Review
Oncology
Takamasa Koga, Kenichi Suda, Tetsuya Mitsudomi
Summary: Ba/F3 cell line is a valuable tool for studying drug resistance and evaluating the efficacy of molecular targeted drugs. Ba/F3 models can help comprehensively identify potential mutations that induce resistance and explore drugs that can overcome resistance.
Article
Endocrinology & Metabolism
Johana Coronel, Jianshi Yu, Nageswara Pilli, Maureen A. Kane, Jaume Amengual
Summary: The over-expression of BCO1 through delivery of an AT-AAV-BCO1 leads to the conversion of f3-carotene to vitamin A in adipocytes, which subsequently results in the reduction of adiposity.
MOLECULAR METABOLISM
(2022)
Review
Plant Sciences
Peiyu Xue, Guangjie Zhang, Jie Zhang, Li Ren
Summary: EA exhibits synergistic effects in radiotherapy/chemotherapy for the treatment of cancers and exerts a great potential in reducing the side effects of chemotherapy and radiotherapy due to its biological activities, such as antioxidant and anti-inflammatory activities.
Review
Biochemistry & Molecular Biology
Simona Aleksandrova, Ralitza Alexova, Stela Dragomanova, Reni Kalfin, Ferdinando Nicoletti, Paolo Fagone, Maria Cristina Petralia, Katia Mangano, Lyubka Tancheva
Summary: Pomegranate is a polyphenol-rich food and medicinal plant that contains various beneficial compounds. Studies have shown that these compounds can target brain cells and support their functions by regulating redox balance, proliferation, and survival. The neuroprotective effects of pomegranate are mediated by its antioxidant and anti-inflammatory properties, ability to activate signaling pathways, and regulation of mitochondrial damage. In vitro and in vivo studies have demonstrated that pomegranate polyphenols can directly affect neuronal and glial cells, as well as influence blood-brain barrier function and increase blood flow to the brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Multidisciplinary
Ze-Rui Sun, Hua-Rong Liu, Di Hu, Mao-Si Fan, Ming-Yue Wang, Meng-Fei An, Yun-Li Zhao, Ze-Min Xiang, Jun Sheng
Summary: Ellagic acid (EA) has been shown to effectively regulate hyperuricemia by inhibiting xanthine oxidase and superoxide anion, reducing uric acid levels through the NLRP3 signaling pathway, and improving histopathology in animal models.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Hermizi Hapidin, Nor Munira Hashim, Mohamad Zahid Kasiram, Hasmah Abdullah
Summary: This study investigates the effect of combining tannic acid with pamidronate on human osteoblast cells. The combination treatment showed synergistic effects, promoting osteoblast proliferation and mineralization, as well as increasing the expression of bone-specific proteins and genes.
Review
Biochemistry & Molecular Biology
Heyu Zhu, Yuanmei Yan, Yi Jiang, Xianfang Meng
Summary: This article reviews the biochemical functions and neuroprotective effects of ellagic acid (EA), demonstrating its clinical value and potential therapeutic benefits for neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and cerebral ischemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Federica Mannino, Chiara Imbesi, Alessandra Bitto, Letteria Minutoli, Francesco Squadrito, Tommaso D'Angelo, Christian Booz, Giovanni Pallio, Natasha Irrera
Summary: Cardiac fibrosis is characterized by excessive deposition of extracellular matrix and increased collagen production, mainly caused by activation of cardiac fibroblasts. Oxidative stress and TGF-01 signaling play important roles in the pathogenesis of cardiac fibrosis. Ellagic acid (EA) and punicic acid (PA) have been shown to have antioxidant, anti-inflammatory and anti-fibrotic effects. In this study, EA and PA were found to reduce pro-fibrotic protein expression and intracellular reactive oxygen species accumulation, inhibit NF-xB pathway, and reduce cytokine levels. Combination of EA and PA had a greater inhibitory effect. These findings suggest that EA, PA, and especially EA+PA, may be effective in reducing fibrosis through antioxidant and anti-inflammatory mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Fabian Stahl, Philip Denner, Dominik Piston, Bernd O. Evert, Laura de Boni, Ina Schmitt, Peter Breuer, Ullrich Wuellner
Summary: Regulation of SNCA expression may be a potential target for Parkinson's disease treatment, and three selective activators have been identified that increase SNCA mRNA and protein levels.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Tae-Young Gil, Chul-Hee Hong, Hyo-Jin An
Summary: Atopic dermatitis is a chronic inflammatory skin disease with no fully effective therapeutic agents. Ellagic acid, a natural compound with anti-inflammatory properties, has shown potential as an alternative treatment for atopic dermatitis by regulating inflammatory signaling pathways and improving skin lesions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
David Shorthouse, Jenna Bradley, Susan E. Critchlow, Claus Bendtsen, Benjamin A. Hall
Summary: The understanding of cellular metabolism in cancer is still in its early stages. Genetic alterations associated with cancer may lead to changes in cellular metabolism, which can provide insight into phenotypic changes, identify detectable metabolic patterns, and reveal vulnerabilities to specific drugs. By analyzing the metabolites of 173 different cancer cell lines from 11 tissues, we were able to correlate known cancer-associated mutations and gene expression programs with metabolic signatures, establishing new connections between known metabolic pathways and cancer driver genes. We also discovered that metabolic activity is correlated with drug sensitivity, allowing us to predict drug response and synergy based on metabolic activity. Additionally, we investigated the metabolic heterogeneity of cancer mutations across tissues and found a range of context-specific and more general metabolic control in genes.
