Article
Neurosciences
Tianxia Jia, Mengjie Wang, Wenjun Yan, Wenjuan Wu, Ruile Shen
Summary: miR-489-3p attenuates cerebral I/R injury by negatively regulating HDAC2.
Article
Biotechnology & Applied Microbiology
LiGuo Song, LuYan Mu, HongLiang Wang
Summary: This study found that elevated miR-489-3p aggravates neuronal apoptosis and oxidative stress induced by cerebral ischemia-reperfusion injury (CIRI) through targeting SIRT1. Down-regulating miR-489-3p or up-regulating SIRT1 can ameliorate the neural functional damage caused by CIRI.
Article
Environmental Sciences
Fuquan Ma, Jin Huang, Weizhi Li, Peijie Li, Mengying Liu, Hui Xue
Summary: MiR-455-3p expression is downregulated in hepatocellular carcinoma (HCC) tissues and cell lines. It inhibits cell proliferation and migration, and promotes cell apoptosis via targeting HDAC2 and activating the p53 pathway. These findings suggest that miR-455-3p could be a potential target for HCC treatment.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Han Seok Koh, SangJoon Lee, Hyo Jin Lee, Jae-Woong Min, Takeshi Iwatsubo, Charlotte E. Teunissen, Hyun-Jeong Cho, Jin-Hyeob Ryu
Summary: Treatment with miR-485-3p ASO reduces A beta plaque accumulation, tau pathology development, neuroinflammation, and cognitive decline in an AD transgenic mouse model by enhancing A beta clearance and reducing apoptosis. Additionally, miR-485-3p ASO administration decreases proinflammatory cytokine secretion, ultimately alleviating cognitive impairment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Rhafaela Lima Causin, Andre Van Helvoort Lengert, Izabela Natalia Faria Gomes, Ana Julia Aguiar De Freitas, Marcela Nunes Rosa, Ricardo Dos Reis, Rui Manuel Reis, Marcia Maria Chiquitelli Marques
Summary: miR-130a-3p is overexpressed in cervical cancer cells and plays a significant role in the development of cervical cancer. Inhibiting miR-130a-3p can significantly reduce the proliferation, migration, and invasion of cervical cancer cells. miR-130a-3p may regulate the biological functions of cervical cancer cells by directly targeting the DLL1 gene. Therefore, miR-130a-3p may serve as a biomarker for determining cervical cancer progression.
Article
Biotechnology & Applied Microbiology
Chanchan Gao, Yazhou Wen, Feng Jiang, Xuyu Gu, Xinhua Zhu
Summary: This study found that circ_0008274 is highly expressed in HCC, promoting proliferation, migration, and invasion of HCC cells. Depleting circ_0008274 inhibits malignant behaviors, with the mechanism involving upregulation of GRN to expedite HCC progression.
Article
Ophthalmology
Chung-Ling Liang, Ku-Chung Chen, Edward Hsi, Jui-Yu Lin, Chien-Yuan Chen, Jung-Kai Tseng, Suh-Hang H. Juo
Summary: This study investigated the role of miR-328-3p in controlling myopia. The results showed that anti-miR-328-3p could reduce the expression of fibromodulin and collagen1A1 in myopic eyes, and it exerted its effects by regulating the expression of TGF-beta 1 and phosphorylation levels of p38-MAPK and JNK. Additionally, retinoic acid was found to up-regulate the expression of miR-328-3p. Animal studies demonstrated that anti-miR-328-3p effectively suppressed axial elongation. The toxicity study showed that anti-miR-328-3p had no adverse effects.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Shun-Hong Mao, Chun-Hua Zhu, Yu Nie, Jian Yu, Lei Wang
Summary: Levobupivacaine induces ferroptosis of gastric cancer cells to repress cell growth by regulating the miR-489-3p/SLC7A11 axis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Cagdas Aktan, Cag Cal, Burcin Kaymaz, Nur Selvi Gunel, Sezgi Kipcak, Buket Ozel, Cumhur Gunduz, Ali Sahin Kucukaslan, Duygu Ayguenes Jafari, Buket Kosova
Summary: In this study, differentially expressed miRNAs that target androgen receptors (ARs) were identified and investigated in castration resistant prostate cancer (CRPC) cells. The expression levels of miR-625-5p and miR-874-3p were significantly increased in CRPC cells compared with androgen dependent cells, and transfection of CRPC cells with anti-miRs suppressed their proliferation and AR protein levels.
Article
Biotechnology & Applied Microbiology
Huey-En Tzeng, Chih-Hsin Tang, Chun-Hao Tsai, Chih-Hui Chiu, Min-Huan Wu, Yun Yen
Summary: Our study demonstrates that ET-1 induces EMT in human squamous cell carcinoma cell lines and promotes migration and invasion by downregulating miR-489-3p and enhancing TWIST signaling, suggesting a novel therapeutic target in OSCC metastasis.
