Article
Infectious Diseases
Michela Galgano, Paolo Capozza, Francesco Pellegrini, Marco Cordisco, Alessio Sposato, Sabina Sblano, Michele Camero, Gianvito Lanave, Giuseppe Fracchiolla, Marialaura Corrente, Francesco Cirone, Adriana Trotta, Maria Tempesta, Domenico Buonavoglia, Annamaria Pratelli
Summary: The study found that essential oils such as lemon, pine, fennel, basil, melissa, thyme, and ginger have broad-spectrum antimicrobial activity. The activity of ginger oil against Staphylococcus aureus strains showed a dose-effect correlation, while fennel oil showed low activity. Pine, melissa, and basil oils showed bactericidal effects against S. aureus, and lemon oil had different effects on different strains. Thyme oil showed complete inhibition of growth for both E. coli and S. aureus.
Article
Biochemistry & Molecular Biology
Yeseul Kim, Sanghun Kim, Kiu-Hyung Cho, Jin-Hyung Lee, Jintae Lee
Summary: Bacterial biofilm formation can be effectively inhibited by cinnamaldehyde and its derivatives, especially 4-nitrocinnamaldehyde. These compounds exhibit strong antibiofilm activities against UPEC and S. aureus, making them promising candidates for the treatment of biofilm-associated diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Merilin Rosenberg, Meeri Visnapuu, Kristjan Saal, Dmytro Danilian, Rainer Parna, Angela Ivask, Vambola Kisand
Summary: In the context of healthcare-acquired infections and the spread of antibiotic resistance, additional passive measures are urgently needed to prevent pathogen carryover. Antimicrobial high-touch surfaces, such as photocatalytic nano-ZnO and nano-ZnO/Ag-based surfaces with significant reduction in bacterial viability, show potential for mitigating the spread of bacteria. It is important to critically evaluate and select appropriate efficacy assessment methods based on end-use conditions for these surfaces.
Article
Biochemistry & Molecular Biology
Iva Sovadinova, Kenichi Kuroda, Edmund F. Palermo
Summary: Cationic and amphiphilic polymers exhibit broad-spectrum antibacterial activity by disrupting cell membranes. While nonspecific binding to hydrophobic components in serum was thought to hinder their effectiveness, it was unexpectedly found that the addition of fetal bovine serum actually enhances their antimicrobial activity against S. aureus but not E. coli.
Article
Biochemistry & Molecular Biology
Huan Peng, Gang Zhou, Xi-Miao Yang, Guo-Jun Chen, Hai-Bin Chen, Zhen-Lin Liao, Qing-Ping Zhong, Li Wang, Xiang Fang, Jie Wang
Summary: Lactobacillus rhamnosus SCB0119 and its cell-free culture supernatant (CFS) could be used as a biocontrol agent against Escherichia coli and Staphylococcus aureus, with mechanisms involving induction of oxidative stress, disruption of cell wall and membrane structure, and alteration of key genes at the transcriptional level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Multidisciplinary
Zhang Hui-lin, Zhao Yi-yang, Zhou Zi-chong, Ding Huan-zhong
Summary: In this study, the susceptibility breakpoints of cefquinome against E. coli and S. aureus in pigs were determined, with low resistance rates observed. Pharmacokinetic/pharmacodynamic cut-off values were established, providing guidance for effective treatment of infections caused by these bacteria strains. Adjustment of dosing regimen showed increased effectiveness for S. aureus infections, highlighting the importance of surveillance and dosage guidance for cefquinome in pigs.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2021)
Article
Chemistry, Multidisciplinary
Xiaojie Wu, Bochen Hu, Di Li, Biyi Chen, Yuanyong Huang, Zhongkai Xie, Longhua Li, Nanjun Shen, Fuchen Yang, Weidong Shi, Ming Chen, Yongfa Zhu
Summary: In this study, a highly efficient photocatalyst for bacterial inactivation under natural light was developed. The catalyst achieved the highest efficiency among all the natural light antibacterial reports, and exhibited negligible toxicity and damage to normal tissue cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Amal Alrashidi, Mohammed Jafar, Niamh Higgins, Ciara Mulligan, Carmine Varricchio, Ryan Moseley, Vildan Celiksoy, David M. J. Houston, Charles M. Heard
Summary: The combination of pomegranate rind extract and Zn (II) ions shows synergistic bactericidal activity against various bacterial strains, indicating potential for the development of a therapeutic system with demonstrable antimicrobial activity for topical applications, such as MRSA infections.
