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Oncology
Michael McNicholas, Antonella De Cola, Zahedeh Bashardanesh, Amelia Foss, Cameron B. Lloyd, Steven Hebert, Damien Faury, Augusto Faria Andrade, Nada Jabado, Claudia L. Kleinman, Manav Pathania
Summary: Pediatric high-grade gliomas (pHGG) are heterogeneous brain tumors driven by clonal mutations in histone genes. We developed models representing 16 pHGG subtypes with different genetic alterations, which showed different treatment sensitivities and invasiveness. These models provide evidence for subtype-specific biology and therapeutic targeting in histone-mutant gliomas.
Article
Pharmacology & Pharmacy
Yudong Cao, Hecheng Zhu, Quan Chen, Hailong Huang, Dongcheng Xie, Xuewen Li, Xingjun Jiang, Caiping Ren, Jiahui Peng
Summary: This study constructed a novel signature composed of nine inflammation response-related genes to predict the prognosis, immune infiltration status, and potential drug targets in lower-grade glioma (LGG). This signature holds promise for screening prognostic biomarkers and guiding immunotherapy for LGG.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Katarzyna Sarad, Monika Stefanska, Izabela Kraszewska, Krzysztof Szade, Judith C. Sluimer, Przemyslaw Blyszczuk, Jozef Dulak, Agnieszka Jazwa-Kusior
Summary: This study analyzed the transcriptome of different Nrf2-deficient macrophage subpopulations from murine atherosclerotic aortas. The results showed that Nrf2 deficiency led to subtype-specific transcriptomic changes associated with inflammation, iron homeostasis, and cell injury or death pathways.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Dorothee Hoelzl, Georg Hutarew, Barbara Zellinger, Hans U. Schlicker, Christoph Schwartz, Peter A. Winkler, Karl Sotlar, Theo F. J. Kraus
Summary: This study found that PD-L1 is highly expressed in a subfraction of glioma cells with strong intertumoral variation. Additionally, PD-L1 expression was correlated with molecular glioma hallmarks, suggesting PD-L1 as a potential new marker in assessing gliomas and exploring novel therapeutic approaches.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Clinical Neurology
Lea M. Stitzlein, Achintyan Gangadharan, Leslie M. Walsh, Deokhwa Nam, Alexsandra B. Espejo, Melissa M. Singh, Kareena H. Patel, Yue Lu, Xiaoping Su, Ravesanker Ezhilarasan, Joy Gumin, Sanjay Singh, Erik Sulman, Frederick F. Lang, Joya Chandra
Summary: In this study, the efficacy of LSD1 inhibitors in patient-derived glioblastoma stem cell (GSC) models was evaluated. The results showed that LSD1 inhibitors had selective cytotoxic effects, but tumor regrowth occurred. Genes that may predict resistance to LSD1 inhibitors were identified using RNA-seq, providing guidance for future combination therapies.
FRONTIERS IN NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hannah Chatwin, Joselyn Cruz Cruz, Adam L. Green
Summary: Pediatric high-grade gliomas (pHGG) are a lethal and heterogenous category requiring more effective treatment options. The review discusses the history of treatment approaches to pHGG, different molecular subgroups of pHGG, targeted treatment options, and novel approaches such as localized convection-enhanced chemotherapy delivery and immunotherapy. It demonstrates the potential for molecularly driven therapy combined with other novel methods to improve prognosis in pHGG.
