Host prion protein expression levels impact prion tropism for the spleen

Prion strain-dependent tropism is maintained between spleen and granuloma and relies on lymphofollicular structures

(2019) Iman Al-Dybiat et al.   Scientific Reports

Complement Regulatory Protein Factor H Is a Soluble Prion Receptor That Potentiates Peripheral Prion Pathogenesis

(2017) Sarah J. Kane et al.   JOURNAL OF IMMUNOLOGY

Divergent prion strain evolution driven by PrPC expression level in transgenic mice

(2017) Annick Le Dur et al.   Nature Communications

PrPSc formation and clearance as determinants of prion tropism

(2017) Ronald A. Shikiya et al.   PLoS Pathogens

Reversible unfolding of infectious prion assemblies reveals the existence of an oligomeric elementary brick

(2017) Angélique Igel-Egalon et al.   PLoS Pathogens

Enhanced neuroinvasion by smaller, soluble prions

(2017) Cyrus Bett et al.   Acta Neuropathologica Communications

Detection of prions in the plasma of presymptomatic and symptomatic patients with variant Creutzfeldt-Jakob disease

(2016) D. Bougard et al.   Science Translational Medicine

Emergence of two prion subtypes in ovine PrP transgenic mice infected with human MM2-cortical Creutzfeldt-Jakob disease prions

(2016) Jérôme Chapuis et al.   Acta Neuropathologica Communications

Transgenic Rabbits Expressing Ovine PrP Are Susceptible to Scrapie

(2015) Pierre Sarradin et al.   PLoS Pathogens

Prion disease tempo determined by host-dependent substrate reduction

(2014) Charles E. Mays et al.   JOURNAL OF CLINICAL INVESTIGATION

Sialylation of Prion Protein Controls the Rate of Prion Amplification, the Cross-Species Barrier, the Ratio of PrPSc Glycoform and Prion Infectivity

(2014) Elizaveta Katorcha et al.   PLoS Pathogens

Prevalent abnormal prion protein in human appendixes after bovine spongiform encephalopathy epizootic: large scale survey

(2013) O. N. Gill et al.   BMJ-British Medical Journal

The contribution of different prion protein types and host polymorphisms to clinicopathological variations in Creutzfeldt-Jakob disease

(2012) Mark W. Head et al.   REVIEWS IN MEDICAL VIROLOGY

The Risk of Prion Zoonoses

(2012) J. Collinge   SCIENCE

Facilitated Cross-Species Transmission of Prions in Extraneural Tissue

(2012) V. Beringue et al.   SCIENCE

Incunabular Immunological Events in Prion Trafficking

(2012) Brady Michel et al.   Scientific Reports

Biochemical Properties of Highly Neuroinvasive Prion Strains

(2012) Cyrus Bett et al.   PLoS Pathogens

Use of Murine Bioassay to Resolve Ovine Transmissible Spongiform Encephalopathy Cases Showing a Bovine Spongiform Encephalopathy Molecular Profile

(2011) Katy E. Beck et al.   BRAIN PATHOLOGY

The Effects of Host Age on the Transport of Complement-Bound Complexes to the Spleen and the Pathogenesis of Intravenous Scrapie Infection

(2011) K. L. Brown et al.   JOURNAL OF VIROLOGY

Follicular Dendritic Cell-Specific Prion Protein (PrPc) Expression Alone Is Sufficient to Sustain Prion Infection in the Spleen

(2011) Laura McCulloch et al.   PLoS Pathogens

Endogenous Proteolytic Cleavage of Disease-associated Prion Protein to Produce C2 Fragments Is Strongly Cell- and Tissue-dependent

(2010) Michel Dron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coinfecting Prion Strains Compete for a Limiting Cellular Resource

(2010) R. A. Shikiya et al.   JOURNAL OF VIROLOGY

B cell follicles and antigen encounters of the third kind

(2010) Jason G Cyster   NATURE IMMUNOLOGY

Marked influence of the route of infection on prion strain apparent phenotype in a scrapie transgenic mouse model

(2010) Christelle Langevin et al.   NEUROBIOLOGY OF DISEASE

Prions of Ruminants Show Distinct Splenotropisms in an Ovine Transgenic Mouse Model

(2010) Thierry Baron et al.   PLoS One

Prion Strain Mutation Determined by Prion Protein Conformational Compatibility and Primary Structure

(2010) R. C. Angers et al.   SCIENCE

The Physical Relationship between Infectivity and Prion Protein Aggregates Is Strain-Dependent

(2010) Philippe Tixador et al.   PLoS Pathogens

Glycosylation-related gene expression profiling in the brain and spleen of scrapie-affected mouse

(2009) F. Guillerme-Bosselut et al.   GLYCOBIOLOGY

The Effects of Host Age on Follicular Dendritic Cell Status Dramatically Impair Scrapie Agent Neuroinvasion in Aged Mice

(2009) K. L. Brown et al.   JOURNAL OF IMMUNOLOGY

Prominent and Persistent Extraneural Infection in Human PrP Transgenic Mice Infected with Variant CJD

(2008) Vincent Béringue et al.   PLoS One

Prion agent diversity and species barrier

(2008) Vincent Béringue et al.   VETERINARY RESEARCH

A C-Terminal Protease-Resistant Prion Fragment Distinguishes Ovine “CH1641-Like” Scrapie from Bovine Classical and L-Type BSE in Ovine Transgenic Mice

(2008) Thierry Baron et al.   PLoS Pathogens

Beyond PrPres Type 1/Type 2 Dichotomy in Creutzfeldt-Jakob Disease

(2008) Emmanuelle Uro-Coste et al.   PLoS Pathogens