Quorum sensing via dynamic cytokine signaling comprehensively explains divergent patterns of effector choice among helper T cells

Quorum Regulation via Nested Antagonistic Feedback Circuits Mediated by the Receptors CD28 and CTLA-4 Confers Robustness to T Cell Population Dynamics

(2020) Simon Zenke et al.   IMMUNITY

Immunity as a continuum of archetypes

(2019) Adriana M. Mujal et al.   SCIENCE

Distributed Adaptive Search in T Cells: Lessons From Ants

(2019) Melanie E. Moses et al.   Frontiers in Immunology

Termination of T cell priming relies on a phase of unresponsiveness promoting disengagement from APCs and T cell division

(2018) Armelle Bohineust et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of CD4 T cell memory by local cellular collectivity

(2018) Michal Polonsky et al.   SCIENCE

Switching between individual and collective motility in B lymphocytes is controlled by cell-matrix adhesion and inter-cellular interactions

(2018) Javier Rey-Barroso et al.   Scientific Reports

Does T Cell Activation Require a Quorum of Lymphocytes?

(2018) Ghassan A. Al-Yassin et al.   JOURNAL OF IMMUNOLOGY

Gene expression variability across cells and species shapes innate immunity

(2018) Tzachi Hagai et al.   NATURE

A Tunable Diffusion-Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell-to-Cell Communication in the Immune System

(2017) Alon Oyler-Yaniv et al.   IMMUNITY

Immune Signaling Networks: Sources of Robustness and Constrained Evolvability during Coevolution

(2017) Edward C Schrom et al.   MOLECULAR BIOLOGY AND EVOLUTION

Diverse continuum of CD4+T-cell states is determined by hierarchical additive integration of cytokine signals

(2017) Inbal Eizenberg-Magar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variability in individual assessment behaviour and its implications for collective decision-making

(2017) Thomas A. O'Shea-Wheller et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Optimal information transfer and stochastic resonance in collective decision making

(2017) Bernd Meyer   Swarm Intelligence

Toxoplasma Co-infection Prevents Th2 Differentiation and Leads to a Helminth-Specific Th1 Response

(2017) Norus Ahmed et al.   Frontiers in Cellular and Infection Microbiology

Regulation of the host immune system by helminth parasites

(2016) Rick M. Maizels et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Helminth-microparasite co-infection in wildlife: lessons from ruminants, rodents and rabbits

(2016) V. O. Ezenwa   PARASITE IMMUNOLOGY

The Dendritic Cell Synapse: A Life Dedicated to T Cell Activation

(2016) Federica Benvenuti   Frontiers in Immunology

Revealing the hidden networks of interaction in mobile animal groups allows prediction of complex behavioral contagion

(2015) Sara Brin Rosenthal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Minimal Regulatory Network of Extrinsic and Intrinsic Factors Recovers Observed Patterns of CD4+ T Cell Differentiation and Plasticity

(2015) Mariana Esther Martinez-Sanchez et al.   PLoS Computational Biology

Three-Dimensional Gradients of Cytokine Signaling between T Cells

(2015) Kevin Thurley et al.   PLoS Computational Biology

IFNγ and IL-12 Restrict Th2 Responses during Helminth/Plasmodium Co-Infection and Promote IFNγ from Th2 Cells

(2015) Stephanie M. Coomes et al.   PLoS Pathogens

Collective sensing and collective responses in quorum-sensing bacteria

(2014) R. Popat et al.   Journal of the Royal Society Interface

Functional heterogeneity of human memory CD4+ T cell clones primed by pathogens or vaccines

(2014) S. Becattini et al.   SCIENCE

Tailored Immune Responses: Novel Effector Helper T Cell Subsets in Protective Immunity

(2014) Ervin E. Kara et al.   PLoS Pathogens

Th1/Th2 Paradigm Extended: Macrophage Polarization as an Unappreciated Pathogen-Driven Escape Mechanism?

(2014) Eric Muraille et al.   Frontiers in Immunology

A Mechanism for Value-Sensitive Decision-Making

(2013) Darren Pais et al.   PLoS One

Stochastic Cytokine Expression Induces Mixed T Helper Cell States

(2013) Miaoqing Fang et al.   PLOS BIOLOGY

Mapping Differentiation under Mixed Culture Conditions Reveals a Tunable Continuum of T Cell Fates

(2013) Yaron E. Antebi et al.   PLOS BIOLOGY

Stable T-bet+GATA-3+ Th1/Th2 Hybrid Cells Arise In Vivo, Can Develop Directly from Naive Precursors, and Limit Immunopathologic Inflammation

(2013) Michael Peine et al.   PLOS BIOLOGY

How many dendritic cells are required to initiate a T-cell response?

(2012) S. Celli et al.   BLOOD

Clinical Impact of Different Classes of Infiltrating T Cytotoxic and Helper Cells (Th1, Th2, Treg, Th17) in Patients with Colorectal Cancer

(2011) Marie Tosolini et al.   CANCER RESEARCH

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

Mammalian Genes Are Transcribed with Widely Different Bursting Kinetics

(2011) D. M. Suter et al.   SCIENCE

Stop Signals Provide Cross Inhibition in Collective Decision-Making by Honeybee Swarms

(2011) T. D. Seeley et al.   SCIENCE

Dynamic Analysis of Stochastic Transcription Cycles

(2011) Claire V. Harper et al.   PLOS BIOLOGY

Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving

(2010) Qing Han et al.   LAB ON A CHIP

Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response

(2010) Ofer Feinerman et al.   Molecular Systems Biology

Sustained signaling by canonical helper T cell cytokines throughout the reactive lymph node

(2010) Georgia Perona-Wright et al.   NATURE IMMUNOLOGY

Heterogeneity and plasticity of T helper cells

(2009) Jinfang Zhu et al.   CELL RESEARCH

Plasticity of CD4+ T Cell Lineage Differentiation

(2009) Liang Zhou et al.   IMMUNITY

From the two-dimensional Th1 and Th2 phenotypes to high-dimensional models for gene regulation

(2008) Henk-Jan van den Ham et al.   INTERNATIONAL IMMUNOLOGY

Variability and Robustness in T Cell Activation from Regulated Heterogeneity in Protein Levels

(2008) O. Feinerman et al.   SCIENCE

Collective cognition in animal groups

(2008) Iain D. Couzin   TRENDS IN COGNITIVE SCIENCES