Aβ-Degrading Proteases: Therapeutic Potential in Alzheimer Disease

Convection-Enhanced Delivery of Neprilysin: A Novel Amyloid-β-Degrading Therapeutic Strategy

(2018) Neil U. Barua et al.   JOURNAL OF ALZHEIMERS DISEASE

Therapeutic strategies for Alzheimer's disease in clinical trials

(2016) Justyna Godyń et al.   Pharmacological Reports

2015 Alzheimer's disease facts and figures

(2015)   Alzheimers & Dementia

Pharmacological Inhibition of BACE1 Impairs Synaptic Plasticity and Cognitive Functions

(2015) Severin Filser et al.   BIOLOGICAL PSYCHIATRY

Cognitive and Functional Decline in Patients With Mild Alzheimer Dementia With or Without Comorbid Diabetes

(2015) Haya Ascher-Svanum et al.   CLINICAL THERAPEUTICS

Neprilysin gene transfer: A promising therapeutic approach for Alzheimer's disease

(2015) Yuanli Li et al.   JOURNAL OF NEUROSCIENCE RESEARCH

An atomic structure of human γ-secretase

(2015) Xiao-chen Bai et al.   NATURE

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

Nerve Growth Factor Gene Therapy

(2015) Mark H. Tuszynski et al.   JAMA Neurology

Lessons from a Failed γ-Secretase Alzheimer Trial

(2014) Bart De Strooper   CELL

A Neuroprotective Brain-penetrating Endopeptidase Fusion Protein Ameliorates Alzheimer Disease Pathology and Restores Neurogenesis

(2014) Brian Spencer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the β secretase BACE1 for Alzheimer's disease therapy

(2014) Riqiang Yan et al.   LANCET NEUROLOGY

Contribution of Alzheimer disease to mortality in the United States

(2014) B. D. James et al.   NEUROLOGY

Aβ degradation—the inside story

(2014) Malcolm A. Leissring   Frontiers in Aging Neuroscience

New roles for Fc receptors in neurodegeneration-the impact on Immunotherapy for Alzheimer's Disease

(2014) James P. Fuller et al.   Frontiers in Neuroscience

Amyloid-beta isoform metabolism quantitation by stable isotope-labeled kinetics

(2013) Kwasi G. Mawuenyega et al.   ANALYTICAL BIOCHEMISTRY

Sustained peripheral depletion of amyloid-β with a novel form of neprilysin does not affect central levels of amyloid-β

(2013) Simon J. Henderson et al.   BRAIN

Optimization of Peptide Hydroxamate Inhibitors of Insulin-Degrading Enzyme Reveals Marked Substrate-Selectivity

(2013) Samer O. Abdul-Hay et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enhanced Proteolytic Clearance of Plasma A  by Peripherally Administered Neprilysin Does Not Result in Reduced Levels of Brain A  in Mice

(2013) J. R. Walker et al.   JOURNAL OF NEUROSCIENCE

Dual Cleavage of Neuregulin 1 Type III by BACE1 and ADAM17 Liberates Its EGF-Like Domain and Allows Paracrine Signaling

(2013) D. Fleck et al.   JOURNAL OF NEUROSCIENCE

Normal cognition in transgenic BRI2-Aβ mice

(2013) Jungsu Kim et al.   Molecular Neurodegeneration

Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice

(2013) Nobuhisa Iwata et al.   Scientific Reports

Regulation of distinct pools of amyloid β-protein by multiple cellular proteases

(2013) Malcolm A Leissring et al.   Alzheimers Research & Therapy

Presenilins and  -Secretase: Structure, Function, and Role in Alzheimer Disease

(2013) B. De Strooper et al.   Cold Spring Harbor Perspectives in Medicine

The Genetics of Alzheimer Disease

(2013) R. E. Tanzi   Cold Spring Harbor Perspectives in Medicine

Proteolytic Degradation of Amyloid  -Protein

(2013) T. Saido et al.   Cold Spring Harbor Perspectives in Medicine

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

(2012) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

Immunotherapy for Alzheimer disease—the challenge of adverse effects

(2012) Yu-Hui Liu et al.   Nature Reviews Neurology

γ-Secretase Substrates and their Implications for Drug Development in Alzheimer's Disease

(2011) Alberto Lleo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Peripheral Delivery of a CNS Targeted, Metalo-Protease Reduces Aβ Toxicity in a Mouse Model of Alzheimer's Disease

(2011) Brian Spencer et al.   PLoS One

The Transcriptionally Active Amyloid Precursor Protein (APP) Intracellular Domain Is Preferentially Produced from the 695 Isoform of APP in a β-Secretase-dependent Pathway

(2010) Nikolai D. Belyaev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circulating neprilysin clears brain amyloid

(2010) Yinxing Liu et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The secretases: enzymes with therapeutic potential in Alzheimer disease

(2010) Bart De Strooper et al.   Nature Reviews Neurology

Formulation of a Medical Food Cocktail for Alzheimer's Disease: Beneficial Effects on Cognition and Neuropathology in a Mouse Model of the Disease

(2010) Anna Parachikova et al.   PLoS One

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Neprilysin Overexpression Inhibits Plaque Formation But Fails to Reduce Pathogenic A  Oligomers and Associated Cognitive Deficits in Human Amyloid Precursor Protein Transgenic Mice

(2009) W. J. Meilandt et al.   JOURNAL OF NEUROSCIENCE

Expression of Neprilysin in Skeletal Muscle Reduces Amyloid Burden in a Transgenic Mouse Model of Alzheimer Disease

(2009) Yinxing Liu et al.   MOLECULAR THERAPY

Alzheimer's disease

(2009) Lennart Mucke   NATURE

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Aβ assembly forms throughout life

(2009) Ganesh M. Shankar et al.   NEUROBIOLOGY OF DISEASE

Small-Molecule Activators of Insulin-Degrading Enzyme Discovered through High-Throughput Compound Screening

(2009) Christelle Cabrol et al.   PLoS One

Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice

(2008) Brian Spencer et al.   BMC NEUROSCIENCE

BACE1 Structure and Function in Health and Alzheimers Disease

(2008) Sarah Cole et al.   Current Alzheimer Research

The AβCs of Aβ-cleaving Proteases

(2008) Malcolm A. Leissring   JOURNAL OF BIOLOGICAL CHEMISTRY

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET

Inhibition and modulation of γ-secretase for Alzheimer’s disease

(2008) Michael S. Wolfe   Neurotherapeutics

Enhanced clearance of A  in brain by sustaining the plasmin proteolysis cascade

(2008) J. S. Jacobsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA