Article
Immunology
David B. Bartlett, Erik D. Hanson, Jordan T. Lee, Chad W. Wagoner, Elizabeth P. Harrell, Stephanie A. Sullivan, Lauren C. Bates, Mohamdod S. Alzer, Dean J. Amatuli, Allison M. Deal, Brian C. Jensen, Grace MacDonald, Michael A. Deal, Hyman B. Muss, Kirsten A. Nyrop, Claudio L. Battaglini
Summary: Breast cancer survivors have an increased risk of infections following therapy due to age and cancer-induced dysregulation of inflammation and neutrophil functions. Exercise training may improve neutrophil functions in these survivors, although limited data exist supporting this assertion.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Christina M. Dieli-Conwright, Nathalie Sami, Mary K. Norris, Junxiang Wan, Hiroshi Kumagai, Su-Jeong Kim, Pinchas Cohen
Summary: MOTS-c, a mitochondrial derived peptide, has exercise mimetic activity with beneficial effects on metabolism and exercise capacity. The effects of MOTS-c in breast cancer survivors are influenced by race and a 16-week exercise intervention can increase MOTS-c levels among non-Hispanic White BCS.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Isley Jesus, Pauline Michel-Flutot, Therese B. Deramaudt, Alexia Paucard, Valentin Vanhee, Stephane Vinit, Marcel Bonay
Summary: This study demonstrated the feasibility of using a mouse model of partial cervical spinal hemisection to investigate the impact of exercise training on locomotor/respiratory plasticity muscles. The results showed that exercise training increased running capacity, improved muscle vascularization, and enhanced fatigue resistance in trained SCI mice, suggesting a promising non-invasive strategy to sustain locomotor and respiratory muscle plasticity following SCI.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Fatemeh Abbasi, Hanieh Pourjalali, Israel Junior Borges do Nascimento, Nikan Zargarzadeh, Seyed Mohammad Mousavi, Rasoul Eslami, Alireza Milajerdi
Summary: Exercise training has a significant impact on inflammatory biomarkers in breast cancer patients, with a notable reduction in CRP levels, especially evident in long-term interventions and concurrent training. However, no significant changes were observed in serum levels of TNF-alpha, IL-6, IL-8, IL-10, INF-gamma, and IL-1I3 following exercise training. Further research is needed to explore more details in this area.
Article
Oncology
Joao Lucas Penteado Gomes, Gabriel Cardial Tobias, Tiago Fernandes, Andre Casanova Silveira, Carlos Eduardo Negrao, Roger Chammas, Patricia Chakur Brum, Edilamar Menezes Oliveira
Summary: The study found that cancer can affect the expression of muscle myomiRs, leading to muscle wasting, while aerobic exercise training can partially prevent this phenomenon. In the colon cancer model, muscle function decreased and the expression of microRNA-486 decreased, while in the breast cancer model, aerobic exercise training preserved muscle function and increased microRNA-206 expression. Circulating microRNA-206 may serve as a potential biomarker for colon and breast cancer.
Article
Oncology
Jason Cohen, Wendy A. Rogers, Steven Petruzzello, Linda Trinh, Sean P. Mullen
Summary: This feasibility trial tested the acute effects of aerobic exercise and technology-guided mindfulness training on cancer-related fatigue among breast cancer survivors. The results indicate that combining aerobic exercise with mindfulness training had more favorable outcomes compared to standalone interventions, showing promising potential for addressing fatigue in BCS. If replicated in longer trials, this combined approach may offer broad-reaching interventions for improved outcomes in BCS.
Article
Cell Biology
Zeyu Xing, Ruojiao Wang, Xin Wang, Jiaqi Liu, Menglu Zhang, Kexin Feng, Xiang Wang
Summary: The study demonstrated that circPDCD11 functions as an oncogene in triple-negative breast cancer (TNBC), promoting metabolic activity and tumor growth. This circRNA serves as a miRNA sponge to upregulate LDHA expression, providing a potential prognostic biomarker for TNBC.
