PIK3C3 regulates the expansion of liver CSCs and PIK3C3 inhibition counteracts liver cancer stem cell activity induced by PI3K inhibitor

Targeting PI3K in cancer: mechanisms and advances in clinical trials

(2019) Jing Yang et al.   Molecular Cancer

Autophagy and cancer stem cells: molecular mechanisms and therapeutic applications

(2019) Francesca Nazio et al.   CELL DEATH AND DIFFERENTIATION

Prolonged inhibition of class I PI3K promotes liver cancer stem cell expansion by augmenting SGK3/GSK-3β/β-catenin signalling

(2018) Fengchao Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Rosmarinic Acid Activates AMPK to Inhibit Metastasis of Colorectal Cancer

(2018) Yo-Han Han et al.   Frontiers in Pharmacology

Targeting Cancer Stemness in the Clinic: From Hype to Hope

(2018) Caner Saygin et al.   Cell Stem Cell

AMPK Promotes SPOP-Mediated NANOG Degradation to Regulate Prostate Cancer Cell Stemness

(2018) Xinbo Wang et al.   DEVELOPMENTAL CELL

Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis

(2017) Daniela Sia et al.   GASTROENTEROLOGY

Shp2 promotes liver cancer stem cell expansion by augmenting β-catenin signaling and predicts chemotherapeutic response of patients

(2017) Daimin Xiang et al.   HEPATOLOGY

The evolving concept of liver cancer stem cells

(2017) Kouki Nio et al.   Molecular Cancer

Vps34 Kinase Domain Dynamics Regulate the Autophagic PI 3-Kinase Complex

(2017) Goran Stjepanovic et al.   MOLECULAR CELL

Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation

(2017) Fergal O’Farrell et al.   NATURE CELL BIOLOGY

Cancer stem cells revisited

(2017) Eduard Batlle et al.   NATURE MEDICINE

Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3

(2017) S Sengupta et al.   ONCOGENE

VPS34 stimulation of p62 phosphorylation for cancer progression

(2017) X Jiang et al.   ONCOGENE

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

(2017) Benoit Bilanges et al.   Nature Communications

The bad seed: Cancer stem cells in tumor development and resistance

(2016) Elle Koren et al.   DRUG RESISTANCE UPDATES

The hVps34‐SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth

(2016) Ruzica Bago et al.   EMBO JOURNAL

Hepatocellular carcinoma

(2016) Josep M. Llovet et al.   Nature Reviews Disease Primers

TGF-β1 acts through miR-155 to down-regulate TP53INP1 in promoting epithelial–mesenchymal transition and cancer stem cell phenotypes

(2015) Fengchao Liu et al.   CANCER LETTERS

AMPK Protects Leukemia-Initiating Cells in Myeloid Leukemias from Metabolic Stress in the Bone Marrow

(2015) Yusuke Saito et al.   Cell Stem Cell

The Long Noncoding RNA lncTCF7 Promotes Self-Renewal of Human Liver Cancer Stem Cells through Activation of Wnt Signaling

(2015) Yanying Wang et al.   Cell Stem Cell

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

(2014) Ruzica Bago et al.   BIOCHEMICAL JOURNAL

Hepatocellular carcinoma: clinical frontiers and perspectives

(2014) Jordi Bruix et al.   GUT

Cancer Epigenetics: Tumor Heterogeneity, Plasticity of Stem-like States, and Drug Resistance

(2014) Hariharan Easwaran et al.   MOLECULAR CELL

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

(2014) William E. Dowdle et al.   NATURE CELL BIOLOGY

A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

(2014) Baptiste Ronan et al.   Nature Chemical Biology

Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells

(2014) A. Janzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prognostic Significance of AMPK Activation and Therapeutic Effects of Metformin in Hepatocellular Carcinoma

(2013) L. Zheng et al.   CLINICAL CANCER RESEARCH

The multifaceted activities of AMPK in tumor progression-why the “one size fits all” definition does not fit at all?

(2013) Marcelo G. Bonini et al.   IUBMB LIFE

Vps34 Deficiency Reveals the Importance of Endocytosis for Podocyte Homeostasis

(2013) W. Bechtel et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

DEDD Interacts with PI3KC3 to Activate Autophagy and Attenuate Epithelial-Mesenchymal Transition in Human Breast Cancer

(2012) Q. Lv et al.   CANCER RESEARCH

Hepatocellular carcinoma

(2012) Alejandro Forner et al.   LANCET

Glioma-Initiating Cell Elimination by Metformin Activation of FOXO3 via AMPK

(2012) Atsushi Sato et al.   Stem Cells Translational Medicine

Unveiling the Secrets of the Ancestral PI3 Kinase Vps34

(2010) Paul Workman et al.   CANCER CELL