The newborn sheep translational model for pulmonary arterial hypertension of the neonate at high altitude

Intervention against hypertension in the next generation programmed by developmental hypoxia

(2019) Kirsty L. Brain et al.   PLOS BIOLOGY

Oxygen radical disease in the newborn, revisited: Oxidative stress and disease in the newborn period

(2019) Marta Perez et al.   FREE RADICAL BIOLOGY AND MEDICINE

Genomic signatures of high-altitude adaptation in Ethiopian sheep populations

(2019) Zewdu Edea et al.   Genes & Genomics

Antenatal melatonin modulates an enhanced antioxidant/pro-oxidant ratio in pulmonary hypertensive newborn sheep

(2019) Alejandro Gonzalez-Candia et al.   Redox Biology

miRNA-PDGFRB/HIF1A-lncRNA CTEPHA1 Network Plays Important Roles in the Mechanism of Chronic Thromboembolic Pulmonary Hypertension

(2019) Maozhou Wang et al.   International Heart Journal

Epigenetic responses and the developmental origins of health and disease

(2019) Dipali Goyal et al.   JOURNAL OF ENDOCRINOLOGY

Gut microbiota adaptation to high altitude in indigenous animals

(2019) Yan Ma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of nitric oxide signaling in pulmonary circulation of high- and low-altitude newborn sheep under basal and acute hypoxic conditions

(2019) Emilio A. Herrera et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Long-Term High-Altitude Hypoxia and Alpha Adrenoceptor-Dependent Pulmonary Arterial Contractions in Fetal and Adult Sheep

(2019) Dafne Moretta et al.   Frontiers in Physiology

Dynamic and diverse changes in the functional properties of vascular smooth muscle cells in pulmonary hypertension

(2018) Kurt R Stenmark et al.   CARDIOVASCULAR RESEARCH

The role of nitric oxide in the cardiopulmonary response to hypoxia in highland and lowland newborn llamas

(2018) Roberto V. Reyes et al.   JOURNAL OF PHYSIOLOGY-LONDON

Altered autonomic control of heart rate variability in the chronically hypoxic fetus

(2018) C. J. Shaw et al.   JOURNAL OF PHYSIOLOGY-LONDON

Long-term high altitude hypoxia during gestation suppresses large conductance Ca2+ -activated K+ channel function in uterine arteries: a causal role for microRNA-210

(2018) Xiang-Qun Hu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Systemic and transdermal melatonin administration prevents neuropathology in response to perinatal asphyxia in newborn lambs

(2018) James D. S. Aridas et al.   JOURNAL OF PINEAL RESEARCH

Circulatory changes during gestational development of the sheep and human fetus

(2018) Abraham M. Rudolph   PEDIATRIC RESEARCH

Persistent pulmonary hypertension alters epigenetic characteristics of endothelial nitric oxide synthase gene in a fetal lamb model

(2018) Xingrao Ke et al.   PHYSIOLOGICAL GENOMICS

Gestational Hypoxia and Developmental Plasticity

(2018) Charles A. Ducsay et al.   PHYSIOLOGICAL REVIEWS

Melatonin Decreases Pulmonary Vascular Remodeling and Oxygen Sensitivity in Pulmonary Hypertensive Newborn Lambs

(2018) Cristian R. Astorga et al.   Frontiers in Physiology

Revisiting the Role of TRP, Orai, and ASIC Channels in the Pulmonary Arterial Response to Hypoxia

(2018) Roberto V. Reyes et al.   Frontiers in Physiology

Newborn screening for congenital heart disease using echocardiography and follow-up at high altitude in China

(2018) Jing-Jing Li et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Improving pregnancy outcomes in humans through studies in sheep

(2018) Janna L. Morrison et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives

(2018) Marc Humbert et al.   EUROPEAN RESPIRATORY JOURNAL

Expression and trafficking of placental microRNAs at the feto-maternal interface

(2017) Guojing Chang et al.   FASEB JOURNAL

Effects of antenatal melatonin therapy on lung structure in growth-restricted newborn lambs

(2017) Graeme R. Polglase et al.   JOURNAL OF APPLIED PHYSIOLOGY

Maternal chronic hypoxia increases expression of genes regulating lung liquid movement and surfactant maturation in male fetuses in late gestation

(2017) Erin V. McGillick et al.   JOURNAL OF PHYSIOLOGY-LONDON

Potential adverse effects of antenatal melatonin as a treatment for intrauterine growth restriction: findings in pregnant sheep