CELL DEATH DISCOVERY
(2021)
Article
Sport Sciences
Anouk E. Hiensch, Sara Mijwel, David Bargiela, Yvonne Wengstrom, Anne M. May, Helene Rundqvist
Summary: The OptiTrain trial demonstrated that supervised resistance and high-intensity interval training partially counteracted the chemotherapy-induced increase in inflammation, leading to lower fatigue levels post intervention. This suggests that exercise intervention can effectively reduce chemotherapy-induced inflammation and subsequent fatigue.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Review
Biochemistry & Molecular Biology
Sherif Attalla, Tarek Taifour, Tung Bui, William Muller
Summary: Understanding breast cancer progression, metastasis, and therapeutic discovery is crucial. The MMTV-PyMT mouse model is a valuable tool that helps researchers better understand the molecular basis of breast cancer.
Article
Education & Educational Research
Yuan Zhao, Chuan Qin, Deming Shu, Dianzhi Liu
Summary: This article explores the impact of short-term aerobic exercise on college students' creativity. Through two studies, it was found that short-term aerobic exercise can immediately improve the performance of convergent creativity and divergent creativity, but it is ineffective after a 30-minute delay.
THINKING SKILLS AND CREATIVITY
(2022)
Review
Oncology
Hong-Juan Zhou, Tao Wang, Yong-Zhi Xu, Yan-Nan Chen, Li-Jing Deng, Chang Wang, Jin-Xiu Chen, Jing-Yu (Benjamin) Tan
Summary: Exercise interventions, particularly yoga and aerobic exercise, have a positive effect on alleviating cancer-related fatigue (CRF) in breast cancer patients. Exercising for over 6 months, three times per week, and for 30 to 60 minutes per session can lead to moderate improvement in CRF. Supervised exercise is more effective in relieving CRF than unsupervised exercise.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Chemistry, Multidisciplinary
Xiujuan Zhang, Fei Luo, Shaliu Luo, Ling Li, Xinxin Ren, Jing Lin, Yingchun Liang, Chao Ma, Lihua Ding, Deyu Zhang, Tianxing Ye, Yanni Lin, Bilian Jin, Shan Gao, Qinong Ye
Summary: Aerobic glycolysis, or the Warburg effect, is a critical process in cancer cell growth and metastasis. This study demonstrates that the transcription factor OVOL2 can directly repress glycolytic gene expression to block the Warburg effect. The activation of OVOL2 by the tumor suppressor p53 through inhibiting MDM2-mediated degradation presents a potential avenue for cancer treatment, particularly in breast cancer.
Article
Oncology
Angelina T. Regua, Austin Arrigo, Daniel Doheny, Grace L. Wong, Hui-Wen Lo
Summary: Transgenic breast cancer mouse models are essential for preclinical studies, allowing for modeling of abnormal genetic events commonly seen in human breast cancers. By employing tissue-specific genetic manipulation, these models can mimic spontaneous mammary tumorigenesis by expressing oncogenes or deleting tumor suppressors. The variability in characteristics and strain-dependent features of these models can be utilized to study different aspects of mammary tumorigenesis and metastasis.
Review
Oncology
Zhu-yue Ma, Shan-shan Yao, Yan-yan Shi, Ning-ning Lu, Fang Cheng
Summary: This study aimed to assess the effects of aerobic exercise (AE) on parameters related to cardiotoxicity in breast cancer patients receiving anthracycline or trastuzumab treatment. The findings of the systematic review and meta-analysis showed that AE significantly improved cardiorespiratory fitness and peak oxygen consumption (VO2 peak), and when combined with resistance exercise, it led to a lower risk of adverse effects and better results. Overall, AE was deemed safe, feasible, and promising for improving the levels of cardiotoxicity in these patients.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Immunology
Janice K. Kiecolt-Glaser, Megan Renna, Juan Peng, John Sheridan, Maryam Lustberg, Bhuvaneswari Ramaswamy, Robert Wesolowski, Jeffrey B. VanDeusen, Nicole O. Williams, Sagar D. Sardesai, Anne M. Noonan, Raquel E. Reinbolt, Daniel G. Stover, Mathew A. Cherian, William B. Malarkey, Rebecca Andridge
Summary: This study investigated the inflammatory responses of breast cancer survivors to a typhoid vaccine as an indicator of their innate immune response to new pathogens. The results showed that chemotherapy and central obesity were associated with smaller vaccine responses. Women with lower fitness levels also had reduced vaccine responses.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
