Venetoclax causes metabolic reprogramming independent of BCL-2 inhibition

Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma

(2020) Richa Bajpai et al.   Nature Communications

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

(2019) Rumani Singh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles

(2019) Aldenor G. Santos et al.   Scientific Reports

Targeting mitochondrial structure sensitizes acute myeloid leukemia to Venetoclax treatment

(2019) Xufeng Chen et al.   Cancer Discovery

Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies

(2019) Romain Guièze et al.   CANCER CELL

Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response

(2019) David Sharon et al.   Science Translational Medicine

MCL-1 is a prognostic indicator and drug target in breast cancer

(2018) Kirsteen J. Campbell et al.   Cell Death & Disease

S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth

(2018) Patrick Casara et al.   Oncotarget

BCL2 and BCL(X)L selective inhibitors decrease mitochondrial ATP production in breast cancer cells and are synthetically lethal when combined with 2-deoxy-D-glucose

(2018) Federico Lucantoni et al.   Oncotarget

BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines

(2018) Delphine Merino et al.   CANCER CELL

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

(2017) Pedro M. Quirós et al.   JOURNAL OF CELL BIOLOGY

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane

(2016) Katelyn L. O'Neill et al.   GENES & DEVELOPMENT

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

(2016) András Kotschy et al.   NATURE

Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia

(2016) Andrew W. Roberts et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondrial dysfunction enhances cisplatin resistance in human gastric cancer cells via the ROS-activated GCN2-eIF2α-ATF4-xCT pathway

(2016) Sheng-Fan Wang et al.   Oncotarget

The Spectrum of Mitochondrial Ultrastructural Defects in Mitochondrial Myopathy

(2016) Amy E. Vincent et al.   Scientific Reports

Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis

(2015) Simone Cardaci et al.   NATURE CELL BIOLOGY

Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice

(2015) T. Wai et al.   SCIENCE

Integrated stress response is critical for gemcitabine resistance in pancreatic ductal adenocarcinoma

(2015) L R Palam et al.   Cell Death & Disease

Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency

(2013) Sara Cogliati et al.   CELL

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

(2013) Eleni D. Lagadinou et al.   Cell Stem Cell

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia

(2013) Julie Adam et al.   Cell Reports

A Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria

(2011) Fabien Llambi et al.   MOLECULAR CELL

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

(2011) Christian Frezza et al.   NATURE

UOK 262 cell line, fumarate hydratase deficient (FH−/FH−) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer

(2009) Youfeng Yang et al.   CANCER GENETICS AND CYTOGENETICS