Article
Chemistry, Applied
Lili Li, Ping Zhou, Yidi Wang, Ying Pan, Min Chen, Ye Tian, Hua Zhou, Baoru Yang, Hecheng Meng, Jie Zheng
Summary: Enzymatic acylation of anthocyanin with fatty acid improves its lipophilic solubility and this study demonstrates that the resulting acylated anthocyanin, C3G-LA, exhibits strong antibacterial activity against Staphylococcus aureus and moderate activity against Escherichia coli. The mechanism of action involves disruption of cell membrane integrity, intracellular ATP concentration, intracellular pH, and changes in cellular morphology.
Article
Biochemistry & Molecular Biology
Layane A. L. Silva, Andre A. L. Silva, Maria A. S. Rios, Manoel P. Brito, Alyne R. Araujo, Durcilene A. Silva, Ramon R. Pena-Garcia, Edson C. Silva-Filho, Janildo L. Magalhaes, Jose M. E. Matos, Josy A. Osajima, Eduardo R. Triboni
Summary: This study investigated the effects of copper doping of hydrated cobalt molybdate on its antibacterial activity and structural changes, demonstrating that increasing copper content led to larger microparticle size and better bactericidal performance against gram-positive bacteria than gram-negative bacteria. However, the use of copper as a doping agent caused an increase in the Minimum Inhibitory Concentration value in the presence of both Escherichia coli and Staphylococcus aureus strains, indicating the need for caution in utilizing copper in biocidal matrices.
Article
Chemistry, Applied
Yu-gang Shi, Run-run Zhang, Chen-min Zhu, Ming-feng Xu, Qing Gu, Rammile Ettelaie, Shan Lin, Yi-fan Wang, Xin-yi Leng
Summary: This study found that the length of alkyl gallates plays a crucial role in their antibacterial activity, with octyl gallate exhibiting excellent bactericidal activity through a multiple bactericidal mechanism and unique advantages in maintaining food freshness.
Article
Environmental Sciences
Sankalp Arya, Alexander Williams, Saul Vazquez Reina, Charles W. Knapp, Jan-Ulrich Kreft, Jon L. Hobman, Dov J. Stekel
Summary: Many antibiotic resistance genes co-occur with resistance genes for transition metals, such as copper, zinc, or mercury. Mathematical modelling is used to predict minimal co-selective concentrations for metals, aiding in the mitigation of risks of antimicrobial resistance.
ENVIRONMENTAL POLLUTION
(2021)
Article
Materials Science, Multidisciplinary
C. Guerra, A. Ringuede, M. I. Azocar, M. Walter, C. Galarce, F. Bedioui, M. Cassir, M. Sancy
Summary: AISI 430 stainless steel is an attractive material for use in the healthcare industry, but shows clear signs of corrosion after two weeks of exposure in a sterile medium.
Article
Food Science & Technology
Hong Yan, Yingying Lu, Xin Li, Yanglei Yi, Xin Wang, Yuanyuan Shan, Bianfang Liu, Yuan Zhou, Xin Lu
Summary: Bacteriocin BM1829 has antimicrobial activity against both Gram-positive and Gram-negative bacteria, and exhibits good stability against various environmental factors. It can disrupt membrane integrity, arrest the cell cycle, and reduce bacterial populations during food storage, suggesting its potential as a food preservative or antibacterial agent.