MOLECULAR SYSTEMS BIOLOGY
(2022)
Article
Nutrition & Dietetics
Bartosz Fotschki, Jerzy Juskiewicz, Adam Jurgonski, Michal Sojka
Summary: The study found that the combination of raspberry polyphenolic extract (RE) with fructo-oligosaccharides (FOSs) or pectins (PECs) reduced the production of short-chain fatty acids in the caecum and had favorable effects on liver lipid metabolism by decreasing liver fat, cholesterol, and triglyceride content, as well as hepatic steatosis. RE and FOSs also reduced inflammatory cell infiltration and IL-6 plasma levels. The most effective dietary treatment in regulating liver lipid metabolism and inflammation induced by an obesogenic diet was found to be the combination of RE with FOSs.
Article
Pharmacology & Pharmacy
Shilpa Mohanty, Amit Chand Gupta, Anil Kumar Maurya, Karuna Shanker, Anirban Pal, Dnyaneshwar Umrao Bawankule
Summary: The study demonstrates that ellagic acid has a mitigating effect on severe malaria pathogenesis by reducing cytokine storms and oxidative stress induced by malarial parasites. Additionally, it shows promising anti-malarial activity and helps improve blood glucose and hemoglobin levels in treated mice. These findings suggest the suitability of ellagic acid as a useful bioflavonoid for further study in managing severe malaria pathogenesis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Aliaa H. Ashoub, Doaa H. Abdel-Naby, Marwa M. Safar, Mona A. El-Ghazaly, Sanaa A. Kenawy
Summary: Nicotine exposure can lead to testicular toxicity and hormonal changes in rats, but treatment with fractionated low-dose radiation and ellagic acid can alleviate these negative effects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Skyler H. Hoang, Hue Dao, Emerson My Lam
Summary: Ellagic acid (EA) is a natural polyphenolic compound found in various fruits and vegetables. It has antioxidant properties and potential health benefits. This study used a network pharmacology approach to investigate the anti-inflammatory properties of EA. Through analysis of inflammation-related targets, signaling pathways, and molecular docking simulations, the study confirmed the anti-inflammatory effects of EA and identified the most probable targets.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Correction
Physiology
Qingqing Liang, Ming Lv, Xiaojuan Zhang, Jun Hu, Ying Wu, Yewei Huang, Xuanjun Wang, Jun Sheng
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Cheng-Ting Zi, Pei-Yuan Sun, Ning Zhang, Han Tang, Hao-Nang Yang, Qi Wang, Yu-Na Wang, Jing Wang, Xuan-Jun Wang, Jun Sheng
JOURNAL OF CHEMICAL RESEARCH
(2020)
Correction
Pharmacology & Pharmacy
Qi Wang, Cheng-Ting Zi, Jing Wang, Yu-Na Wang, Ye-Wei Huang, Xue-Qi Fu, Xuan-Jun Wang, Jun Sheng
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Plant Sciences
Cheng-Ting Zi, Liu Yang, Yue Hu, Pan Zhang, Han Tang, Bang-Lei Zhang, Xiao-Jing Shen, Qing-Hua Kong, Ya Wang, Xuan-Jun Wang, Jun Sheng
Summary: Two new (-)-epigallocatechin-3-gallate-4 beta-triazolopodophyllotoxin conjugates (7 and 8) were synthesized and evaluated for biological activity. Compound 8 showed highly potent anticancer activity against A-549 cell line with the highest selectivity index value (SI = 14.5) in A-549 cells, indicating its potential as a promising candidate for further development.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2021)
Article
Medicine, Research & Experimental
Huanhuan Xu, Litian Wang, Boya Shi, Lihong Hu, Chunxia Gan, Ya Wang, Zemin Xiang, Xuanjun Wang, Jun Sheng
BIOMEDICINE & PHARMACOTHERAPY
(2020)
Article
Biochemistry & Molecular Biology
Fujun Miao, Chunlan Shan, Syed Aftab Hussain Shah, Rana Waseem Akhtar, Xuanjun Wang, Delu Ning
Summary: The study found that walnut oil has antioxidant, anti-inflammatory, immune-enhancing, and gut microbiota regulation effects in mice, reducing oxidative stress, inflammation, and promoting beneficial gut bacteria.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Food Science & Technology
Fujun Miao, Chunlan Shan, Syed Aftab Hussain Shah, Rana Waseem Akhtar, Shuxiang Geng, Delu Ning, Xuanjun Wang
Summary: Walnut oil has protective effects on LPS-induced acute intestinal injury by reducing inflammatory cytokine levels, increasing antioxidant enzyme levels, and inhibiting the TLR4/NF-kappa B signaling pathway.