(2016) Alejandro González-Candia et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

2-Aminoethyldiphenylborinate modifies the pulmonary circulation in pulmonary hypertensive newborn lambs partially gestated at high altitude

(2016) S. Castillo-Galán et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Decreased endothelial nitric oxide synthase expression and function contribute to impaired mitochondrial biogenesis and oxidative stress in fetal lambs with persistent pulmonary hypertension

(2016) Adeleye J. Afolayan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Role of the RhoA/ROCK pathway in high-altitude associated neonatal pulmonary hypertension in lambs

(2016) Nandy C. Lopez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Placental Hypoxia During Early Pregnancy Causes Maternal Hypertension and Placental Insufficiency in the Hypoxic Guinea Pig Model

(2016) L. P. Thompson et al.   BIOLOGY OF REPRODUCTION

Assessment ofin vivofetal growth and placental vascular function in a novel intrauterine growth restriction model of progressive uterine artery occlusion in guinea pigs

(2016) Emilio A. Herrera et al.   JOURNAL OF PHYSIOLOGY-LONDON

Fetalin vivocontinuous cardiovascular function during chronic hypoxia

(2016) B. J. Allison et al.   JOURNAL OF PHYSIOLOGY-LONDON

Genome-wide analysis reveals adaptation to high altitudes in Tibetan sheep

(2016) Caihong Wei et al.   Scientific Reports

Genomic analysis identified a potential novel molecular mechanism for high-altitude adaptation in sheep at the Himalayas

(2016) Neena Amatya Gorkhali et al.   Scientific Reports

Increased lung prolyl hydroxylase and decreased glucocorticoid receptor are related to decreased surfactant protein in the growth-restricted sheep fetus

(2015) Sandra Orgeig et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Epigenetics and Metabolism

(2015) S. T. Keating et al.   CIRCULATION RESEARCH

Cardiovascular function in term fetal sheep conceived, gestated and studied in the hypobaric hypoxia of the Andeanaltiplano

(2015) Emilio A. Herrera et al.   JOURNAL OF PHYSIOLOGY-LONDON

Melatonin reduces oxidative stress and improves vascular function in pulmonary hypertensive newborn sheep

(2015) Flavio Torres et al.   JOURNAL OF PINEAL RESEARCH

Uterine artery blood flow, fetal hypoxia and fetal growth

(2015) V. A. Browne et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Understanding the epigenetics of neurodevelopmental disorders and DOHaD

(2015) T. Kubota et al.   Journal of Developmental Origins of Health and Disease

Disturbances in Maternal Steroidogenesis and Appearance of Intrauterine Growth Retardation at High-Altitude Environments Are Established from Early Pregnancy. Effects of Treatment with Antioxidant Vitamins

(2015) Victor H. Parraguez et al.   PLoS One

Chronic intrauterine pulmonary hypertension increases main pulmonary artery stiffness and adventitial remodeling in fetal sheep

(2014) R. Blair Dodson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Maternal melatonin administration mitigates coronary stiffness and endothelial dysfunction, and improves heart resilience to insult in growth restricted lambs

(2014) Marianne Tare et al.   JOURNAL OF PHYSIOLOGY-LONDON

Melatonin improves cerebrovascular function and decreases oxidative stress in chronically hypoxic lambs

(2014) Emilio A. Herrera et al.   JOURNAL OF PINEAL RESEARCH

Early Developmental Conditioning of Later Health and Disease: Physiology or Pathophysiology?

(2014) M. A. Hanson et al.   PHYSIOLOGICAL REVIEWS

MicroRNA expression profile in intrauterine hypoxia-induced pulmonary hypoplasia in rats

(2014) HUIYI HUO et al.   Experimental and Therapeutic Medicine

The placental pursuit for an adequate oxidant balance between the mother and the fetus

(2014) Emilio A. Herrera et al.   Frontiers in Pharmacology

Store-operated channels in the pulmonary circulation of high- and low-altitude neonatal lambs

(2013) Daniela Parrau et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Serotonin contributes to high pulmonary vascular tone in a sheep model of persistent pulmonary hypertension of the newborn

(2013) Cassidy Delaney et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Antenatal Hypoxia and Pulmonary Vascular Function and Remodeling

(2013) Demosthenes Papamatheakis et al.   Current Vascular Pharmacology

Calcium Homeostasis and Sensitization in Pulmonary Arterial Smooth Muscle

(2013) Nikki L. Jernigan et al.   MICROCIRCULATION

Effect of Prenatal Hypoxia in Transgenic Mouse Models of Preeclampsia and Fetal Growth Restriction

