Disruption of the ERLIN–TM6SF2–APOB complex destabilizes APOB and contributes to non-alcoholic fatty liver disease

Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P2 and extended synaptotagmins

(2019) Jian Xiao et al.   Science China-Life Sciences

Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing

(2019) Liang Chen et al.   JOURNAL OF LIPID RESEARCH

Regulation of glucose and lipid metabolism in health and disease

(2019) Ligong Chen et al.   Science China-Life Sciences

The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids

(2019) Sebastian Prill et al.   Scientific Reports

Mechanisms and regulation of cholesterol homeostasis

(2019) Jie Luo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolic Features of Nonalcoholic Fatty Liver (NAFL) in Obese Adolescents: Findings from a Multi-ethnic Cohort

(2018) Domenico Tricò et al.   HEPATOLOGY

ALIMA1variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption

(2018) Ying-Yu Zhang et al.   SCIENCE

Risk of Hepatocellular Cancer in Patients With Non-Alcoholic Fatty Liver Disease

(2018) Fasiha Kanwal et al.   GASTROENTEROLOGY

Hepatic Tm6sf2 overexpression affects cellular ApoB-trafficking, plasma lipid levels, hepatic steatosis and atherosclerosis

(2017) Nicole Ehrhardt et al.   HUMAN MOLECULAR GENETICS

Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD

(2017) Panu K. Luukkonen et al.   JOURNAL OF HEPATOLOGY

Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation

(2017) Yong-Jian Wang et al.   NATURE CELL BIOLOGY

Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci

(2017) Stefan Stender et al.   NATURE GENETICS

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Hepatic Transmembrane 6 Superfamily Member 2 Regulates Cholesterol Metabolism in Mice

(2016) Yanbo Fan et al.   GASTROENTEROLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

The rs2294918 E434K variant modulates patatin-like phospholipase domain-containing 3 expression and liver damage

(2016) Benedetta Donati et al.   HEPATOLOGY

Inactivation ofTm6sf2, a Gene Defective in Fatty Liver Disease, Impairs Lipidation but Not Secretion of Very Low Density Lipoproteins

(2016) Eriks Smagris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Additive Effects of the Risk Alleles of PNPLA3 and TM6SF2 on Non-alcoholic Fatty Liver Disease (NAFLD) in a Chinese Population

(2016) Xiaoliang Wang et al.   Frontiers in Genetics

Nonalcoholic fatty liver disease: A precursor of the metabolic syndrome

(2015) Amedeo Lonardo et al.   DIGESTIVE AND LIVER DISEASE

Role of TM6SF2 rs58542926 in the pathogenesis of nonalcoholic pediatric fatty liver disease: A multiethnic study

(2015) Martina Goffredo et al.   HEPATOLOGY

Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease

(2015) Paola Dongiovanni et al.   HEPATOLOGY

Genetic analysis of nonalcoholic fatty liver disease within a Caribbean-Hispanic population

(2015) Deborah Edelman et al.   Molecular Genetics & Genomic Medicine

Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk

(2014) Oddgeir L Holmen et al.   NATURE GENETICS

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

(2014) Julia Kozlitina et al.   NATURE GENETICS

TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content

(2014) H. Mahdessian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome

(2014) Hannele Yki-Järvinen   Lancet Diabetes & Endocrinology

The ERLIN1-CHUK-CWF19L1 gene cluster influences liver fat deposition and hepatic inflammation in the NHLBI Family Heart Study

(2013) Mary F. Feitosa et al.   ATHEROSCLEROSIS

Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis

(2013) Michael D. Huber et al.   JOURNAL OF CELL BIOLOGY

Ablation of gp78 in Liver Improves Hyperlipidemia and Insulin Resistance by Inhibiting SREBP to Decrease Lipid Biosynthesis

(2012) Tong-Fei Liu et al.   Cell Metabolism

NAFLD in the Absence of Metabolic Syndrome: Different Epidemiology, Pathogenetic Mechanisms, Risk Factors for Disease Progression?

(2012) Yusuf Yilmaz   SEMINARS IN LIVER DISEASE

Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques

(2011) Jing-Jie Tang et al.   Cell Metabolism

Membrane-associated Ubiquitin Ligase Complex Containing gp78 Mediates Sterol-accelerated Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase

(2011) Youngah Jo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apolipoprotein B Knockdown by AAV-delivered shRNA Lowers Plasma Cholesterol in Mice

(2011) Annemart Koornneef et al.   MOLECULAR THERAPY

Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits

(2011) Elizabeth K. Speliotes et al.   PLoS Genetics

An Endoplasmic Reticulum (ER) Membrane Complex Composed of SPFH1 and SPFH2 Mediates the ER-associated Degradation of Inositol 1,4,5-Trisphosphate Receptors

(2009) Margaret M. P. Pearce et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Cholesterol Absorption Inhibitor Ezetimibe Acts by Blocking the Sterol-Induced Internalization of NPC1L1

(2008) Liang Ge et al.   Cell Metabolism

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS