Review
Cell Biology
Shusheng Wu, Longfei Du
Summary: Despite the differences between ischemic stroke and neurodegenerative diseases, they share similarities in terms of inflammation and oxidative stress. Protein aggregation plays a significant role in both conditions, but the mechanisms and prevention of protein aggregation after cerebral ischemia remain unclear.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Review
Food Science & Technology
Xinxin Chang, Yudan Wang, Bing Zheng, Yi Chen, Jianhua Xie, Yiming Song, Xiaomeng Ding, Xiaoyi Hu, Xiaobo Hu, Qiang Yu
Summary: Neurodegenerative diseases involve the loss of specific neurons, which is often caused by environmental pollutants like acrolein. Acrolein is highly active and contributes to oxidative stress, polyamine metabolism, and neuronal damage, thereby impacting the progression of neurodegenerative diseases.
Review
Medicine, Research & Experimental
Rahul Kumar, T. Amruthanjali, Siva Singothu, Shashi Bala Singh, Vasundhra Bhandari
Summary: Mitochondrial uncoupling proteins (UCP) play a critical role in regulating mitochondrial function and preventing neuronal loss and death, making them a potential therapeutic target for neurodegenerative diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Gianluca Antonio Franco, Livia Interdonato, Marika Cordaro, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: Neurodegenerative disorders are characterized by neuroinflammation, oxidative stress, and neuronal depletion, and there is currently no cure for these diseases. The Mediterranean diet, rich in antioxidants and omega-3 fatty acids, may have a protective effect on neurodegeneration. This review focuses on the therapeutic potential of natural products and the associations between the Mediterranean-style diet, neurodegenerative diseases, and markers and mechanisms of neurodegeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Shofiul Azam, Md Ezazul Haque, Rengasamy Balakrishnan, In-Su Kim, Dong-Kug Choi
Summary: Ageing is a natural process that leads to physiological deterioration and increased vulnerability to diseases. Neurodegenerative diseases like Alzheimer's and Parkinson's are closely associated with ageing, posing significant challenges and costs to individuals and society.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Prajakta Teli, Vaijayanti Kale, Anuradha Vaidya
Summary: This study investigates neurodegenerative diseases and establishes an in vitro neurodegenerative model system. The research shows that oxidative stress significantly affects neurite outgrowth and neuronal marker expression. Additionally, the conditioned medium derived from mesenchymal stromal cells (MSCs) can improve these abnormalities. The findings suggest the potential for MSC-derived secretome in reversing neurogenesis loss caused by oxidative stress.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Clinical Neurology
Diego Romero-Miguel, Nicolas Lamanna-Rama, Marta Casquero-Veiga, Vanessa Gomez-Rangel, Manuel Desco, Maria Luisa Soto-Montenegro
Summary: Minocycline has been shown to be effective in animal models, but clinical outcomes have shown discrepancies, with some studies showing positive results while others showing no significant improvements. Improving protocols and animal models could help determine the efficacy of minocycline in treating these diseases.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Cristina Solana-Manrique, Francisco Jose Sanz, Guillermo Martinez-Carrion, Nuria Paricio
Summary: Neurodegenerative diseases pose a significant challenge and burden to human health globally, and carnosine, a natural molecule, shows potential neuroprotective effects, particularly in the most common neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.
Article
Immunology
Yingying Nie, Jingming Yang, Longjian Zhou, Zhiyou Yang, Jinyue Liang, Yayue Liu, Xiaoxiang Ma, Zhongji Qian, Pengzhi Hong, Allan Kalueff, Cai Song, Yi Zhang
Summary: In this study, BTL-I was found to be a potential therapeutic agent for preventing CNS deficits caused by inflammation, neurotoxicity, and gut flora imbalance.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
Yue Han, Haiqiong Ye, Ping Li, Yifan Zeng, Jing Yang, Meng Gao, Zhengding Su, Yongqi Huang
Summary: Tau, a major microtubule-associated protein, can form liquid droplets. 14-3-3 zeta protein can be recruited into tau droplets and regulate their formation through electrostatic and hydrophobic interactions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Physical
T. B. Thompson, G. Meisl, T. P. J. Knowles, A. Goriely
Summary: The deposition of pathological protein aggregates in the brain plays a central role in cognitive decline and structural damage associated with neurodegenerative diseases. In vivo clearance mechanisms are believed to play an essential role in limiting the formation of aggregates and preventing disease emergence. Small variations in the efficiency of the clearance process can lead to a sudden shift from a healthy to a disease state.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Review
Pharmacology & Pharmacy
Ziqian Cheng, Chenglan Kang, Songtian Che, Jingyun Su, Qihan Sun, Tongtong Ge, Yi Guo, Jiayin Lv, Zhihui Sun, Wei Yang, Bingjin Li, Xin Li, Ranji Cui
Summary: Berberine, a natural alkaloid compound, has been studied for its effects on neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's. Current evidence shows that it can inhibit neuroinflammation, oxidative stress, and endoplasmic reticulum stress, reducing neuron damage and apoptosis. Further research is needed to fully understand the specific mechanisms involved.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Viorica Rarinca, Mircea Nicusor Nicoara, Dorel Ureche, Alin Ciobica
Summary: Oxidative stress occurs when there is an excess of reactive oxygen species in the body, leading to cell and tissue damage. Quercetin, a flavonoid compound found in vegetables and fruits, has been shown to have antioxidant, anticancer, and anti-inflammatory properties, with the potential to improve cognitive function and prevent neurodegenerative diseases. This review focuses on experimental studies supporting the neuroprotective effects of Quercetin in Alzheimer's disease, Parkinson's disease, Huntington's disease, and epilepsy.