Article
Nanoscience & Nanotechnology
Maricely Ramirez-Hernandez, Javiera Norambuena, Hongnan Hu, Belvin Thomas, Chaoyun Tang, Jeffrey M. Boyd, Tewodros Asefa
Summary: The urgent need for materials that can more efficiently deliver antimicrobial agents has arisen due to the increase in microbial resistance to traditional antibiotics. This study presents the synthesis of amine-functionalized SBA-15 mesoporous silica nanomaterials loaded with rafoxanide and anchored Cu(II) ions, which exhibit enhanced antimicrobial efficacy against pathogenic Staphylococcus aureus. The structurally characterized nanomaterials demonstrate 10 times the bactericidal action compared to nanomaterials loaded with rafoxanide only, and the synthetic sequence used in the production significantly impacts their bactericidal efficacy.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Analytical
Huda Alghamdi, Majidah Alsaeedi, Alyah Buzid, Jeremy D. Glennon, John H. T. Luong
Summary: The study utilized GC and BDD electrodes for the detection of BAK homologs in a non-aqueous medium, with BDD showing better reproducibility and a detection limit of 0.4 μg/mL, in agreement with manufacturer specifications.
Article
Chemistry, Multidisciplinary
Arumugam Saravanan, Moorthy Maruthapandi, Poushali Das, John H. T. Luong, Aharon Gedanken
Summary: Carbon dots (CDs) prepared from medicinal turmeric leaves exhibited strong bactericidal activities against common pathogens, with stable fluorescence properties under different environmental conditions. The release of reactive oxygen species played a crucial role in bacterial cell death.
Review
Chemistry, Multidisciplinary
Arulppan Durairaj, Moorthy Maruthapandi, Arumugam Saravanan, John H. T. Luong, Aharon Gedanken
Summary: The increased usage of fossil fuels due to industrialization and population growth has led to significant CO2 emissions, causing a serious environmental issue. Sustainable and environmentally friendly materials, such as cellulose nanocrystals (CNCs) derived from biomass, are being considered as alternatives to petroleum-based plastics. CNCs exhibit unique physicochemical properties and have been proven to be useful in energy applications, including energy storage devices and supercapacitors.
Article
Acoustics
Moorthy Maruthapandi, Akanksha Gupta, Arumugam Saravanan, Gila Jacobi, Ehud Banin, John H. T. Luong, Aharon Gedanken
Summary: Under ultrasonication, Cu2O microparticles are fragmented into NPs and strongly interact with alkali lignin to form a nanocomposite. The L-Cu nanocomposite exhibits enhanced antibiofilm activities against various pathogens. Experimental evidence reveals the destruction of bacterial cell walls by L-Cu, leading to the loss of structural morphology. The MICs for biofilm inhibition and bacterial eradication vary for different pathogens, highlighting the potential of L-Cu as an alternative to neutralize MDR pathogens.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Chemistry, Physical
Sengodan Prabhu, Moorthy Maruthapandi, Arulappan Durairaj, Srinivasan Arun Kumar, John H. T. Luong, Rajendran Ramesh, Aharon Gedanken
Summary: Ni(1-alpha)Co(alpha)MoO4 (alpha = 0, 0.1, 0.3, and 0.5 M) nanorods were successfully synthesized via a hydrothermal method and proved to be excellent electrode materials for a hybrid supercapacitor. The electrochemical properties of the nanorods were found to be dependent on the Ni/Co ratio, as shown by various electrochemical techniques. Ni0.5Co0.5MoO4 (alpha = 0.5 M) exhibited a specific capacity (Qg) of 354 Cg-1@1 Ag-1 with a notable retention capacity of 92% after 8000 repeated cycles at 10 Ag-1. Ni0.5Co0.5MoO4 with a high surface area outperformed mono-metallic (NiMoO4) and bimetallic (Ni0.9Co0.1MoO4 and Ni0.7Co0.3MoO4) nanostructures. The hybrid supercapacitor (Ni0.5Co0.5MoO4//activated carbon) delivered a maximum Qcell of 53 Cg-1 at 1 Ag-1 with an energy density of 16.2 Wh kg-1 and a power density of 725 W kg-1.
ACS APPLIED ENERGY MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Poushali Das, Sayan Ganguly, Arumugam Saravanan, Shlomo Margel, Aharon Gedanken, Seshasai Srinivasan, Amin Reza Rajabzadeh
Summary: Apium graveolens-derived carbon dots (ACDs) were synthesized via a one-step hydrothermal process and used to reinforce a polymer hydrogel. The resulting hydrogel exhibited mechanical robustness, fluorescent behavior, natural adhesivity, as well as self-healing, controlled release, and antibacterial properties. This material holds great potential as an alternative to soft biomaterials and soft robotics.
