Journal
VIRUSES-BASEL
Volume 12, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/v12070742
Keywords
bacteriophages; safety; Salmonella; antibiotic alternative
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Bacteriophages are bacterial predators, which are garnering much interest nowadays vis-a-vis the global phenomenon of antimicrobial resistance. Bacteriophage preparations seem to be an alternative to antibiotics, which can be used at all levels of the food production chain. Their safety and efficacy, however, are of public concern. In this study, a detailed evaluation of BAFASAL(R)preparation was performed. BAFASAL(R)is a bacteriophage cocktail that reducesSalmonellain poultry farming. In vivo acute and sub-chronic toxicity studies on rats and tolerance study on targeted animals (chicken broiler) conducted according to GLP and OECD guidelines did not reveal any signs of toxicity, which could be associated with BAFASAL(R)administration. In addition, no evidences of genotoxicity were observed. The tolerance study with 100-times concentrated dose also did not show any statistically significant differences in the assessed parameters. The in vitro crop assay, mimicking normal feed storage and feed application conditions showed that BAFASAL(R)reduced the number ofSalmonellabacteria in experimentally contaminated feed. Moreover, reductions were observed for all examined forms (liquid, powder, spray). Furthermore, the in vivo efficacy study showed that treatment with BAFASAL(R)significantly decreasedSalmonellacontent in caeca of birds infected withSalmonellaEnteritidis. Detailed examination of BAFASAL(R)in terms of safety and efficacy, adds to the body of evidence that bacteriophages are harmless to animals and effective in the struggle against bacteria.
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