Review
Biochemistry & Molecular Biology
Ricardo Pardillo-Diaz, Patricia Perez-Garcia, Carmen Castro, Pedro Nunez-Abades, Livia Carrascal
Summary: Neurodegenerative diseases are characterized by selective loss of neuronal systems and can be influenced by oxidative stress, inflammation, and increased neuronal excitability.
Review
Geriatrics & Gerontology
Virna Margarita Martin Gimenez, Natalia de las Heras, Vicente Lahera, Jesus A. F. Tresguerres, Russel J. Reiter, Walter Manucha
Summary: Aging is a gradual process that leads to increased vulnerability to weakness, disease, and death. It affects cellular, organ, and overall organism functions, resulting in various dysfunctions and impairments. Aging is associated with the development and progression of diseases, particularly in the cardiovascular and central nervous systems.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Ali Mohd Lone, Nawab John Dar, Abid Hamid, Wajaht Amin Shah, Muzamil Ahmad, Bilal A. Bhat
ACS CHEMICAL NEUROSCIENCE
(2016)
Review
Biochemistry & Molecular Biology
Nawab John Dar, Abid Hamid, Muzamil Ahmad
CELLULAR AND MOLECULAR LIFE SCIENCES
(2015)
Article
Neurosciences
Nawab John Dar, Javeed Ahmad Bhat, Naresh Kumar Satti, Parduman Raj Sharma, Abid Hamid, Muzamil Ahmad
MOLECULAR NEUROBIOLOGY
(2017)
Article
Neurosciences
Nawab John Dar, Naresh Kumar Satti, Prabhu Dutt, Abid Hamid, Muzamil Ahmad
MOLECULAR NEUROBIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Rauf Ahmad Najar, Nissar Ahmad Wani, Javeed Ahmad Bhat, Nawab John Dar, Beenish Rahat, Ajai Prakash Gupta, Jaspreet Kaur, Jyotdeep Kaur, Abid Hamid
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2018)
Article
Neurosciences
Muzamil Ahmad, Nawab J. Dar, Zubair S. Bhat, Aehtesham Hussain, Ayatullah Shah, Hao Liu, Steven H. Graham
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2014)
Review
Biochemistry & Molecular Biology
Nawab John Dar, Gordon W. Glazner
CELLULAR AND MOLECULAR LIFE SCIENCES
(2020)
Review
Plant Sciences
Nawab John Dar, MuzamilAhmad
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Liuji Chen, Nawab John Dar, Ren Na, Kirsten Danae McLane, Kwangsun Yoo, Xianlin Han, Qitao Ran
Summary: This study demonstrates that enhanced defense against ferroptosis can improve cognitive impairment and decrease neurodegeneration in AD mice. The findings support the notion that ferroptosis is a key contributor to AD pathogenesis.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Cell Biology
Nawab John Dar, Ren Na, Qitao Ran
Summary: This study suggests that the deficiency of lipid peroxidation defense contributes to functional decline of neural stem cells in Alzheimer's disease.
Article
Food Science & Technology
Muzamil Ahmad, Nawab J. Dar
SUSTAINED ENERGY FOR ENHANCED HUMAN FUNCTIONS AND ACTIVITY
(2017)
Meeting Abstract
Oncology
Javeed Ahmad Bhat, Mudassier Ahmad, Nawab John Dar, Aashiq Hussain, Rauf Ahmad Najar, Simmi Sharma, Mubashir Javeed Minto, Dilip Manikrao Mondhe, Vaqar M. Adhami, Bhahwal Ali Shah, Neena Caplash, Abid Hamid
Article
Environmental Sciences
Mohammad Iqbal Lone, Arisa Nabi, Nawab John Dar, Aashiq Hussain, Nazia Nazam, Abid Hamid, Waseem Ahmad