ACS APPLIED BIO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Arulappan Durairaj, Moorthy Maruthapandi, John H. T. Luong, Ilana Perelshtein, Aharon Gedanken
Summary: This study demonstrated the preparation of CD-coated fabrics with superior properties, including excellent UV-blocking capability and 100% antibacterial activity against E. coli and S. aureus. The CDs/fabrics also showed the ability to adsorb Hg2+ and Fe3+ and were utilized for the removal and detection of these ions.
ACS APPLIED BIO MATERIALS
(2022)
Article
Energy & Fuels
Sengodan Prabhu, Moorthy Maruthapandi, Arulappan Durairaj, John H. T. Luong, Aharon Gedanken
Summary: Capsule-like CuO/CDs (CuO@CDs) with a surface area of 33.12 m2 g-1 were synthesized through hydrothermal treatment, compared to 19.02 m2 g-1 for pristine CuO. A hybrid solid-state supercapacitor (HSSC) was fabricated using capsule-like CuO@CDs as the anode, activated carbon (AC) as the cathode, and PVA/1M KOH as the electrolyte. The three-electrode system exhibited a specific capacitance of 1208.88 F/g (at 2 A/g current density) and maintained a remarkable life cycle (retention) of 93% and Coulombic efficiency (CF) of 98% after 5000 charge-discharge cycles at 10 A/g. In terms of performance, the HSSC delivered 1.5 V and 102.60 F/g (50.74 C/g) at 2 A/g, with a power density of 8437.50 W/kg and an energy density of 36.90 Wh/kg. The HSSC retained 92% of cyclic stability and 83% of CF after 10,000 cycles.
Article
Engineering, Environmental
Belal Abu Salha, Arumugam Saravanan, Moorthy Maruthapandi, Ilana Perelshtein, Aharon Gedanken
Summary: In this study, nitrogen-doped carbon dots (N-CDs) were prepared from Piper betle leaves using a simple hydrothermal method. The synthesized N-CDs were characterized and it was found that treating strawberry plants with N-CDs resulted in increased chlorophyll and carbohydrate content, as well as increased production of secondary metabolites. These findings suggest that biomass-based, betel leaf-derived N-CDs can be used as an effective fertilizer for global agricultural production.
ACS ES&T ENGINEERING
(2023)
Article
Nanoscience & Nanotechnology
Poushali Das, Sayan Ganguly, Arumugam Saravanan, Shlomo Margel, Aharon Gedanken, Seshasai Srinivasan, Amin Reza Rajabzadeh
Summary: In this study, celery-derived carbon dots (ACDs) were synthesized without the use of aggressive chemicals or ligands. The ACDs showed robustness, fluorescent behavior, and natural adhesivity, making them a potential alternative to soft biomaterials and soft robotics. The ACDs-reinforced hydrogels exhibited elastic sustainability, self-healing behavior, controlled release, and high antibacterial activity, demonstrating their versatility and potential applications.
ACS APPLIED BIO MATERIALS
(2022)
Review
Engineering, Biomedical
Albert Donald Luong, Alyah Buzid, John H. T. Luong
Summary: Epithelial cells and leukocytes release AMPs as a defense mechanism against oral pathogens. However, the concentrations of AMPs are low and they are unstable under physiological conditions. Efforts have been made to synthesize stable and low-cytotoxicity AMPs and improve their antimicrobial activity using nanomaterials and biomolecules. Future research should focus on developing AMPs that promote remineralization and antibacterial adhesion. Nanostructured AMPs are a promising alternative to antibiotics due to their broad-spectrum antimicrobial activity and ease of synthesis and modification.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Akanksha Gupta, Moorthy Maruthapandi, Poushali Das, Arumugam Saravanan, Gila Jacobi, Michal Natan, Ehud Banin, John H. T. Luong, Aharon Gedanken
Summary: This study developed a simple sonochemical method to coat Cu2O nanoparticles on flexible substrates, which can effectively inhibit the growth of planktonic and biofilm bacteria and prevent microbial contamination in hospitals and industrial environments.
ACS APPLIED BIO MATERIALS
(2022)
