Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia

Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain

(2019) Lihong Zhan et al.   PLOS BIOLOGY

Progranulin Stimulates the In Vitro Maturation of Pro-Cathepsin D at Acidic pH

(2019) Victoria J. Butler et al.   JOURNAL OF MOLECULAR BIOLOGY

Coupling APEX labeling to imaging mass spectrometry of single organelles reveals heterogeneity in lysosomal protein turnover

(2019) Derek P. Narendra et al.   JOURNAL OF CELL BIOLOGY

Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis

(2018) Andrew E. Arrant et al.   JOURNAL OF NEUROSCIENCE

Microglia-targeted candidates push the Alzheimer drug envelope

(2018) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice

(2018) Julia K. Götzl et al.   Molecular Neurodegeneration

AAV-Mediated Progranulin Delivery to a Mouse Model of Progranulin Deficiency Causes T Cell-Mediated Toxicity

(2018) Defne A. Amado et al.   MOLECULAR THERAPY

The Gene Ontology Resource: 20 years and still GOing strong

(2018)   NUCLEIC ACIDS RESEARCH

Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes

(2017) Yoshinori Tanaka et al.   HUMAN MOLECULAR GENETICS

Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients

(2017) Clarissa Valdez et al.   HUMAN MOLECULAR GENETICS

Microglia in Alzheimer’s disease

(2017) Heela Sarlus et al.   JOURNAL OF CLINICAL INVESTIGATION

Microglial NFκB-TNFα hyperactivation induces obsessive–compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia

(2017) Grietje Krabbe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis

(2017) Michael E. Ward et al.   Science Translational Medicine

Modifiers of GRN -Associated Frontotemporal Lobar Degeneration

(2017) Eline Wauters et al.   TRENDS IN MOLECULAR MEDICINE

Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution

(2017) Hansruedi Mathys et al.   Cell Reports

Autophagy and the Cell Cycle: A Complex Landscape

(2017) Søs Grønbæk Mathiassen et al.   Frontiers in Oncology

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

(2016) Hansen Lui et al.   CELL

Targeting microglia for the treatment of Alzheimer's Disease

(2016) Paul D. Wes et al.   GLIA

Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia

(2016) Christopher J. Holler et al.   Molecular Neurodegeneration

Suberoylanilide hydroxamic acid increases progranulin production in iPSC-derived cortical neurons of frontotemporal dementia patients

(2016) Sandra Almeida et al.   NEUROBIOLOGY OF AGING

Effects of the kappa opioid receptor antagonist nor-binaltorphimine (nor-BNI) on cocaine versus food choice and extended-access cocaine intake in rhesus monkeys

(2015) Blake A. Hutsell et al.   ADDICTION BIOLOGY

The kappa-opioid receptor antagonist, nor-binaltorphimine (nor-BNI), decreases morphine withdrawal and the consequent conditioned place aversion in rats

(2015) John E. Kelsey et al.   BEHAVIOURAL BRAIN RESEARCH

Inflammatory molecules in Frontotemporal Dementia: Cerebrospinal fluid signature of progranulin mutation carriers

(2015) D. Galimberti et al.   BRAIN BEHAVIOR AND IMMUNITY

Plasma levels of progranulin and interleukin-6 in frontotemporal lobar degeneration

(2015) Linda Gibbons et al.   NEUROBIOLOGY OF AGING

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Normalization of RNA-seq data using factor analysis of control genes or samples

(2014) Davide Risso et al.   NATURE BIOTECHNOLOGY

STRING v10: protein–protein interaction networks, integrated over the tree of life

(2014) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Autophagy-Mediated Tumor Promotion

(2013) Jessie Yanxiang Guo et al.   CELL

Improved Quenched Fluorescent Probe for Imaging of Cysteine Cathepsin Activity

(2013) Martijn Verdoes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury

(2012) Lauren Herl Martens et al.   JOURNAL OF CLINICAL INVESTIGATION

Versatile pathway-centric approach based on high-throughput sequencing to anticancer drug discovery

(2012) H. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suberoylanilide Hydroxamic Acid (Vorinostat) Up-regulates Progranulin Transcription

(2011) Basar Cenik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients

(2011) Paola Bossù et al.   Journal of Neuroinflammation

Alteration in cell cycle-related proteins in lymphoblasts from carriers of the c.709-1G>A PGRN mutation associated with FTLD-TDP dementia

(2011) Carolina Alquezar et al.   NEUROBIOLOGY OF AGING

Protective Effects of Positive Lysosomal Modulation in Alzheimer's Disease Transgenic Mouse Models

(2011) David Butler et al.   PLoS One

Progranulin expression in the developing and adult murine brain

(2010) Terri L. Petkau et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

(2009) Fangfang Yin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Dysphoric Component of Stress Is Encoded by Activation of the Dynorphin  -Opioid System

(2008) B. B. Land et al.   JOURNAL OF NEUROSCIENCE

Cyclic AMP decreases the production of NO and CCL2 by macrophages stimulated with Trypanosoma cruzi GPI-mucins

(2008) Andre Talvani et al.   PARASITOLOGY RESEARCH