Soluplus-Mediated Diosgenin Amorphous Solid Dispersion with High Solubility and High Stability: Development, Characterization and Oral Bioavailability

Polymer/lipid interplay in altering in vitro supersaturation and plasma concentration of a model poorly soluble drug

(2020) Rui Peng et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Drug-carrier binding and enzymatic carrier digestion in amorphous solid dispersions containing proteins as carrier

(2019) Timothy Pas et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Hot melt extrusion technology for improved dissolution, solubility and “spring-parachute” processes of amorphous self-micellizing solid dispersions containing BCS II drugs indomethacin and fenofibrate: Profiles and mechanisms

(2019) Nian-Qiu Shi et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Stability and Bioavailability Enhancement of Telmisartan Ternary Solid Dispersions: the Synergistic Effect of Polymers and Drug-Polymer(s) Interactions

(2019) Xiangjun Shi et al.   AAPS PHARMSCITECH

The role of sodium alginate on the supersaturation state of the poorly soluble drug chlorthalidone

(2019) Maria Terezinha França et al.   CARBOHYDRATE POLYMERS

Drug–polymer miscibility, interactions, and precipitation inhibition studies for the development of amorphous solid dispersions for the poorly soluble anticancer drug flutamide

(2019) Anne Trivino et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Diosgenin ameliorates testicular damage in streptozotocin-diabetic rats through attenuation of apoptosis, oxidative stress, and inflammation

(2019) Zeinab Khosravi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Daunorubicin oral bioavailability enhancement by surface coated natural biodegradable macromolecule chitosan based polymeric nanoparticles

(2019) Niyaz Ahmad et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Solubility and stability enhancement of curcumin in Soluplus® polymeric micelles: a spectroscopic study

(2019) Swati Rani et al.   JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY

Solubility and bioavailability enhancement study of lopinavir solid dispersion matrixed with a polymeric surfactant - Soluplus

(2019) Peng Zi et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Complex amorphous solid dispersions based on poly(2-hydroxyethyl methacrylate): Study of drug release from a hydrophilic insoluble polymeric carrier in the presence and absence of a porosity increasing agent

(2019) Melissa Everaerts et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Andrographolide solid dispersions formulated by Soluplus to enhance interface wetting, dissolution, and absorption

(2019) Bing Song et al.   JOURNAL OF APPLIED POLYMER SCIENCE

Comparative study of the potential of poly(2-ethyl-2-oxazoline) as carrier in the formulation of amorphous solid dispersions of poorly soluble drugs

(2019) Eline Boel et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Mechanisms of increased bioavailability through amorphous solid dispersions: a review

(2019) Andreas Schittny et al.   DRUG DELIVERY

Solid dispersions of telaprevir with improved solubility prepared by co-milling: formulation, physicochemical characterization, and cytotoxicity evaluation

(2019) Xinnuo Xiong et al.   Materials Science & Engineering C-Materials for Biological Applications

Approaches to increase mechanistic understanding and aid in the selection of precipitation inhibitors for supersaturating formulations - a PEARRL review

(2018) Daniel J. Price et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Microbial biotransformation of bioactive and clinically useful steroids and some salient features of steroids and biotransformation

(2018) Nighat Sultana   STEROIDS

Influence of novel carrier Soluplus® on aqueous stability, oral bioavailability, and anticancer activity of Morin hydrate

(2018) Abhijeet D. Kulkarni et al.   DRYING TECHNOLOGY

Design, optimization, characterization and in-vivo evaluation of Quercetin enveloped Soluplus®/P407 micelles in diabetes treatment

(2018) Juhi Singh et al.   Artificial Cells Nanomedicine and Biotechnology

Cellulose based polymers in development of amorphous solid dispersions

(2018) Rahul B Chavan et al.   Asian Journal of Pharmaceutical Sciences

Screening, preparation and characterization of diosgenin versatile solvates

(2018) Ningbo Gong et al.   STEROIDS

Effect of orally ingested diosgenin into diet on skin collagen content in a low collagen skin mouse model and its mechanism of action

(2017) Akinori Haratake et al.   LIFE SCIENCES

Preparation and Evaluation of Diosgenin Nanocrystals to Improve Oral Bioavailability

(2016) Cui-zhe Liu et al.   AAPS PHARMSCITECH

Amorphous solid dispersions: Rational selection of a manufacturing process

(2016) Teófilo Vasconcelos et al.   ADVANCED DRUG DELIVERY REVIEWS

Non-invasive insight into the release mechanisms of a poorly soluble drug from amorphous solid dispersions by confocal Raman microscopy