(2013) C. F. Rueda-Clausen et al.   Reproductive Sciences

Developmental programming of cardiovascular disease by prenatal hypoxia

(2013) D. A. Giussani et al.   Journal of Developmental Origins of Health and Disease

Pulmonary artery smooth muscle cell proliferation and migration in fetal lambs acclimatized to high-altitude long-term hypoxia: role of histone acetylation

(2012) Qiwei Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Decreases in manganese superoxide dismutase expression and activity contribute to oxidative stress in persistent pulmonary hypertension of the newborn

(2012) Adeleye J. Afolayan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Effect of chronic perinatal hypoxia on the role of rho-kinase in pulmonary artery contraction in newborn lambs

(2012) Arlin B. Blood et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Physiology of Transition from Intrauterine to Extrauterine Life

(2012) Noah H. Hillman et al.   CLINICS IN PERINATOLOGY

Hypoxia induces downregulation of soluble guanylyl cyclase  1 by miR-34c-5p

(2012) X. Xu et al.   JOURNAL OF CELL SCIENCE

Hypoxic Pulmonary Vasoconstriction

(2012) J. T. Sylvester et al.   PHYSIOLOGICAL REVIEWS

Fetal stress and programming of hypoxic/ischemic-sensitive phenotype in the neonatal brain: Mechanisms and possible interventions

(2012) Yong Li et al.   PROGRESS IN NEUROBIOLOGY

NFATc3 is required for chronic hypoxia-induced pulmonary hypertension in adult and neonatal mice

(2011) R. Bierer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Fetal and postnatal pulmonary circulation in the Alto Andino

(2011) A.J. Llanos et al.   PLACENTA

On the Origin of Tibetans and Their Genetic Basis in Adapting High-Altitude Environments

(2011) Binbin Wang et al.   PLoS One

Epigenetic Mechanisms of Pulmonary Hypertension

(2011) Gene H. Kim et al.   Pulmonary Circulation

Long-term exposure to high-altitude chronic hypoxia during gestation induces neonatal pulmonary hypertension at sea level

(2010) Emilio A. Herrera et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Effects of Rho-Kinase Inhibition on Pulmonary Hypertension, Lung Growth, and Structure in Neonatal Rats Chronically Exposed to Hypoxia

(2010) Adrian J A Ziino et al.   PEDIATRIC RESEARCH

Milrinone enhances relaxation to prostacyclin and iloprost in pulmonary arteries isolated from lambs with persistent pulmonary hypertension of the newborn

(2009) Satyan Lakshminrusimha et al.   Pediatric Critical Care Medicine

Sildenafil Reverses Hypoxic Pulmonary Hypertension in Highland and Lowland Newborn Sheep

(2009) Emilio A Herrera et al.   PEDIATRIC RESEARCH

Betamethasone Attenuates Oxidant Stress in Endothelial Cells from Fetal Lambs with Persistent Pulmonary Hypertension

(2009) Indira Chandrasekar et al.   PEDIATRIC RESEARCH

Endothelin receptor blockade in the management of pulmonary arterial hypertension: Selective and dual antagonism

(2009) Terence K. Trow et al.   RESPIRATORY MEDICINE

Superoxide dismutase restores eNOS expression and function in resistance pulmonary arteries from neonatal lambs with persistent pulmonary hypertension

(2008) Kathryn N. Farrow et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Chronic hypoxia induces Rho kinase-dependent myogenic tone in small pulmonary arteries

(2008) Brad R. S. Broughton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Upregulation of vascular calcium channels in neonatal piglets with hypoxia-induced pulmonary hypertension

(2008) Dinesh K. Hirenallur-S. et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

NOX4 mediates hypoxia-induced proliferation of human pulmonary artery smooth muscle cells: the role of autocrine production of transforming growth factor-β1 and insulin-like growth factor binding protein-3

(2008) Saleh Ismail et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Child health and living at high altitude

(2008) S Niermeyer et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Effect of long-term high-altitude hypoxia on fetal pulmonary vascular contractility

(2008) Qin Xue et al.   JOURNAL OF APPLIED PHYSIOLOGY

Molecular pathogenesis of pulmonary arterial hypertension

(2008) Marlene Rabinovitch   JOURNAL OF CLINICAL INVESTIGATION