ONCOTARGETS AND THERAPY
(2021)
Article
Oncology
Kyohei Yugawa, Tomoharu Yoshizumi, Yohei Mano, Shinji Itoh, Noboru Harada, Toru Ikegami, Kenichi Kohashi, Yoshinao Oda, Masaki Mori
Summary: The study revealed that the loss of miR-150-3p in CAFs-derived exosomes significantly promotes HCC progression. Exosomal miR-150-3p may serve as a potential prognostic biomarker, and transferring miR-150-3p-loaded exosomes to HCC cells could be a novel therapeutic option.
Article
Medicine, Research & Experimental
Jian Cui, Fei Xu, Wei Bai, Tiantian Zhao, Junbo Hong, Wei Zuo
Summary: The HDAC inhibitor ITF2357 restores miR-130a-3p expression by inhibiting HDAC2, thereby repressing Rad51 and ultimately diminishing the resistance of mutant KRAS NSCLC to pemetrexed.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Hongmei You, Ling Wang, Fangtian Bu, Hongwu Meng, Xueyin Pan, Juanjuan Li, Yafei Zhang, Ao Wang, Nana Yin, Cheng Huang, Jun Li
Summary: MiR-455-3p acts as a liver fibrosis suppressor by targeting HDAC2, and its deficiency further aggravates the reversal phase of fibrosis. Overexpression of miR-455-3p promotes apoptosis and reduces the expression of pro-fibrotic markers and proliferation in activated cells.
Article
Biochemistry & Molecular Biology
Guofeng Zhang, Yonglin Zhu, Chengzhen Jin, Qingpeng Shi, Xiaochun An, Licheng Song, Fengguang Gao, Shanhui Li
Summary: Circular RNA (circRNA) associated ceRNA network plays a critical role in the initiation and progression of osteosarcoma by upregulating CDK14 in a miR-330-3p-dependent manner.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Medicine, General & Internal
Xinling Cao, Jingjing Zhang, Shadike Apaer, Gang Yao, Tao Li
Summary: This study investigates the combined effects and mechanisms of miR-19a-3p and miR-376c-3p in hepatocellular carcinoma (HCC) cells, demonstrating their activation of the Wnt/beta-catenin pathway via targeting SOX6 to promote biological functions of HCC cells.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Mingzhe Jiang, Shuangjie Liu, Jiaxing Lin, Wenjun Hao, Baojun Wei, Ying Gao, Chuize Kong, Meng Yu, Yuyan Zhu
Summary: The study systematically analyzed the molecular changes and clinical correlations of HK family genes in 33 types of cancer from over 10,000 subjects, revealing extensive genetic changes in HK family genes with potential for predicting prognosis and therapeutic efficacy, as well as identifying HK1, HK2, and HK3 as potential oncogenes in various cancer types.
Review
Medicine, Research & Experimental
Chang Liu, Zhe Yang, Rong Li, Yanju Wu, Ming Chi, Shuting Gao, Xun Sun, Xin Meng, Biao Wang
Summary: m6A modification, a common internal modification on RNA molecules, has been linked to various human diseases, making it a research hotspot. This modification plays a regulatory role in immune responses, affecting disease development.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Baojun Wei, Meng Yu, Jihang Yao, Mingzhe Jiang, Jun An, Jieping Yang, Jiaxing Lin, Yongkang Zhao, Yuyan Zhu
Summary: The study comprehensively evaluated the immune microenvironment of KIRP and found that patients exhibited hot tumor characteristics, but CD8+ T cells did not limit tumor progression. Reversing CD8+ T-cell exhaustion may provide higher clinical benefits for patients with KIRP.
FRONTIERS IN IMMUNOLOGY
(2021)
Correction
Biotechnology & Applied Microbiology
Yexiang Huang, Yuyan Zhu, Zhe Zhang, Zhenhua Li, Chuize Kong
CANCER GENE THERAPY
(2022)
Correction
Oncology
Yang Du, Chuize Kong, Yuyan Zhu, Meng Yu, Zeliang Li, Jianbin Bi, Zhenhua Li, Xiankui Liu, Zhe Zhang, Xiuyue Yu
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Immunology
Jun Chen, Aihua Mei, Xinxin Liu, Zachary Braunstein, Yingying Wei, Biao Wang, Lihua Duan, Xiaoquan Rao, Sanjay Rajagopalan, Lingli Dong, Jixin Zhong
Summary: This study confirms the expression of GLP-1R in macrophages in inflammatory diseases. Deficiency of GLP-1R reduces macrophage migration and enhances interleukin-6 expression. In a gout model, recruitment of macrophages is suppressed in GLP-1R knockout mice.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Jiaxing Lin, Xiao Xu, Tianren Li, Jihang Yao, Meng Yu, Yuyan Zhu, Dan Sun
Summary: OLFML2B has been identified as a robust prognostic marker for bladder cancer, showing correlation with prognosis across multiple cohorts and affecting patient outcomes through influencing immune cell infiltration and cellular vitality.