(2016) Kateřina Punčochová et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Solvent-shift strategy to identify suitable polymers to inhibit humidity-induced solid-state crystallization of lacidipine amorphous solid dispersions

(2016) Mengchi Sun et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Effect of Liuwei Dihuang decoction, a traditional Chinese medicinal prescription, on the neuroendocrine immunomodulation network

(2016) Wenxia Zhou et al.   PHARMACOLOGY & THERAPEUTICS

UPLC-QTOF-MS identification of metabolites in rat biosamples after oral administration of Dioscorea saponins: A comparative study

(2015) Yi-Na Tang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Effect of β-Cyclodextrin Derivatives on the Diosgenin Absorption in Caco-2 Cell Monolayer and Rats

(2014) Masaki Okawara et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The effects of diosgenin in the Regulation of renal proximal tubular fibrosis

(2014) Wei-Cheng Wang et al.   EXPERIMENTAL CELL RESEARCH

Effect of liquid crystals with cyclodextrin on the bioavailability of a poorly water-soluble compound, diosgenin, after its oral administration to rats

(2014) Masaki Okawara et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Biological ingredient analysis of traditional Chinese medicine preparation based on high-throughput sequencing: the story for Liuwei Dihuang Wan

(2014) Xinwei Cheng et al.   Scientific Reports

Crosslinked hydrogels—a promising class of insoluble solid molecular dispersion carriers for enhancing the delivery of poorly soluble drugs

(2014) Dajun D. Sun et al.   Acta Pharmaceutica Sinica B

Both solubility and chemical stability of curcumin are enhanced by solid dispersion in cellulose derivative matrices

(2013) Bin Li et al.   CARBOHYDRATE POLYMERS

HPMC as a potential enhancer of nimodipine biopharmaceutical properties via ball-milled solid dispersions

(2013) Manoela Klüppel Riekes et al.   CARBOHYDRATE POLYMERS

Characterization and performance assessment of solid dispersions prepared by hot melt extrusion and spray drying process

(2013) Anjali M. Agrawal et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Diosgenin improves vascular function by increasing aortic eNOS expression, normalize dyslipidemia and ACE activity in chronic renal failure rats

(2013) Jeganathan Manivannan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Impact of amorphous and semicrystalline polymers on the dissolution and crystallization inhibition of pioglitazone solid dispersions

(2013) Nian-Qiu Shi et al.   POWDER TECHNOLOGY

Solid dispersions containing ursolic acid in Poloxamer 407 and PEG 6000: A comparative study of fusion and solvent methods

(2013) Josimar Oliveira Eloy et al.   POWDER TECHNOLOGY

Protein Carbonylation, Mitochondrial Dysfunction, and Insulin Resistance

(2013) Brigitte I. Frohnert et al.   Advances in Nutrition

Diosgenin promotes oligodendrocyte progenitor cell differentiation through estrogen receptor-mediated ERK1/2 activation to accelerate remyelination

(2012) Lin Xiao et al.   GLIA

Solution Behavior of PVP-VA and HPMC-AS-Based Amorphous Solid Dispersions and Their Bioavailability Implications

(2012) Feng Qian et al.   PHARMACEUTICAL RESEARCH

Application of Drug Nanocrystal Technologies on Oral Drug Delivery of Poorly Soluble Drugs

(2012) Lei Gao et al.   PHARMACEUTICAL RESEARCH

Soluplus®: A novel polymeric solubilizer for optimization of Carvedilol solid dispersions: Formulation design and effect of method of preparation

(2012) Rehab N. Shamma et al.   POWDER TECHNOLOGY

Effect of different preparation methods on the dissolution behaviour of amorphous indomethacin

(2011) Pranav Karmwar et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Solvent shift method for anti-precipitant screening of poorly soluble drugs using biorelevant medium and dimethyl sulfoxide

(2011) Taro Yamashita et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Excipient-Mediated Supersaturation Stabilization in Human Intestinal Fluids

(2011) Jan Bevernage et al.   MOLECULAR PHARMACEUTICS

Coexistence of passive and carrier-mediated processes in drug transport

(2010) Kiyohiko Sugano et al.   NATURE REVIEWS DRUG DISCOVERY

Acute toxicity and sub-chronic toxicity of steroidal saponins from Dioscorea zingiberensis C.H.Wright in rodents

(2009) Yuan Qin et al.   JOURNAL OF ETHNOPHARMACOLOGY

Polymorph control: past, present and future

(2008) Antonio Llinàs et al.   DRUG DISCOVERY TODAY