FOOD SCIENCE & NUTRITION
(2021)
Article
Immunology
Fujun Miao, Chunlan Shan, Ting Ma, Shuxiang Geng, Delu Ning
Summary: The study found that walnut oil has anti-inflammatory effects on DSS-induced colitis in mice by inhibiting NLRP3 inflammasome activation and modulating gut microbiota, improving pathological morphology, reducing oxidative stress, inflammation, and apoptosis, shifting microbiota towards probiotics, and increasing short-chain fatty acids levels.
MICROBIAL PATHOGENESIS
(2021)
Article
Biochemistry & Molecular Biology
Fujun Miao, Chunlan Shan, Delu Ning
Summary: The study demonstrated that walnut oil has anti-inflammatory effects on LPS-induced intestinal injury by inhibiting the TLR4/MyD88/NF-kappa B pathway activation, ameliorating pathological morphology, inhibiting cell apoptosis, and down-regulating the expression of pro-inflammatory cytokines. These findings suggest walnut oil could be a potential candidate in the treatment of inflammatory bowel diseases and in functional food formulations.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Nutrition & Dietetics
Fujun Miao
Summary: Hydroxytyrosol exerts anti-inflammatory effects in a model of ulcerative colitis by enhancing colonic antioxidant capacities, inhibiting NLRP3 inflammasome activation, and modulating gut microbiota.
Article
Agriculture, Dairy & Animal Science
Chunlan Shan, Fujun Miao
Summary: Hydroxytyrosol (HT), an important olive component, has immunomodulatory and antioxidant effects, enhancing immunity and antioxidant activities in the local mucosa of small intestines in broilers.
Article
Agriculture, Dairy & Animal Science
Fujun Miao, Chunlan Shan, Shuxiang Geng, Delu Ning
Summary: This study aimed to investigate the ameliorative effect of oleocanthal (OC) on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in chickens and its possible mechanisms. The results showed that OC treatment improved the pathological morphology and suppressed apoptosis in LPS-induced ALI chickens. OC supplementation also enhanced antioxidant capacity and inhibited the activation of the toll-like receptor 4/nuclear factor-kappa B (TLR4/NF-κB) pathway in LPS group. Overall, OC supplementation can alleviate LPS-induced ALI in chickens by suppressing apoptosis, enhancing lung antioxidant capacities, and inhibiting TLR4/NF-κB pathway activation.
Article
Chemistry, Multidisciplinary
Yu-Na Wang, Jing Wang, Hao-Nan Yang, Bang-Lei Zhang, Pan Zhang, Pei-Yuan Sun, Nin Zhang, Ya Wang, Jun Sheng, Xuan-Jun Wang, Cheng-Ting Zi
Article
Oncology
Masashi Nishimura, Yoshifumi Kimizuka, Takunori Ogawa, Motohiro Tsuchiya, Yoshiki Kato, Akira Matsukida, Shunya Igarashi, Koki Ito, Yusuke Serizawa, Tomomi Tanigaki, Yuji Fujikura, Yuka Katsurada, Sho Ogata, Akihiko Kawana
Summary: This study reports a case of IgG4-related retroperitoneal fibrosis occurring after chemotherapy. The patient showed improvement after discontinuing immunotherapy and receiving steroid treatment.
Article
Oncology
Yuta Ohishi, Yoko Nakanishi, Yukari Hirotani, Atsuko Suzuki, Tomoyuki Tanino, Haruna Nishimaki-Watanabe, Hiroko Kobayashi, Fumi Nozaki, Sumie Ohni, Xiaoyan Tang, Kentaro Hayashi, Yoshiko Nakagawa, Tetsuo Shimizu, Ichiro Tsujino, Noriaki Takahashi, Yasuhiro Gon, Shinobu Masuda
Summary: This study aimed to investigate the clinicopathological differences and therapeutic response of NSCLC patients with SDC4::ROS1 fusion to crizotinib. The study found that different ROS1 fusion partners may affect the efficacy of crizotinib and patient prognosis. In addition, higher expression levels of ROS1 and pERK1/2 in tumor cells of case 2 may be related to the therapeutic response and prognosis.
Review
Oncology
Zitong Zheng, Juanjuan Liu, Junling Ma, Runting Kang, Zhen Liu, Jiangyong Yu
Summary: Small cell lung cancer (SCLC) is a highly aggressive malignancy with limited treatment options. Over the past decade, immunotherapy has made progress in the treatment of SCLC, but current immune checkpoint inhibitors have limited benefits for patient survival. Therefore, it is important to explore new targets and develop drugs with novel mechanisms for immunotherapy in SCLC.
Article
Oncology
Kazuto Sugai, Kojiro Nakaoka, Rika Tobita, Shinji Kikuchi, Kei Inoue, Midori Enokido, Moriyuki Kiyoshima
Summary: This article presents a case of multilocular mediastinal cyst leading to the development of thymic cancer. Resection of multilocular anterior mediastinal cysts should be considered due to the challenges in preoperative diagnosis, the potential for coexisting tumors with cysts, and the risk of malignant tumor development.