Article
Biology
Jnanendra Prasad Sarkar, Indrajit Saha, Anasua Sarkar, Ujjwal Maulik
Summary: Breast cancer is the second most common cancer type among females, and microRNAs play a crucial role in regulating gene expressions in the post-transcriptional phase. Through the use of Next Generation Sequencing techniques, significant miRNA biomarkers have been identified, and a Machine Learning approach has been proposed for feature selection and survival analysis.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Oncology
Bo Wang, Jiaxing Gan, Zhengyan Liu, Zhixuan Hui, Jinhui Wei, Xiaolian Gu, Yabing Mu, Guangxiang Zang
Summary: This study established the first organoid biobank with multiple subtypes of SGTs and identified subtype-specific biomarkers, revealing molecular differences among the subtypes of SGTs.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Immunology
Li Zhang, Xiaoyu Fang, Suhua Wang, Shasha Ma, Jinyan Zhang, Xiang Dong, Jing Dai, Chuanmiao Liu, Yu Gao
Summary: This study identified differentially expressed lncRNAs and mRNAs in patients with decompensated cirrhosis, revealing functional changes and potential pathways involved in the progression of the disease.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Hematology
Diana O. Treaba, Dennis M. Bonal, Anna Chorzalska, Mireia Castillo-Martin, Alissa Oakes, Makayla Pardo, Max Petersen, Christoph Schorl, Kelsey Hopkins, Dean Melcher, Ting C. Zhao, Olin Liang, Eui-Young So, John Reagan, Adam J. Olszewski, James Butera, Douglas C. Anthony, Peter Rintels, Peter Quesenberry, Patrycja M. Dubielecka
Summary: This study evaluated the impact of anthracycline- and cytarabine-based induction chemotherapy on the bone marrow microenvironment in acute myeloid leukemia (AML). Using RNA-seq and histological analysis, the researchers found distinct osteogenic and mesenchymal transcriptome profiles in responders and non-responders to chemotherapy. These findings provide valuable insights into the specific treatment response of AML and may inform optimized therapeutic strategies.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Oncology
Beata Szeitz, Zsolt Megyesfalvi, Nicole Woldmar, Zsuzsanna Valko, Anna Schwendenwein, Nandor Barany, Sandor Paku, Viktoria Laszlo, Helga Kiss, Edina Bugyik, Christian Lang, Attila Marcell Szasz, Luciana Pizzatti, Krisztina Bogos, Mir Alireza Hoda, Konrad Hoetzenecker, Gyorgy Marko-Varga, Peter Horvatovich, Balazs Dome, Karin Schelch, Melinda Rezeli
Summary: This study reveals the protein expression differences among subtypes of small-cell lung cancer (SCLC) and identifies potential subtype-specific therapeutic vulnerabilities and diagnostic biomarkers.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Anna L. V. Johansson, Cassia B. Trewin, Irma Fredriksson, Kristin V. Reinertsen, Hege Russnes, Giske Ursin
Summary: In breast cancer, the risk of death is influenced by factors such as IHC subtypes, grade, tumor size, and nodal status. Even with modern breast cancer treatment, stage, grade, and molecular subtype (reflected by IHC subtypes) continue to impact prognosis.
BREAST CANCER RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Shamaine Wei Ting Ho, Taotao Sheng, Manjie Xing, Wen Fong Ooi, Chang Xu, Raghav Sundar, Kie Kyon Huang, Zhimei Li, Vikrant Kumar, Kalpana Ramnarayanan, Feng Zhu, Supriya Srivastava, Zul Fazreen Bin Adam Isa, Chukwuemeka George Anene-Nzelu, Milad Razavi-Mohseni, Dustin Shigaki, Haoran Ma, Angie Lay Keng Tan, Xuewen Ong, Ming Hui Lee, Su Ting Tay, Yu Amanda Guo, Weitai Huang, Shang Li, Michael A. Beer, Roger Sik Yin Foo, Ming Teh, Anders Jacobsen Skanderup, Bin Tean Teh, Patrick Tan
Summary: This study derived and applied a consensus Mes-GC classifier to define the Mes-GC enhancer landscape, identifying the vulnerabilities of this subtype.
Article
Respiratory System
Cristina Baciu, Andrew Sage, Ricardo Zamel, Jason Shin, Xiao-Hui Bai, Olivia Hough, Mamatha Bhat, Jonathan C. Yeung, Marcelo Cypel, Shaf Keshavjee, Mingyao Liu
Summary: Gene expression profiling revealed distinguishable biological transcriptome signatures in DBD and DCD lungs, with DBD lungs showing upregulation of inflammatory pathways and DCD lungs displaying transcriptome signatures associated with cell death. Specific drug targets for rehabilitating DBD lungs were identified, and activation of certain signaling pathways were observed in EVLP-treated DBD lungs.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Plant Sciences
Federico Apelt, Eleni Mavrothalassiti, Saurabh Gupta, Frank Machin, Justyna Jadwiga Olas, Maria Grazia Annunziata, Dana Schindelasch, Friedrich Kragler
Summary: This study used single-cell RNA sequencing to investigate the roots and above-ground tissues of Arabidopsis, revealing marker genes, differences and similarities in cell types, and transcriptome changes throughout the day.
