study reveals the important role of lysozyme in tear film lipid layer functionality, improving ocular health through increased tear evaporation and resistance to bacterial invasion.
Article
Biochemistry & Molecular Biology
Saki Sakakura, Emi Inagaki, Yuichiro Ochiai, Masatoshi Yamamoto, Naofumi Takai, Taeko Nagata, Kazunari Higa, Yasunori Sato, Hiroshi Toshida, Dogru Murat, Masatoshi Hirayama, Yoko Ogawa, Kazuno Negishi, Shigeto Shimmura
Summary: The tear film stability of a rabbit dry eye model induced by dacryoadenectomy was assessed in this study. The results showed that this model partially captured the phenotypes of human short TBUT-type dry eye, making it a potentially useful animal model for investigating potential drug candidates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Atsushi Kawahara
Summary: Dry eye disease is a multifactorial disorder characterized by tear fluid imbalance. In Asia, the focus of treatment is on tear film stabilization. Traditional therapies like artificial tears and steroids have limitations, while new generation therapies have shown to be more effective in Asia.
Review
Ophthalmology
Leif Hynnekleiv, Morten Magno, Emily Moschowits, Kim Alexander Tonseth, Jelle Vehof, Tor P. Utheim
Summary: Dry eye disease (DED) is a common and debilitating condition. Hyaluronic acid (HA) has been widely used as a safe and effective treatment for DED. This study aimed to summarize and critically evaluate the literature comparing HA with other active ingredients in the treatment of DED.
ACTA OPHTHALMOLOGICA
(2023)
Article
Multidisciplinary Sciences
Hsuan-Yu Chen, Benny Wei-Yun Hsu, Yu-Kai Yin, Feng-Huei Lin, Tsung-Han Yang, Rong-Sen Yang, Chih-Kuo Lee, Vincent S. Tseng
Summary: Using a deep convolutional neural network for vertebral fracture identification on plain abdominal radiographs can improve accuracy. The study found that only 46.6% of fractures were diagnosed in the original reports. Additionally, the algorithm showed good accuracy in vertebral fracture identification.
Editorial Material
Cardiac & Cardiovascular Systems
Heng-Yu Pan, Tao-Yu Wu, Hsuan-Yu Chen, Jiun-Yi Wu, Min-Tsun Liao
Summary: Additional digital content is available in the text.
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Article
Polymer Science
Chih-Hao Chang, Chih-Hung Chang, Ya-Wen Yang, Hsuan-Yu Chen, Shu-Jyuan Yang, Wei-Cheng Yao, Chi-Yang Chao
Summary: This study successfully synthesized a novel polystyrene-block-quaternized polyisoprene amphipathic block copolymer and controlled the antibacterial activity by regulating the block composition, side chain length, and polymer morphology. The polymers with N,N-dimethyldodecylamine side chains formed polymersome structures in aqueous solutions, exhibiting the best inhibiting bacterial growth efficiency.
Article
Pharmacology & Pharmacy
Cheng-Han Tsai, Le Ngoc Hoang, Chun Che Lin, Liang-Chen Pan, Chiao-Li Wu, I-Chan Lin, Peng-Yuan Wang, Ching-Li Tseng
Summary: Posterior eye diseases, such as age-related macular degeneration and diabetic retinopathy, are difficult to treat due to ineffective drug delivery. In this study, self-assembling nanoparticles made from gelatin-epigallocatechin gallate (EGCG) and surface-decorated with hyaluronic acid (HA) were successfully used for drug delivery to the retinal/choroidal area. The nanoparticles, characterized by a positive surface and HA decoration, showed high drug delivery efficiency to the posterior eye through eye drops and subconjunctival injection.
Article
Biochemistry & Molecular Biology
Subhaini Jakfar, Tzu-Chieh Lin, Zhi-Yu Chen, I-Hsuan Yang, Basri A. Gani, Diana Setya Ningsih, Hendra Kusuma, Chia-Tien Chang, Feng-Huei Lin
Summary: An investigation into the use of BSP blended with MC and MP to create hydrogel dressings showed that the M8B2 hydrogel had superior cell viability and wound-healing properties compared to other formulations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Hung-Kuan Yen, Chih-Wei Chen, Wei-Hsin Lin, Zhong-Yu Wang, Chuan-Ching Huang, Hsuan-Yu Chen, Shu-Hua Yang, Ming-Hsiao Hu
Summary: This study aimed to create a new scoring system (ATS) based on the revised Tokuhashi score (RTS) that predicts 6-month survival for patients with spinal metastases more accurately. The study found that target therapy and the Z score of BMI were additional independent prognostic factors. With optimization, surgeons can choose a more individualized treatment for patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Hsuan-Yu Chen, Tuoh Wu, Sheng-Pin Tseng, Chia-Yu Lin, Chih-Wei Chen, Tze-Hong Wong, Yuh-Fen Wei, Ya-Fang Chen
Summary: Tomosynthesis outperforms plain radiography in the diagnosis and healing assessment of VCFs, with higher accuracy and anatomical details, and it is preferred by healthcare professionals. It is a promising tool for VCF screening and diagnosis in patients with osteoporosis, and for monitoring fracture healing status at a low radiation dose and cost.