FRONTIERS IN ONCOLOGY
(2021)
Editorial Material
Oncology
Yusuke Suenaga, Christer Einvik, Atsushi Takatori, Yuyan Zhu
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Ming Chi, Jiao Liu, Chenxue Mei, Yaxing Shi, Nanqi Liu, Xuefeng Jiang, Chang Liu, Nan Xue, Hong Hong, Jisheng Xie, Xun Sun, Bo Yin, Xin Meng, Biao Wang
Summary: This study identified BLCA-related genes and found that TEAD4 plays an important role in EMT dysregulation. Overexpression of TEAD4 is associated with poor prognosis, invasion, and metastasis of BLCA, mediated through the regulation of the PI3K/AKT pathway. Therefore, TEAD4 is not only an effective biomarker for predicting prognosis but also a potential target for the treatment of metastatic BLCA.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Horticulture
Yue Li, Weijia Jia, Qiong Wang, Biao Wang, Shu Wang
Summary: This study identified floral scent compounds in Chimonanthus praecox using headspace solid-phase microextraction gas chromatography-mass spectrometry. The results showed that the number and composition of floral scent compounds varied between different varieties of C. praecox, as well as with circadian rhythms, temperature, humidity, and light intensity. These findings contribute to the understanding of the biosynthesis and emission mechanisms of floral scent compounds in C. praecox.
SCIENTIA HORTICULTURAE
(2022)
Article
Medicine, Research & Experimental
Jingyan Gao, Chao Li, Xialu Wang, Xiaojie Sun, Rong Zhang, Chengcheng Chen, Meng Yu, Yongxiang Liu, Yuyan Zhu, Jie Chen
Summary: Oridonin has the potential to alleviate pneumonia and pulmonary fibrosis in experimental silicosis by suppressing inducible nitric oxide synthase (iNOS) expression and activity, reducing injury and inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Immunology
Haitao Hu, Ting Ma, Nanqi Liu, Hong Hong, Lujiao Yu, Dantong Lyu, Xin Meng, Biao Wang, Xuefeng Jiang
Summary: Vasculogenic mimicry (VM) is a vessel-like structure independent of endothelial cells, commonly found in solid tumors. It is closely associated with tumor proliferation, invasion, metastasis, and poor patient prognosis. Various factors, including immune cells, cytokines, and signaling molecules, have been reported to be involved in ovarian cancer progression and VM formation. This review discusses the mechanisms regulating VM formation in ovarian cancer, the impact of cells, cytokines, and signaling molecules in the tumor microenvironment on VM formation, and the current clinical application of drugs targeting VM formation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Shuangjie Liu, Lei Dou, Miao Miao, Xiaojun Man, Baojun Wei, Zhaowei Jiang, Yongze Ouyang, Toshinori Ozaki, Meng Yu, Yuyan Zhu
Summary: miR-138-2 functions as a novel epigenetic regulator of pro-oncogenic NOTCH1 pathway in renal cell carcinoma (RCC). It directly targets APH1A, MAML1, and NOTCH1 for the synergistic inhibition of NOTCH1 signaling. The feedback regulatory loop composed of HES1, miR-138-2, and NOTCH1 contributes to the malignant development of RCC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Immunology
Yan Xu, Zhixiu Xia, Xiaoyu Sun, Baojun Wei, Yang Fu, Du Shi, Yuyan Zhu
Summary: A novel Glutamine Metabolism Immunity Index (GMII) was established to predict the prognosis and therapeutic response of bladder cancer patients based on the analysis of glutamine metabolism-related genes. The GMII showed promising accuracy in predicting survival and immunotherapeutic efficacy in bladder cancer patients and identified potential small-molecule drugs targeting the GMII core target proteins.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Chang Liu, Yang Song, DeMing Li, Biao Wang
Summary: The tumor immune microenvironment (TIME) consists of immune cells, stromal cells, and tumor cells, and plays a crucial role in cancer progression and treatment outcomes. The Hippo pathway, a critical signaling pathway, has interactions with immune cells in the TIME, influencing cancer biology and therapy. Understanding the role of the Hippo pathway in immune responses and its potential as a therapeutic target can contribute to innovative cancer treatment strategies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)