Review
Biochemistry & Molecular Biology
Benjamin D. Landry, David C. Clarke, Michael J. Lee
JOURNAL OF MOLECULAR BIOLOGY
(2015)
Editorial Material
Biochemistry & Molecular Biology
Michael J. Lee
Article
Biochemistry & Molecular Biology
Michael J. Lee, Albert S. Ye, Alexandra K. Gardino, Anne Margriet Heijink, Peter K. Sorger, Gavin MacBeath, Michael B. Yaffe
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Biochemistry & Molecular Biology
Michael J. Lee, Henrik G. Dohlman
Article
Biochemistry & Molecular Biology
Matthew P. Torres, Michael J. Lee, Feng Ding, Carrie Purbeck, Brian Kuhlman, Nikolay V. Dokholyan, Henrik G. Dohlman
JOURNAL OF BIOLOGICAL CHEMISTRY
(2009)
Article
Biochemistry & Molecular Biology
Andrea R. Tentner, Michael J. Lee, Gerry J. Ostheimer, Leona D. Samson, Douglas A. Lauffenburger, Michael B. Yaffe
MOLECULAR SYSTEMS BIOLOGY
(2012)
Article
Biochemistry & Molecular Biology
Benjamin D. Landry, Thomas Leete, Ryan Richards, Peter Cruz-Gordillo, Hannah R. Schwartz, Megan E. Honeywell, Gary Ren, Alyssa D. Schwartz, Shelly R. Peyton, Michael J. Lee
MOLECULAR SYSTEMS BIOLOGY
(2018)
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Multidisciplinary Sciences
Scott R. Floyd, Michael E. Pacold, Qiuying Huang, Scott M. Clarke, Fred C. Lam, Ian G. Cannell, Bryan D. Bryson, Jonathan Rameseder, Michael J. Lee, Emily J. Blake, Anna Fydrych, Richard Ho, Benjamin A. Greenberger, Grace C. Chen, Amanda Maffa, Amanda M. Del Rosario, David E. Root, Anne E. Carpenter, William C. Hahn, David M. Sabatini, Clark C. Chen, Forest M. White, James E. Bradner, Michael B. Yaffe
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Biochemistry & Molecular Biology
Stephen W. Morton, Michael J. Lee, Zhou J. Deng, Erik C. Dreaden, Elise Siouve, Kevin E. Shopsowitz, Nisarg J. Shah, Michael B. Yaffe, Paula T. Hammond
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Cell Biology
Anne Margriet Heijink, Marieke Everts, Megan E. Honeywell, Ryan Richards, Yannick P. Kok, Elisabeth G. E. de Vries, Michael J. Lee, Marcel A. T. M. van Vugt
Article
Oncology
Asia N. Matthew-Onabanjo, Jenny Janusis, Jose Mercado-Matos, Anne E. Carlisle, Dohoon Kim, Fayola Levine, Peter Cruz-Gordillo, Ryan Richards, Michael J. Lee, Leslie M. Shaw
Article
Biochemistry & Molecular Biology
Ryan Richards, Hannah R. Schwartz, Megan E. Honeywell, Mariah S. Stewart, Peter Cruz-Gordillo, Anna J. Joyce, Benjamin D. Landry, Michael J. Lee
NATURE CHEMICAL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Peter Cruz-Gordillo, Megan E. Honeywell, Nicholas W. Harper, Thomas Leete, Michael J. Lee
Article
Biochemistry & Molecular Biology
YQ Wang, LA Marotti, MJ Lee, HG Dohlman
JOURNAL OF BIOLOGICAL CHEMISTRY
(2005)