FRONTIERS IN MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Tzu-Chieh Lin, Jhih-Ni Lin, I-Hsuan Yang, Christina Soong, Ya-Jyun Liang, Subhaini Jakfar, Chun-Che Yen, Hwa-Chang Liu, Hsuan-Yu Chen, Feng-Huei Lin
Summary: Osteoarthritis of the knee is a degenerative disease with no current effective treatment to prevent or reverse disease progression. A recent study found that a combination of resveratrol and Bletilla striata polysaccharide can alleviate inflammation and oxidative stress, offering a potential alternative therapeutic strategy for early osteoarthritis.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jackson Choo, Chun-Huei Liao, Ching-Li Tseng, Jiunn-Liang Chen, Huey-Chuan Cheng, Chung-Ling Liang, Suh-Hang Hank Juo
Summary: We investigated the effects of anti-miR-328 on mucin expression and goblet cells in dry eye disease. MiR-328 was found to be increased in goblet cells under desiccating stress or treatment with benzalkonium chloride (BAC). Bioinformatics analysis revealed that miR-328 directly targets the CREB1 transcription factor, which promotes mucin5AC expression.
Article
Pharmacology & Pharmacy
Basri A. Gani, Cut Soraya, Vinna Kurniawati Sugiaman, Fitri Yunita Batubara, Dharli Syafriza, Silvia Naliani, Sri Rezeki, Subhani Jakfar, Muhammad Nazar, Kemala Hayati
Summary: This study evaluates the fungistatic effect of Moringa oleifera leaves ethanolic extract (MOLE) on the metabolism changes of Candida albicans cells associated with growth and biofilm formation. The results showed that MOLE could inhibit the growth and biofilm formation of C. albicans at all incubation times (24, 48, and 72 h).
JOURNAL OF PHARMACY & PHARMACOGNOSY RESEARCH
(2023)
Article
Medicine, General & Internal
Shau-Huai Fu, Ping-Ying Yu, Chung-Yi Li, Chih-Chien Hung, Chia-Che Lee, Hsuan-Yu Chen, Ta-Wei Tai, Jawl-Shan Hwang, Rong-Sen Yang, Hongsen Chiang, Sung-Yen Lin, Chih-Hsing Wu, Ling-Chiao Liao, Chin-Ju Chuang, Chiu-Yi Wu, Cheng-Ying Chang, Ming-Tsung Lee, Chung-Hwan Chen, Chen-Yu Wang
Summary: This study aimed to validate existing algorithms for identifying second hip fractures and propose two new algorithms. The algorithms that integrated the concepts of periprosthetic fractures and laterality of the ICD-10 coding system showed satisfactory validity in defining second hip fractures.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Oncology
Yaoru Huang, Nidita Roy, Eshita Dhar, Umashankar Upadhyay, Muhammad Ashad Kabir, Mohy Uddin, Ching-Li Tseng, Shabbir Syed-Abdul
Summary: Palliative care is improved by using deep learning models to predict survival outcomes for end-stage cancer patients. Comparisons were made between wearable technology and traditional prognostic tools, with the former showing better performance when combined with clinical data. These findings are novel in the field of palliative care.
Article
Nanoscience & Nanotechnology
Pranjyan Dash, Senthilkumar Thirumurugan, Ching-Li Tseng, Yu-Chien Lin, Sung-Lung Chen, Udesh Dhawan, Ren-Jei Chung
Summary: This study developed dumbbell-shaped nanocomposites consisting of titanium dioxide/gold nanorods coated with mesoporous silica shells. Methotrexate was loaded onto the nanocomposites and upconversion nanoparticles were decorated to enhance the therapeutic effects. In vitro and in vivo experiments demonstrated the synergistic photodynamic therapy, photothermal therapy, and chemotherapy effects of the nanocomposites, making them a promising candidate for cancer treatment using near-infrared light.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Physical
Asmaa Khalil, Alexandre Barras, Rabah Boukherroub, Ching-Li Tseng, David Devos, Thierry Burnouf, Winfried Neuhaus, Sabine Szunerits
Summary: Paracellular permeability is regulated by tight junctions, which not only restrict the diffusion of ions and hydrophilic molecules, but also play important roles in cell polarization and protein localization. New understanding of tight junction components has challenged the traditional concept of diffusion barriers. Nanotechnological approaches and nanomaterials offer potential solutions for enhancing drug delivery across tight junctions.
NANOSCALE HORIZONS
(2023)